KEGG   ORTHOLOGY: K04432Help
Entry
K04432                      KO                                     

Name
MAP2K3, MKK3
Definition
mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04015  Rap1 signaling pathway
ko04218  Cellular senescence
ko04620  Toll-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05145  Toxoplasmosis
ko05164  Influenza A
ko05169  Epstein-Barr virus infection
Module
M00689  MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04010 MAPK signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04013 MAPK signaling pathway - fly
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04668 TNF signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04624 Toll and Imd signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04664 Fc epsilon RI signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09167 Infectious diseases
   05164 Influenza A
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05169 Epstein-Barr virus infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05145 Toxoplasmosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00689  MAPK (p38) signaling
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5606(MAP2K3)
PTR: 107972404
PPS: 100975020(MAP2K3)
GGO: 101145420(MAP2K3)
PON: 100457536(MAP2K3)
NLE: 100588703(MAP2K3)
MCC: 705195(MAP2K3)
MCF: 102116823(MAP2K3)
CSAB: 103242535(MAP2K3)
RRO: 104678467(MAP2K3)
RBB: 108521513(MAP2K3)
CJC: 100398593(MAP2K3)
SBQ: 101034633(MAP2K3)
MMU: 26397(Map2k3)
RNO: 108348082 303200(Map2k3)
CGE: 100756793(Map2k3)
NGI: 103724822(Map2k3)
HGL: 101718318(Map2k3)
CCAN: 109692052(Map2k3)
OCU: 100339953(MAP2K3)
TUP: 102499419(MAP2K3)
CFA: 489547(MAP2K3)
AML: 100476678(MAP2K3)
UMR: 103658475(MAP2K3)
ORO: 101378651(MAP2K3)
FCA: 101082274(MAP2K3)
PTG: 102949954(MAP2K3)
AJU: 106981449(MAP2K3)
BTA: 516039(MAP2K3)
BOM: 102267773(MAP2K3)
BIU: 109574182(MAP2K3)
PHD: 102315849(MAP2K3)
CHX: 102173967(MAP2K3)
OAS: 101122959(MAP2K3)
SSC: 110256149(MAP2K3)
CFR: 102523780(MAP2K3)
CDK: 105100607(MAP2K3)
BACU: 103019100(MAP2K3)
LVE: 103091611(MAP2K3)
OOR: 101275666(MAP2K3)
ECB: 100053481(MAP2K3)
EPZ: 103563092(MAP2K3)
EAI: 106825518(MAP2K3)
MYB: 102259712(MAP2K3)
MYD: 102765923(MAP2K3)
HAI: 109390353(MAP2K3)
RSS: 109437043(MAP2K3)
PALE: 102886389(MAP2K3)
LAV: 100675607(MAP2K3)
TMU: 101355711
MDO: 100016872(MAP2K3)
SHR: 100925586(MAP2K3)
OAA: 100080734(MAP2K3)
GGA: 416496(MAP2K3)
MGP: 100542290(MAP2K3)
CJO: 107320760(MAP2K3)
APLA: 101803371(MAP2K3)
ACYG: 106032094(MAP2K3)
TGU: 100229860(MAP2K3)
GFR: 102039295(MAP2K3)
FAB: 101809415(MAP2K3)
PHI: 102109535(MAP2K3)
PMAJ: 107211348(MAP2K3)
CCW: 104684789(MAP2K3)
FPG: 101919170(MAP2K3)
FCH: 102052703(MAP2K3)
CLV: 102085143(MAP2K3)
EGZ: 104132608(MAP2K3)
AAM: 106486833
ASN: 102383945(MAP2K3)
AMJ: 102566638(MAP2K3)
PSS: 102454019(MAP2K3)
CMY: 102939584(MAP2K3)
CPIC: 101936976(MAP2K3)
ACS: 100561588(map2k3)
PVT: 110087206(MAP2K3)
PBI: 103065723(MAP2K3)
GJA: 107120519
XLA: 108706146
SFM: 108923933(map2k3) 108941534
LCM: 102351267(MAP2K3)
CMK: 103185143
SKO: 102808764
DME: Dmel_CG12244(lic)
DSI: Dsimw501_GD24803(Dsim_lic)
MDE: 101897152
AAG: 5571505
AME: 725374(GB16739)
BIM: 100750211
BTER: 100650253
SOC: 105196733
AEC: 105144410
ACEP: 105622342
PBAR: 105431216
HST: 105192423
CFO: 105257778
LHU: 105669425
PGC: 109853168
NVI: 100120952
TCA: 661608
DPA: 109536941
NVL: 108559292
BMOR: 101744017
PMAC: 106718087
PRAP: 110992502
PXY: 105380228
API: 100164531
DNX: 107163491
ZNE: 110837639
FCD: 110850082
TSP: Tsp_02206
OBI: 106875802
SHX: MS3_03614
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8900184
  Authors
Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K, Nishida E
  Title
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.
  Journal
J Biol Chem 271:26981-8 (1996)
DOI:10.1074/jbc.271.43.26981
  Sequence
[hsa:5606] [mmu:26397]
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5606]

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