KEGG   ORTHOLOGY: K04440Help
Entry
K04440                      KO                                     

Name
JNK
Definition
mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Pathway
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04024  cAMP signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04212  Longevity regulating pathway - worm
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04310  Wnt signaling pathway
ko04380  Osteoclast differentiation
ko04391  Hippo signaling pathway - fly
ko04510  Focal adhesion
ko04530  Tight junction
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04723  Retrograde endocannabinoid signaling
ko04728  Dopaminergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04926  Relaxin signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05133  Pertussis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05164  Influenza A
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00688  MAPK (JNK) signaling
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04010 MAPK signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04013 MAPK signaling pathway - fly
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04012 ErbB signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04310 Wnt signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04391 Hippo signaling pathway -fly
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04668 TNF signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04068 FoxO signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04071 Sphingolipid signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04024 cAMP signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04137 Mitophagy - animal
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09143 Cell growth and death
   04210 Apoptosis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04214 Apoptosis - fly
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04215 Apoptosis - multiple species
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04217 Necroptosis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04530 Tight junction
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04624 Toll and Imd signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04621 NOD-like receptor signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04622 RIG-I-like receptor signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04625 C-type lectin receptor signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04658 Th1 and Th2 cell differentiation
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04659 Th17 cell differentiation
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04657 IL-17 signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04664 Fc epsilon RI signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04920 Adipocytokine signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04912 GnRH signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04914 Progesterone-mediated oocyte maturation
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04917 Prolactin signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04926 Relaxin signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09156 Nervous system
   04728 Dopaminergic synapse
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04723 Retrograde endocannabinoid signaling
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04722 Neurotrophin signaling pathway
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09158 Development
   04380 Osteoclast differentiation
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09149 Aging
   04212 Longevity regulating pathway - worm
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05231 Choline metabolism in cancer
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05210 Colorectal cancer
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05212 Pancreatic cancer
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04931 Insulin resistance
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05132 Salmonella infection
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05131 Shigellosis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05133 Pertussis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05152 Tuberculosis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05164 Influenza A
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05161 Hepatitis B
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05160 Hepatitis C
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05168 Herpes simplex infection
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05169 Epstein-Barr virus infection
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05145 Toxoplasmosis
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
   05142 Chagas disease (American trypanosomiasis)
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
  09168 Drug resistance
   01522 Endocrine resistance
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase)
BRITE hierarchy
Other DBs
GO: 0004705
Genes
HSA: 5599(MAPK8) 5601(MAPK9) 5602(MAPK10)
PTR: 450445(MAPK8) 461358(MAPK10) 462336(MAPK9)
PPS: 100982480(MAPK8) 100984173(MAPK10) 100990080(MAPK9)
GGO: 101124033(MAPK8) 101133141(MAPK10) 101152026(MAPK9)
PON: 100174482(MAPK10) 100437424(MAPK8) 100459133(MAPK9)
NLE: 100581677(MAPK9) 100602081(MAPK10) 100605285(MAPK8)
MCC: 699736(MAPK10) 711115(MAPK8) 715782(MAPK9)
MCF: 102118497(MAPK9) 102121272(MAPK10) 102126339(MAPK8)
CSAB: 103215844(MAPK8) 103235918(MAPK10) 103245120(MAPK9)
RRO: 104668007(MAPK10) 104676194(MAPK9) 104678447(MAPK8)
RBB: 108517508 108521141(MAPK10) 108537794(MAPK8)
CJC: 100387686(MAPK9) 100390109(MAPK10) 100392721(MAPK8)
SBQ: 101027742(MAPK9) 101039160(MAPK8) 101048066(MAPK10)
MMU: 26414(Mapk10) 26419(Mapk8) 26420(Mapk9)
RNO: 116554(Mapk8) 25272(Mapk10) 50658(Mapk9)
CGE: 100754361(Mapk10) 100764964(Mapk9) 100771734(Mapk8)
NGI: 103735023(Mapk8) 103748972(Mapk10) 103749366(Mapk9)
HGL: 101698286(Mapk9) 101712980(Mapk10) 101715259(Mapk8)
OCU: 100337999(MAPK10) 100342664(MAPK9) 100346929(MAPK8)
TUP: 102472233(MAPK8) 102475730(MAPK10) 102497095(MAPK9)
CFA: 474652(MAPK9) 477746(MAPK8) 478464(MAPK10)
AML: 100477600(MAPK9) 100477951(MAPK10) 100482196(MAPK8)
UMR: 103667893(MAPK8) 103676947(MAPK10) 103679990(MAPK9)
ORO: 101367488(MAPK10) 101374143(MAPK8) 101376185(MAPK9)
FCA: 101084765(MAPK9) 101091310(MAPK8) 101101463(MAPK10)
PTG: 102950880(MAPK8) 102959159(MAPK10) 102963096(MAPK9)
AJU: 106969894(MAPK9) 106970668(MAPK10) 106989581(MAPK8)
BTA: 534125(MAPK9) 537631(MAPK10) 539941(MAPK8)
BOM: 102266960(MAPK9) 102272421(MAPK10) 102277976(MAPK8)
BIU: 109553773(MAPK8) 109560650(MAPK10) 109561331(MAPK9)
PHD: 102323252(MAPK9) 102334117(MAPK8) 102344390(MAPK10)
CHX: 100861087(MAPK8) 102170408(MAPK9) 102182774(MAPK10)
OAS: 101116201(MAPK8) 101120665(MAPK10) 101120826(MAPK9)
SSC: 100521736(MAPK10) 396609(MAPK9) 396610(MAPK8)
CFR: 102503577(MAPK8) 102509448(MAPK10) 102518561(MAPK9)
CDK: 105091591(MAPK10) 105094659(MAPK8) 105100625(MAPK9)
BACU: 102997603(MAPK8) 103007019(MAPK9) 103008728(MAPK10)
LVE: 103078792(MAPK10) 103084630(MAPK8) 103087676(MAPK9)
OOR: 101277656(MAPK10) 101281228(MAPK8) 101287701(MAPK9)
ECB: 100051798(MAPK8) 100052608(MAPK10) 100057961(MAPK9)
EPZ: 103549414(MAPK8) 103553980(MAPK10) 103567629(MAPK9)
EAI: 106831384(MAPK8) 106839421(MAPK10) 106843729(MAPK9)
MYB: 102246292(MAPK8) 102259984(MAPK9) 102263026(MAPK10)
MYD: 102764416(MAPK8) 102772062(MAPK9) 102775351
HAI: 109377948 109392215(MAPK8) 109392748(MAPK9)
RSS: 109437630(MAPK9) 109446580(MAPK8) 109447204(MAPK10)
PALE: 102885064(MAPK10) 102890689(MAPK9) 102892777(MAPK8)
LAV: 100654943(MAPK9) 100673395(MAPK10) 100674229(MAPK8)
MDO: 100028089(MAPK9) 100618895(MAPK10)
SHR: 100924267(MAPK9) 100928480(MAPK10) 100930815(MAPK8)
OAA: 100073424(MAPK9) 100076033(MAPK8) 100082590(MAPK10)
GGA: 395983(MAPK9) 422592(MAPK10) 423778(MAPK8)
MGP: 100541011(MAPK9) 100542628(MAPK10) 100547737(MAPK8)
CJO: 107313439(MAPK10) 107315851(MAPK8) 107320159(MAPK9)
APLA: 101793594(MAPK8) 101799011(MAPK9) 101799776(MAPK10)
ACYG: 106032805(MAPK9) 106041872(MAPK10) 106047189(MAPK8)
TGU: 100220867(MAPK8) 100223519(MAPK10) 100225285(MAPK9)
GFR: 102036009(MAPK8) 102043222(MAPK9) 102043776(MAPK10)
FAB: 101809052(MAPK10) 101817339(MAPK8) 101819306(MAPK9)
PHI: 102099159(MAPK10) 102106744(MAPK9) 102114724(MAPK8)
PMAJ: 107203419(MAPK10) 107206805(MAPK8) 107210724(MAPK9)
CCW: 104689594(MAPK9) 104696634(MAPK8) 104697227(MAPK10)
FPG: 101917138(MAPK10) 101921076(MAPK9) 101924129(MAPK8)
FCH: 102047380(MAPK8) 102054176(MAPK10) 102055660(MAPK9)
CLV: 102085027(MAPK9) 102085840(MAPK10) 102087983(MAPK8)
EGZ: 104128427(MAPK9) 104129145(MAPK8) 104133994(MAPK10)
AAM: 106493457(MAPK9) 106496655(MAPK10) 106497812(MAPK8)
ASN: 102374542(MAPK10) 102376040(MAPK9) 102376154(MAPK8)
AMJ: 102566087(MAPK10) 102570366(MAPK8) 102570628(MAPK9)
PSS: 102453224(MAPK9) 102459702(MAPK8) 102460734(MAPK10)
CMY: 102932835(MAPK10) 102934812(MAPK9) 102935187(MAPK8)
CPIC: 101931056(MAPK8) 101936886(MAPK10) 101952425(MAPK9)
ACS: 100558211(mapk10) 100561907(mapk8) 100565814(mapk9)
PVT: 110073473(MAPK9) 110085327(MAPK10) 110087777(MAPK8)
PBI: 103049456(MAPK10) 103059296(MAPK9) 103060996
XLA: 108704101 108711504 379876(mapk8.L) 398499(mapk10.L)
XTR: 100170194(mapk8) 779515(mapk10)
NPR: 108794648 108804455(MAPK10)
DRE: 100149273(mapk9) 562720(mapk8a) 569698(mapk10) 65236(mapk8b)
IPU: 108263675(mapk8b) 108274025 108278438 108278622(mapk9)
TRU: 101067839(mapk10) 101070190(mapk8) 101073575 101078548(mapk9)
LCO: 104922720(mapk9) 104924269 104926477(mapk10) 104928586(mapk8)
NCC: 104954536(mapk10) 104962527(mapk8) 104965693(mapk9)
MZE: 101476882 101477577 101480702(mapk8) 101486303(mapk10)
XMA: 102221148(mapk8) 102226476(mapk10) 102234094 102237237
PRET: 103471253 103473893(mapk10) 103476945 103482024(mapk8)
NFU: 107374715(mapk10) 107375638(mapk8) 107375912 107388204
BPEC: 110157114 110157667 110159805(mapk8) 110160610(mapk10)
LCM: 102351693(MAPK9) 102351958(MAPK10) 102357573(MAPK8)
CMK: 103180867(mapk10) 103183732(mapk9) 103185857(mapk8)
CIN: 778660(jnk)
SPU: 580919
APLC: 110979079
SKO: 100374258
DME: Dmel_CG5680(bsk)
DSI: Dsimw501_GD22289(Dsim_GD22289)
AAG: 5570857
AME: 409286(bsk)
BIM: 100740816
BTER: 100631091
SOC: 105195964
AEC: 105148788
ACEP: 105619924
PBAR: 105426774
HST: 105191959
CFO: 105253069
LHU: 105670179
PGC: 109856677
NVI: 100121916
TCA: 663836(bsk)
DPA: 109542184
NVL: 108560378
BMOR: 100126162(Jnk)
PMAC: 106713114
PRAP: 110999109
API: 100163276
DNX: 107172095
ZNE: 110831056
FCD: 110845183
TUT: 107361712
CEL: CELE_B0478.1(jnk-1) CELE_T07A9.3(kgb-1) CELE_ZC416.4(kgb-2)
CBR: CBG05733(Cbr-jnk-1)
BMY: Bm1_40555
TSP: Tsp_05770
CRG: 105338795
OBI: 106878992
LAK: 106176904
SHX: MS3_08855
EPA: 110249370
ADF: 107341807
HMG: 100201400
AQU: 100636234
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8137421
  Authors
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ
  Title
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
  Journal
Cell 76:1025-37 (1994)
DOI:10.1016/0092-8674(94)90380-8
  Sequence
[hsa:5599]
Reference
  Authors
Miotto B, Struhl K
  Title
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
  Journal
Mol Cell 44:62-71 (2011)
DOI:10.1016/j.molcel.2011.06.021
Reference
  Authors
Kawasaki M, Hisamoto N, Iino Y, Yamamoto M, Ninomiya-Tsuji J, Matsumoto K
  Title
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
  Journal
EMBO J 18:3604-15 (1999)
DOI:10.1093/emboj/18.13.3604
  Sequence

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