KEGG   ORTHOLOGY: K04441Help
Entry
K04441                      KO                                     

Name
P38
Definition
p38 MAP kinase [EC:2.7.11.24]
Pathway
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04011  MAPK signaling pathway - yeast
ko04013  MAPK signaling pathway - fly
ko04015  Rap1 signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04139  Mitophagy - yeast
ko04212  Longevity regulating pathway - worm
ko04218  Cellular senescence
ko04261  Adrenergic signaling in cardiomyocytes
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04714  Thermogenesis
ko04722  Neurotrophin signaling pathway
ko04723  Retrograde endocannabinoid signaling
ko04728  Dopaminergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04917  Prolactin signaling pathway
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05133  Pertussis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05205  Proteoglycans in cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00689  MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04441  P38; p38 MAP kinase
   04010 MAPK signaling pathway
    K04441  P38; p38 MAP kinase
   04013 MAPK signaling pathway - fly
    K04441  P38; p38 MAP kinase
   04011 MAPK signaling pathway - yeast
    K04441  P38; p38 MAP kinase
   04370 VEGF signaling pathway
    K04441  P38; p38 MAP kinase
   04668 TNF signaling pathway
    K04441  P38; p38 MAP kinase
   04068 FoxO signaling pathway
    K04441  P38; p38 MAP kinase
   04071 Sphingolipid signaling pathway
    K04441  P38; p38 MAP kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04139 Mitophagy - yeast
    K04441  P38; p38 MAP kinase
  09143 Cell growth and death
   04218 Cellular senescence
    K04441  P38; p38 MAP kinase
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04441  P38; p38 MAP kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04441  P38; p38 MAP kinase
   04620 Toll-like receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04624 Toll and Imd signaling pathway
    K04441  P38; p38 MAP kinase
   04621 NOD-like receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04622 RIG-I-like receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04625 C-type lectin receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04660 T cell receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04658 Th1 and Th2 cell differentiation
    K04441  P38; p38 MAP kinase
   04659 Th17 cell differentiation
    K04441  P38; p38 MAP kinase
   04657 IL-17 signaling pathway
    K04441  P38; p38 MAP kinase
   04664 Fc epsilon RI signaling pathway
    K04441  P38; p38 MAP kinase
   04670 Leukocyte transendothelial migration
    K04441  P38; p38 MAP kinase
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04441  P38; p38 MAP kinase
   04914 Progesterone-mediated oocyte maturation
    K04441  P38; p38 MAP kinase
   04917 Prolactin signaling pathway
    K04441  P38; p38 MAP kinase
   04926 Relaxin signaling pathway
    K04441  P38; p38 MAP kinase
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04441  P38; p38 MAP kinase
  09156 Nervous system
   04728 Dopaminergic synapse
    K04441  P38; p38 MAP kinase
   04723 Retrograde endocannabinoid signaling
    K04441  P38; p38 MAP kinase
   04722 Neurotrophin signaling pathway
    K04441  P38; p38 MAP kinase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04441  P38; p38 MAP kinase
  09158 Development
   04380 Osteoclast differentiation
    K04441  P38; p38 MAP kinase
  09149 Aging
   04212 Longevity regulating pathway - worm
    K04441  P38; p38 MAP kinase
  09159 Environmental adaptation
   04714 Thermogenesis
    K04441  P38; p38 MAP kinase
 09160 Human Diseases
  09161 Cancers
   05205 Proteoglycans in cancer
    K04441  P38; p38 MAP kinase
  09163 Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04441  P38; p38 MAP kinase
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04441  P38; p38 MAP kinase
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04441  P38; p38 MAP kinase
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04441  P38; p38 MAP kinase
   05132 Salmonella infection
    K04441  P38; p38 MAP kinase
   05131 Shigellosis
    K04441  P38; p38 MAP kinase
   05133 Pertussis
    K04441  P38; p38 MAP kinase
   05152 Tuberculosis
    K04441  P38; p38 MAP kinase
   05164 Influenza A
    K04441  P38; p38 MAP kinase
   05160 Hepatitis C
    K04441  P38; p38 MAP kinase
   05163 Human cytomegalovirus infection
    K04441  P38; p38 MAP kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04441  P38; p38 MAP kinase
   05169 Epstein-Barr virus infection
    K04441  P38; p38 MAP kinase
   05145 Toxoplasmosis
    K04441  P38; p38 MAP kinase
   05140 Leishmaniasis
    K04441  P38; p38 MAP kinase
   05142 Chagas disease (American trypanosomiasis)
    K04441  P38; p38 MAP kinase
  09168 Drug resistance
   01522 Endocrine resistance
    K04441  P38; p38 MAP kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04441  P38; p38 MAP kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00689  MAPK (p38) signaling
     K04441  P38; p38 MAP kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     K04441  P38; p38 MAP kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   K04441  P38; p38 MAP kinase
BRITE hierarchy
Other DBs
COG: COG0515
GO: 0004707
Genes
HSA: 1432(MAPK14) 5600(MAPK11) 5603(MAPK13) 6300(MAPK12)
PTR: 104003820(MAPK11) 450161(MAPK14) 462644(MAPK13) 747077(MAPK12)
PPS: 100980937(MAPK11) 100981268(MAPK12) 100982544(MAPK13) 100983649(MAPK14)
GGO: 101134492(MAPK12) 101134843(MAPK11) 101148438(MAPK13) 101152640(MAPK14)
PON: 100437263(MAPK12) 100438358(MAPK11) 100449269(MAPK14) 100449853(MAPK13)
NLE: 100580599(MAPK12) 100589036(MAPK11) 100595369(MAPK13) 100600225(MAPK14)
MCC: 715745(MAPK12) 715794(MAPK11) 718976(MAPK14) 719085(MAPK13)
MCF: 101867305(MAPK12) 101867352(MAPK13) 101926770(MAPK14) 102134421(MAPK11)
CSAB: 103221595(MAPK13) 103221596(MAPK14) 103223551(MAPK11) 103223553(MAPK12)
RRO: 104660767(MAPK12) 104660769(MAPK11) 104682867(MAPK14) 104682868(MAPK13)
RBB: 108528326(MAPK14) 108528327(MAPK13) 108539403(MAPK12) 108539422(MAPK11)
CJC: 100396611(MAPK11) 100396967(MAPK12) 100404377(MAPK14) 100405093(MAPK13)
SBQ: 101037444(MAPK14) 101040899(MAPK12) 101044137(MAPK13) 101052690(MAPK11)
MMU: 19094(Mapk11) 26415(Mapk13) 26416(Mapk14) 29857(Mapk12)
RNO: 29513(Mapk13) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CGE: 100689104(Mapk14) 100754042(Mapk12) 100759172(Mapk11) 100763519(Mapk13)
NGI: 103735473(Mapk12) 103735474(Mapk11) 103739659(Mapk13) 103739660(Mapk14)
HGL: 101705370(Mapk11) 101706002(Mapk12) 101715692(Mapk13) 106007524(Mapk14)
CCAN: 109689849(Mapk14) 109689865(Mapk13) 109697389(Mapk11) 109697648(Mapk12)
OCU: 100341695(MAPK14) 100344161(MAPK13) 100350614(MAPK12) 103346035(MAPK11)
TUP: 102481241(MAPK13) 102487603(MAPK11) 102495693(MAPK14) 102501733(MAPK12)
CFA: 403856(MAPK14) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML: 100465223(MAPK13) 100465476(MAPK14) 100480235(MAPK12) 100480483(MAPK11)
UMR: 103665451(MAPK14) 103665538(MAPK13) 103674004(MAPK11) 103674115(MAPK12)
ORO: 101377143(MAPK13) 101377430(MAPK14) 101382259(MAPK11) 101382558(MAPK12)
FCA: 101091536(MAPK13) 101101135(MAPK14) 105260786(MAPK11) 111556320(MAPK12)
PTG: 102960306(MAPK12) 102960590(MAPK11) 102968191(MAPK13) 102968482(MAPK14)
AJU: 106972759(MAPK14) 106972806(MAPK13) 106987636(MAPK12) 106987637(MAPK11)
BTA: 512943(MAPK12) 534492(MAPK14) 535327(MAPK13) 618906(MAPK11)
BOM: 102271030(MAPK13) 102271320(MAPK14) 102285848(MAPK12) 106701244(MAPK11)
BIU: 109577010(MAPK14) 109577419(MAPK13)
PHD: 102321680(MAPK13) 102322031(MAPK14) 102331873(MAPK12)
CHX: 100860996(MAPK13) 102180926(MAPK12) 102189174(MAPK14)
OAS: 100194428(MAPK13) 100217411(MAPK14) 101115956(MAPK12) 101116223
SSC: 100155841(MAPK13) 100156630(MAPK14) 574062(MAPK12)
CFR: 102511078(MAPK14) 102511298(MAPK13) 102516847(MAPK12) 102519781(MAPK11)
CDK: 105090355(MAPK11) 105090356(MAPK12) 105101337(MAPK13) 105101338(MAPK14)
BACU: 102999798 103002378(MAPK13) 103008537(MAPK14) 103009561(MAPK11) 103009947(MAPK12)
LVE: 103077530(MAPK12) 103078049(MAPK14) 103078710(MAPK13) 103083209(MAPK11)
OOR: 101269212(MAPK13) 101269458(MAPK14) 101287579(MAPK12) 101287833(MAPK11)
ECB: 100056239(MAPK12) 100056278(MAPK11) 100063532(MAPK14) 106782258(MAPK13)
EPZ: 103559485(MAPK12) 103559491(MAPK11) 103563198(MAPK13) 103565534(MAPK14)
EAI: 106824547(MAPK14) 106824582(MAPK13) 106846005(MAPK12) 106846006(MAPK11)
MYB: 102248097(MAPK14) 102254628(MAPK12) 102254920(MAPK11) 106723559(MAPK13)
MYD: 102755728(MAPK14) 102756012(MAPK13) 102770021(MAPK12) 102770309(MAPK11)
HAI: 109395979(MAPK14) 109395980(MAPK13) 109396629(MAPK12) 109396630(MAPK11)
RSS: 109434907(MAPK11) 109434908(MAPK12) 109450962(MAPK14) 109450996(MAPK13)
PALE: 102877720(MAPK13) 102888602(MAPK11) 102888845(MAPK12) 102895900(MAPK14)
LAV: 100656926(MAPK13) 100661039(MAPK12) 100673331(MAPK14)
MDO: 100010279(MAPK12) 100010891(MAPK11) 100026324(MAPK14) 100028821(MAPK13)
SHR: 100925013(MAPK14) 100925447(MAPK13) 100928729(MAPK12) 100928990(MAPK11)
GGA: 417739(MAPK11) 421183(MAPK14) 769763(MAPK12) 771145(MAPK13)
MGP: 100540259(MAPK12) 100540416(MAPK11) 100546983(MAPK13)
CJO: 107306769 107308531 107308592(MAPK11) 107324607(MAPK13) 107324616(MAPK14)
APLA: 101792057(MAPK11) 101793591(MAPK12) 101802116(MAPK13) 101805023(MAPK14)
ACYG: 106040461 106040490 106046149(MAPK14) 106046150(MAPK13)
TGU: 100225101(MAPK11) 100227852(MAPK14) 100227993(MAPK12) 105758887(MAPK13)
GFR: 102038787(MAPK11) 102042160(MAPK13) 102043521(MAPK12) 102044158(MAPK14)
FAB: 101807358(MAPK12) 101814783(MAPK11) 101817434(MAPK13) 101819980(MAPK14)
PHI: 102109820(MAPK11) 102110009(MAPK12) 102110807(MAPK13) 102111004(MAPK14)
PMAJ: 107204408(MAPK12) 107204409(MAPK11) 107214801(MAPK13) 107214802(MAPK14)
FPG: 101920170(MAPK12) 101920353(MAPK11) 101921635(MAPK14) 101922433(MAPK13)
FCH: 102051874(MAPK12) 102052038(MAPK11) 102054359(MAPK13) 102059377(MAPK14)
EGZ: 104125670(MAPK12) 104125693(MAPK11) 104125710(MAPK13) 104125751(MAPK14)
AAM: 106487858(MAPK13) 106487877(MAPK14) 106495922(MAPK12) 106495935(MAPK11)
ASN: 102374196(MAPK12) 102375835(MAPK11) 102375954(MAPK13) 102376541(MAPK14)
AMJ: 102565670(MAPK14) 102571177(MAPK11) 102571419(MAPK12) 106736779(MAPK13)
PSS: 102448785(MAPK14) 102455939(MAPK13) 102462429(MAPK11) 102462672(MAPK12)
CMY: 102934859(MAPK14) 102938087(MAPK11) 102940215(MAPK12) 102941338(MAPK13)
CPIC: 101946632(MAPK13) 101948637(MAPK14) 101952286(MAPK12) 101952546(MAPK11)
ACS: 100563538(mapk12) 100563731(mapk11) 100567479(mapk13) 100567676(mapk14)
PVT: 110079793(MAPK14) 110079814(MAPK13) 110089644 110089645
PBI: 103053438(MAPK14) 103053997(MAPK13) 103063187(MAPK12) 103063888(MAPK11)
GJA: 107110949(MAPK12) 107110955(MAPK11) 107110973 107110975 107119112(MAPK13)
XLA: 100329215(p38-beta) 108708144 108711159 108715909 379992(mapk14.S) 398592(mapk12.S) 494669(mapk11.S) 735153(LOC100145045.L)
XTR: 100101766(mapk11) 100144715(mapk13) 100145045(mapk12) 448296(mapk14) 549834(mapk12)
NPR: 108787378 108788240 108804838(MAPK12) 108804839(MAPK11)
DRE: 100002318(mapk13) 266756(mapk14b) 30681(mapk12a) 415185(mapk11) 557810(mapk12b) 562552(zgc:171775) 65237(mapk14a)
LCM: 102354316(MAPK11) 102354774(MAPK12) 102358042(MAPK14)
CMK: 103176608 103177012(mapk11) 103177013(mapk12) 103179134(mapk14) 103179136
CIN: 778927(p38)
SPU: 577728
APLC: 110982110
SKO: 100313652
DME: Dmel_CG33338(p38c) Dmel_CG5475(p38a) Dmel_CG7393(p38b)
DSI: Dsimw501_GD18318(Dsim_GD18318) Dsimw501_GD18319(Dsim_GD18319) Dsimw501_GD23919(Dsim_GD23919)
MDE: 101898223
AAG: 5570571
AME: 411915(p38b)
BIM: 100743495
BTER: 100648398
SOC: 105200628
AEC: 105152195
ACEP: 105622634
PBAR: 105432414
HST: 105182275
CFO: 105252862
LHU: 105672601
PGC: 109859454
NVI: 100114440(P38mapk)
TCA: 660539
DPA: 109540885
NVL: 108568750
BMOR: 692545(P38mapk)
PMAC: 106709262
PRAP: 111003831
PXY: 105391720
DNX: 107162001
ZNE: 110841257
FCD: 110848493
TUT: 107371307
CEL: CELE_B0218.3(pmk-1) CELE_F42G8.3(pmk-2) CELE_F42G8.4(pmk-3)
CBR: CBG01553(Cbr-pmk-3) CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1)
TSP: Tsp_03128
CRG: 105347124
MYI: 110452642
SHX: MS3_08464
EPA: 110236778
ADF: 107339756
SCE: YLR113W(HOG1)
ERC: Ecym_4266
KMX: KLMA_40175(HOG1)
NCS: NCAS_0C03380(NCAS0C03380)
NDI: NDAI_0G02700(NDAI0G02700)
TPF: TPHA_0A01630(TPHA0A01630)
TBL: TBLA_0H01330(TBLA0H01330)
TDL: TDEL_0F04290(TDEL0F04290)
KAF: KAFR_0B02980(KAFR0B02980)
CAL: CAALFM_C203330CA(HOG1)
CDU: CD36_18080(HOG1)
CAUR: QG37_04557
SLB: AWJ20_3640(HOG1)
NCR: NCU07024(os-2)
NTE: NEUTE1DRAFT121521(NEUTE1DRAFT_121521)
SMP: SMAC_09127(putative os2)
MGR: MGG_01822
TRE: TRIREDRAFT_45018(tmk3)
MAW: MAC_08084
MAJ: MAA_05126
CMT: CCM_04200
BFU: BCIN_15g03580(Bcsak1)
MBE: MBM_02950
ANG: ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
ABE: ARB_01456
TVE: TRV_02393
PTE: PTT_10964
BSC: COCSADRAFT_94680(HOG1)
ZTR: MYCGRDRAFT_76502(MgHog1)
SPO: SPAC24B11.06c(sty1)
CNE: CNC06590
CNB: CNBC0610
ABP: AGABI1DRAFT22411(AGABI1DRAFT_22411)
ABV: AGABI2DRAFT41003(AGABI2DRAFT_41003)
MGL: MGL_0949
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9744864
  Authors
O'Rourke SM, Herskowitz I
  Title
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae.
  Journal
Genes Dev 12:2874-86 (1998)
DOI:10.1101/gad.12.18.2874
  Sequence
[sce:YLR113W]
Reference
PMID:8633070
  Authors
Lechner C, Zahalka MA, Giot JF, Moller NP, Ullrich A
  Title
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.
  Journal
Proc Natl Acad Sci U S A 93:4355-9 (1996)
DOI:10.1073/pnas.93.9.4355
  Sequence
[hsa:6300]

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