KEGG   ORTHOLOGY: K04459Help
Entry
K04459                      KO                                     

Name
DUSP, MKP
Definition
dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
Pathway
ko04010  MAPK signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
    3.1.3.48  protein-tyrosine-phosphatase
     K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
BRITE hierarchy
Other DBs
GO: 0017017 0004725
Genes
HSA: 1844(DUSP2) 1846(DUSP4) 1847(DUSP5) 1849(DUSP7) 1850(DUSP8) 80824(DUSP16)
PTR: 464497(DUSP4) 465297(DUSP16) 470826(DUSP7) 738584(DUSP5) 741723(DUSP2) 746336(DUSP8)
PPS: 100976729(DUSP5) 100982627(DUSP4) 100983333(DUSP2) 100988699(DUSP7) 100991340(DUSP16) 100995665(DUSP8)
GGO: 101124273(DUSP8) 101133211(DUSP5) 101137316(DUSP7) 101146122(DUSP16) 101147735(DUSP4) 101150765(DUSP2) 101151115
PON: 100441872(DUSP2) 100444636(DUSP8) 100448820(DUSP16) 100457966(DUSP5) 100460640(DUSP4) 112132767(DUSP7)
NLE: 100583427(DUSP5) 100588614(DUSP16) 100589601(DUSP8) 100592473(DUSP4) 100593746(DUSP2) 100598626(DUSP7)
MCC: 696332(DUSP16) 698178(DUSP5) 698473(DUSP7) 714290(DUSP4) 718442(DUSP2) 720960(DUSP8)
MCF: 102115345(DUSP16) 102118860(DUSP2) 102121929(DUSP8) 102122216(DUSP4) 102136160(DUSP5) 102139955(DUSP7)
CSAB: 103215558(DUSP4) 103216504(DUSP5) 103218643(DUSP16) 103227714(DUSP7) 103236522(DUSP8) 103241063(DUSP2)
RRO: 104661483(DUSP2) 104663719(DUSP7) 104667777(DUSP5) 104668237(DUSP4) 104668339(DUSP16) 104680688(DUSP8)
RBB: 108518550(DUSP4) 108520939(DUSP2) 108522360(DUSP7) 108530312(DUSP16) 108531310(DUSP8) 108538870(DUSP5)
CJC: 100387312(DUSP7) 100388584(DUSP16) 100399230(DUSP8) 100403846(DUSP4) 100409549(DUSP2) 100411575(DUSP5)
SBQ: 101027516(DUSP2) 101029060(DUSP16) 101029870(DUSP8) 101037946(DUSP7) 101039861(DUSP5) 101047987(DUSP4)
MMU: 13537(Dusp2) 18218(Dusp8) 235584(Dusp7) 240672(Dusp5) 319520(Dusp4) 70686(Dusp16)
RNO: 171109(Dusp5) 297682(Dusp16) 300980(Dusp7) 311406(Dusp2) 361679(Dusp8) 60587(Dusp4)
CGE: 100756233(Dusp4) 100757670(Dusp2) 100758694(Dusp5) 100765417(Dusp7) 100768862(Dusp8) 100774758(Dusp16)
NGI: 103733713(Dusp4) 103737701(Dusp16) 103738278(Dusp2) 103741080(Dusp5) 103747440(Dusp7) 103751102(Dusp8)
HGL: 101699953(Dusp7) 101700389(Dusp16) 101702046(Dusp2) 101716391(Dusp8) 101719827(Dusp4) 101726329(Dusp5)
CCAN: 109676463(Dusp4) 109677688(Dusp5) 109684642 109684643(Dusp16) 109685355(Dusp7) 109689766(Dusp8) 109695218(Dusp2)
OCU: 100343162(DUSP5) 100344731(DUSP7) 100351542(DUSP4) 100353754(DUSP2) 100358230 103346402 103348976(DUSP16)
TUP: 102470411(DUSP8) 102476191 102488964(DUSP7) 102491845(DUSP16) 102495637(DUSP5) 102501251(DUSP2)
CFA: 483660(DUSP8) 484742(DUSP7) 486683(DUSP16) 486884(DUSP5) 611653(DUSP2)
AML: 100464243(DUSP8) 100468072(DUSP16) 100470219(DUSP4) 100474524(DUSP5) 100479162(DUSP7) 105240775(DUSP2)
UMR: 103659107(DUSP4) 103659190(DUSP5) 103671048(DUSP8) 103671881(DUSP2) 103675073(DUSP7) 103677757(DUSP16)
ORO: 101370923(DUSP4) 101371435(DUSP7) 101373538(DUSP2) 101378307(DUSP5) 101380502(DUSP8) 101386622(DUSP16)
FCA: 101088832(DUSP4) 101090684(DUSP2) 101091792(DUSP16) 101095132(DUSP8) 101098828(DUSP5) 101101624(DUSP7)
PTG: 102949610(DUSP5) 102954146(DUSP8) 102958695(DUSP4) 102960345(DUSP7) 102969948(DUSP2) 102972331(DUSP16)
AJU: 106965645(DUSP16) 106976008(DUSP2) 106984660 106984771(DUSP5) 106987008(DUSP7) 106987387(DUSP8)
BTA: 507061(DUSP5) 539140(DUSP2) 540380(DUSP4) 615727(DUSP8) 618644(DUSP16) 785016(DUSP7)
BOM: 102265023(DUSP2) 102269548(DUSP8) 102275116(DUSP7) 102276523(DUSP4) 102279617(DUSP16) 102287805(DUSP5)
BIU: 109553192(DUSP5) 109553555(DUSP4) 109554163(DUSP8) 109559646(DUSP16) 109565742(DUSP2) 109576294(DUSP7)
PHD: 102319033 102319094(DUSP8) 102325077(DUSP2) 102338654(DUSP16) 102341129(DUSP5) 102344947(DUSP7)
CHX: 102168517(DUSP16) 102173395(DUSP2) 102173698(DUSP7) 102174186(DUSP4) 102178150(DUSP8) 102186181(DUSP5)
OAS: 101103535(DUSP4) 101112604(DUSP7) 101115699(DUSP2) 101118748(DUSP5) 101118942(DUSP16) 101122905(DUSP8)
SSC: 100157144(DUSP5) 100514374(DUSP4) 100521473(DUSP7) 100620494(DUSP16) 100622812(DUSP2) 110259213(DUSP8)
CFR: 102509624(DUSP16) 102510084(DUSP5) 102511459(DUSP8) 102513163(DUSP2) 102515857(DUSP4) 102520352(DUSP7)
CDK: 105091713(DUSP5) 105092844(DUSP2) 105093526(DUSP7) 105094241 105094242 105095790(DUSP4) 105104480(DUSP8)
BACU: 103001364(DUSP5) 103007545(DUSP16) 103009109(DUSP7) 103018532(DUSP8) 103020012(DUSP4) 103020779(DUSP2)
LVE: 103071909(DUSP16) 103082798(DUSP8) 103083844(DUSP7) 103087986(DUSP5) 103089756(DUSP2)
OOR: 101269819(DUSP2) 101272160(DUSP5) 101280333(DUSP8) 101288049(DUSP7) 101288180(DUSP16) 101290153(DUSP4)
ECB: 100051611(DUSP2) 100058453(DUSP4) 100060559(DUSP7) 100063475(DUSP16) 100068966(DUSP5) 100146958(DUSP8)
EAI: 106821751(DUSP7) 106824571(DUSP4) 106825299(DUSP8) 106826715(DUSP16) 106837561(DUSP5)
MYB: 102244210(DUSP4) 102250829(DUSP8) 102253801(DUSP16) 102254748(DUSP7) 102256351(DUSP2) 102260729(DUSP5)
MYD: 102753896(DUSP7) 102754339(DUSP8) 102754387 102763513(DUSP4) 102765113(DUSP2) 102768617(DUSP16) 102773333(DUSP5)
HAI: 109375840(DUSP7) 109383157(DUSP16) 109384920(DUSP5) 109387249(DUSP4) 109392025(DUSP2) 109395932(DUSP8)
RSS: 109436286(DUSP8) 109442945 109444038(DUSP5) 109444546(DUSP2) 109454264(DUSP16) 109457302 109457568(DUSP4) 109459096(DUSP7)
PALE: 102879408(DUSP16) 102882088(DUSP5) 102887581(DUSP8) 102889742(DUSP4) 102893973(DUSP7) 102898243(DUSP2)
LAV: 100662664(DUSP7) 100662989(DUSP2) 100662994(DUSP8) 100673084(DUSP5) 100673552(DUSP16) 100677364(DUSP4)
MDO: 100013791(DUSP8) 100015073(DUSP16) 100020686(DUSP4) 100028017(DUSP5) 100031101(DUSP7) 100033190(DUSP2)
SHR: 100918580 100923803(DUSP4) 100926616(DUSP2) 100928829(DUSP16) 100930552(DUSP5) 100934414(DUSP7)
OAA: 100074749(DUSP7) 100077401(DUSP16) 100077666 100082126(DUSP5)
GGA: 395642(DUSP4) 415891(DUSP7) 423890(DUSP5) 431336(DUSP16) 770435(DUSP8)
MGP: 100540603(DUSP7) 100541970(DUSP8) 100544063(DUSP16) 100545175(DUSP5) 100549821(DUSP4)
CJO: 107313435(DUSP4) 107314534(DUSP8) 107316107(DUSP5) 107317778(DUSP16) 107319551(DUSP7)
APLA: 101790773 101790899(DUSP16) 101791342(DUSP5) 101798567(DUSP8) 101802321(DUSP7)
ACYG: 106030867(DUSP16) 106031929(DUSP5) 106042632(DUSP8) 106042791(DUSP7) 106046072(DUSP4)
TGU: 100222007(DUSP16) 100223600(DUSP4) 100226803(DUSP8) 100229727(DUSP7) 100232367(DUSP5)
GFR: 102032096(DUSP4) 102032382(DUSP7) 102035606(DUSP5) 102038395(DUSP16) 102043394(DUSP8)
FAB: 101807181(DUSP16) 101811455(DUSP5) 101813908(DUSP7) 101820672(DUSP4) 101821126(DUSP8)
PHI: 102100835(DUSP4) 102108567(DUSP5) 102108932(DUSP7) 102113493(DUSP8) 102114558(DUSP16)
PMAJ: 107203160(DUSP4) 107204211(DUSP16) 107206116(DUSP8) 107207150(DUSP5) 107210476(DUSP7)
CCW: 104683441(DUSP7) 104687977(DUSP8) 104696103(DUSP16) 104697154(DUSP4) 104697873(DUSP5)
FPG: 101917866(DUSP5) 101918148(DUSP4) 101918910(DUSP8) 101920011(DUSP16) 101922767(DUSP7)
FCH: 102051166(DUSP16) 102053756(DUSP8) 102053945(DUSP5) 102057901(DUSP7) 102058143(DUSP4)
CLV: 102086801(DUSP4) 102091394(DUSP16) 102092913(DUSP7) 102094151(DUSP8) 102095405(DUSP5)
EGZ: 104122687(DUSP4) 104124228(DUSP16) 104124922(DUSP8) 104126677(DUSP7) 104130432(DUSP5)
AAM: 106487045(DUSP7) 106488320 106488605 106495394(DUSP5) 106495837(DUSP4) 106497152(DUSP8)
ASN: 102369916(DUSP4) 102376200(DUSP5) 102378875(DUSP7) 102387269(DUSP8) 102388707(DUSP16)
AMJ: 102560060(DUSP4) 102565247(DUSP7) 102566065(DUSP16) 102568234(DUSP8) 102574381(DUSP5)
PSS: 102444390(DUSP7) 102447187(DUSP4) 102449249(DUSP8) 102449403(DUSP5) 102451801(DUSP16)
CMY: 102929344(DUSP8) 102933465(DUSP2) 102935667(DUSP16) 102937092(DUSP5) 102940901 102947093(DUSP7)
CPIC: 101931249(DUSP8) 101934159(DUSP2) 101938881(DUSP7) 101948585(DUSP4) 101952216(DUSP16) 101953375(DUSP5)
ACS: 100557549(dusp5) 100558989(dusp7) 100562331(dusp8) 100563421(dusp4) 100567200(dusp16) 100567888(dusp2)
PVT: 110071954(DUSP5) 110072222(DUSP2) 110074973(DUSP16) 110076535(DUSP8) 110080632(DUSP7) 110089720(DUSP4)
PBI: 103053182(DUSP4) 103053472 103053837(DUSP16) 103057413(DUSP7) 103057602(DUSP2) 103058017(DUSP5) 107326293
GJA: 107106747(DUSP2) 107107456(DUSP7) 107108139(DUSP16) 107109909(DUSP8) 107121825(DUSP5) 107122585(DUSP4)
XLA: 108695998(dusp5.L) 108704379(dusp16.L) 108712239(dusp4.L) 108712565(dusp16.S) 108714619(dusp7.L) 108715842(dusp7.S) 398829(dusp6.L) 444752(dusp5.S) 495060 495963
XTR: 100036691(dusp16) 548573(dusp5) 548863(dusp4) 733814(dusp7)
NPR: 108791570(DUSP16) 108791934(DUSP5) 108794413 108794525(DUSP4)
DRE: 114436(dusp5) 327246(dusp7) 393854(dusp8a) 394146(dusp4) 406523(dusp16) 445057(dusp2)
IPU: 108254865(dusp7) 108259432(dusp5) 108264845 108265928(Dusp2) 108274976 108279297(dusp4) 108279916(dusp16) 108280354
LCO: 104919616 104920482(dusp8) 104921069(dusp4) 104922130(dusp5) 104931398(dusp7) 104933399(dusp16) 104934000(dusp2) 104940092
NCC: 104940828(dusp8) 104943290(dusp2) 104948608 104950748(dusp4) 104957862(dusp5) 104958736
OLA: 101157459 101158099(dusp7) 101158832(dusp5) 101161296(dusp8) 101166402(dusp4) 101174193 101175078 111946967(dusp16)
CSEM: 103380359(dusp8) 103382470(dusp16) 103384075(dusp5) 103385438 103386366(dusp7) 103390320 103393504 103397797(dusp2)
ELS: 105007393(dusp8) 105012120(dusp5) 105013553(dusp7) 105014742(dusp4) 105026527(dusp16) 105029097 105029132
LCM: 102345316(DUSP5) 102352074(DUSP7) 102358462(DUSP2) 102364337 102366865(DUSP8) 102367101(DUSP16)
CIN: 100183860 778580(dusp8.16)
DME: Dmel_CG14080(Mkp3)
DSI: Dsimw501_GD12305(Dsim_GD12305)
MDE: 101893471
AAG: 5568595
AME: 411820(Mkp3)
BIM: 100750024
BTER: 100646969
SOC: 105197411
AEC: 105148274
ACEP: 105624451
PBAR: 105429215
HST: 105189102
CFO: 105247940
LHU: 105675176
PGC: 109861266
NVI: 100680219
TCA: 660318
NVL: 108559161
BMOR: 101740325
PMAC: 106715023
PRAP: 110995882
PXY: 105383044
API: 100168996
DNX: 107173649
ZNE: 110829252
CEL: CELE_C05B10.1(lip-1) CELE_F08B1.1(vhp-1)
CBR: CBG02372(Cbr-vhp-1) CBG05704(Cbr-lip-1)
BMY: Bm1_21370
EPA: 110241684
ADF: 107357199
HMG: 100214438
AQU: 100637025
ATH: AT2G04550(IBR5)
ALY: ARALYDRAFT_899261(IBR5)
CRB: 17890913
THJ: 104808865
CPAP: 110808837
CIT: 102631010
TCC: 18612380
EGR: 104424702
CCAJ: 109791462
CAM: 101507352
ADU: 107496878
AIP: 107609037
LJA: Lj2g3v2856060.1(Lj2g3v2856060.1)
FVE: 101294867
PPER: 18782990
PXB: 103955017
ZJU: 107417407
CSV: 101211000
CMO: 103491664
MCHA: 111016771
RCU: 8265581
JCU: 105640878
POP: 7455681
VVI: 100249965
INI: 109155980
SIND: 105167448
LSV: 111878861
BVG: 104902737
SOE: 110791479
DOSA: Os02t0720300-01(Os02g0720300) Os06t0308100-01(Os06g0308100)
ATS: 109759711(LOC109759711) 109780628(LOC109780628)
DCT: 110099499
ATR: 18429694
MNG: MNEG_3058
SCE: YBR276C(PPS1)
ERC: Ecym_6282
KMX: KLMA_50077(PPS1)
NCS: NCAS_0B07490(NCAS0B07490)
NDI: NDAI_0B04820(NDAI0B04820)
TPF: TPHA_0I02700(TPHA0I02700)
TBL: TBLA_0F01370(TBLA0F01370)
TDL: TDEL_0D01800(TDEL0D01800)
KAF: KAFR_0C04160(KAFR0C04160)
PIC: PICST_60041(PPS1)
CAL: CAALFM_C700840CA(CaO19.7033)
CAUR: QG37_07538
SLB: AWJ20_3173(PPS1)
NCR: NCU03426
NTE: NEUTE1DRAFT84631(NEUTE1DRAFT_84631)
MGR: MGG_03130
MAW: MAC_09128
MAJ: MAA_05299
BFU: BCIN_13g04330(Bcpps1)
MBE: MBM_09581
ANI: AN0129.2
ANG: ANI_1_1242164(An18g03040)
ABE: ARB_03110
TVE: TRV_01744
PTE: PTT_17750
ZTR: MYCGRDRAFT_48113(MgPTP1)
CNE: CNH02800
CNB: CNBL2850
ABP: AGABI1DRAFT107372(AGABI1DRAFT_107372)
ABV: AGABI2DRAFT177482(AGABI2DRAFT_177482)
MGL: MGL_0454
DFA: DFA_01652
EHI: EHI_048550(107.t00002) EHI_053090(4.t00016) EHI_059820(101.t00013) EHI_079260(183.t00006)
SMIN: v1.2.000695.t1(symbB.v1.2.000695.t1) v1.2.022435.t1(symbB.v1.2.022435.t1) v1.2.025730.t1(symbB.v1.2.025730.t1) v1.2.028180.t1(symbB.v1.2.028180.t1) v1.2.028180.t2(symbB.v1.2.028180.t2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bermudez O, Pages G, Gimond C
  Title
The dual-specificity MAP kinase phosphatases: critical roles in development and cancer.
  Journal
Am J Physiol Cell Physiol 299:C189-202 (2010)
DOI:10.1152/ajpcell.00347.2009
Reference
  Authors
Keyse SM
  Title
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
  Journal
Cancer Metastasis Rev 27:253-61 (2008)
DOI:10.1007/s10555-008-9123-1
Reference
  Authors
Kondoh K, Nishida E
  Title
Regulation of MAP kinases by MAP kinase phosphatases.
  Journal
Biochim Biophys Acta 1773:1227-37 (2007)
DOI:10.1016/j.bbamcr.2006.12.002
Reference
  Authors
Patterson KI, Brummer T, O'Brien PM, Daly RJ
  Title
Dual-specificity phosphatases: critical regulators with diverse cellular targets.
  Journal
Biochem J 418:475-89 (2009)
DOI:10.1042/BJ20082234

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