KEGG   ORTHOLOGY: K04467Help
Entry
K04467                      KO                                     

Name
IKBKA, IKKA, CHUK
Definition
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05212  Pancreatic cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00686  Toll-like receptor signaling
Disease
H00882  Cocoon syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04010 MAPK signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04064 NF-kappa B signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04668 TNF signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04068 FoxO signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04151 PI3K-Akt signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04150 mTOR signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04621 NOD-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04622 RIG-I-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04623 Cytosolic DNA-sensing pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04625 C-type lectin receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04660 T cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04658 Th1 and Th2 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04659 Th17 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04657 IL-17 signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04662 B cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04062 Chemokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09158 Development
   04380 Osteoclast differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05212 Pancreatic cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05221 Acute myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05220 Chronic myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05215 Prostate cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05222 Small cell lung cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05131 Shigellosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05166 HTLV-I infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05162 Measles
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05161 Hepatitis B
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05160 Hepatitis C
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05168 Herpes simplex infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05163 Human cytomegalovirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05169 Epstein-Barr virus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05165 Human papillomavirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05145 Toxoplasmosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09168 Drug resistance
   01523 Antifolate resistance
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
BRITE hierarchy
Other DBs
GO: 0008384
Genes
HSA: 1147(CHUK)
PTR: 450673(CHUK)
PPS: 100995228(CHUK)
GGO: 101137405(CHUK) 109025098
PON: 100174735(CHUK)
NLE: 100596225(CHUK)
MCC: 709511(CHUK)
MCF: 102115964(CHUK)
CSAB: 103216382(CHUK)
RRO: 104656469(CHUK)
RBB: 108535077(CHUK)
SBQ: 101044006(CHUK)
MMU: 12675(Chuk)
RNO: 309361(Chuk)
CGE: 100754432(Chuk)
NGI: 103743976(Chuk)
HGL: 101719306(Chuk)
CCAN: 109681514(Chuk)
OCU: 100355888(CHUK)
TUP: 102501308(CHUK)
CFA: 477796(CHUK)
AML: 100464675(CHUK)
UMR: 103658916(CHUK)
ORO: 101364103(CHUK)
FCA: 101095617(CHUK)
PTG: 102949289(CHUK)
AJU: 106966935(CHUK)
BTA: 281073(CHUK)
BOM: 102281886(CHUK)
BIU: 109553086(CHUK)
PHD: 102332461(CHUK)
CHX: 102181262(CHUK)
OAS: 101111143(CHUK)
SSC: 100135662(CHUK)
CFR: 102503497(CHUK)
CDK: 105084316(CHUK)
BACU: 103015414(CHUK)
LVE: 103085220(CHUK)
OOR: 101281072(CHUK)
ECB: 100070393(CHUK)
EPZ: 103567228(CHUK)
EAI: 106846705(CHUK)
MYB: 102261467(CHUK)
MYD: 102760888(CHUK)
HAI: 109379632(CHUK)
RSS: 109443941(CHUK)
PALE: 102879469(CHUK)
LAV: 100664361(CHUK)
TMU: 101341290
MDO: 100027952(CHUK)
SHR: 100913624(CHUK)
OAA: 100082351(CHUK)
GGA: 423669(CHUK)
MGP: 100542478(CHUK)
CJO: 107315625(CHUK)
APLA: 101801064(CHUK)
ACYG: 106030064(CHUK)
TGU: 100221281(CHUK) 100224042
GFR: 102042264(CHUK)
FAB: 101812706(CHUK)
PHI: 102107801(CHUK)
PMAJ: 107206726(CHUK)
CCW: 104695067(CHUK)
FPG: 101914413(CHUK)
FCH: 102053491(CHUK)
CLV: 102084658(CHUK)
EGZ: 104125140(CHUK)
AAM: 106495295(CHUK)
ASN: 102374729(CHUK)
AMJ: 106736873(CHUK)
PSS: 102454064(CHUK)
CMY: 102932800(CHUK)
CPIC: 101931080(CHUK)
ACS: 100565922(chuk)
PVT: 110087236(CHUK)
PBI: 103061898(CHUK)
GJA: 107117758(CHUK)
XLA: 444556(chuk.S)
XTR: 101732839 549654(chuk)
NPR: 108797654(CHUK)
DRE: 393287(chuk)
CCAR: 109092137 109100658(chuk)
IPU: 108263650(chuk)
AMEX: 103033415(chuk)
SFM: 108933554(chuk)
LCM: 102361819(CHUK)
CMK: 103181859(chuk)
SKO: 102806810
ZNE: 110838212
FCD: 110852083
MYI: 110456994
EPA: 110254140
HMG: 100207607
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9244310
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X
  Sequence
[hsa:1147]
Reference
  Authors
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G
  Title
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
  Journal
Sci Signal 3:ra41 (2010)
DOI:10.1126/scisignal.2000778

KEGG   ORTHOLOGY: K07209Help
Entry
K07209                      KO                                     

Name
IKBKB, IKKB
Definition
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05418  Fluid shear stress and atherosclerosis
Module
M00686  Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04010 MAPK signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04064 NF-kappa B signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04668 TNF signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04068 FoxO signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04151 PI3K-Akt signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04150 mTOR signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04624 Toll and Imd signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04621 NOD-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04622 RIG-I-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04623 Cytosolic DNA-sensing pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04625 C-type lectin receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04660 T cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04658 Th1 and Th2 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04659 Th17 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04657 IL-17 signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04662 B cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04062 Chemokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04920 Adipocytokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09158 Development
   04380 Osteoclast differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05206 MicroRNAs in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05212 Pancreatic cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05221 Acute myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05220 Chronic myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05215 Prostate cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05222 Small cell lung cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04931 Insulin resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05131 Shigellosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05166 HTLV-I infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05164 Influenza A
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05161 Hepatitis B
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05160 Hepatitis C
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05168 Herpes simplex infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05163 Human cytomegalovirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05169 Epstein-Barr virus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05165 Human papillomavirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05145 Toxoplasmosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05142 Chagas disease (American trypanosomiasis)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09168 Drug resistance
   01523 Antifolate resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
BRITE hierarchy
Other DBs
GO: 0008384
Genes
HSA: 3551(IKBKB)
PTR: 472749(IKBKB)
PPS: 100989390(IKBKB)
GGO: 101141659(IKBKB)
PON: 100440586(IKBKB)
NLE: 100588081(IKBKB)
MCC: 704683(IKBKB)
MCF: 102146604(IKBKB)
CSAB: 103215686(IKBKB)
RRO: 104666046(IKBKB)
RBB: 108540719(IKBKB)
CJC: 100393096(IKBKB)
SBQ: 101052971(IKBKB)
MMU: 16150(Ikbkb)
RNO: 84351(Ikbkb)
CGE: 100750488(Ikbkb)
NGI: 103726621(Ikbkb)
HGL: 101711077(Ikbkb)
CCAN: 109696400(Ikbkb)
OCU: 100356401(IKBKB)
TUP: 102467954(IKBKB)
CFA: 482839(IKBKB)
AML: 100471679(IKBKB)
UMR: 103677059(IKBKB)
ORO: 101375346(IKBKB)
FCA: 100142682(IKBKB)
PTG: 102963734(IKBKB)
AJU: 106990012(IKBKB)
BTA: 281854(IKBKB)
BOM: 102281443(IKBKB)
BIU: 109553353(IKBKB)
PHD: 102337166(IKBKB)
CHX: 102177406(IKBKB)
OAS: 780484(IKBKB)
SSC: 100101471(IKBKB)
CFR: 102508142(IKBKB)
CDK: 105086448(IKBKB)
BACU: 103015119(IKBKB)
LVE: 103088633(IKBKB)
OOR: 101285763(IKBKB)
ECB: 100050167(IKBKB)
EPZ: 103562903(IKBKB)
EAI: 106828957(IKBKB)
MYB: 102261405(IKBKB)
MYD: 102773824(IKBKB)
HAI: 109386279(IKBKB)
RSS: 109452845(IKBKB)
PALE: 102893261(IKBKB)
LAV: 100657363(IKBKB)
TMU: 101351256
MDO: 100033031(IKBKB)
SHR: 100928932(IKBKB)
OAA: 100078925(IKBKB)
GGA: 426792(IKBKB)
MGP: 100542558(IKBKB)
CJO: 107323740(IKBKB)
APLA: 101790255(IKBKB)
ACYG: 106044397(IKBKB)
TGU: 100225072(IKBKB)
GFR: 102035648(IKBKB)
FAB: 101809821(IKBKB)
PHI: 102100562(IKBKB)
PMAJ: 107213912(IKBKB)
CCW: 104694916(IKBKB)
FPG: 101922064(IKBKB)
FCH: 102058892(IKBKB)
CLV: 102087238(IKBKB)
EGZ: 104135306(IKBKB)
AAM: 106487776(IKBKB)
ASN: 102377560(IKBKB)
AMJ: 102561936(IKBKB)
PSS: 102454676(IKBKB)
CMY: 102932073(IKBKB)
CPIC: 101945515(IKBKB)
ACS: 100551699(ikbkb)
PVT: 110072148(IKBKB)
PBI: 103052688(IKBKB)
GJA: 107107812(IKBKB)
XLA: 432200(ikbkb.L)
XTR: 448125(ikbkb)
NPR: 108791446(IKBKB)
DRE: 563560(ikbkb)
SANH: 107671012
SGH: 107559596(ikbkb)
CCAR: 109095150(ikbkb)
IPU: 108265675(ikbkb)
AMEX: 103040024(ikbkb)
TRU: 101062431(ikbkb)
LCO: 104921662(ikbkb)
NCC: 104956687(ikbkb)
MZE: 101472803(ikbkb)
OLA: 101170684(ikbkb)
XMA: 102223773(ikbkb)
PRET: 103470025(ikbkb)
NFU: 107394259(ikbkb)
CSEM: 103397763(ikbkb)
LCF: 108881598(ikbkb)
HCQ: 109525796
BPEC: 110155462(ikbkb)
SASA: 106580426(ikbkb)
ELS: 105014298(ikbkb)
SFM: 108920198(ikbkb)
LCM: 102349717 102358966(IKBKB)
CMK: 103172650
CIN: 778921(ikk-alpha/beta)
DME: Dmel_CG4201(IKKbeta)
DSI: Dsimw501_GD20310(Dsim_ird5)
DYA: Dyak_GE26340(Dyak_ird5)
MDE: 101888056
AGA: AgaP_AGAP009166(IKK1)
AAG: 5577620
AME: 726760(GB18611)
BIM: 100744732
BTER: 100642917
SOC: 105197895
AEC: 105147535
ACEP: 105623150
HST: 105186757
CFO: 105251219
LHU: 105679052
PGC: 109861528
NVI: 100116284
TCA: 655324 658393(ikkb)
DPA: 109540103
NVL: 108569535
BMOR: 101747125
PMAC: 106711966
PRAP: 111001847
PXY: 105396222
MYI: 110444551
OBI: 106868427
ADF: 107346562
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC
  Title
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
  Journal
Cell 117:225-37 (2004)
DOI:10.1016/S0092-8674(04)00302-2
Reference
PMID:9346485
  Authors
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV
  Title
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
  Journal
Science 278:866-9 (1997)
DOI:10.1126/science.278.5339.866
  Sequence
[hsa:3551]

KEGG   ORTHOLOGY: K07210Help
Entry
K07210                      KO                                     

Name
IKBKG, IKKG, NEMO
Definition
inhibitor of nuclear factor kappa-B kinase subunit gamma
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05212  Pancreatic cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05340  Primary immunodeficiency
ko05418  Fluid shear stress and atherosclerosis
Module
M00686  Toll-like receptor signaling
Disease
H00095  Ectodermal dysplasia associated immunodeficiency (EDA-ID)
H00540  Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)
H00645  Incontinentia pigmenti
H01245  Immunodeficiency without anhidrotic ectodermal dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04010 MAPK signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04064 NF-kappa B signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04668 TNF signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04151 PI3K-Akt signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04621 NOD-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04622 RIG-I-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04623 Cytosolic DNA-sensing pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04625 C-type lectin receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04660 T cell receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04658 Th1 and Th2 cell differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04659 Th17 cell differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04657 IL-17 signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04662 B cell receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04062 Chemokine signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09158 Development
   04380 Osteoclast differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05203 Viral carcinogenesis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05212 Pancreatic cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05221 Acute myeloid leukemia
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05220 Chronic myeloid leukemia
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05215 Prostate cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05222 Small cell lung cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09162 Immune diseases
   05340 Primary immunodeficiency
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09167 Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05131 Shigellosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05166 HTLV-I infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05161 Hepatitis B
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05160 Hepatitis C
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05168 Herpes simplex infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05163 Human cytomegalovirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05169 Epstein-Barr virus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05165 Human papillomavirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05145 Toxoplasmosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05142 Chagas disease (American trypanosomiasis)
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09168 Drug resistance
   01523 Antifolate resistance
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
BRITE hierarchy
Genes
HSA: 8517(IKBKG)
PTR: 100609537(IKBKG) 100610002
PPS: 100987483(IKBKG)
GGO: 101126088 101145841(IKBKG)
PON: 100449496(IKBKG)
NLE: 100602932(IKBKG) 100603768
MCC: 701237(IKBKG)
MCF: 102115368(IKBKG)
CSAB: 103232832(IKBKG)
RRO: 104667046(IKBKG)
RBB: 108518784(IKBKG)
CJC: 100390258(IKBKG)
SBQ: 101043425(IKBKG)
MMU: 16151(Ikbkg)
RNO: 309295(Ikbkg)
CGE: 100759762(Ikbkg)
NGI: 103731232(Ikbkg)
HGL: 101712077(Ikbkg)
CCAN: 109691919(Ikbkg)
OCU: 100328905(IKBKG)
TUP: 102476758(IKBKG)
CFA: 612576(IKBKG)
AML: 100470223(IKBKG)
UMR: 103679680(IKBKG)
ORO: 101384959(IKBKG)
FCA: 101086544(IKBKG)
PTG: 102967956(IKBKG)
AJU: 106988817(IKBKG)
BTA: 281855(IKBKG)
BOM: 102287968(IKBKG)
BIU: 109555319(IKBKG)
PHD: 102321023(IKBKG)
CHX: 102171591(IKBKG)
OAS: 101107332(IKBKG)
SSC: 100127355(IKBKG)
CFR: 102516920(IKBKG) 102519782
CDK: 105106603(IKBKG) 105106641
BACU: 103017855
LVE: 103074882(IKBKG)
OOR: 101272428(IKBKG)
ECB: 100058432(IKBKG)
EAI: 106828814(IKBKG)
MYB: 102252013(IKBKG)
MYD: 102772051(IKBKG)
HAI: 109377344(IKBKG)
RSS: 109438977(IKBKG)
PALE: 102880203(IKBKG)
LAV: 100661492(IKBKG)
TMU: 101347574
MDO: 100022918(IKBKG)
SHR: 100926701(IKBKG)
OAA: 100073613(IKBKG)
PHI: 102113899(IKBKG)
PMAJ: 107198881(IKBKG)
ASN: 102374662(IKBKG)
AMJ: 102561500(IKBKG)
PSS: 102445093(IKBKG)
CMY: 102938812(IKBKG)
CPIC: 101942490(IKBKG)
ACS: 100567119(ikbkg)
PVT: 110089205(IKBKG)
PBI: 103053675(IKBKG)
GJA: 107114301
XLA: 735069(ikbkg.L)
XTR: 100145270(ikbkg)
NPR: 108791352(IKBKG)
DRE: 541530(ikbkg)
IPU: 108275953(ikbkg)
AMEX: 103043929(ikbkg)
TRU: 101069645
LCO: 104933745(ikbkg)
MZE: 101466977(ikbkg)
OLA: 101162681(ikbkg)
XMA: 102233509(ikbkg)
PRET: 103466941(ikbkg)
NFU: 107391543(ikbkg)
CSEM: 103384713(ikbkg)
HCQ: 109528595(ikbkg)
BPEC: 110162114(ikbkg)
ELS: 105030753(ikbkg)
LCM: 102351908(IKBKG)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9751060
  Authors
Rothwarf DM, Zandi E, Natoli G, Karin M
  Title
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
  Journal
Nature 395:297-300 (1998)
DOI:10.1038/26261
  Sequence
[hsa:8517]
Reference
  Authors
Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM
  Title
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
  Journal
Nature 427:167-71 (2004)
DOI:10.1038/nature02273

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