KEGG   ORTHOLOGY: K04492
Entry
K04492                      KO                                     
Symbol
LEF1
Name
lymphoid enhancer-binding factor 1
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map04936  Alcoholic liver disease
map05132  Salmonella infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04934 Cushing syndrome
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
Genes
HSA: 51176(LEF1)
PTR: 461425(LEF1)
PPS: 100995847(LEF1)
GGO: 101140253(LEF1)
PON: 100447785(LEF1)
NLE: 100593051(LEF1)
HMH: 116479176(LEF1)
MCC: 695776(LEF1)
MCF: 101925349(LEF1)
MTHB: 126954934
MNI: 105486288(LEF1)
CSAB: 103236088(LEF1)
CATY: 105571411(LEF1)
PANU: 101017352(LEF1)
TGE: 112624710(LEF1)
MLEU: 105546575(LEF1)
RRO: 104670045(LEF1)
RBB: 108515891(LEF1)
TFN: 117085762(LEF1)
PTEH: 111547880(LEF1)
CANG: 105514397(LEF1)
CJC: 100399759(LEF1)
SBQ: 101047688(LEF1)
CIMI: 108289579(LEF1)
CSYR: 103252452(LEF1)
MMUR: 105872329(LEF1)
LCAT: 123627736(LEF1)
PCOQ: 105818969(LEF1)
OGA: 100958411(LEF1)
MMU: 16842(Lef1)
MCAL: 110290892(Lef1)
MPAH: 110319903(Lef1)
RNO: 161452(Lef1)
MCOC: 116093789(Lef1)
ANU: 117706912(Lef1)
MUN: 110553391(Lef1)
CGE: 100761200(Lef1)
MAUA: 101823226(Lef1)
PROB: 127223025(Lef1)
PLEU: 114682816(Lef1)
MORG: 121450203(Lef1)
MFOT: 126509833
AAMP: 119800683(Lef1)
NGI: 103742515(Lef1)
HGL: 101711023(Lef1)
CPOC: 100716066(Lef1)
CCAN: 109688935
DORD: 105991153(Lef1)
DSP: 122127220(Lef1)
PLOP: 125341448(Lef1)
NCAR: 124994528
MMMA: 107141378(Lef1)
OCU: 100352691
OPI: 101525298(LEF1)
TUP: 102474621(LEF1)
GVR: 103593743(LEF1)
CFA: 478507(LEF1)
CLUD: 112671621(LEF1)
VVP: 112934208(LEF1)
VLG: 121493895(LEF1)
NPO: 129521205(LEF1)
AML: 100465982(LEF1)
UMR: 103661728(LEF1)
UAH: 113255544(LEF1)
UAR: 123793375(LEF1)
ELK: 111154120
LLV: 125093264
MPUF: 101689480(LEF1)
MNP: 132002001(LEF1)
MLK: 131829467(LEF1)
NVS: 122889282(LEF1)
ORO: 101372325(LEF1)
EJU: 114222653(LEF1)
ZCA: 113925268(LEF1)
MLX: 118027079(LEF1)
NSU: 110575521(LEF1)
LWW: 102737827(LEF1)
FCA: 101088077(LEF1)
PYU: 121031433(LEF1)
PCOO: 112858040(LEF1)
PBG: 122477660(LEF1)
LRUF: 124520997
PTG: 102970026(LEF1)
PPAD: 109247814(LEF1)
PUC: 125923001
AJU: 106983664
HHV: 120236146(LEF1)
BTA: 535399(LEF1)
BOM: 102266946(LEF1)
BIU: 109560266(LEF1)
BBUB: 102409520(LEF1)
BBIS: 105002090(LEF1)
CHX: 100860901(LEF1)
OAS: 780521(LEF1)
BTAX: 128049642(LEF1)
ODA: 120861741(LEF1)
CCAD: 122422034(LEF1)
MBEZ: 129561748(LEF1)
SSC: 100170126(LEF1)
CFR: 102510619(LEF1)
CBAI: 105067944(LEF1)
CDK: 105105289(LEF1)
VPC: 102541243(LEF1)
BACU: 103020844(LEF1)
LVE: 103068879(LEF1)
OOR: 101287631(LEF1)
DLE: 111171490(LEF1)
PCAD: 102996605(LEF1)
PSIU: 116753891(LEF1)
NASI: 112397669(LEF1)
ECB: 100072938(LEF1)
EPZ: 103557035(LEF1)
EAI: 106829814(LEF1)
MYB: 102255910(LEF1)
MYD: 102767379(LEF1)
MMYO: 118673131(LEF1)
MLF: 102439262(LEF1)
MNA: 107538292(LEF1)
PKL: 118702904(LEF1)
EFUS: 103293875(LEF1)
HAI: 109379461(LEF1)
DRO: 112321441(LEF1)
SHON: 118977082(LEF1)
AJM: 119061436(LEF1)
PDIC: 114492280(LEF1)
PHAS: 123806910(LEF1)
MMF: 118637343(LEF1)
RFQ: 117022359(LEF1)
PPAM: 129085299(LEF1)
PALE: 102886933(LEF1)
PGIG: 120591231(LEF1)
PVP: 105293004(LEF1)
RAY: 107511497(LEF1)
MJV: 108405595(LEF1)
TOD: 119242944(LEF1)
SARA: 101547696(LEF1)
LAV: 100658960(LEF1)
TMU: 101345125
ETF: 101645834(LEF1)
DNM: 101428006(LEF1)
MDO: 100011783(LEF1)
SHR: 100934638(LEF1)
AFZ: 127539946
PCW: 110218610(LEF1)
OAA: 100079818(LEF1)
GGA: 395865(LEF1)
PCOC: 116238078(LEF1)
MGP: 100542839(LEF1)
CJO: 107313267(LEF1)
TPAI: 128079992(LEF1)
LMUT: 125692117(LEF1)
NMEL: 110398346(LEF1)
APLA: 101792052(LEF1)
ACYG: 106038656(LEF1)
CATA: 118246221(LEF1)
AFUL: 116489255(LEF1)
TGU: 100228376(LEF1)
LSR: 110468005(LEF1)
SCAN: 103826009(LEF1)
PMOA: 120502824(LEF1)
OTC: 121331416(LEF1)
PRUF: 121360221(LEF1)
GFR: 102034937(LEF1)
FAB: 101821185(LEF1)
OMA: 130252146(LEF1)
PHI: 102109576(LEF1)
PMAJ: 107203557(LEF1)
CCAE: 111928334(LEF1)
CCW: 104697293(LEF1)
CBRC: 103617392(LEF1)
ETL: 114057906(LEF1)
ZAB: 102060741(LEF1)
ACHL: 103808312(LEF1)
SVG: 106854401(LEF1)
HRT: 120753290(LEF1)
FPG: 101917929(LEF1)
FCH: 102050307(LEF1)
CLV: 102084626(LEF1)
EGZ: 104135527(LEF1)
NNI: 104021166(LEF1)
PCRI: 104034615(LEF1)
PLET: 104622331(LEF1)
EHS: 104516011(LEF1)
PCAO: 104042542(LEF1)
ACUN: 113479673(LEF1)
TALA: 104357711(LEF1)
PADL: 103919538(LEF1)
AFOR: 103894233(LEF1)
ACHC: 115343254(LEF1)
HALD: 104314291(LEF1)
HLE: 104843344(LEF1)
AGEN: 126044961
GCL: 127015863
CSTI: 104558670(LEF1)
CMAC: 104483274(TCF7)
MUI: 104543451(LEF1)
BREG: 104637927(LEF1)
FGA: 104083813
GSTE: 104254847(LEF1)
LDI: 104353941(LEF1)
MNB: 103777011(LEF1)
OHA: 104327260(LEF1)
NNT: 104411041(LEF1)
SHAB: 115610292(LEF1)
DPUB: 104301797(LEF1)
PGUU: 104463233(LEF1)
ACAR: 104518792(LEF1)
CPEA: 104394492(LEF1)
AVIT: 104274896(LEF1)
CVF: 104286847(LEF1)
RTD: 128910491(LEF1)
CUCA: 104062883(LEF1)
TEO: 104377670
AAM: 106491833(LEF1)
AROW: 112972206(LEF1)
NPD: 112957317(LEF1)
TGT: 104578540(LEF1)
DNE: 112987873(LEF1)
SCAM: 104153503(LEF1)
ASN: 102385539(LEF1)
AMJ: 102560337(LEF1)
CPOO: 109309400(LEF1)
GGN: 109301061(LEF1)
PSS: 102456780(LEF1)
CMY: 102930185(LEF1)
CCAY: 125635259(LEF1)
DCC: 119854349(LEF1)
CPIC: 101953582(LEF1)
TST: 117878225(LEF1)
CABI: 116837678(LEF1)
MRV: 120406221(LEF1)
ACS: 100556215(lef1)
ASAO: 132776935(LEF1)
PVT: 110080460(LEF1)
SUND: 121931875(LEF1)
PBI: 103064656(LEF1)
PMUR: 107302616(LEF1)
CTIG: 120308252(LEF1)
TSR: 106556004(LEF1)
PGUT: 117679923(LEF1)
APRI: 131192571 131203264(LEF1)
PTEX: 113434797(LEF1)
NSS: 113412826(LEF1)
VKO: 123023106(LEF1)
PMUA: 114603846(LEF1)
PRAF: 128421275(LEF1)
ZVI: 118083338(LEF1)
HCG: 128326173(LEF1)
GJA: 107123114(LEF1)
STOW: 125439978(LEF1)
EMC: 129337067(LEF1)
XLA: 398238(lef1.L) 779101(lef1.S)
XTR: 100493178(lef1)
NPR: 108785415(LEF1) 108801973
RTEM: 120917892(LEF1)
BBUF: 120989930(LEF1)
BGAR: 122920359(LEF1)
MUO: 115461172(LEF1)
GSH: 117365667(LEF1)
DRE: 30701(lef1)
SGH: 107583218(lef1) 107594427
CCAR: 109046851
PTET: 122353119(lef1)
LROH: 127170696(lef1)
OMC: 131549781(lef1)
PPRM: 120491182(lef1)
RKG: 130087325(lef1)
MAMB: 125271927(lef1)
CIDE: 127516640
TROS: 130552707(lef1)
TDW: 130412426(lef1)
MANU: 129444131(lef1)
IPU: 108262963
IFU: 128606021(lef1)
PHYP: 113538151(lef1)
SMEO: 124377280(lef1)
TFD: 113642358(lef1)
TVC: 132847602(lef1)
AMEX: 103033630(lef1)
CMAO: 118810856(lef1)
EEE: 113568617(lef1)
CHAR: 105903964(lef1)
TRU: 101064872(lef1) 115251054
TFS: 130527750(lef1)
LCO: 104927262(lef1)
NCC: 104953587
TBEN: 117482301(lef1)
CGOB: 115010760(lef1)
PGEO: 117449389(lef1)
ELY: 117255366(lef1)
EFO: 125884388(lef1)
PLEP: 121942444(lef1)
SLUC: 116034295(lef1)
ECRA: 117957879(lef1)
ESP: 116670487(lef1)
PFLV: 114567774(lef1)
GAT: 120825743(lef1)
PPUG: 119217776(lef1)
AFB: 129095654(lef1)
CLUM: 117733594(lef1)
MSAM: 119898915(lef1) 119898916
SCHU: 122872868(lef1)
CUD: 121508857(lef1)
ALAT: 119020711(lef1)
MZE: 101464688(lef1)
ONL: 100704365(lef1)
OAU: 116330136(lef1)
OLA: 101167344(lef1)
OML: 112157252(lef1)
XMA: 102226301(lef1) 111609564
XCO: 114144420(lef1) 114149416
XHE: 116719693(lef1)
PRET: 103472749(lef1)
PFOR: 103143923(lef1)
PLAI: 106958163(lef1)
PMEI: 106930845(lef1)
GAF: 122829090(lef1)
PPRL: 129351107(lef1)
CVG: 107094620(lef1)
CTUL: 119779063(lef1)
GMU: 124868243(lef1)
NFU: 107375038(lef1)
KMR: 108230929(lef1)
ALIM: 106517066(lef1)
NWH: 119422647(lef1)
AOCE: 111586156(lef1)
MCEP: 125003806(lef1)
SSEN: 122770862(lef1)
HHIP: 117768294(lef1)
HSP: 118123659(lef1)
LCF: 108888246
SDU: 111236636(lef1)
SLAL: 111671174(lef1)
XGL: 120800237(lef1)
SSCV: 125969039
SBIA: 133504478 133505552(lef1)
PEE: 133404502(lef1)
PTAO: 133476854(lef1)
BPEC: 110165341(lef1)
MALB: 109955531(lef1) 109972141
BSPL: 114862393(lef1)
SJO: 128380243(lef1)
SASA: 106602294 106610340(lef1)
STRU: 115191730(lef1)
OTW: 112239252(lef1)
OGO: 124001502
OKI: 109876660(lef1)
OKE: 118373433(lef1)
SNH: 120034764 120035026(lef1)
CCLU: 121580693(lef1)
ELS: 105020989(lef1)
PKI: 111837376(lef1) 111852095
AANG: 118226723(lef1) 118232500
LOC: 102686059(lef1)
PSPA: 121296434 121321759(lef1)
PSEX: 120532281(lef1)
LCM: 102354030(LEF1)
CMK: 103182161
CPLA: 122539466(lef1)
HOC: 132833260(lef1)
LERI: 129701019(lef1)
LPOL: 106470972
 » show all
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056

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