KEGG   ORTHOLOGY: K04500Help
Entry
K04500                      KO                                     

Name
SMAD2_3
Definition
mothers against decapentaplegic homolog 2/3
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05321  Inflammatory bowel disease (IBD)
Module
M00680  TGF-beta signaling
M00681  Activin signaling
Disease
H00020  Colorectal cancer
H00800  Loeys-Dietz syndrome (LDS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04390 Hippo signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04371 Apelin signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04068 FoxO signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cell growth and death
   04110 Cell cycle
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04218 Cellular senescence
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cellular community - eukaryotes
   04520 Adherens junction
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04550 Signaling pathways regulating pluripotency of stem cells
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Endocrine system
   04926 Relaxin signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05210 Colorectal cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05212 Pancreatic cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05225 Hepatocellular carcinoma
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05226 Gastric cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Infectious diseases
   05166 HTLV-I infection
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05142 Chagas disease (American trypanosomiasis)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
    M00681  Activin signaling
     K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
BRITE hierarchy
Other DBs
GO: 0070410
Genes
HSA: 4087(SMAD2) 4088(SMAD3)
PTR: 455407(SMAD2) 748161(SMAD3)
PPS: 100980706(SMAD2) 100993322(SMAD3)
GGO: 101154310(SMAD2) 109025264(SMAD3)
PON: 100173357(SMAD2) 100448249(SMAD3)
NLE: 100583279(SMAD3) 100589735(SMAD2)
MCC: 697581(SMAD2) 711355(SMAD3)
MCF: 101925163(SMAD2) 102146086(SMAD3)
CSAB: 103222457(SMAD2) 103245436(SMAD3)
RRO: 104657832(SMAD2) 104662580(SMAD3)
RBB: 108514714(SMAD3) 108519603(SMAD2)
CJC: 100393808(SMAD3) 100396826(SMAD2)
SBQ: 101039593(SMAD3) 101040653(SMAD2)
MMU: 17126(Smad2) 17127(Smad3)
RNO: 25631(Smad3) 29357(Smad2)
CGE: 100759220(Smad3) 100771578(Smad2)
NGI: 103727836(Smad2) 103736807(Smad3)
HGL: 101713378(Smad3) 101714203(Smad2) 101723857
CCAN: 109700302 109701514(Smad3)
OCU: 100346303(SMAD3) 100359137(SMAD2)
TUP: 102473158(SMAD3) 102499541(SMAD2)
CFA: 480144(SMAD2) 610902(SMAD3)
AML: 100467069(SMAD2) 100479304(SMAD3)
UMR: 103663939(SMAD2) 103679154(SMAD3)
ORO: 101367515(SMAD3) 101385419(SMAD2)
FCA: 101087179(SMAD2) 101101387(SMAD3)
PTG: 102971687(SMAD2) 102971888(SMAD3)
AJU: 106972947(SMAD2) 106980367(SMAD3)
BTA: 515125(SMAD3) 516010(SMAD2)
BOM: 102282627(SMAD3) 102286495(SMAD2)
BIU: 109564704(SMAD3) 109577854(SMAD2)
PHD: 102323907(SMAD2) 102333447(SMAD3)
CHX: 102169293(SMAD3) 102188455(SMAD2)
OAS: 101114231(SMAD2) 443169(SMAD3)
SSC: 100155304(SMAD2) 397260(SMAD3)
CFR: 102508588(SMAD2) 102523073(SMAD3)
CDK: 105093274(SMAD3) 105097587(SMAD2)
BACU: 103005078(SMAD2) 103019152(SMAD3)
LVE: 103069124(SMAD2) 103085090(SMAD3)
OOR: 101278299(SMAD2) 101288074(SMAD3)
ECB: 100033843(SMAD2) 100033845(SMAD3)
EPZ: 103548562(SMAD2) 103549637(SMAD3)
EAI: 106831216(SMAD2) 106840608(SMAD3)
MYB: 102256193(SMAD2) 102259468(SMAD3)
MYD: 102758819(SMAD2) 102769241(SMAD3)
HAI: 109385242(SMAD3) 109388212(SMAD2)
RSS: 109441075(SMAD2) 109444315(SMAD3)
PALE: 102893928(SMAD2) 102895268(SMAD3)
LAV: 100663495(SMAD2) 100677673(SMAD3)
MDO: 100014493(SMAD2) 100018703(SMAD3)
SHR: 100914956(SMAD2) 100923201(SMAD3)
OAA: 100073364(SMAD2) 100085963(SMAD3)
GGA: 395132(SMAD3) 395247(SMAD2Z)
MGP: 100544037(SMAD3)
CJO: 107305704(SMAD2) 107318915(SMAD3)
APLA: 101801230(SMAD3) 101803787 101805334(SMAD2)
ACYG: 106037327(SMAD2) 106043666(SMAD3)
TGU: 100225108(SMAD2) 100228359(SMAD3)
GFR: 102040325(SMAD3) 102040865 102044404(SMAD2)
FAB: 101806307(SMAD3) 101818681(SMAD2)
PHI: 102100805(SMAD2) 102110827(SMAD3)
PMAJ: 107198156(SMAD2) 107209417(SMAD3)
CCW: 104683877(SMAD3) 104695695(SMAD2)
FPG: 101918546(SMAD2) 101924726(SMAD3)
FCH: 102053568(SMAD3) 102059402(SMAD2)
CLV: 102085910(SMAD2) 102095468(SMAD3)
EGZ: 104125236(SMAD3) 104134175(SMAD2)
AAM: 106487670(SMAD3) 106497650(SMAD2)
ASN: 102370509(SMAD2) 102379863(SMAD3)
AMJ: 102564680(SMAD3) 102564903(SMAD2)
PSS: 102449871(SMAD3) 102457921(SMAD2)
CMY: 102940642(SMAD2) 102942832 102946629(SMAD3)
CPIC: 101939963(SMAD2) 101949856(SMAD3)
ACS: 100554929(smad2) 100562178(smad3)
PVT: 110085053(SMAD2) 110087999(SMAD3)
PBI: 103058841(SMAD2) 103067237(SMAD3)
GJA: 107105564(SMAD3) 107118628(SMAD2)
XLA: 108712801(smad3) 378633(smad3.L) 399442(mad2) 432023(smad2.S)
XTR: 493272(smad3) 496586(smad2)
NPR: 108784107(SMAD3) 108786433(SMAD2) 108800436
DRE: 30639(smad2) 58092(smad3a)
IPU: 108259569(SMAD3) 108264458 108277249(smad2)
SFM: 108934681(smad3) 108936291(smad2) 108938101
LCM: 102356317(SMAD3) 102360430(SMAD2)
CMK: 103187354(smad2) 103189587(smad3)
CIN: 100178575(Smad2/3b) 778755(smad2/3a) 778756(smad2/3b)
SPU: 577345
SKO: 100313734(Smad2/3)
DME: Dmel_CG2262(Smox)
DSI: Dsimw501_GD24642(Dsim_GD24642)
MDE: 101890260
AAG: 5570959
AME: 412601(SMAD3)
BIM: 100740756
BTER: 100646575
SOC: 105193574
AEC: 105152835
ACEP: 105624937
PBAR: 105424505
HST: 105184734
CFO: 105256957
LHU: 105679381
PGC: 109857096
NVI: 100114895(Smox)
TCA: 662450
DPA: 109536357
NVL: 108567240
BMOR: 101738552
PRAP: 110993832
API: 100164536
DNX: 107167109
ZNE: 110837117
FCD: 110849299
TUT: 107364231
BMY: Bm1_03720
TSP: Tsp_05943
OBI: 106878050
EPA: 110238115
ADF: 107337755(AdiSmad2/3)
HMG: 100205127
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8673135
  Authors
Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B
  Title
Mad-related genes in the human.
  Journal
Nat Genet 13:347-9 (1996)
DOI:10.1038/ng0796-347
  Sequence
[hsa:4087 4088]

DBGET integrated database retrieval system