KEGG   ORTHOLOGY: K04501Help
Entry
K04501                      KO                                     

Name
SMAD4
Definition
mothers against decapentaplegic homolog 4
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04310  Wnt signaling pathway
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05161  Hepatitis B
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00679  BMP signaling
M00680  TGF-beta signaling
M00681  Activin signaling
Disease
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00533  Hereditary hemorrhagic telangiectasia (HHT)
H01023  Juvenile polyposis syndrome
H02102  Myhre syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04371 Apelin signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Cellular community - eukaryotes
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05225 Hepatocellular carcinoma
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05226 Gastric cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  Infectious diseases
   05166 HTLV-I infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00679  BMP signaling
     K04501  SMAD4; mothers against decapentaplegic homolog 4
    M00680  TGF-beta signaling
     K04501  SMAD4; mothers against decapentaplegic homolog 4
    M00681  Activin signaling
     K04501  SMAD4; mothers against decapentaplegic homolog 4
BRITE hierarchy
Other DBs
GO: 0070412
Genes
HSA: 4089(SMAD4)
PTR: 468537(SMAD4)
PPS: 100991127(SMAD4)
GGO: 101153595(SMAD4) 101153944
PON: 100439171(SMAD4)
NLE: 100599586(SMAD4)
MCC: 701803(SMAD4)
MCF: 102142438(SMAD4)
CSAB: 103222414(SMAD4)
RRO: 104672916(SMAD4)
RBB: 108533135(SMAD4)
CJC: 100409302(SMAD4)
SBQ: 101032066(SMAD4)
MMU: 17128(Smad4)
RNO: 50554(Smad4)
CGE: 100770737(Smad4)
NGI: 103726635(Smad4)
HGL: 101703764(Smad4)
CCAN: 109687032(Smad4)
OCU: 100342294(SMAD4)
TUP: 102494008(SMAD4)
CFA: 476196(SMAD4)
AML: 100465063(SMAD4)
UMR: 103664305(SMAD4)
ORO: 101374152(SMAD4)
FCA: 101093650(SMAD4)
PTG: 102961093(SMAD4)
AJU: 106974966(SMAD4)
BTA: 540248(SMAD4)
BOM: 102265995(SMAD4)
BIU: 109577834(SMAD4)
PHD: 102316189(SMAD4)
CHX: 100861019(SMAD4)
OAS: 443171(SMAD4)
SSC: 397142(SMAD4)
CFR: 102507868(SMAD4)
CDK: 105103392(SMAD4)
BACU: 103014916(SMAD4)
LVE: 103084261(SMAD4)
OOR: 101285250(SMAD4)
ECB: 100033846(SMAD4)
EPZ: 103558026(SMAD4)
EAI: 106834799(SMAD4)
MYB: 102259994(SMAD4)
MYD: 102752949(SMAD4)
HAI: 109373579(SMAD4)
RSS: 109441566(SMAD4)
PALE: 102886521(SMAD4)
LAV: 100659509(SMAD4)
TMU: 101358763
MDO: 100010143(SMAD4)
SHR: 100923569(SMAD4)
OAA: 100077136(SMAD4)
GGA: 107055136(SMAD4)
CJO: 107306999(SMAD4) 107324374
APLA: 101805274(SMAD4)
ACYG: 106037328(SMAD4)
GFR: 102041942 102043998(SMAD4)
FAB: 101815515(SMAD4)
PHI: 102111851 102113882(SMAD4)
PMAJ: 107198457(SMAD4) 107214624
CCW: 104686787(SMAD4)
FPG: 101918184(SMAD4) 101924446
FCH: 102048236 102057734(SMAD4)
CLV: 102095020(SMAD4)
EGZ: 104134164(SMAD4)
AAM: 106494875(SMAD4)
ASN: 102373921 102375399(SMAD4)
AMJ: 102572775 102576984(SMAD4)
PSS: 102451711(SMAD4)
CMY: 102945070 102945563(SMAD4)
CPIC: 101944321 101946126(SMAD4)
ACS: 100552093(smad4)
PVT: 110088492 110088634(SMAD4)
PBI: 103061201(SMAD4)
GJA: 107110886 107122009(SMAD4)
XLA: 108700426 108707339 403356(smad4.2.L) 403398(smad4.2.S) 779167 780764(smad4.1.L)
XTR: 100038088(smad4.1)
DRE: 559111(smad4a) 560317(si:dkey-222b8.1)
LCM: 102353847(SMAD4) 102358988
CMK: 103187334(smad4)
CIN: 778905(smad4)
SPU: 575230
APLC: 110974480
SKO: 100369846
DME: Dmel_CG1775(Med)
DSI: Dsimw501_GD21590(Dsim_GD21590)
MDE: 101896100
AAG: 5578896
AME: 409321(Med)
BIM: 100745462
BTER: 100644192
SOC: 105196014
AEC: 105151202
PBAR: 105424697
HST: 105185083
CFO: 105249584
LHU: 105675683
PGC: 109853770
TCA: 660074(Med)
NVL: 108564214
BMOR: 101745398
PMAC: 106721123
PRAP: 110994482
PXY: 105390488
DNX: 107162437
ZNE: 110836883
FCD: 110848123
TUT: 107363666
CEL: CELE_F25E2.5(daf-3) CELE_R12B2.1(sma-4)
CBR: CBG08108(Cbr-daf-3) CBG09090(Cbr-sma-4)
BMY: Bm1_38760
CRG: 105331371
MYI: 110466964
OBI: 106876392
SHX: MS3_10165
EPA: 110239172
ADF: 107335512 107357814(AdiSmad4)
HMG: 100198878
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8553070
  Authors
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE
  Title
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
  Journal
Science 271:350-3 (1996)
DOI:10.1126/science.271.5247.350
  Sequence
[hsa:4089]

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