KEGG ORTHOLOGY: K04533

ORTHOLOGY: K04533

Entry

K04533                      KO

Symbol

Name

huntingtin

Pathway

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00059

Huntington disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04533  HD; huntingtin
   05022 Pathways of neurodegeneration - multiple diseases
    K04533  HD; huntingtin
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K04533  HD; huntingtin
   04131 Membrane trafficking
    K04533  HD; huntingtin
   03029 Mitochondrial biogenesis
    K04533  HD; huntingtin
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K04533  HD; huntingtin
Membrane trafficking [BR:ko04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K04533  HD; huntingtin
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K04533  HD; huntingtin

Genes

HSA:

3064(HTT)

PTR:	461084(HTT)

PPS:	100978882(HTT)

GGO:	101125657(HTT)

PON:	100442500(HTT)

NLE:	100595586(HTT)

HMH:	116457078(HTT)

MCC:	700306(HTT)

MCF:	102128821(HTT)

MTHB:

126955552

MNI:	105483865(HTT)

CSAB:

103246449(HTT)

CATY:

105585458(HTT)

PANU:

101000758(HTT)

TGE:	112624600(HTT)

MLEU:

105555310(HTT)

RRO:	104678957(HTT)

RBB:	108522748(HTT)

TFN:	117085071(HTT)

PTEH:

111539097(HTT)

CANG:

105507075(HTT)

CJC:	100403524(HTT)

SBQ:	101027463(HTT)

CIMI:

108293090(HTT)

CSYR:

103258066(HTT)

MMUR:

105856002(HTT)

LCAT:

123622114(HTT)

PCOQ:

105818911(HTT)

OGA:	100946793(HTT)

MMU:	15194(Htt)

MCAL:

110295148(Htt)

MPAH:

110330941(Htt)

RNO:	29424(Htt)

MCOC:

116070014(Htt)

ANU:	117712477(Htt)

MUN:	110552401(Htt)

CGE:	100764729(Htt)

MAUA:

101830681(Htt)

PROB:

127233716(Htt)

PLEU:

114694077(Htt)

MORG:

121436398 121459250

MFOT:

126500753

AAMP:

119800776(Htt)

NGI:	103741151(Htt)

HGL:	101697599(Htt)

CPOC:

100713322(Htt)

CCAN:

109687432(Htt)

DORD:

105991274(Htt)

DSP:	122100652(Htt)

PLOP:

125365045(Htt)

NCAR:

124994030

MMMA:

107139096(Htt)

OCU:

100351801

TUP:	102496123(HTT)

GVR:	103594719(HTT)

CFA:	479074(HTT)

CLUD:

112653709(HTT)

VVP:	112922672(HTT)

VLG:	121489071(HTT)

NPO:	129510518(HTT)

AML:	100466808(HTT)

UMR:	103677033(HTT)

UAH:	113245750(HTT)

UAR:	123775561(HTT)

ELK:

111149245

LLV:

125093489

MPUF:

101687209(HTT)

MNP:	132003969(HTT)

MLK:	131826799(HTT)

NVS:	122919092(HTT)

ORO:	101375437(HTT)

EJU:	114196594(HTT)

ZCA:	113924758(HTT)

MLX:	118010767(HTT)

NSU:	110569778(HTT)

FCA:	101086476(HTT)

PYU:	121039045(HTT)

PCOO:

112858239(HTT)

PBG:	122479104(HTT)

PVIV:

125159170(HTT)

LRUF:

124522605

PTG:	102961886(HTT)

PPAD:

109269744(HTT)

PUC:

125922575

AJU:

106978831

HHV:	120231854(HTT)

BTA:	615059(HTT)

BOM:	102283586(HTT)

BIU:	109560744(HTT)

BBUB:

102416640(HTT)

BBIS:

104994477(HTT)

CHX:	102183227(HTT)

OAS:	100216476(HTT)

BTAX:

128049460(HTT)

ODA:	120861814(HTT)

CCAD:

122428460(HTT)

MBEZ:

129562208(HTT)

SSC:	397014(HTT)

CFR:	102521890(HTT)

CBAI:

105072567(HTT)

CDK:	105103925(HTT)

VPC:	102539614(HTT)

BACU:

103013686(HTT)

BMUS:

118895248(HTT)

LVE:	103073863(HTT)

OOR:	101289696(HTT)

DLE:	111164902(HTT)

PCAD:

102987968(HTT)

PSIU:

116754056(HTT)

NASI:

112399745(HTT)

ECB:	100053721(HTT)

EPZ:	103558676(HTT)

EAI:	106842003(HTT)

MYB:	102250928(HTT)

MYD:	102768616(HTT)

MMYO:

118666002(HTT)

MLF:	102421627(HTT)

PKL:	118707187(HTT)

EFUS:

103294564(HTT)

MNA:	107524070(HTT)

DRO:	112316670(HTT)

SHON:

118987450(HTT)

AJM:	119035592(HTT)

PDIC:

114489960(HTT)

PHAS:

123815603(HTT)

MMF:	118638852(HTT)

PPAM:

129077491(HTT)

HAI:	109390906(HTT)

RFQ:	117022642(HTT)

PALE:

102896722(HTT)

PGIG:

120582881(HTT)

PVP:	105301227(HTT)

RAY:	107517979(HTT)

MJV:	108395692(HTT)

TOD:	119260654(HTT)

SARA:

101554954(HTT)

LAV:	100670335(HTT)

TMU:

101360779

ETF:	101639805(HTT)

DNM:	101427036(HTT)

MDO:	100015315(HTT)

GAS:	123252472(HTT)

SHR:	100930812(HTT)

AFZ:

127540865

PCW:	110212213(HTT)

OAA:	103169301(HTT)

GGA:	422878(HTT)

PCOC:

116225762(HTT)

MGP:

100540532

CJO:	107313923(HTT)

TPAI:

128080023(HTT)

LMUT:

125691709(HTT)

NMEL:

110397762(HTT)

APLA:

101789649(HTT)

ACYG:

106034665(HTT)

CATA:

118248416(HTT)

AFUL:

116488763(HTT)

TGU:	100219938(HTT)

LSR:	110481892(HTT)

SCAN:

103823923(HTT)

PMOA:

120509336(HTT)

OTC:	121334924(HTT)

PRUF:

121364108(HTT)

GFR:	102039142(HTT)

FAB:	101807378(HTT)

OMA:	130252211(HTT)

PHI:	102109876(HTT)

PMAJ:

107202828(HTT)

CCAE:

111928237(HTT)

CCW:	104690918(HTT)

CBRC:

103611183(HTT)

ETL:	114061216(HTT)

ZAB:	102070356(HTT)

ACHL:

103802674(HTT)

SVG:	106865302(HTT)

MMEA:

130573098(HTT)

HRT:	120752517(HTT)

FPG:	101912601(HTT)

FCH:	102053260(HTT)

CLV:	102097560(HTT)

EGZ:	104130204(HTT)

NNI:	104018056(HTT)

PCRI:

104033564(HTT)

PLET:

104623263(HTT)

EHS:	104509107(HTT)

PCAO:

104044097(HTT)

ACUN:

113479031(HTT)

TALA:

104359717(HTT)

PADL:

103920991(HTT)

AFOR:

103904045(HTT)

ACHC:

115337829(HTT)

HALD:

104320272(HTT)

HLE:	104841686(HTT)

AGEN:

126037548

GCL:

127016217

CCRI:

104168266(HTT)

CSTI:

104549566(HTT)

CMAC:

104473308(HTT)

MUI:	104547922(HTT)

BREG:

104637799(HTT)

FGA:	104069426(HTT)

GSTE:

104261461(HTT)

LDI:	104355114(HTT)

MNB:	103771420(HTT)

OHA:	104335208(HTT)

NNT:	104406158(HTT)

SHAB:

115610363(HTT)

DPUB:

104308860(HTT)

PGUU:

104464991(HTT)

ACAR:

104532135(HTT)

CPEA:

104391069(HTT)

AVIT:

104273412(HTT)

CVF:	104291324(HTT)

RTD:	128909827(HTT)

CUCA:

104062567(HTT)

BRHI:

104490845(HTT)

AAM:	106498723(HTT)

AROW:

112965522(HTT)

NPD:	112943012(HTT)

TGT:	104565807(HTT)

DNE:	112996534(HTT)

SCAM:

104151373(HTT)

ASN:	102381087(HTT)

AMJ:	102572238(HTT)

CPOO:

109322114(HTT)

GGN:	109303789(HTT)

PSS:	102450502(HTT)

CMY:	102938975(HTT)

CCAY:

125636221(HTT)

DCC:	119854565(HTT)

CPIC:

101939389(HTT)

TST:	117878311(HTT)

CABI:

116825220(HTT)

MRV:	120406296(HTT)

ACS:	100565638(htt)

ASAO:

132776404(HTT)

PVT:	110091151(HTT) 110091731

SUND:

121931667(HTT)

PBI:	103059334(HTT)

PMUR:

107298580(HTT)

CTIG:

120316192(HTT)

APRI:

131203343(HTT)

PTEX:

113435757(HTT)

NSS:	113426012(HTT)

VKO:	123016993(HTT)

PMUA:

114604110(HTT)

PRAF:

128421112(HTT)

ZVI:	118083633(HTT)

HCG:	128325946(HTT)

GJA:	107118340(HTT)

STOW:

125439912

EMC:	129343060(HTT)

XLA:	108697843(htt.L)

XTR:	493287(htt)

NPR:	108785827(HTT)

RTEM:

120924398(HTT)

BBUF:

120990392(HTT)

BGAR:

122939600(HTT)

MUO:	115461377(HTT)

GSH:	117363084(HTT)

DRE:	30214(htt)

SRX:	107714228 107749891(htt)

SANH:

107674220 107679870

SGH:	107551186 107556526

CCAR:

109098744 109098746

CAUA:

113075089 113097521

CGIB:

127948774 127972782 127973003

PTET:

122341945(htt)

LROH:

127165538(htt)

OMC:	131537200(htt)

PPRM:

120492122(htt)

RKG:	130076299(htt)

MAMB:

125272163(htt)

CIDE:

127520237

MASI:

127443871 127444768

TROS:

130552696(htt)

TDW:	130438967(htt)

MANU:

129444335(htt)

IPU:

108263566

IFU:	128605996(htt)

PHYP:

113538549(htt)

SMEO:

124397612(htt)

TFD:	113642389(htt)

TVC:	132847539(htt)

AMEX:

103040957(htt)

CMAO:

118810775(htt)

EEE:	113571465(htt)

CHAR:

105908374(htt)

TRU:	101065600(htt)

TFS:	130527103(htt)

TNG:	GSTEN00022637G001

LCO:	104921948(htt)

NCC:

104946108

TBEN:

117481449(htt)

CGOB:

115021827(htt)

PGEO:

117451179(htt)

GACU:

117537245(htt)

EMAC:

134864441(htt)

ELY:	117255419(htt)

EFO:	125883411(htt)

PLEP:

121941461(htt)

SLUC:

116039544(htt)

ECRA:

117953073(htt)

ESP:	116695991(htt)

PFLV:

114565134(htt)

GAT:	120824974(htt)

PPUG:

119217461(htt)

AFB:	129095321(htt)

CLUM:

117739593(htt)

PSWI:

130190277(htt)

MSAM:

119899653(htt)

SCHU:

122873598(htt)

CUD:	121508384(htt)

ALAT:

119026077(htt)

MZE:	101475773(htt)

ONL:	100703195(htt)

OAU:	116331591(htt)

OLA:	101174004(htt)

OML:	112139371(htt)

CSAI:

133447313(htt)

XMA:	102230889(htt)

XCO:	114144472(htt)

XHE:	116720571(htt)

PRET:

103464399(htt)

PFOR:

103133471(htt)

PLAI:

106957083(htt)

PMEI:

106930924(htt)

GAF:	122829218(htt)

PPRL:

129366926(htt)

CVG:	107093761(htt)

CTUL:

119798014(htt)

GMU:	124868215(htt)

NFU:	107393230(htt)

KMR:	108236369(htt)

ALIM:

106524348(htt)

NWH:	119423251(htt)

AOCE:

111567212(htt)

MCEP:

125004507(htt)

CSEM:

103384197(htt)

POV:	109627550(htt)

SSEN:

122770715(htt)

HHIP:

117762804(htt)

HSP:	118117589(htt)

SMAU:

118312247(htt)

LCF:

108875667

SDU:	111217939(htt)

SLAL:

111664606(htt)

XGL:	120799912(htt)

HCQ:	109527350(htt)

SSCV:

125969594

SBIA:

133505928(htt)

PEE:	133403516(htt)

PTAO:

133476363(htt)

BPEC:

110175726(htt)

MALB:

109957861(htt)

BSPL:

114853636(htt)

SJO:	128368816(htt)

STRU:

115184253 115184257

OTW:	112241182 112242282

OMY:	110511504 110516172

OGO:	124023970(htt)

OKI:

109904908

OKE:

127907901

CCLU:

121562085(htt)

ELS:	105020824(htt)

SFM:	108925735(htt)

PKI:	111853089(htt)

AANG:

118228513 118232078

LOC:	102696567(htt)

PSPA:

121325047(htt) 121330443

ARUT:

117409069 117420682

PSEX:

120527804(htt)

LCM:	102363933(HTT)

CMK:	103186321(htt)

RTP:	109933868(htt)

CPLA:

122556681(htt)

HOC:	132821834(htt)

LERI:

129695389(htt)

PMRN:

116940405(HTT)

LRJ:	133343257(HTT)

BFO:	118408460 118408470

BBEL:

109478414

CIN:	100145818(htt)

SCLV:

120339448

SPU:	373520 591027

LPIC:

129273453

APLC:

110973838

SKO:	100329031(Htt)

DME:	Dmel_CG9995(htt)

DER:

6555425

DSE:

6612602

DSI:	Dsimw501_GD21379(Dsim_GD21379)

DYA:	Dyak_GE23798

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22240

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ004120

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209103

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105384186 105387789 105391361

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM577330

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_106588

DMK:

116931745

DPZ:

124340770

PVM:

113820996

PJA:	122249370 122256716

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

LPOL:

BMY:	BM_BM10959(Bm10959)

LOA:	LOAG_18001

TSP:

Tsp_02358

HRO:	HELRODRAFT_170769

LGI:	LOTGIDRAFT_160793

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:	125645443 125658073

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_165420

SHX:	MS3_00004397(SNAI2_2)

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_28161

AQU:

105312249

MBR:	MONBRDRAFT_33791

SRE:	PTSG_00669

DDI:	DDB_G0272344(hd)

DPP:	DICPUDRAFT_95859

DFA:	DFA_08956(hd)

ACAN:

ACA1_131840

» show all

Reference

PMID:8458085

Title

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Journal

Cell 72:971-83 (1993)
DOI:10.1016/0092-8674(93)90585-e

Sequence

[hsa:3064]

Reference

PMID:24407293

Authors

Tourette C, Li B, Bell R, O'Hare S, Kaltenbach LS, Mooney SD, Hughes RE

Title

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.

Journal

J Biol Chem 289:6709-26 (2014)
DOI:10.1074/jbc.M113.523696

Sequence

[hsa:3064]

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DRUG (2)   
Gene (3041)   
   KEGG GENES (630)   
   KEGG MGENES (1084)   
   RefGene (1320)   
   OC (7)   
Literature (2)   
   PubMed (2)   
All databases (3054)   

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