ko:K04606 : No such data.
ko:K04609 : No such data.
ko:K04610 : No such data.

KEGG   ORTHOLOGY: K04603Help
Entry
K04603                      KO                                     

Name
GRM1
Definition
metabotropic glutamate receptor 1
Pathway
ko04020  Calcium signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04540  Gap junction
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04730  Long-term depression
ko04742  Taste transduction
ko04915  Estrogen signaling pathway
Disease
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04020 Calcium signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04072 Phospholipase D signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04603  GRM1; metabotropic glutamate receptor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04603  GRM1; metabotropic glutamate receptor 1
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K04603  GRM1; metabotropic glutamate receptor 1
   04720 Long-term potentiation
    K04603  GRM1; metabotropic glutamate receptor 1
   04730 Long-term depression
    K04603  GRM1; metabotropic glutamate receptor 1
   04723 Retrograde endocannabinoid signaling
    K04603  GRM1; metabotropic glutamate receptor 1
  09157 Sensory system
   04742 Taste transduction
    K04603  GRM1; metabotropic glutamate receptor 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K04603  GRM1; metabotropic glutamate receptor 1
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04603  GRM1; metabotropic glutamate receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04603  GRM1; metabotropic glutamate receptor 1
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04603  GRM1; metabotropic glutamate receptor 1
BRITE hierarchy
Other DBs
GO: 0001639
TC: 9.A.14.7.1
Genes
HSA: 2911(GRM1)
PTR: 463049(GRM1)
PPS: 100968079(GRM1)
GGO: 101150458(GRM1)
PON: 100451342(GRM1)
NLE: 100592587(GRM1)
MCC: 698736(GRM1)
MCF: 102145647(GRM1)
CSAB: 103240205(GRM1)
RRO: 104653776(GRM1)
RBB: 108533191(GRM1)
CJC: 100410312(GRM1)
SBQ: 101036619(GRM1)
MMU: 14816(Grm1)
RNO: 24414(Grm1)
CGE: 100751598(Grm1)
NGI: 103737030(Grm1)
HGL: 101712477(Grm1)
OCU: 100356201(GRM1)
TUP: 102479064(GRM1)
CFA: 484024(GRM1)
AML: 100479929(GRM1)
UMR: 103666935(GRM1)
ORO: 101366183 101370296(GRM1)
FCA: 101094104(GRM1)
PTG: 102961964(GRM1) 107180681
AJU: 106965803
BTA: 540485(GRM1)
BOM: 102280395(GRM1)
BIU: 109563668(GRM1)
PHD: 102325561(GRM1)
CHX: 102185002(GRM1)
OAS: 443101(GRM1)
SSC: 100625610(GRM1)
CFR: 102522216 102523079(GRM1)
CDK: 105092074(GRM1)
BACU: 102999780(GRM1)
LVE: 103085587(GRM1)
OOR: 101286756(GRM1)
ECB: 100060603(GRM1)
EPZ: 103564725(GRM1)
EAI: 106837226(GRM1)
MYB: 102262360(GRM1)
MYD: 102757163 102768205(GRM1)
HAI: 109380898(GRM1)
RSS: 109454117(GRM1)
PALE: 102878912(GRM1)
TMU: 101357087
MDO: 100026724(GRM1)
SHR: 100919608 100929416(GRM1)
OAA: 100075372 103165077(GRM1)
GGA: 421614(GRM1)
MGP: 100540165(GRM1)
CJO: 107311576(GRM1)
APLA: 101803914(GRM1)
ACYG: 106034294(GRM1)
TGU: 751999(GRM1)
GFR: 102038278(GRM1)
FAB: 101807135(GRM1)
PHI: 102107527(GRM1)
PMAJ: 107202384(GRM1)
CCW: 104689210(GRM1)
FPG: 101920400(GRM1)
FCH: 102046326 102050937(GRM1)
CLV: 102091439(GRM1)
EGZ: 104133563(GRM1)
AAM: 106486778(GRM1)
ASN: 102378290(GRM1)
AMJ: 102563002(GRM1)
PSS: 102460135(GRM1)
CMY: 102932638(GRM1)
CPIC: 101940955(GRM1)
ACS: 100564433(grm1)
PVT: 110088369(GRM1)
PBI: 103054361 103054861(GRM1)
GJA: 107111120(GRM1)
XTR: 100495945(grm1)
NPR: 108787741(GRM1)
DRE: 100150246(grm1b) 555576(grm1a)
IPU: 108270069(grm1) 108279026
LCO: 104929400 104934310(grm1)
MZE: 101467938 101483242(grm1)
OLA: 101165118(grm1) 101170976
XMA: 102224833(grm1) 102226132
PRET: 103457526(grm1) 103458356
NFU: 107377567(grm1) 107391977
CSEM: 103380242 103381085(grm1)
HCQ: 109527746(grm1)
BPEC: 110155964(grm1) 110172139
ELS: 105015396 105029905(grm1)
LCM: 102359097(GRM1)
CMK: 103179290(grm1)
SKO: 100366462(GRM5) 100368806
NVI: 100118400(GRM1)
DPA: 109543383
NVL: 108560290
DPX: DAPPUDRAFT_64876(Grm5)
MYI: 110452574
EPA: 110248569
HMG: 100206629
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:1847995
  Authors
Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S
  Title
Sequence and expression of a metabotropic glutamate receptor.
  Journal
Nature 349:760-5 (1991)
DOI:10.1038/349760a0
  Sequence
[rno:24414]

KEGG   ORTHOLOGY: K04605Help
Entry
K04605                      KO                                     

Name
GRM2_3
Definition
metabotropic glutamate receptor 2/3
Pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04724  Glutamatergic synapse
ko05030  Cocaine addiction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
 09160 Human Diseases
  09164 Substance dependence
   05030 Cocaine addiction
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
BRITE hierarchy
Other DBs
GO: 0001641
Genes
HSA: 2912(GRM2) 2913(GRM3)
PTR: 100611779(GRM2) 746019(GRM3)
PPS: 100979630(GRM3) 100994960(GRM2)
GGO: 101136022(GRM3) 101141235(GRM2)
PON: 100172627(GRM3) 100445531(GRM2)
NLE: 100594386(GRM3) 100599760(GRM2)
MCC: 700214(GRM2) 706645(GRM3)
MCF: 101925540(GRM3) 102126215(GRM2)
CSAB: 103226618(GRM3) 103227697(GRM2)
RRO: 104668024(GRM3) 104676756(GRM2)
RBB: 108515138(GRM3) 108539926(GRM2)
CJC: 100392187 100408550(GRM3) 100413741(GRM2)
SBQ: 101033315(GRM2) 101049103(GRM3)
MMU: 108068(Grm2) 108069(Grm3)
RNO: 24415(Grm2) 24416(Grm3)
CGE: 100760036(Grm3) 100772929(Grm2)
NGI: 103725169(Grm3) 103747305(Grm2)
HGL: 101713039(Grm3) 101722804(Grm2)
CCAN: 109689413(Grm2) 109702358(Grm3)
OCU: 100343810(GRM2) 100356452(GRM3)
TUP: 102474413(GRM2) 102483840(GRM3)
CFA: 100683236(GRM3) 484751(GRM2)
AML: 100474356(GRM3) 100475146(GRM2)
UMR: 103658785(GRM3) 103674782(GRM2)
ORO: 101366239(GRM3) 101376087(GRM2)
FCA: 101095810(GRM3) 101098611(GRM2)
PTG: 102952925(GRM2) 102956816(GRM3) 107179117
AJU: 106971747(GRM3) 106987051(GRM2)
BTA: 519904(GRM2) 541056(GRM3)
BOM: 102280421(GRM3) 102282435(GRM2)
BIU: 109557324(GRM3) 109575969(GRM2)
PHD: 102323701(GRM3) 102331452(GRM2)
CHX: 102181359(GRM3) 102190178(GRM2)
OAS: 101113057(GRM3) 101116870(GRM2)
SSC: 100520271(GRM2) 100521916(GRM3)
CFR: 102513392(GRM3) 102516735(GRM2)
CDK: 105087246(GRM2) 105087351(GRM3)
BACU: 102997832(GRM2) 102999582(GRM3)
LVE: 103079932(GRM2) 103089829(GRM3)
OOR: 101275396(GRM3) 101284234(GRM2)
ECB: 100049918(GRM3) 100052178(GRM2)
EPZ: 103562299(GRM3) 103566922(GRM2)
EAI: 106830749(GRM2) 106838945(GRM3)
MYB: 102240199(GRM2) 102262324(GRM3)
MYD: 102764328(GRM3) 102774795(GRM2)
HAI: 109371302(GRM3) 109375835(GRM2)
RSS: 109457107(GRM3) 109459079(GRM2)
PALE: 102881876(GRM3) 102883719(GRM2)
LAV: 100663502(GRM3) 100664937(GRM2)
MDO: 100012410(GRM3)
SHR: 100914275(GRM2) 100929851(GRM3)
OAA: 100085098(GRM3) 100089261(GRM2)
GGA: 418644(GRM3) 427575(GRM2)
MGP: 100549789(GRM2) 100549860(GRM3)
CJO: 107319627(GRM2) 107320082(GRM3)
APLA: 101798622(GRM2) 101803353(GRM3)
ACYG: 106035553(GRM3) 106049494(GRM2)
TGU: 751955(GRM2) 751962(GRM3)
GFR: 102035741(GRM2) 102044527(GRM3)
FAB: 101806833(GRM2) 101817776(GRM3)
PHI: 102105121(GRM2) 102113129(GRM3)
PMAJ: 107205045(GRM3) 107210417(GRM2)
CCW: 104683251(GRM2) 104694485(GRM3)
FPG: 101911554(GRM2) 101913502(GRM3)
FCH: 102049507(GRM2) 102057003(GRM3)
CLV: 102084053(GRM3) 102086489(GRM2)
EGZ: 104126736(GRM2) 104132384(GRM3)
AAM: 106485312(GRM3) 106495124(GRM2)
ASN: 102383301(GRM2) 102387340(GRM3)
AMJ: 102562670(GRM3) 102568116(GRM2)
PSS: 102447321(GRM3) 102456777(GRM2)
CMY: 102935313(GRM3) 102939137(GRM2) 102948083
CPIC: 101930971(GRM2) 101948606(GRM3)
ACS: 100554492(grm3) 100566733(grm2)
PVT: 110082715(GRM3) 110084471(GRM2)
PBI: 103048220(GRM2) 103057760
GJA: 107115924(GRM2) 107125951(GRM3)
XLA: 108711210(grm3.L) 108713057(grm3.S) 108714614(grm2.L) 108715835(grm2.S)
XTR: 100380092(grm2) 100492610(grm3)
NPR: 108793453(GRM2) 108794073(GRM3)
DRE: 336153(grm2a) 564461(grm2b) 565256(grm3)
TRU: 101065312 101065663(grm3) 101079845(grm2)
LCO: 104918117(grm3) 104920514 104930497(grm2)
LCM: 102362012(GRM2) 102363231(GRM3)
CMK: 103172906 103176760(grm2)
SPU: 579746(grm3)
DME: Dmel_CG11144(mGluR)
DSI: Dsimw501_GD28322(Dsim_GD28322)
AME: 406151(mGlutR1)
BIM: 100749307
BTER: 100650736
SOC: 105202369
AEC: 105144594
ACEP: 105623618
PBAR: 105426484
HST: 105183564
CFO: 105254229
LHU: 105676744
PGC: 109856438
TCA: 661133
DPA: 109533892
DPX: DAPPUDRAFT_44069(Grm1)
CEL: CELE_ZC506.4(mgl-1)
CBR: CBG01949(Cbr-mgl-1)
TSP: Tsp_07699
HMG: 100209185
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:7620613
  Authors
Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R
  Title
Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.
  Journal
Eur J Neurosci 7:622-9 (1995)
DOI:10.1111/j.1460-9568.1995.tb00666.x
  Sequence
[hsa:2912]

KEGG   ORTHOLOGY: K04607Help
Entry
K04607                      KO                                     

Name
GRM4
Definition
metabotropic glutamate receptor 4
Pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04724  Glutamatergic synapse
ko04742  Taste transduction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K04607  GRM4; metabotropic glutamate receptor 4
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04607  GRM4; metabotropic glutamate receptor 4
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04607  GRM4; metabotropic glutamate receptor 4
  09157 Sensory system
   04742 Taste transduction
    K04607  GRM4; metabotropic glutamate receptor 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04607  GRM4; metabotropic glutamate receptor 4
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04607  GRM4; metabotropic glutamate receptor 4
BRITE hierarchy
Other DBs
GO: 0001642
Genes
HSA: 2914(GRM4)
PTR: 471986(GRM4)
PPS: 100978855(GRM4)
GGO: 101128354(GRM4)
PON: 100453700(GRM4)
NLE: 100589155(GRM4)
MCC: 718489(GRM4)
MCF: 102144159(GRM4)
CSAB: 103221643(GRM4)
RRO: 104658139(GRM4)
RBB: 108516261(GRM4)
SBQ: 101050705(GRM4)
MMU: 268934(Grm4)
RNO: 24417(Grm4)
CGE: 100757229(Grm4)
NGI: 103739690(Grm4)
HGL: 101704191(Grm4)
CCAN: 109686662(Grm4)
OCU: 100347907(GRM4)
TUP: 102489984(GRM4) 106736267
CFA: 481749(GRM4)
AML: 100470828(GRM4)
UMR: 103665551(GRM4)
ORO: 101381961(GRM4)
FCA: 101094419(GRM4)
PTG: 102952540(GRM4)
BTA: 790333(GRM4)
BOM: 102281329
BIU: 109577410(GRM4)
PHD: 102332685(GRM4)
CHX: 102171388(GRM4)
OAS: 101119427(GRM4)
SSC: 100152616(GRM4)
CFR: 102512191(GRM4)
CDK: 105101369(GRM4)
BACU: 103020258(GRM4)
LVE: 103071494(GRM4)
OOR: 101279209(GRM4)
ECB: 100061879(GRM4)
EPZ: 103542493 103557769(GRM4)
EAI: 106834580(GRM4)
MYB: 102258679(GRM4)
MYD: 102755234(GRM4)
HAI: 109392436(GRM4)
RSS: 109450967(GRM4)
PALE: 102882871(GRM4)
LAV: 100668676(GRM4)
TMU: 101355156
MDO: 100027811(GRM4)
SHR: 100919335(GRM4)
OAA: 100091057
GGA: 419906(GRM4)
CJO: 107324919(GRM4)
APLA: 101791483(GRM4)
ACYG: 106046173(GRM4)
TGU: 752006(GRM4)
GFR: 102040405(GRM4)
FAB: 101809082(GRM4)
PHI: 102110281(GRM4)
PMAJ: 107214967(GRM4)
CCW: 104692379(GRM4)
FPG: 101911115(GRM4)
FCH: 102056863(GRM4)
CLV: 102098023(GRM4)
EGZ: 104125720(GRM4)
AAM: 106490932(GRM4)
ASN: 102377568(GRM4)
AMJ: 102568871(GRM4)
PSS: 102450322(GRM4)
CMY: 102938268(GRM4)
CPIC: 101946270(GRM4)
ACS: 100563466(grm4)
PVT: 110080204(GRM4)
GJA: 107118545
XLA: 108709442
XTR: 100491626(grm4) 108645782
NPR: 108787273(GRM4) 108790356
DRE: 567181(grm4)
TRU: 101061936(grm4)
NFU: 107385024(grm4) 107391254
LCF: 108882111(grm4) 108888091
SFM: 108939353(grm4)
LCM: 102365100(GRM4)
CMK: 103179169(grm4)
CIN: 100176499
ADF: 107336358
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:1309649
  Authors
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S
  Title
A family of metabotropic glutamate receptors.
  Journal
Neuron 8:169-79 (1992)
DOI:10.1016/0896-6273(92)90118-W
  Sequence
[rno:24417]

KEGG   ORTHOLOGY: K04604Help
Entry
K04604                      KO                                     

Name
GRM5
Definition
metabotropic glutamate receptor 5
Pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04540  Gap junction
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko05016  Huntington disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
   04072 Phospholipase D signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04604  GRM5; metabotropic glutamate receptor 5
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04604  GRM5; metabotropic glutamate receptor 5
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04604  GRM5; metabotropic glutamate receptor 5
   04720 Long-term potentiation
    K04604  GRM5; metabotropic glutamate receptor 5
   04723 Retrograde endocannabinoid signaling
    K04604  GRM5; metabotropic glutamate receptor 5
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05016 Huntington disease
    K04604  GRM5; metabotropic glutamate receptor 5
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04604  GRM5; metabotropic glutamate receptor 5
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04604  GRM5; metabotropic glutamate receptor 5
BRITE hierarchy
Other DBs
GO: 0001639
Genes
HSA: 2915(GRM5)
PTR: 451472(GRM5)
PPS: 100988134(GRM5)
GGO: 101148125(GRM5)
PON: 100452002(GRM5)
NLE: 100595085(GRM5)
MCC: 705445(GRM5)
MCF: 101926080(GRM5)
CSAB: 103248193(GRM5)
RRO: 104657433(GRM5)
RBB: 108539155(GRM5)
CJC: 100400074(GRM5)
SBQ: 101043023(GRM5) 104652498
MMU: 108071(Grm5)
RNO: 24418(Grm5)
CGE: 100763614(Grm5)
NGI: 103742957(Grm5)
HGL: 101696979(Grm5)
CCAN: 109674757
OCU: 100340633(GRM5)
TUP: 102486954(GRM5)
CFA: 485146(GRM5)
AML: 100466868(GRM5)
UMR: 103675379(GRM5)
ORO: 101364945(GRM5) 101372426
FCA: 101091895(GRM5)
PTG: 102957191(GRM5)
AJU: 106967780(GRM5)
BTA: 100336861(GRM5)
BOM: 102273282(GRM5)
BIU: 109554000(GRM5)
PHD: 102331335(GRM5)
CHX: 102182568(GRM5)
OAS: 443069(GRM5)
SSC: 102161751(GRM5)
CFR: 102510039(GRM5)
CDK: 105098361(GRM5)
BACU: 103017209(GRM5)
LVE: 103089884(GRM5)
OOR: 101280226(GRM5)
ECB: 100060364(GRM5)
EPZ: 103547854(GRM5)
EAI: 106822674 106848216(GRM5)
MYB: 102243205(GRM5) 102261422
MYD: 102763091(GRM5)
HAI: 109375479(GRM5)
RSS: 109451409(GRM5)
PALE: 102894122(GRM5)
LAV: 100676641(GRM5)
TMU: 101340926
MDO: 100009917(GRM5)
SHR: 100913241(GRM5)
OAA: 100080549(GRM5)
GGA: 373933(GRM5)
CJO: 107308455(GRM5)
APLA: 101805339(GRM5) 106018480
ACYG: 106034184(GRM5)
TGU: 752008(GRM5)
GFR: 102035609(GRM5)
FAB: 101814322(GRM5)
PHI: 102104616(GRM5)
PMAJ: 107207537(GRM5)
CCW: 104690322(GRM5)
FPG: 101915830(GRM5)
FCH: 102054087(GRM5)
CLV: 102093525(GRM5)
EGZ: 104128833(GRM5)
AAM: 106482085(GRM5)
ASN: 102385450(GRM5)
AMJ: 102576482(GRM5)
PSS: 102454127(GRM5)
CMY: 102935827(GRM5)
CPIC: 101935299(GRM5)
ACS: 100563209(grm5)
PVT: 110088579(GRM5)
PBI: 103056145(GRM5) 103060240
GJA: 107113358(GRM5)
XTR: 100485273(grm5)
NPR: 108794764(GRM5)
DRE: 100332913(grm5b) 568406(grm5a)
IPU: 108277301(grm5) 108277953
TRU: 101064551(grm5) 101079916
LCO: 104920135(grm5) 104923830
NCC: 104959637 104963006(grm5)
OLA: 101164491(grm5) 101173805
XMA: 102230735 102230987(grm5)
PRET: 103474487(grm5) 103475526
NFU: 107380453(grm5) 107386961
LCF: 108886623(grm5) 108893271
HCQ: 109509731 109525514(grm5)
BPEC: 110158381 110174304(grm5)
ELS: 105024084(grm5) 105026648
SFM: 108923808 108932228(grm5)
LCM: 102352410 102366420(GRM5)
CMK: 103184347(grm5)
TCA: 657397
NVL: 108556944
CEL: CELE_F45H11.4(mgl-2)
CBR: CBG02196(Cbr-mgl-2)
BMY: Bm1_13620
TSP: Tsp_11217
MYI: 110446254
EPA: 110245306
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Xiao XL, Ma DL, Wu J, Tang FR
  Title
Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
  Journal
Brain Res 1493:1-12 (2013)
DOI:10.1016/j.brainres.2012.11.015
  Sequence
[mmu:108071]

KEGG   ORTHOLOGY: K04608Help
Entry
K04608                      KO                                     

Name
GRM6_7_8
Definition
metabotropic glutamate receptor 6/7/8
Pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04724  Glutamatergic synapse
Disease
H00787  Congenital stationary night blindness (CSNB)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
BRITE hierarchy
Other DBs
GO: 0001642
Genes
HSA: 2916(GRM6) 2917(GRM7) 2918(GRM8)
PTR: 460140(GRM7) 462323(GRM6) 472502(GRM8) 743409
PPS: 100976563 100980484(GRM6) 100988058(GRM8) 100990615 100994362
GGO: 101123810(GRM7) 101125346 101126075 101141393(GRM6)
PON: 100171884(GRM7) 100436264(GRM8) 100447061(GRM6)
NLE: 100583361(GRM8) 100586584 100589726(GRM7) 100604632(GRM6)
MCC: 697465(GRM8) 702731(GRM7) 713339(GRM6)
MCF: 102127153(GRM6) 102128797(GRM8)
CSAB: 103226837(GRM8) 103227955(GRM7) 103245094(GRM6)
RRO: 104658686 104658730 104667482(GRM7) 104674474(GRM8) 104676216(GRM6)
RBB: 108525103 108530774(GRM8) 108530952(GRM7) 108539295(GRM6)
CJC: 100390040(GRM8) 100390090(GRM7) 100395536(GRM6)
SBQ: 101040561(GRM6) 101051755(GRM8) 101053518(GRM7) 104652145
MMU: 108072(Grm6) 108073(Grm7) 14823(Grm8)
RNO: 24419(Grm6) 60590(Grm8) 81672(Grm7)
CGE: 100758817(Grm8) 100764098 100768692(Grm6) 100774073(Grm7)
NGI: 103744576(Grm8) 103749383(Grm6) 103751403(Grm7)
HGL: 101697666(Grm8) 101711694(Grm7) 101717017(Grm6)
OCU: 100009501(GRM6) 100344818(GRM8) 100346053(GRM7)
TUP: 102478241(GRM7) 102479399(GRM8) 102480521 102486281(GRM6)
CFA: 481452(GRM6) 482270(GRM8) 484674(GRM7)
AML: 100471025(GRM6) 100472571(GRM8)
UMR: 103669589(GRM7) 103676623(GRM8) 103680010(GRM6)
ORO: 101366084(GRM8) 101371932(GRM7) 101381223(GRM6)
FCA: 101090088(GRM7) 101097449(GRM6) 101098127(GRM8)
BTA: 529656(GRM6) 535362(GRM7) 538360(GRM8)
BOM: 102266408(GRM8) 102278887(GRM7) 102285964(GRM6)
PHD: 102321557(GRM7) 102323128(GRM8) 102344482(GRM6)
CHX: 102170113(GRM8) 102182961(GRM6) 102190560(GRM7)
OAS: 101108742(GRM8) 443292(GRM6) 443520(GRM7)
SSC: 100524120(GRM8) 100621119(GRM7) 102162790(GRM6)
CFR: 102506395(GRM8) 102507290(GRM6) 102516607 102523757(GRM7)
CDK: 105085351(GRM8) 105093150(GRM7) 105100644(GRM6)
BACU: 103008338(GRM8) 103012357(GRM6) 103012850(GRM7)
OOR: 101279194(GRM8) 101283631(GRM6) 101284337(GRM7)
ECB: 100052696(GRM7) 100067731(GRM6) 100071655(GRM8)
EPZ: 103540009(GRM6) 103546392(GRM8) 103549493(GRM7)
MYD: 102752739(GRM7) 102764125 102766104(GRM8) 102768204(GRM6)
RSS: 109439449(GRM6) 109443581 109456186(GRM7) 109456639(GRM8)
PALE: 102878333(GRM7) 102894346(GRM6) 102898832(GRM8)
LAV: 100662461(GRM8) 100664172(GRM7) 100673918(GRM6)
MDO: 100013595(GRM7) 100014205(GRM8) 100018484(GRM6)
SHR: 100921583(GRM7) 100922771(GRM6) 100927951(GRM8)
OAA: 100077390(GRM8) 100086700 100092360(GRM6)
GGA: 416112(GRM7) 427853(GRM8)
MGP: 100540879(GRM8) 104913208(GRM7)
CJO: 107308659 107308676(GRM8) 107319945(GRM7)
APLA: 101791637(GRM7) 101796179(GRM8)
ACYG: 106036762(GRM7) 106040497(GRM8)
TGU: 100220449(GRM7) 751963(GRM8)
GFR: 102035073(GRM7) 102038282(GRM8)
FAB: 101815638(GRM8) 101817877(GRM7)
PHI: 102104191(GRM6) 102107228(GRM7) 102110564(GRM8)
PMAJ: 107204551(GRM8) 107210125(GRM7)
CCW: 104683518(GRM7) 104686828(GRM8)
FPG: 101916947(GRM7) 101917886(GRM8) 101923815
FCH: 102049020(GRM8) 102051550(GRM7) 102059094
EGZ: 104121789(GRM7) 104125669(GRM8)
AAM: 106489806(GRM7) 106495901 106495926(GRM8)
AMJ: 102561244(GRM7) 102565037 102568236(GRM8)
PSS: 102460589(GRM8) 102462852 102463673(GRM7)
CMY: 102936161 102937256(GRM8) 102938629(GRM7)
CPIC: 101934943(GRM8) 101943447(GRM7) 101952037(GRM6)
ACS: 100564323(grm8) 100565811(grm6) 100567449(grm7)
PVT: 110077874(GRM7) 110080934(GRM8) 110081176(GRM6)
XTR: 100127664(grm7) 100489237 100497088(grm8)
DRE: 100331190 565450(grm6b) 568484(grm6a) 569768(grm8b) 792371(grm8a)
LCM: 102353019(GRM8) 102353695 102361845(GRM7)
CMK: 103181848 103181894(grm8) 103185046(grm7)
SPU: 574680 575563 582475(grm7)
SKO: 100369975
AME: 411760(mGlutR2)
BIM: 100741155
BTER: 100642618
SOC: 105197884
AEC: 105145514
ACEP: 105626603
PBAR: 105431406
HST: 105191861
CFO: 105249479
LHU: 105667909
PGC: 109852659
NVI: 100123431(GRM7)
NVL: 108560036
DNX: 107165300
ZNE: 110834962
TUT: 107361405
CEL: CELE_Y4C6A.2(mgl-3)
CBR: CBG19941(Cbr-mgl-3)
BMY: Bm1_34975
OBI: 106877299
ADF: 107351380
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Devi S, Markandeya Y, Maddodi N, Dhingra A, Vardi N, Balijepalli RC, Setaluri V
  Title
Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.
  Journal
Pigment Cell Melanoma Res 26:348-56 (2013)
DOI:10.1111/pcmr.12083
  Sequence
[hsa:2916]

KEGG   ORTHOLOGY: K04611Help
Entry
K04611                      KO                                     

Name
MXR
Definition
metabotropic X receptor
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04611  MXR; metabotropic X receptor
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04611  MXR; metabotropic X receptor
BRITE hierarchy
Genes
BFO: BRAFLDRAFT_67395 BRAFLDRAFT_67396
CIN: 100179609
APLC: 110979109
SKO: 100371196 100372453 102810020
DME: Dmel_CG30361(mtt)
DPO: Dpse_GA24510
DAN: Dana_GF12584
DER: Dere_GG10638
DPE: Dper_GL10858
DSE: Dsec_GM20683
DSI: Dsimw501_GD15273(Dsim_GD15273)
AGA: AgaP_AGAP005034(GPRMGL5)
AAG: 5572476
AME: 406150(Glurb) 726424
SOC: 105200285
AEC: 105143230
PBAR: 105422030
HST: 105188887
CFO: 105256251
LHU: 105675425
PGC: 109860108
TCA: 656715
DPA: 109545398
NVL: 108560202
DNX: 107165205
TUT: 107360009
OBI: 106884394
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Mitri C, Parmentier ML, Pin JP, Bockaert J, Grau Y
  Title
Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects.
  Journal
J Biol Chem 279:9313-20 (2004)
DOI:10.1074/jbc.M310878200

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