KEGG   ORTHOLOGY: K04630Help
Entry
K04630                      KO                                     

Name
GNAI
Definition
guanine nucleotide-binding protein G(i) subunit alpha
Pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04360  Axon guidance
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04670  Leukocyte transendothelial migration
ko04713  Circadian entrainment
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04971  Gastric acid secretion
ko05012  Parkinson disease
ko05030  Cocaine addiction
ko05032  Morphine addiction
ko05034  Alcoholism
ko05133  Pertussis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05163  Human cytomegalovirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
Module
M00695  cAMP signaling
Disease
H00033  Adrenal carcinoma
H01019  Catecholaminergic polymorphic ventricular tachycardia
H01884  Auriculocondylar syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04371 Apelin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04071 Sphingolipid signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04024 cAMP signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04022 cGMP - PKG signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04670 Leukocyte transendothelial migration
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04062 Chemokine signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocyte
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04915 Estrogen signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04914 Progesterone-mediated oocyte maturation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04921 Oxytocin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04926 Relaxin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04928 Parathyroid hormone synthesis, secretion and action
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04916 Melanogenesis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04924 Renin secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09154 Digestive system
   04971 Gastric acid secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04727 GABAergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04725 Cholinergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04728 Dopaminergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04726 Serotonergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04730 Long-term depression
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09158 Development
   04360 Axon guidance
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09163 Neurodegenerative diseases
   05012 Parkinson disease
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09164 Substance dependence
   05030 Cocaine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05032 Morphine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05034 Alcoholism
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09167 Infectious diseases
   05133 Pertussis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05163 Human cytomegalovirus infection
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05145 Toxoplasmosis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04031 GTP-binding proteins
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
BRITE hierarchy
Genes
HSA: 2770(GNAI1) 2771(GNAI2) 2773(GNAI3)
PTR: 457093(GNAI3) 472425(GNAI1) 744773(GNAI2)
PPS: 100968961(GNAI3) 100974334(GNAI2) 100985590(GNAI1)
GGO: 101125616(GNAI3) 101150178(GNAI2) 101154597(GNAI1)
PON: 100172679(GNAI1) 100456074(GNAI3) 100458137(GNAI2)
NLE: 100583621(GNAI3) 100588993(GNAI2) 100604896(GNAI1)
MCC: 699310(GNAI3) 703780(GNAI2) 708940(GNAI1)
MCF: 101926144(GNAI2) 102119905(GNAI3) 102140224(GNAI1)
CSAB: 103224284(GNAI3) 103226652(GNAI1) 103227664(GNAI2)
RRO: 104655987(GNAI3) 104667102(GNAI2) 104673307 104675555
RBB: 108519632(GNAI3) 108526962(GNAI2) 108534866(GNAI1)
CJC: 100388113(GNAI1) 100404474(GNAI2) 100405745(GNAI3)
SBQ: 101032105(GNAI3) 101041681(GNAI2) 101042629(GNAI1)
MMU: 14677(Gnai1) 14678(Gnai2) 14679(Gnai3)
RNO: 25643(Gnai3) 25686(Gnai1) 81664(Gnai2)
CGE: 100689068(Gnai2) 100689070(Gnai1) 100689072(Gnai3)
NGI: 103724646 103732220(Gnai1) 103747835(Gnai3) 103750163(Gnai2)
HGL: 101698645(Gnai2) 101702965(Gnai1) 101703043(Gnai3)
CCAN: 109688838(Gnai3) 109693226(Gnai2) 109702253(Gnai1)
OCU: 100338391(GNAI1) 100339066(GNAI2) 100359147(GNAI3)
TUP: 102475420(GNAI2) 102476737(GNAI3) 102479323(GNAI1)
CFA: 442957(GNAI2) 478227(GNAI1) 611810(GNAI3)
AML: 100471767(GNAI2) 100484933(GNAI1)
UMR: 103658775(GNAI1) 103674803(GNAI2) 103675000(GNAI3)
ORO: 101367568(GNAI3) 101367936(GNAI2) 101376186(GNAI1)
FCA: 101089679(GNAI2) 101092837(GNAI1) 101100320(GNAI3)
PTG: 102951159(GNAI3) 102954501(GNAI1) 102962946(GNAI2)
AJU: 106977809(GNAI3) 106979196(GNAI2) 106982494(GNAI1)
BTA: 281790(GNAI1) 281791(GNAI2) 539521(GNAI3)
BOM: 102273920(GNAI1) 102274651(GNAI2) 102285228(GNAI3)
BIU: 109555970(GNAI3) 109557337(GNAI1) 109576257(GNAI2)
PHD: 102319715(GNAI1) 102322883(GNAI2) 102326697(GNAI3)
CHX: 100860765(GNAI2) 102185804(GNAI1) 108635583(GNAI3)
OAS: 100302341(GNAI2) 101103693(GNAI3) 101116393(GNAI1)
SSC: 100144419(GNAI1) 100144421(GNAI3) 397523(GNAI2)
CFR: 102504487(GNAI3) 102518290(GNAI1) 102522331(GNAI2)
CDK: 105085647(GNAI3) 105087520(GNAI2) 105100375(GNAI1)
BACU: 103008589(GNAI3) 103010531(GNAI2) 103017385(GNAI1)
LVE: 103077308(GNAI2) 103080185(GNAI3) 103081367(GNAI1)
OOR: 101271719(GNAI1) 101276500(GNAI2) 101277471(GNAI3)
ECB: 100055673(GNAI1) 100058238(GNAI3) 100062085(GNAI2)
EPZ: 103552141 103553052(GNAI3) 103557343(GNAI2)
EAI: 106827362(GNAI3) 106830727(GNAI2) 106833450(GNAI1)
MYB: 102239557(GNAI3) 102249318(GNAI2) 102256872(GNAI1)
MYD: 102754275(GNAI2) 102765504(GNAI3) 102766400(GNAI1)
HAI: 109375288(GNAI3) 109377665(GNAI2) 109392892(GNAI1)
RSS: 109435292(GNAI1) 109443439(GNAI2) 109446758(GNAI3)
PALE: 102885642(GNAI1) 102892785(GNAI3) 102898665(GNAI2)
LAV: 100666344(GNAI1) 100667957(GNAI3) 100670234(GNAI2)
MDO: 100013052(GNAI1) 100030095(GNAI3) 100032986(GNAI2)
SHR: 100914706(GNAI2) 100916740(GNAI1) 100928725
OAA: 100075665(GNAI1) 100089995
GGA: 374097(GNAI3) 396367(GNAI2) 396368(GNAI1)
MGP: 100540821 100542305(GNAI1) 100543856(GNAI2)
CJO: 107319651(GNAI2) 107320948 107324730(GNAI3)
APLA: 101789621 101797591(GNAI1) 101798529(GNAI2) 101803759(GNAI3)
ACYG: 106035549(GNAI1) 106042860 106049766(GNAI3)
TGU: 100219656(GNAI1) 100225910(GNAI2) 100232622(GNAI3)
GFR: 102034568(GNAI2) 102042928(GNAI1) 102045421(GNAI3)
FAB: 101806522(GNAI3) 101807650(GNAI2) 101818889(GNAI1)
PHI: 102100320(GNAI3) 102105798(GNAI2) 102111212(GNAI1)
PMAJ: 107204764 107210461(GNAI2) 107214903(GNAI3)
CCW: 104683249 104686889(GNAI1) 104692441(GNAI3)
FPG: 101917880(GNAI1) 101918521(GNAI3) 101924920(GNAI2)
FCH: 102051232(GNAI2) 102056299(GNAI3) 102059982(GNAI1)
CLV: 102086179(GNAI1) 102095096(GNAI2) 102096204(GNAI3)
EGZ: 104126738(GNAI2) 104127759(GNAI3) 104132374(GNAI1)
AAM: 106485672(GNAI1) 106495133(GNAI2) 106496939
ASN: 102377099(GNAI2) 102379966(GNAI3) 102383800(GNAI1)
AMJ: 102567683(GNAI3) 102571369(GNAI1) 106737098(GNAI2)
PSS: 102446233 102452618(GNAI1) 102453613(GNAI3)
CMY: 102932239(GNAI3) 102934526(GNAI2) 102948273(GNAI1)
CPIC: 101941167(GNAI3) 101946186(GNAI2) 101948588(GNAI1)
ACS: 100553120(gnai3) 100559069(gnai1) 100562211(gnai2)
PVT: 110076779(GNAI2) 110077193(GNAI1) 110085272(GNAI3)
GJA: 107118867(GNAI2) 107120788(GNAI3) 107121247(GNAI1)
XLA: 108714595 379236(gnai3.S) 380034(gnai1.L) 399463(gnai1.S) 779438(gnai2.S)
XTR: 100038283(gnai1) 394861(gnai2) 496962(gnai3)
NPR: 108795703(GNAI3) 108796157(GNAI1) 108803716
DRE: 100006888(gnai3) 323509(gnaia) 327650(gnai2b) 336421(gnai2a) 393946(gnai1)
IPU: 100526828(gnai1) 108254730(gnai2) 108265813(GNAI3) 108271854(GNAI2) 108279833(Gnai1)
LCM: 102361424(GNAI2) 102362833(GNAI3) 102364585
CMK: 103176615(gnai2) 103176999(gnai1) 103182452
SPU: 414054
DME: Dmel_CG10060(Galphai)
DSI: Dsimw501_GD13099(Dsim_GD13099)
AAG: 5574452
AME: 411704
BIM: 100749490
BTER: 100649199
SOC: 105199791
AEC: 105148007
ACEP: 105623462
PBAR: 105427877
HST: 105190201
CFO: 105250004
LHU: 105676136
PGC: 109852600
TCA: 103314873
DPA: 109537189
NVL: 108565005
API: 100164033
DNX: 107166241
ZNE: 110827220
FCD: 110856662
TUT: 107365545
CEL: CELE_T07A9.7(gpa-4) CELE_Y95B8A.5(gpa-16)
CBR: CBG13491(Cbr-gpa-4) CBG18548(Cbr-gpa-16)
BMY: Bm1_35125
TSP: Tsp_07815
CRG: 105342518
LAK: 106151815
ADF: 107343810
HMG: 100192225(gnai4)
EGR: 104418794
NTA: 107805718
NSY: 104222296
SIND: 105167470
OEU: 111386349
DOSA: Os10t0117800-01(Os10g0117800)
SCE: YER020W(GPA2)
ERC: Ecym_7187
NCS: NCAS_0A14970(NCAS0A14970)
NDI: NDAI_0J00490(NDAI0J00490)
TPF: TPHA_0I02990(TPHA0I02990)
TBL: TBLA_0J00340(TBLA0J00340)
TDL: TDEL_0H00740(TDEL0H00740)
KAF: KAFR_0B00560(KAFR0B00560)
CAL: CAALFM_C302240CA(GPA2)
CAUR: QG37_07198
SLB: AWJ20_2465(GPA2)
NCR: NCU05206(gna-3) NCU06493(gna-1)
NTE: NEUTE1DRAFT62526(NEUTE1DRAFT_62526) NEUTE1DRAFT80570(NEUTE1DRAFT_80570)
SMP: SMAC_05328 SMAC_07195(putative gna3)
BFU: BCIN_05g06770(bcg1)
ANG: ANI_1_824074(An08g05820) ANI_1_860074(An08g06130)
PNO: SNOG_06158(SNOG_06157) SNOG_10086(AY327542)
SPO: SPAC23H3.13c(gpa2)
ABP: AGABI1DRAFT102615(AGABI1DRAFT_102615) AGABI1DRAFT116493(AGABI1DRAFT_116493) AGABI1DRAFT123478(AGABI1DRAFT_123478) AGABI1DRAFT132402(AGABI1DRAFT_132402) AGABI1DRAFT36876(AGABI1DRAFT_36876)
ABV: AGABI2DRAFT150479(AGABI2DRAFT_150479) AGABI2DRAFT151207(AGABI2DRAFT_151207) AGABI2DRAFT188871(AGABI2DRAFT_188871) AGABI2DRAFT196019(AGABI2DRAFT_196019) AGABI2DRAFT211352(AGABI2DRAFT_211352)
MGL: MGL_0613
DDI: DDB_G0276267(gpaB) DDB_G0283349(gpaA)
DFA: DFA_03705(gpaA) DFA_06634(gpaI) DFA_07593 DFA_08287(gpaB)
EHI: EHI_140350(150.t00020)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3110783
  Authors
Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M
  Title
Human cDNA clones for an alpha subunit of Gi signal-transduction protein.
  Journal
Proc Natl Acad Sci U S A 84:5115-9 (1987)
DOI:10.1073/pnas.84.15.5115
  Sequence
[hsa:2770]
Reference
PMID:3120178
  Authors
Beals CR, Wilson CB, Perlmutter RM
  Title
A small multigene family encodes Gi signal-transduction proteins.
  Journal
Proc Natl Acad Sci U S A 84:7886-90 (1987)
DOI:10.1073/pnas.84.22.7886
  Sequence
[hsa:2771 2773]

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