KEGG   ORTHOLOGY: K04630Help
Entry
K04630                      KO                                     

Name
GNAI
Definition
guanine nucleotide-binding protein G(i) subunit alpha
Pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04360  Axon guidance
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04670  Leukocyte transendothelial migration
ko04713  Circadian entrainment
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04971  Gastric acid secretion
ko05012  Parkinson disease
ko05030  Cocaine addiction
ko05032  Morphine addiction
ko05034  Alcoholism
ko05133  Pertussis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Module
M00695  cAMP signaling
Disease
H00033  Adrenal carcinoma
H01019  Catecholaminergic polymorphic ventricular tachycardia
H01884  Auriculocondylar syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04371 Apelin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04071 Sphingolipid signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04024 cAMP signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04022 cGMP - PKG signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04670 Leukocyte transendothelial migration
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04062 Chemokine signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocyte
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04915 Estrogen signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04914 Progesterone-mediated oocyte maturation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04921 Oxytocin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04926 Relaxin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04928 Parathyroid hormone synthesis, secretion and action
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04916 Melanogenesis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04924 Renin secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09154 Digestive system
   04971 Gastric acid secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04727 GABAergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04725 Cholinergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04728 Dopaminergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04726 Serotonergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04730 Long-term depression
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09158 Development
   04360 Axon guidance
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09163 Neurodegenerative diseases
   05012 Parkinson disease
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09164 Substance dependence
   05030 Cocaine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05032 Morphine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05034 Alcoholism
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09167 Infectious diseases
   05133 Pertussis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05163 Human cytomegalovirus infection
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05145 Toxoplasmosis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04031 GTP-binding proteins
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
BRITE hierarchy
Genes
HSA: 2770(GNAI1) 2771(GNAI2) 2773(GNAI3)
PTR: 457093(GNAI3) 472425(GNAI1) 744773(GNAI2)
PPS: 100968961(GNAI3) 100974334(GNAI2) 100985590(GNAI1)
GGO: 101125616(GNAI3) 101150178(GNAI2) 101154597(GNAI1)
PON: 100172679(GNAI1) 100456074(GNAI3) 100458137(GNAI2)
NLE: 100583621(GNAI3) 100588993(GNAI2) 100604896(GNAI1)
MCC: 699310(GNAI3) 703780(GNAI2) 708940(GNAI1)
MCF: 101926144(GNAI2) 102119905(GNAI3) 102140224(GNAI1)
CSAB: 103224284(GNAI3) 103226652(GNAI1) 103227664(GNAI2)
RRO: 104655987(GNAI3) 104667102(GNAI2) 104673307 104675555
RBB: 108519632(GNAI3) 108526962(GNAI2) 108534866(GNAI1)
CJC: 100388113(GNAI1) 100404474(GNAI2) 100405745(GNAI3)
SBQ: 101032105(GNAI3) 101041681(GNAI2) 101042629(GNAI1)
MMU: 14677(Gnai1) 14678(Gnai2) 14679(Gnai3)
RNO: 25643(Gnai3) 25686(Gnai1) 81664(Gnai2)
CGE: 100689068(Gnai2) 100689070(Gnai1) 100689072(Gnai3)
NGI: 103724646 103732220(Gnai1) 103747835(Gnai3) 103750163(Gnai2)
HGL: 101698645(Gnai2) 101702965(Gnai1) 101703043(Gnai3)
CCAN: 109688838(Gnai3) 109693226(Gnai2) 109702253(Gnai1)
OCU: 100338391(GNAI1) 100339066(GNAI2) 100359147(GNAI3)
TUP: 102475420(GNAI2) 102476737(GNAI3) 102479323(GNAI1)
CFA: 442957(GNAI2) 478227(GNAI1) 611810(GNAI3)
AML: 100471767(GNAI2) 100484933(GNAI1)
UMR: 103658775(GNAI1) 103674803(GNAI2) 103675000(GNAI3)
ORO: 101367568(GNAI3) 101367936(GNAI2) 101376186(GNAI1)
FCA: 101089679(GNAI2) 101092837(GNAI1) 101100320(GNAI3)
PTG: 102951159(GNAI3) 102954501(GNAI1) 102962946(GNAI2)
AJU: 106977809(GNAI3) 106979196(GNAI2) 106982494(GNAI1)
BTA: 281790(GNAI1) 281791(GNAI2) 539521(GNAI3)
BOM: 102273920(GNAI1) 102274651(GNAI2) 102285228(GNAI3)
BIU: 109555970(GNAI3) 109557337(GNAI1) 109576257(GNAI2)
PHD: 102319715(GNAI1) 102322883(GNAI2) 102326697(GNAI3)
CHX: 100860765(GNAI2) 102185804(GNAI1) 108635583(GNAI3)
OAS: 100302341(GNAI2) 101103693(GNAI3) 101116393(GNAI1)
SSC: 100144419(GNAI1) 100144421(GNAI3) 397523(GNAI2)
CFR: 102504487(GNAI3) 102518290(GNAI1) 102522331(GNAI2)
CDK: 105085647(GNAI3) 105087520(GNAI2) 105100375(GNAI1)
BACU: 103008589(GNAI3) 103010531(GNAI2) 103017385(GNAI1)
LVE: 103077308(GNAI2) 103080185(GNAI3) 103081367(GNAI1)
OOR: 101271719(GNAI1) 101276500(GNAI2) 101277471(GNAI3)
ECB: 100055673(GNAI1) 100058238(GNAI3) 100062085(GNAI2)
EPZ: 103552141 103553052(GNAI3) 103557343(GNAI2)
EAI: 106827362(GNAI3) 106830727(GNAI2) 106833450(GNAI1)
MYB: 102239557(GNAI3) 102249318(GNAI2) 102256872(GNAI1)
MYD: 102754275(GNAI2) 102765504(GNAI3) 102766400(GNAI1)
HAI: 109375288(GNAI3) 109377665(GNAI2) 109392892(GNAI1)
RSS: 109435292(GNAI1) 109443439(GNAI2) 109446758(GNAI3)
PALE: 102885642(GNAI1) 102892785(GNAI3) 102898665(GNAI2)
LAV: 100666344(GNAI1) 100667957(GNAI3) 100670234(GNAI2)
MDO: 100013052(GNAI1) 100030095(GNAI3) 100032986(GNAI2)
SHR: 100914706(GNAI2) 100916740(GNAI1) 100928725
OAA: 100075665(GNAI1) 100089995
GGA: 374097(GNAI3) 396367(GNAI2) 396368(GNAI1)
MGP: 100540821 100542305(GNAI1) 100543856(GNAI2)
CJO: 107319651(GNAI2) 107320948 107324730(GNAI3)
APLA: 101789621 101797591(GNAI1) 101798529(GNAI2) 101803759(GNAI3)
ACYG: 106035549(GNAI1) 106042860 106049766(GNAI3)
TGU: 100219656(GNAI1) 100225910(GNAI2) 100232622(GNAI3)
GFR: 102034568(GNAI2) 102042928(GNAI1) 102045421(GNAI3)
FAB: 101806522(GNAI3) 101807650(GNAI2) 101818889(GNAI1)
PHI: 102100320(GNAI3) 102105798(GNAI2) 102111212(GNAI1)
PMAJ: 107204764 107210461(GNAI2) 107214903(GNAI3)
CCW: 104683249 104686889(GNAI1) 104692441(GNAI3)
FPG: 101917880(GNAI1) 101918521(GNAI3) 101924920(GNAI2)
FCH: 102051232(GNAI2) 102056299(GNAI3) 102059982(GNAI1)
CLV: 102086179(GNAI1) 102095096(GNAI2) 102096204(GNAI3)
EGZ: 104126738(GNAI2) 104127759(GNAI3) 104132374(GNAI1)
AAM: 106485672(GNAI1) 106495133(GNAI2) 106496939
ASN: 102377099(GNAI2) 102379966(GNAI3) 102383800(GNAI1)
AMJ: 102567683(GNAI3) 102571369(GNAI1) 106737098(GNAI2)
PSS: 102446233 102452618(GNAI1) 102453613(GNAI3)
CMY: 102932239(GNAI3) 102934526(GNAI2) 102948273(GNAI1)
CPIC: 101941167(GNAI3) 101946186(GNAI2) 101948588(GNAI1)
ACS: 100553120(gnai3) 100559069(gnai1) 100562211(gnai2)
PVT: 110076779(GNAI2) 110077193(GNAI1) 110085272(GNAI3)
GJA: 107118867(GNAI2) 107120788(GNAI3) 107121247(GNAI1)
XLA: 108714595 379236(gnai3.S) 380034(gnai1.L) 399463(gnai1.S) 779438(gnai2.S)
XTR: 100038283(gnai1) 394861(gnai2) 496962(gnai3)
NPR: 108795703(GNAI3) 108796157(GNAI1) 108803716
DRE: 100006888(gnai3) 323509(gnaia) 327650(gnai2b) 336421(gnai2a) 393946(gnai1)
IPU: 100526828(gnai1) 108254730(gnai2) 108265813(GNAI3) 108271854(GNAI2) 108279833(Gnai1)
LCM: 102361424(GNAI2) 102362833(GNAI3) 102364585
CMK: 103176615(gnai2) 103176999(gnai1) 103182452
SPU: 414054
DME: Dmel_CG10060(Galphai)
DSI: Dsimw501_GD13099(Dsim_GD13099)
AAG: 5574452
AME: 411704
BIM: 100749490
BTER: 100649199
SOC: 105199791
AEC: 105148007
ACEP: 105623462
PBAR: 105427877
HST: 105190201
CFO: 105250004
LHU: 105676136
PGC: 109852600
TCA: 103314873
DPA: 109537189
NVL: 108565005
API: 100164033
DNX: 107166241
ZNE: 110827220
FCD: 110856662
TUT: 107365545
CEL: CELE_T07A9.7(gpa-4) CELE_Y95B8A.5(gpa-16)
CBR: CBG13491(Cbr-gpa-4) CBG18548(Cbr-gpa-16)
BMY: Bm1_35125
TSP: Tsp_07815
CRG: 105342518
LAK: 106151815
ADF: 107343810
HMG: 100192225(gnai4)
EGR: 104418794
NTA: 107805718
NSY: 104222296
SIND: 105167470
OEU: 111386349
DOSA: Os10t0117800-01(Os10g0117800)
SCE: YER020W(GPA2)
ERC: Ecym_7187
NCS: NCAS_0A14970(NCAS0A14970)
NDI: NDAI_0J00490(NDAI0J00490)
TPF: TPHA_0I02990(TPHA0I02990)
TBL: TBLA_0J00340(TBLA0J00340)
TDL: TDEL_0H00740(TDEL0H00740)
KAF: KAFR_0B00560(KAFR0B00560)
CAL: CAALFM_C302240CA(GPA2)
CAUR: QG37_07198
SLB: AWJ20_2465(GPA2)
NCR: NCU05206(gna-3) NCU06493(gna-1)
NTE: NEUTE1DRAFT62526(NEUTE1DRAFT_62526) NEUTE1DRAFT80570(NEUTE1DRAFT_80570)
SMP: SMAC_05328 SMAC_07195(putative gna3)
BFU: BCIN_05g06770(bcg1)
ANG: ANI_1_824074(An08g05820) ANI_1_860074(An08g06130)
PNO: SNOG_06158(SNOG_06157) SNOG_10086(AY327542)
SPO: SPAC23H3.13c(gpa2)
ABP: AGABI1DRAFT102615(AGABI1DRAFT_102615) AGABI1DRAFT116493(AGABI1DRAFT_116493) AGABI1DRAFT123478(AGABI1DRAFT_123478) AGABI1DRAFT132402(AGABI1DRAFT_132402) AGABI1DRAFT36876(AGABI1DRAFT_36876)
ABV: AGABI2DRAFT150479(AGABI2DRAFT_150479) AGABI2DRAFT151207(AGABI2DRAFT_151207) AGABI2DRAFT188871(AGABI2DRAFT_188871) AGABI2DRAFT196019(AGABI2DRAFT_196019) AGABI2DRAFT211352(AGABI2DRAFT_211352)
MGL: MGL_0613
DDI: DDB_G0276267(gpaB) DDB_G0283349(gpaA)
DFA: DFA_03705(gpaA) DFA_06634(gpaI) DFA_07593 DFA_08287(gpaB)
EHI: EHI_140350(150.t00020)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3110783
  Authors
Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M
  Title
Human cDNA clones for an alpha subunit of Gi signal-transduction protein.
  Journal
Proc Natl Acad Sci U S A 84:5115-9 (1987)
DOI:10.1073/pnas.84.15.5115
  Sequence
[hsa:2770]
Reference
PMID:3120178
  Authors
Beals CR, Wilson CB, Perlmutter RM
  Title
A small multigene family encodes Gi signal-transduction proteins.
  Journal
Proc Natl Acad Sci U S A 84:7886-90 (1987)
DOI:10.1073/pnas.84.22.7886
  Sequence
[hsa:2771 2773]

KEGG   ORTHOLOGY: K04534Help
Entry
K04534                      KO                                     

Name
GNAO, G-ALPHA-O
Definition
guanine nucleotide-binding protein G(o) subunit alpha
Pathway
ko04015  Rap1 signaling pathway
ko04713  Circadian entrainment
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko05032  Morphine addiction
ko05034  Alcoholism
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05163  Human cytomegalovirus infection
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04921 Oxytocin signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04926 Relaxin signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04916 Melanogenesis
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04727 GABAergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04725 Cholinergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04728 Dopaminergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04726 Serotonergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04730 Long-term depression
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 09160 Human Diseases
  09164 Substance dependence
   05032 Morphine addiction
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05034 Alcoholism
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09167 Infectious diseases
   05163 Human cytomegalovirus infection
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05145 Toxoplasmosis
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04031 GTP-binding proteins
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
BRITE hierarchy
Genes
HSA: 2775(GNAO1)
PTR: 450173(GNAO1)
PPS: 100991540(GNAO1)
GGO: 101150695(GNAO1)
PON: 100454626(GNAO1)
NLE: 100599912(GNAO1) 105739342
MCC: 574394(GNAO1)
MCF: 102131761(GNAO1)
CSAB: 103233012(GNAO1)
RRO: 104664017 104664074
RBB: 108533839(GNAO1)
CJC: 100389396(GNAO1) 103789429(GNAO1)
SBQ: 101049046(GNAO1)
MMU: 14681(Gnao1)
RNO: 50664(Gnao1)
CGE: 100689069(Gnao1)
NGI: 103749858(Gnao1)
HGL: 101723580(Gnao1)
CCAN: 109700326(Gnao1)
OCU: 100342283(GNAO1)
TUP: 102483059(GNAO1)
CFA: 609157(GNAO1)
AML: 100466130(GNAO1)
ORO: 101376297(GNAO1)
FCA: 101101353(GNAO1)
PTG: 102958483(GNAO1)
BTA: 281792(GNAO1)
BOM: 102280695(GNAO1)
BIU: 109572786(GNAO1)
PHD: 102320226(GNAO1)
CHX: 102186145(GNAO1)
OAS: 101119495(GNAO1)
SSC: 100516976(GNAO1)
CDK: 105096168(GNAO1)
BACU: 103011674(GNAO1)
LVE: 103091025(GNAO1)
OOR: 101284566(GNAO1)
ECB: 100051282(GNAO1)
EPZ: 103555391(GNAO1)
EAI: 106822188(GNAO1)
MYB: 102263380(GNAO1)
MYD: 102765603(GNAO1)
RSS: 109459434(GNAO1)
PALE: 102884654(GNAO1)
LAV: 100658419(GNAO1) 111752342
TMU: 101357613
MDO: 100015137(GNAO1)
OAA: 100074566(GNAO1)
GGA: 415698(GNAO1)
MGP: 100543011(GNAO1)
CJO: 107319187(GNAO1)
APLA: 101791437(GNAO1) 101805099
ACYG: 106043102(GNAO1)
TGU: 100226617(GNAO1)
GFR: 102040380(GNAO1)
FAB: 101810253(GNAO1)
PHI: 102101605(GNAO1)
PMAJ: 107209802(GNAO1)
CCW: 104687499(GNAO1)
FPG: 101920934(GNAO1)
FCH: 102052678(GNAO1)
CLV: 102098346(GNAO1)
EGZ: 104130276(GNAO1)
AAM: 106496793(GNAO1)
ASN: 102370246(GNAO1)
AMJ: 102575346(GNAO1)
PSS: 102448010(GNAO1)
CMY: 102938723(GNAO1)
CPIC: 101939865(GNAO1)
ACS: 100561396(gnao1) 103282364
PVT: 110085725(GNAO1)
GJA: 107118988(GNAO1)
XLA: 108714022 394423(gnao1.L) 397896(gna0) 398037
XTR: 549749(gnao1)
NPR: 108793915(GNAO1)
DRE: 393760(gnao1a) 393801(gnao1b)
AMEX: 103039135(gnao1) 111191720
TRU: 101079681(gnao1)
NCC: 104961471 104965823(gnao1)
OLA: 101166207(gnao1) 101167706
NFU: 107381402(gnao1) 107396198
BPEC: 110169647(gnao1) 110175486
SASA: 106560843(gnao1) 106562227 106573727(gnao1) 106587424
ELS: 105016280 105018488(gnao1)
SFM: 108918980(gnao1)
LCM: 102363494(GNAO1)
SPU: 576911
APLC: 110988978
SKO: 100377101
DME: Dmel_CG2204(Galphao)
DSI: Dsimw501_GD10742(Dsim_GD10742)
MDE: 101887825
AAG: 5570867
AME: 725140
BIM: 100742795
BTER: 100642305
SOC: 105195608
AEC: 105144590
ACEP: 105618355
PBAR: 105431709
HST: 105185321
CFO: 105253347
LHU: 105678675
PGC: 109854118
NVI: 100118592(Gnao)
TCA: 655023
DPA: 109534130
NVL: 108568503
BMOR: 692460(Go)
PMAC: 106716736
PRAP: 110995785
PXY: 105383314
API: 100168757(Gnao1)
DNX: 107171271
ZNE: 110832380
TUT: 107359521
CEL: CELE_C26C6.2(goa-1) CELE_E02C12.5(gpa-3) CELE_F38E1.5(gpa-2) CELE_M04C7.1(gpa-15) CELE_R10H10.5(gpa-7) CELE_T19C4.6(gpa-1)
CBR: CBG08377(Cbr-gpa-7) CBG11277(Cbr-gpa-2) CBG19263(Cbr-gpa-3) CBG23127(Cbr-gpa-1) CBG24698(Cbr-goa-1)
BMY: Bm1_51315
CRG: 105346725
MYI: 110453591
OBI: 106882189
LAK: 106169108
SHX: MS3_00187
EPA: 110232413
ADF: 107355015
HMG: 100204078
AQU: 109588455
DFA: DFA_07048(gpaH)
TPS: THAPSDRAFT_264137(GPA2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1901650
  Authors
Tsukamoto T, Toyama R, Itoh H, Kozasa T, Matsuoka M, Kaziro Y
  Title
Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.
  Journal
Proc Natl Acad Sci U S A 88:2974-8 (1991)
  Sequence
[hsa:2775]

KEGG   ORTHOLOGY: K04535Help
Entry
K04535                      KO                                     

Name
GNAZ
Definition
guanine nucleotide-binding protein G(z) subunit alpha
Pathway
ko04730  Long-term depression
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04730 Long-term depression
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
BRITE hierarchy
Genes
HSA: 2781(GNAZ)
PTR: 458693(GNAZ)
PPS: 100973910(GNAZ)
GGO: 101130405(GNAZ)
PON: 100461603(GNAZ)
NLE: 100592745(GNAZ)
MCC: 706704(GNAZ)
MCF: 102143621(GNAZ)
CSAB: 103222900(GNAZ)
RRO: 104672492(GNAZ)
RBB: 108540632(GNAZ)
CJC: 100391403(GNAZ)
SBQ: 101043815(GNAZ)
MMU: 14687(Gnaz)
RNO: 25740(Gnaz)
CGE: 100767381(Gnaz)
NGI: 103734697(Gnaz)
HGL: 101714256(Gnaz)
CCAN: 109698317(Gnaz)
OCU: 100356759(GNAZ)
TUP: 102490381(GNAZ)
CFA: 607445(GNAZ)
AML: 100467701(GNAZ)
UMR: 103669195(GNAZ)
ORO: 101382032(GNAZ)
FCA: 101100923(GNAZ)
PTG: 102956507(GNAZ)
AJU: 106979694(GNAZ)
BTA: 112442078(GNAZ)
BOM: 102282969(GNAZ)
PHD: 102323554
CHX: 106501838(GNAZ)
OAS: 106991715(GNAZ)
SSC: 100151867(GNAZ)
CFR: 102510081(GNAZ)
CDK: 105095185(GNAZ)
BACU: 103009880(GNAZ)
LVE: 103078351(GNAZ)
OOR: 101279995(GNAZ)
ECB: 100049992(GNAZ)
EPZ: 103560313(GNAZ)
EAI: 106847135(GNAZ)
MYB: 102242558(GNAZ)
MYD: 102759123(GNAZ)
HAI: 109394891(GNAZ)
RSS: 109433821(GNAZ)
PALE: 107195444(GNAZ)
LAV: 100673517(GNAZ)
TMU: 101352149
MDO: 100016996(GNAZ)
SHR: 100916887(GNAZ)
OAA: 100088957(GNAZ)
GGA: 770226(GNAZ)
MGP: 100547187(GNAZ)
CJO: 107321383(GNAZ)
APLA: 101799262(GNAZ)
ACYG: 106031320(GNAZ)
TGU: 100227663(GNAZ)
GFR: 102041313(GNAZ)
FAB: 101813576(GNAZ)
PHI: 102100063(GNAZ)
PMAJ: 107211761(GNAZ)
CCW: 104688566(GNAZ)
FPG: 101923915(GNAZ)
FCH: 102053137(GNAZ)
CLV: 102095261(GNAZ)
EGZ: 104130087(GNAZ)
AAM: 106486304(GNAZ)
ASN: 102378442(GNAZ)
AMJ: 102560086(GNAZ)
PSS: 102456402 102462115(GNAZ)
CMY: 102945651(GNAZ)
CPIC: 101945996(GNAZ)
ACS: 100557798(gnaz)
PVT: 110081941(GNAZ)
PBI: 103053469(GNAZ)
GJA: 107115084(GNAZ)
XLA: 108707114(gnaz.S) 108716026(gnaz.L)
XTR: 780044(gnaz)
NPR: 108787775(GNAZ)
DRE: 564915(gnaz)
IPU: 108277250(gnaz)
AMEX: 103042294(gnaz)
TRU: 101066109(gnaz)
LCO: 104923426(gnaz)
NCC: 104961029(gnaz)
MZE: 101463857(gnaz)
OLA: 101167809(gnaz)
XMA: 102228140(gnaz)
PRET: 103473672(gnaz)
NFU: 107372764(gnaz)
CSEM: 103389074(gnaz)
LCF: 108879282(gnaz)
HCQ: 109517063(gnaz)
BPEC: 110174131(gnaz)
ELS: 105014976(gnaz)
LCM: 102353158(GNAZ)
CMK: 103188671(gnaz)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
DOI:10.1038/sj.bjp.0706405
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

KEGG   ORTHOLOGY: K04632Help
Entry
K04632                      KO                                     

Name
GNAS
Definition
guanine nucleotide-binding protein G(s) subunit alpha
Pathway
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04724  Glutamatergic synapse
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04962  Vasopressin-regulated water reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05032  Morphine addiction
ko05034  Alcoholism
ko05110  Vibrio cholerae infection
ko05142  Chagas disease (American trypanosomiasis)
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Disease
H00244  Pseudohypoparathyroidism
H00441  Progressive osseous heteroplasia (POH)
H00501  Fibrous dysplasia, polyostotic
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01483  Acromegaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04020 Calcium signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04072 Phospholipase D signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04024 cAMP signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09152 Endocrine system
   04911 Insulin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04922 Glucagon signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04923 Regulation of lipolysis in adipocyte
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04912 GnRH signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04913 Ovarian Steroidogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04915 Estrogen signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04921 Oxytocin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04926 Relaxin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04918 Thyroid hormone synthesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04928 Parathyroid hormone synthesis, secretion and action
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04916 Melanogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04924 Renin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04925 Aldosterone synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04927 Cortisol synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04270 Vascular smooth muscle contraction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09154 Digestive system
   04970 Salivary secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04971 Gastric acid secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04972 Pancreatic secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04976 Bile secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04728 Dopaminergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04726 Serotonergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04730 Long-term depression
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04714 Thermogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09164 Substance dependence
   05030 Cocaine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05031 Amphetamine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05032 Morphine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05034 Alcoholism
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09167 Infectious diseases
   05110 Vibrio cholerae infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05163 Human cytomegalovirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05165 Human papillomavirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05146 Amoebiasis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09168 Drug resistance
   01522 Endocrine resistance
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04031 GTP-binding proteins
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of colorectal cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of bladder cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
BRITE hierarchy
Genes
HSA: 2778(GNAS)
PTR: 469986(GNAS)
PPS: 100978090
GGO: 101132215(GNAS) 109023045(XL)
PON: 100442753(GNAS)
NLE: 100604281(GNAS)
MCC: 694289(GNAS)
MCF: 102145630(GNAS)
CSAB: 103243509(GNAS)
RRO: 104663797
RBB: 108541624(GNAS)
CJC: 100408515(GNAS)
SBQ: 101041933 101043452(GNAS)
MMU: 14683(Gnas)
RNO: 24896(Gnas)
CGE: 100689067(Gnas)
NGI: 103741475(Gnas)
HGL: 101705689 101716905(Gnas)
CCAN: 109692784(Gnas)
OCU: 100008904(GNAS)
TUP: 102489563(GNAS)
CFA: 403943(GNAS)
AML: 100473680(GNAS)
UMR: 103670935
ORO: 101364060(GNAS)
FCA: 101098453
PTG: 102964541(GNAS)
AJU: 106969942(GNAS)
BTA: 281793(GNAS)
BOM: 102266153
BIU: 109567291
PHD: 102338964
CHX: 102188874(GNAS)
OAS: 101115640
SSC: 100049657(GNAS)
CFR: 102513869(GNAS)
CDK: 105095656
BACU: 102998098 103004432(GNAS)
LVE: 103089051(GNAS)
OOR: 101286834
ECB: 100056464
EPZ: 103565402
MYB: 102252262
MYD: 102774843
HAI: 109380071
RSS: 109461157
PALE: 102889764
LAV: 100655206
TMU: 101361837
MDO: 100021523(GNAS) 100029582
SHR: 100930666(GNAS)
OAA: 100080392(GNAS)
GGA: 419313(GNAS)
MGP: 100550361(GNAS)
CJO: 107323051(GNAS)
APLA: 101791631(GNAS)
ACYG: 106042176(GNAS)
TGU: 100232476(GNAS)
GFR: 102041915(GNAS)
FAB: 101810765(GNAS)
PHI: 102103803(GNAS)
PMAJ: 107213286(GNAS)
CCW: 104687623(GNAS)
FPG: 101922321(GNAS)
FCH: 102059934(GNAS)
CLV: 102095310(GNAS)
EGZ: 104130645(GNAS)
AAM: 106492804
ASN: 102384106(GNAS)
AMJ: 102563836(GNAS)
PSS: 102447036(GNAS)
CMY: 102934181
CPIC: 101939195(GNAS)
PVT: 110084741(GNAS)
GJA: 107119835(GNAS)
XLA: 394414(gnas.S) 399059
XTR: 407931(gnas)
NPR: 108784456 108802775(GNAS)
DRE: 557353(gnas)
TRU: 101064507(gnas) 101065996
LCO: 104933618 104936173(gnas)
MZE: 101467861 101481065(gnas)
OLA: 101163657(gnas) 101166373
XMA: 102220069(gnas) 102237275
PRET: 103464384 103468030(gnas)
NFU: 107385351 107390594(gnas)
CSEM: 103384508(gnas) 103386688
LCF: 108884112 108891667(gnas)
HCQ: 109517765(gnas) 109529200
BPEC: 110170217 110174705(gnas)
SFM: 108928411(gnas) 108930457
LCM: 102352483(GNAS)
CMK: 103171631(gnas)
CIN: 100185405
SPU: 414053
DME: Dmel_CG2835(Galphas)
DSI: Dsimw501_GD11812(Dsim_GD11812)
MDE: 101899076
AGA: AgaP_AGAP012095(GNAS_ANOGA)
AAG: 5563900
AME: 411011
BIM: 100743421
BTER: 100642353
SOC: 105205688
AEC: 105148870
ACEP: 105625855
PBAR: 105431600
HST: 105187166
CFO: 105255386
LHU: 105677705
PGC: 109860532
NVI: 100122520
DPA: 109544329
NVL: 108560534
PXY: 105388866
API: 100159067
DNX: 107166913
ZNE: 110833990
FCD: 110848319
DPX: DAPPUDRAFT_191575(Gnas)
TUT: 107371146
CEL: CELE_R06A10.2(gsa-1)
CBR: CBG22078(Cbr-gsa-1)
BMY: Bm1_48675
TSP: Tsp_05311
OBI: 106869212
EPA: 110248771
ADF: 107348778
HMG: 100192291(gnal) 100200225
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3093273
  Authors
Mattera R, Codina J, Crozat A, Kidd V, Woo SL, Birnbaumer L
  Title
Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase.
  Journal
FEBS Lett 206:36-42 (1986)
DOI:10.1016/0014-5793(86)81336-9
  Sequence
[hsa:2778]
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

KEGG   ORTHOLOGY: K04346Help
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
ko04010  MAPK signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04270  Vascular smooth muscle contraction
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP - PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09156 Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09167 Infectious diseases
   05163 Human cytomegalovirus infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04031 GTP-binding proteins
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA: 2768(GNA12)
PTR: 463234(GNA12)
PPS: 100979605(GNA12)
GGO: 101147243(GNA12)
PON: 100173387(GNA12)
NLE: 100591916(GNA12)
MCC: 100429106(GNA12)
MCF: 101867258(GNA12)
CSAB: 103246857(GNA12)
RRO: 104664964(GNA12)
RBB: 108543875(GNA12)
CJC: 100387912(GNA12)
SBQ: 101042405(GNA12)
MMU: 14673(Gna12)
RNO: 81663(Gna12)
CGE: 100760944(Gna12)
NGI: 103748670(Gna12)
HGL: 101697421(Gna12)
CCAN: 109683409(Gna12)
OCU: 100347293(GNA12)
TUP: 102501406(GNA12)
CFA: 102154318(GNA12)
AML: 100465369(GNA12)
UMR: 103669942(GNA12)
ORO: 101371250(GNA12)
FCA: 101093316(GNA12)
PTG: 102961052(GNA12)
AJU: 106984497(GNA12)
BTA: 515159(GNA12)
BOM: 102265273(GNA12)
BIU: 109578204(GNA12)
PHD: 102322053(GNA12)
CHX: 102185175(GNA12)
OAS: 101111070(GNA12)
SSC: 100525156(GNA12)
CFR: 102524525(GNA12)
CDK: 105090390(GNA12)
BACU: 103009974(GNA12)
LVE: 103069136(GNA12)
OOR: 101281075(GNA12)
ECB: 100060005(GNA12)
EPZ: 103549418(GNA12)
EAI: 106834780(GNA12)
MYB: 102260289(GNA12)
MYD: 102763801(GNA12)
HAI: 109380223(GNA12)
RSS: 109461354(GNA12)
PALE: 102891706(GNA12)
LAV: 100676444(GNA12)
TMU: 101351796
MDO: 100010453(GNA12)
SHR: 100916443(GNA12)
OAA: 100082592(GNA12)
GGA: 769924(GNA12)
MGP: 100550659(GNA12)
CJO: 107320696(GNA12)
APLA: 101798445(GNA12)
ACYG: 106032065(GNA12)
TGU: 100225137(GNA12)
GFR: 102044790(GNA12)
FAB: 101818259(GNA12)
PHI: 102104762(GNA12)
PMAJ: 107211274(GNA12)
CCW: 104684810(GNA12)
FPG: 101917262(GNA12)
FCH: 102059010(GNA12)
CLV: 102088372(GNA12)
EGZ: 104132621(GNA12)
AAM: 106483939(GNA12)
ASN: 102377286(GNA12)
AMJ: 102559993(GNA12)
PSS: 102445616(GNA12)
CMY: 102931254(GNA12)
CPIC: 101947834(GNA12)
ACS: 100564021(gna12)
PVT: 110083721(GNA12)
PBI: 103050241(GNA12)
GJA: 107116703(GNA12) 107125403
DRE: 503589(gna12a)
IPU: 108257129(gna12)
AMEX: 103024018(gna12)
TRU: 101078184(gna12)
LCO: 104929956(gna12)
NCC: 104953206 104953227(gna12)
MZE: 101473086(gna12)
OLA: 101166935(gna12)
XMA: 102222306(gna12)
PRET: 103462653(gna12)
NFU: 107388805(gna12)
CSEM: 103383240(gna12)
LCF: 108888452(gna12)
HCQ: 109511425(gna12)
BPEC: 110153513(gna12)
ELS: 105006302(gna12)
SFM: 108927048(gna12)
LCM: 102367557(GNA12)
CMK: 103185131(gna12)
SPU: 414055
SKO: 100371005
DME: Dmel_CG17678(cta)
DSI: Dsimw501_GD17672(Dsim_GD17672)
DYA: Dyak_GE22695(Dyak_cta)
MDE: 101898580
AAG: 5570853
AME: 410906(GB12482) 727645
BIM: 100745931
BTER: 100649951
SOC: 105200292
AEC: 105147295
ACEP: 105624301
PBAR: 105431792
HST: 105181192
CFO: 105259283
LHU: 105675078
PGC: 109863777
NVI: 100115318(cta)
TCA: 661072
DPA: 109541992
BMOR: 100862775(Galpha12)
PMAC: 106720633
PRAP: 111001958
PXY: 105391521
API: 100165181
DNX: 107169778
ZNE: 110838798
FCD: 110848091
DPX: DAPPUDRAFT_190301(Gna12)
TUT: 107368817
CEL: CELE_F18G5.3(gpa-12)
CBR: CBG16182(Cbr-gpa-12)
BMY: Bm1_00355
TSP: Tsp_00479
CRG: 105341702
MYI: 110465109
LAK: 106174984
SHX: MS3_06267
EPA: 110251752
ADF: 107350389
HMG: 100192290(gna12)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8423800
  Authors
Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA
  Title
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
  Journal
Mol Cell Biol 13:762-8 (1993)
  Sequence
[hsa:2768]
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]

KEGG   ORTHOLOGY: K04639Help
Entry
K04639                      KO                                     

Name
GNA13
Definition
guanine nucleotide-binding protein subunit alpha-13
Pathway
ko04022  cGMP-PKG signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04072 Phospholipase D signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04071 Sphingolipid signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04022 cGMP - PKG signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09156 Nervous system
   04730 Long-term depression
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09167 Infectious diseases
   05163 Human cytomegalovirus infection
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04031 GTP-binding proteins
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  Exosomal proteins of colorectal cancer cells
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
BRITE hierarchy
Genes
HSA: 10672(GNA13)
PTR: 454827(GNA13)
PPS: 100988877(GNA13)
GGO: 101152866(GNA13)
PON: 100461065(GNA13)
NLE: 100589821(GNA13)
MCC: 718144(GNA13)
MCF: 102127819(GNA13)
CSAB: 103243186(GNA13)
RRO: 104675436(GNA13)
RBB: 108517753(GNA13)
CJC: 100394016(GNA13)
SBQ: 101034540(GNA13)
MMU: 14674(Gna13)
RNO: 303634(Gna13)
CGE: 100689071(Gna13)
NGI: 103742208(Gna13)
HGL: 101719378(Gna13)
CCAN: 109696711(Gna13)
OCU: 100352794(GNA13)
TUP: 102488219(GNA13)
CFA: 490901(GNA13)
AML: 100474482(GNA13)
UMR: 103665670(GNA13)
ORO: 101386508(GNA13)
FCA: 101087625(GNA13)
PTG: 102964498(GNA13)
AJU: 106975340(GNA13)
BTA: 505611(GNA13)
BOM: 102275435(GNA13)
BIU: 109573379(GNA13)
PHD: 102344724(GNA13)
CHX: 102170818(GNA13)
OAS: 101117003(GNA13)
SSC: 100522824(GNA13)
CFR: 102523556(GNA13)
CDK: 105085708(GNA13)
BACU: 103007094(GNA13)
LVE: 103071564(GNA13)
OOR: 101277931(GNA13)
ECB: 100062972(GNA13)
EPZ: 103553497(GNA13)
EAI: 106835353(GNA13)
MYB: 102252423(GNA13)
MYD: 102764420(GNA13)
HAI: 109380315(GNA13)
RSS: 109448066(GNA13)
PALE: 102891607(GNA13)
LAV: 100664965(GNA13)
TMU: 101346987
MDO: 100024566(GNA13)
SHR: 100932191(GNA13)
GGA: 417434(GNA13)
MGP: 100540964(GNA13)
CJO: 107322109(GNA13)
APLA: 101801355(GNA13)
ACYG: 106034698(GNA13)
GFR: 102040291(GNA13)
FAB: 101812192(GNA13)
PHI: 102099584(GNA13)
PMAJ: 107212551(GNA13)
CCW: 104696029(GNA13)
FPG: 101922831(GNA13)
FCH: 102052233(GNA13)
CLV: 102084052(GNA13)
EGZ: 104132822(GNA13)
AAM: 106493143(GNA13)
ASN: 102376261(GNA13)
AMJ: 102568562(GNA13)
PSS: 102458860(GNA13)
CMY: 102940587(GNA13)
CPIC: 101953084(GNA13)
ACS: 100554119(gna13)
PVT: 110085885(GNA13)
PBI: 103050681(GNA13)
GJA: 107105951(GNA13)
XLA: 108701204(gna13.L) 496349(gna13.S)
XTR: 100145489(gna13)
NPR: 108802992(GNA13)
DRE: 326825(gna13a)
IPU: 108273768(GNA13) 108278714
XMA: 102222912 102227062(gna13)
BPEC: 110164386(gna13)
LCM: 102364864(GNA13)
CMK: 103175515(gna13)
CIN: 100180076
APLC: 110980280
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2508088
  Authors
Strathmann M, Wilkie TM, Simon MI
  Title
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.
  Journal
Proc Natl Acad Sci U S A 86:7407-9 (1989)
DOI:10.1073/pnas.86.19.7407
Reference
PMID:7791744
  Authors
Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD
  Title
Expression of GTP-binding protein alpha subunits in human thymocytes.
  Journal
Mol Cell Biochem 144:45-51 (1995)
  Sequence
[hsa:10672]

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