KEGG   ORTHOLOGY: K04632Help
Entry
K04632                      KO                                     

Name
GNAS
Definition
guanine nucleotide-binding protein G(s) subunit alpha
Pathway
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04724  Glutamatergic synapse
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04962  Vasopressin-regulated water reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05032  Morphine addiction
ko05034  Alcoholism
ko05110  Vibrio cholerae infection
ko05142  Chagas disease (American trypanosomiasis)
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Disease
H00244  Pseudohypoparathyroidism
H00441  Progressive osseous heteroplasia (POH)
H00501  Fibrous dysplasia, polyostotic
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01483  Acromegaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04020 Calcium signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04072 Phospholipase D signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04024 cAMP signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09152 Endocrine system
   04911 Insulin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04922 Glucagon signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04923 Regulation of lipolysis in adipocyte
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04912 GnRH signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04913 Ovarian Steroidogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04915 Estrogen signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04921 Oxytocin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04926 Relaxin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04918 Thyroid hormone synthesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04928 Parathyroid hormone synthesis, secretion and action
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04916 Melanogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04924 Renin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04925 Aldosterone synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04927 Cortisol synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04270 Vascular smooth muscle contraction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09154 Digestive system
   04970 Salivary secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04971 Gastric acid secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04972 Pancreatic secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04976 Bile secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04728 Dopaminergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04726 Serotonergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04730 Long-term depression
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04714 Thermogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09164 Substance dependence
   05030 Cocaine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05031 Amphetamine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05032 Morphine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05034 Alcoholism
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09167 Infectious diseases
   05110 Vibrio cholerae infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05163 Human cytomegalovirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05165 Human papillomavirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05146 Amoebiasis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09168 Drug resistance
   01522 Endocrine resistance
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04031 GTP-binding proteins
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of colorectal cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of bladder cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
BRITE hierarchy
Genes
HSA: 2778(GNAS)
PTR: 469986(GNAS)
PPS: 100978090
GGO: 101132215(GNAS) 109023045(XL)
PON: 100442753(GNAS)
NLE: 100604281(GNAS)
MCC: 694289(GNAS)
MCF: 102145630(GNAS)
CSAB: 103243509(GNAS)
RRO: 104663797
RBB: 108541624(GNAS)
CJC: 100408515(GNAS)
SBQ: 101041933 101043452(GNAS)
MMU: 14683(Gnas)
RNO: 24896(Gnas)
CGE: 100689067(Gnas)
NGI: 103741475(Gnas)
HGL: 101705689 101716905(Gnas)
CCAN: 109692784(Gnas)
OCU: 100008904(GNAS)
TUP: 102489563(GNAS)
CFA: 403943(GNAS)
AML: 100473680(GNAS)
UMR: 103670935
ORO: 101364060(GNAS)
FCA: 101098453
PTG: 102964541(GNAS)
AJU: 106969942(GNAS)
BTA: 281793(GNAS)
BOM: 102266153
BIU: 109567291
PHD: 102338964
CHX: 102188874(GNAS)
OAS: 101115640
SSC: 100049657(GNAS)
CFR: 102513869(GNAS)
CDK: 105095656
BACU: 102998098 103004432(GNAS)
LVE: 103089051(GNAS)
OOR: 101286834
ECB: 100056464
EPZ: 103565402
MYB: 102252262
MYD: 102774843
HAI: 109380071
RSS: 109461157
PALE: 102889764
LAV: 100655206
TMU: 101361837
MDO: 100021523(GNAS) 100029582
SHR: 100930666(GNAS)
OAA: 100080392(GNAS)
GGA: 419313(GNAS)
MGP: 100550361(GNAS)
CJO: 107323051(GNAS)
APLA: 101791631(GNAS)
ACYG: 106042176(GNAS)
TGU: 100232476(GNAS)
GFR: 102041915(GNAS)
FAB: 101810765(GNAS)
PHI: 102103803(GNAS)
PMAJ: 107213286(GNAS)
CCW: 104687623(GNAS)
FPG: 101922321(GNAS)
FCH: 102059934(GNAS)
CLV: 102095310(GNAS)
EGZ: 104130645(GNAS)
AAM: 106492804
ASN: 102384106(GNAS)
AMJ: 102563836(GNAS)
PSS: 102447036(GNAS)
CMY: 102934181
CPIC: 101939195(GNAS)
PVT: 110084741(GNAS)
GJA: 107119835(GNAS)
XLA: 394414(gnas.S) 399059
XTR: 407931(gnas)
NPR: 108784456 108802775(GNAS)
DRE: 557353(gnas)
TRU: 101064507(gnas) 101065996
LCO: 104933618 104936173(gnas)
MZE: 101467861 101481065(gnas)
OLA: 101163657(gnas) 101166373
XMA: 102220069(gnas) 102237275
PRET: 103464384 103468030(gnas)
NFU: 107385351 107390594(gnas)
CSEM: 103384508(gnas) 103386688
LCF: 108884112 108891667(gnas)
HCQ: 109517765(gnas) 109529200
BPEC: 110170217 110174705(gnas)
SFM: 108928411(gnas) 108930457
LCM: 102352483(GNAS)
CMK: 103171631(gnas)
CIN: 100185405
SPU: 414053
DME: Dmel_CG2835(Galphas)
DSI: Dsimw501_GD11812(Dsim_GD11812)
MDE: 101899076
AGA: AgaP_AGAP012095(GNAS_ANOGA)
AAG: 5563900
AME: 411011
BIM: 100743421
BTER: 100642353
SOC: 105205688
AEC: 105148870
ACEP: 105625855
PBAR: 105431600
HST: 105187166
CFO: 105255386
LHU: 105677705
PGC: 109860532
NVI: 100122520
DPA: 109544329
NVL: 108560534
PXY: 105388866
API: 100159067
DNX: 107166913
ZNE: 110833990
FCD: 110848319
DPX: DAPPUDRAFT_191575(Gnas)
TUT: 107371146
CEL: CELE_R06A10.2(gsa-1)
CBR: CBG22078(Cbr-gsa-1)
BMY: Bm1_48675
TSP: Tsp_05311
OBI: 106869212
EPA: 110248771
ADF: 107348778
HMG: 100192291(gnal) 100200225
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3093273
  Authors
Mattera R, Codina J, Crozat A, Kidd V, Woo SL, Birnbaumer L
  Title
Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase.
  Journal
FEBS Lett 206:36-42 (1986)
DOI:10.1016/0014-5793(86)81336-9
  Sequence
[hsa:2778]
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

KEGG   ORTHOLOGY: K04633Help
Entry
K04633                      KO                                     

Name
GNAL
Definition
guanine nucleotide-binding protein G(olf) subunit alpha
Pathway
ko04020  Calcium signaling pathway
ko04728  Dopaminergic synapse
ko04740  Olfactory transduction
ko05012  Parkinson disease
ko05142  Chagas disease (American trypanosomiasis)
ko05146  Amoebiasis
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
  09157 Sensory system
   04740 Olfactory transduction
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05012 Parkinson disease
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
  09167 Infectious diseases
   05146 Amoebiasis
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
BRITE hierarchy
Genes
HSA: 2774(GNAL)
PTR: 455285(GNAL)
PPS: 100975164(GNAL)
GGO: 101129289(GNAL)
PON: 100453901(GNAL)
NLE: 100597944(GNAL)
MCF: 102137826(GNAL)
CSAB: 103222785(GNAL)
RRO: 104670245(GNAL)
RBB: 108527485(GNAL)
CJC: 100387535(GNAL)
SBQ: 101050072(GNAL)
MMU: 14680(Gnal)
RNO: 24611(Gnal)
CGE: 100760304(Gnal)
NGI: 103735431(Gnal)
HGL: 101718578(Gnal)
CCAN: 109676005 109696090(Gnal)
OCU: 100348829(GNAL)
TUP: 102478287(GNAL)
CFA: 607658(GNAL)
AML: 100479878(GNAL)
UMR: 103673370 103673377(GNAL)
ORO: 101380718(GNAL)
FCA: 101098171(GNAL)
PTG: 102952450(GNAL)
AJU: 106981474(GNAL)
BTA: 100124520(GNAL)
BOM: 102272478(GNAL)
BIU: 109577812(GNAL)
PHD: 102329649(GNAL)
CHX: 100861281(GNAL)
OAS: 101105461(GNAL)
SSC: 100736677(GNAL)
CFR: 102508705(GNAL)
CDK: 105086482(GNAL)
BACU: 102997876(GNAL)
LVE: 103070661(GNAL)
OOR: 101276531(GNAL)
ECB: 100050622(GNAL)
EPZ: 103540366(GNAL)
EAI: 106823408(GNAL)
MYB: 102263508(GNAL)
MYD: 102759466(GNAL)
HAI: 109373565(GNAL)
RSS: 109434435(GNAL)
PALE: 102886226(GNAL)
LAV: 100665771(GNAL)
TMU: 101346169
MDO: 100013751(GNAL)
SHR: 100931638(GNAL)
OAA: 100077658(GNAL)
GGA: 474379(GNAL)
MGP: 100546747(GNAL)
CJO: 107310002(GNAL)
APLA: 101803485(GNAL)
ACYG: 106034938(GNAL)
TGU: 100219216(GNAL)
GFR: 102045470(GNAL)
FAB: 101813676(GNAL)
PHI: 102107758(GNAL)
PMAJ: 107199749(GNAL)
CCW: 104687270(GNAL)
FPG: 101914068(GNAL)
FCH: 102055293(GNAL)
CLV: 102096038(GNAL)
EGZ: 104132886(GNAL)
AAM: 106484403(GNAL)
ASN: 102370678(GNAL) 102376477
AMJ: 106737002(GNAL)
PSS: 102454123(GNAL)
CMY: 102943864(GNAL)
CPIC: 101953562(GNAL)
PVT: 110078908(GNAL)
PBI: 103059175(GNAL)
GJA: 107113095(GNAL)
XLA: 378630(gnal.S) 443714
XTR: 100216229(gnal)
NPR: 108787315(GNAL) 108798434
DRE: 492467(gnal)
IPU: 108256214(gnal) 108262790
TRU: 101066394 101077363(gnal)
LCO: 104936418(gnal) 104939455
MZE: 101474191 101482928(gnal)
OLA: 101161386 101174132(gnal)
XMA: 102227168(gnal) 102232671
PRET: 103460154 103479907(gnal)
NFU: 107383531(gnal) 107396846
LCF: 108884251(gnal) 108890118
HCQ: 109524101(gnal) 109526311
BPEC: 110173238 110174910(gnal)
ELS: 105019515
SFM: 108927555 108930092(gnal)
LCM: 102351759(GNAL)
CMK: 103172506
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
DOI:10.1038/sj.bjp.0706405
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

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