KEGG   ORTHOLOGY: K04674Help
Entry
K04674                      KO                                     

Name
TGFBR1, ALK5
Definition
TGF-beta receptor type-1 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00680  TGF-beta signaling
Disease
H00018  Gastric cancer
H00800  Loeys-Dietz syndrome (LDS)
H00801  Familial thoracic aortic aneurysm and dissection (TAAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04350 TGF-beta signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04390 Hippo signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04371 Apelin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04068 FoxO signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Cell growth and death
   04218 Cellular senescence
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Cellular community - eukaryotes
   04520 Adherens junction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Endocrine system
   04926 Relaxin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Development
   04380 Osteoclast differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05210 Colorectal cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05212 Pancreatic cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05225 Hepatocellular carcinoma
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05226 Gastric cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05220 Chronic myeloid leukemia
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  Infectious diseases
   05166 HTLV-I infection
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05161 Hepatitis B
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05142 Chagas disease (American trypanosomiasis)
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
BRITE hierarchy
Other DBs
GO: 0005025
Genes
HSA: 7046(TGFBR1)
PTR: 472992(TGFBR1)
PPS: 100984463(TGFBR1)
GGO: 101128510(TGFBR1)
PON: 100450864(TGFBR1)
NLE: 100592854(TGFBR1)
MCC: 714952(TGFBR1)
MCF: 102115287(TGFBR1)
CSAB: 103219139(TGFBR1)
RRO: 104657765(TGFBR1)
RBB: 108512466(TGFBR1)
CJC: 100389596(TGFBR1)
SBQ: 101030583(TGFBR1)
MMU: 21812(Tgfbr1)
RNO: 29591(Tgfbr1)
CGE: 100772727(Tgfbr1)
NGI: 103744902(Tgfbr1)
HGL: 101718090(Tgfbr1)
CCAN: 109691424(Tgfbr1)
OCU: 100345812(TGFBR1)
TUP: 102476700(TGFBR1)
CFA: 481628(TGFBR1)
AML: 100475698(TGFBR1)
UMR: 103678627(TGFBR1)
ORO: 101379465(TGFBR1)
FCA: 101094057(TGFBR1)
PTG: 102950020(TGFBR1)
AJU: 106972043(TGFBR1)
BTA: 282382(TGFBR1)
BOM: 102283685(TGFBR1)
BIU: 109563078(TGFBR1)
PHD: 102324779(TGFBR1)
CHX: 102187767(TGFBR1)
OAS: 554326(TGFBR1)
SSC: 396665(TGFBR1)
CFR: 102522485(TGFBR1)
CDK: 105086891(TGFBR1)
BACU: 102999446(TGFBR1)
LVE: 103071954(TGFBR1)
OOR: 101287555(TGFBR1)
ECB: 100034117(TGFBR1)
EPZ: 103555266(TGFBR1)
EAI: 106842924(TGFBR1)
MYB: 102241353(TGFBR1)
MYD: 102765185(TGFBR1)
HAI: 109386421(TGFBR1)
RSS: 109446110(TGFBR1)
PALE: 102880759(TGFBR1)
LAV: 100656286(TGFBR1)
TMU: 101359953
MDO: 100011507(TGFBR1)
SHR: 100913844(TGFBR1)
OAA: 100092358(TGFBR1)
GGA: 374094(TGFBR1)
MGP: 100543917(TGFBR1)
CJO: 107309773(TGFBR1)
APLA: 101805328(TGFBR1)
ACYG: 106038346(TGFBR1)
TGU: 100230911(TGFBR1)
GFR: 102037879(TGFBR1)
FAB: 101809241(TGFBR1)
PHI: 102113190(TGFBR1)
PMAJ: 107200568(TGFBR1)
CCW: 104688870(TGFBR1)
FPG: 101922518(TGFBR1)
FCH: 102055038(TGFBR1)
CLV: 102095465(TGFBR1)
EGZ: 104125437(TGFBR1)
AAM: 106491015(TGFBR1)
ASN: 102370778(TGFBR1)
AMJ: 102568992(TGFBR1)
CMY: 102942001(TGFBR1)
CPIC: 101944287(TGFBR1)
ACS: 100566944(tgfbr1)
PVT: 110086076(TGFBR1)
GJA: 107109116(TGFBR1)
XLA: 108719029 399295(tgfbr1.S)
XTR: 548715(tgfbr1)
NPR: 108799247(TGFBR1)
DRE: 560578(tgfbr1a) 792928(tgfbr1b)
IPU: 108271704(tgfbr1)
AMEX: 103034175
TRU: 101062282(tgfbr1) 101076538
LCO: 104920074(acvr1c) 104931778(tgfbr1)
NCC: 104964102
MZE: 101479229
XMA: 102222719
PRET: 103482409
NFU: 107374334
CSEM: 103376883
LCF: 108898453
HCQ: 109530275
BPEC: 110165570
LCM: 102350402(TGFBR1)
CMK: 103181552
CIN: 445775(tgfbr-ic)
APLC: 110989541
SKO: 100370253
DME: Dmel_CG8224(babo)
DSI: Dsimw501_GD10620(Dsim_GD10620)
MDE: 101895175
AAG: 5572069
AME: 550930(babo)
BIM: 100740693
BTER: 100643263
SOC: 105193383
AEC: 105149442
ACEP: 105627280
PBAR: 105427063
HST: 105191563
CFO: 105256068
LHU: 105676036
PGC: 109857803
NVI: 100114832
TCA: 659969(babo)
DPA: 109542240
NVL: 108562386
BMOR: 101742113
PMAC: 106717233
PRAP: 110998149
PXY: 105398137
API: 100164283
DNX: 107173148
ZNE: 110839262
FCD: 110842324
DPX: DAPPUDRAFT_347223(BABO)
TUT: 107367555
BMY: Bm1_44900
CRG: 105318607
MYI: 110458522
OBI: 106868204
LAK: 106153365
SHX: MS3_01247
EPA: 110234755
HMG: 100212672
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8242743
  Authors
Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin CH, Miyazono K
  Title
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
  Journal
Cell 75:681-92 (1993)
DOI:10.1016/0092-8674(93)90489-D
  Sequence
[hsa:7046]

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