KEGG   ORTHOLOGY: K04674Help
Entry
K04674                      KO                                     

Name
TGFBR1, ALK5
Definition
TGF-beta receptor type-1 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00680  TGF-beta signaling
Disease
H00018  Gastric cancer
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04350 TGF-beta signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04390 Hippo signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04371 Apelin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04068 FoxO signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09143 Cell growth and death
   04218 Cellular senescence
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09158 Development
   04380 Osteoclast differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05210 Colorectal cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05212 Pancreatic cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05225 Hepatocellular carcinoma
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05226 Gastric cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05220 Chronic myeloid leukemia
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09167 Infectious diseases
   05166 HTLV-I infection
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05161 Hepatitis B
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05142 Chagas disease (American trypanosomiasis)
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
BRITE hierarchy
Other DBs
GO: 0005025
Genes
HSA: 7046(TGFBR1)
PTR: 472992(TGFBR1)
PPS: 100984463(TGFBR1)
GGO: 101128510(TGFBR1)
PON: 100450864(TGFBR1)
NLE: 100592854(TGFBR1)
MCC: 714952(TGFBR1)
MCF: 102115287(TGFBR1)
CSAB: 103219139(TGFBR1)
RRO: 104657765(TGFBR1)
RBB: 108512466(TGFBR1)
CJC: 100389596(TGFBR1)
SBQ: 101030583(TGFBR1)
MMU: 21812(Tgfbr1)
RNO: 29591(Tgfbr1)
CGE: 100772727(Tgfbr1)
NGI: 103744902(Tgfbr1)
HGL: 101718090(Tgfbr1)
CCAN: 109691424(Tgfbr1)
OCU: 100345812(TGFBR1)
TUP: 102476700(TGFBR1)
CFA: 481628(TGFBR1)
AML: 100475698(TGFBR1)
UMR: 103678627(TGFBR1)
ORO: 101379465(TGFBR1)
FCA: 101094057(TGFBR1)
PTG: 102950020(TGFBR1)
AJU: 106972043(TGFBR1)
BTA: 282382(TGFBR1)
BOM: 102283685(TGFBR1)
BIU: 109563078(TGFBR1)
PHD: 102324779(TGFBR1)
CHX: 102187767(TGFBR1)
OAS: 554326(TGFBR1)
SSC: 396665(TGFBR1)
CFR: 102522485(TGFBR1)
CDK: 105086891(TGFBR1)
BACU: 102999446(TGFBR1)
LVE: 103071954(TGFBR1)
OOR: 101287555(TGFBR1)
ECB: 100034117(TGFBR1)
EPZ: 103555266(TGFBR1)
EAI: 106842924(TGFBR1)
MYB: 102241353(TGFBR1)
MYD: 102765185(TGFBR1)
HAI: 109386421(TGFBR1)
RSS: 109446110(TGFBR1)
PALE: 102880759(TGFBR1)
LAV: 100656286(TGFBR1)
TMU: 101359953
MDO: 100011507(TGFBR1)
SHR: 100913844(TGFBR1)
OAA: 100092358(TGFBR1)
GGA: 374094(TGFBR1)
MGP: 100543917(TGFBR1)
CJO: 107309773(TGFBR1)
APLA: 101805328(TGFBR1)
ACYG: 106038346(TGFBR1)
TGU: 100230911(TGFBR1)
GFR: 102037879(TGFBR1)
FAB: 101809241(TGFBR1)
PHI: 102113190(TGFBR1)
PMAJ: 107200568(TGFBR1)
CCW: 104688870(TGFBR1)
FPG: 101922518(TGFBR1)
FCH: 102055038(TGFBR1)
CLV: 102095465(TGFBR1)
EGZ: 104125437(TGFBR1)
AAM: 106491015(TGFBR1)
ASN: 102370778(TGFBR1)
AMJ: 102568992(TGFBR1)
CMY: 102942001(TGFBR1)
CPIC: 101944287(TGFBR1)
ACS: 100566944(tgfbr1)
PVT: 110086076(TGFBR1)
GJA: 107109116(TGFBR1)
XLA: 108719029 399295(tgfbr1.S)
XTR: 548715(tgfbr1)
NPR: 108799247(TGFBR1)
DRE: 560578(tgfbr1a) 792928(tgfbr1b)
IPU: 108271704(tgfbr1)
AMEX: 103034175
TRU: 101062282(tgfbr1) 101076538
LCO: 104920074(acvr1c) 104931778(tgfbr1)
NCC: 104964102
MZE: 101479229
XMA: 102222719
PRET: 103482409
NFU: 107374334
CSEM: 103376883
LCF: 108898453
HCQ: 109530275
BPEC: 110165570
LCM: 102350402(TGFBR1)
CMK: 103181552
CIN: 445775(tgfbr-ic)
APLC: 110989541
SKO: 100370253
DME: Dmel_CG8224(babo)
DSI: Dsimw501_GD10620(Dsim_GD10620)
MDE: 101895175
AAG: 5572069
AME: 550930(babo)
BIM: 100740693
BTER: 100643263
SOC: 105193383
AEC: 105149442
ACEP: 105627280
PBAR: 105427063
HST: 105191563
CFO: 105256068
LHU: 105676036
PGC: 109857803
NVI: 100114832
TCA: 659969(babo)
DPA: 109542240
NVL: 108562386
BMOR: 101742113
PMAC: 106717233
PRAP: 110998149
PXY: 105398137
API: 100164283
DNX: 107173148
ZNE: 110839262
FCD: 110842324
DPX: DAPPUDRAFT_347223(BABO)
TUT: 107367555
BMY: Bm1_44900
CRG: 105318607
MYI: 110458522
OBI: 106868204
LAK: 106153365
SHX: MS3_01247
EPA: 110234755
HMG: 100212672
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8242743
  Authors
Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin CH, Miyazono K
  Title
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
  Journal
Cell 75:681-92 (1993)
DOI:10.1016/0092-8674(93)90489-D
  Sequence
[hsa:7046]

KEGG   ORTHOLOGY: K04388Help
Entry
K04388                      KO                                     

Name
TGFBR2
Definition
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00680  TGF-beta signaling
Disease
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  09143 Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09158 Development
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancers
    K04388  TGFBR2; TGF-beta receptor type-2
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05226 Gastric cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
  09167 Infectious diseases
   05166 HTLV-I infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05142 Chagas disease (American trypanosomiasis)
    K04388  TGFBR2; TGF-beta receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04388  TGFBR2; TGF-beta receptor type-2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
BRITE hierarchy
Other DBs
GO: 0005026
Genes
HSA: 7048(TGFBR2)
PTR: 460243(TGFBR2)
PPS: 100985497(TGFBR2)
GGO: 101146131(TGFBR2)
PON: 100459236(TGFBR2)
NLE: 100606849(TGFBR2)
MCC: 703088(TGFBR2)
MCF: 102134273(TGFBR2)
CSAB: 103241808(TGFBR2)
RRO: 104655082(TGFBR2)
RBB: 108516558(TGFBR2)
CJC: 100404359(TGFBR2)
SBQ: 101034142(TGFBR2)
MMU: 21813(Tgfbr2)
RNO: 81810(Tgfbr2)
CGE: 100773953(Tgfbr2)
NGI: 103744639(Tgfbr2)
HGL: 101704397(Tgfbr2)
CCAN: 109681522(Tgfbr2)
OCU: 100344335(TGFBR2)
TUP: 102486518(TGFBR2)
CFA: 477039(TGFBR2)
AML: 100482939(TGFBR2)
UMR: 103682015(TGFBR2)
ORO: 101364575(TGFBR2)
FCA: 101091725(TGFBR2)
PTG: 102958413(TGFBR2)
AJU: 106984570(TGFBR2)
BTA: 535376(TGFBR2)
BOM: 102267018(TGFBR2)
BIU: 109576148(TGFBR2)
PHD: 102330019(TGFBR2)
CHX: 100861300(TGFBR2)
OAS: 494191(TGFBR2)
SSC: 100038019(TGFBR2)
CFR: 102509744(TGFBR2)
CDK: 105087202(TGFBR2)
BACU: 103005777(TGFBR2)
LVE: 103077265(TGFBR2)
OOR: 101289351(TGFBR2)
ECB: 100033860(TGFBR2)
EPZ: 103566847 103567708(TGFBR2)
EAI: 106830994(TGFBR2)
MYB: 102248472(TGFBR2)
MYD: 102767756(TGFBR2)
HAI: 109394441(TGFBR2)
RSS: 109454546(TGFBR2)
PALE: 102889618(TGFBR2)
LAV: 100671392(TGFBR2)
TMU: 101354258
MDO: 100031897(TGFBR2)
SHR: 100913352(TGFBR2)
OAA: 100076965(TGFBR2)
GGA: 396399(TGFBR2) 424261(AMHR2)
MGP: 100546861(TGFBR2) 100549829
CJO: 107309296(TGFBR2) 107316805
APLA: 101794795(TGFBR2) 101801641
TGU: 100220619(TGFBR2) 100224677
GFR: 102040558(TGFBR2) 102044945
FAB: 101808986 101811048(TGFBR2)
PHI: 102099204 102112281(TGFBR2)
PMAJ: 107200593(TGFBR2) 107207553
CCW: 104689295(TGFBR2) 104694032
FPG: 101911268(TGFBR2) 101924328
FCH: 102048632 102053489(TGFBR2)
CLV: 102083591(TGFBR2) 102091992
EGZ: 104122957(TGFBR2) 104128099
AAM: 106491249(TGFBR2) 106498480
ASN: 102371879 102380434(TGFBR2)
AMJ: 102567839(TGFBR2) 102573702
PSS: 102444710(TGFBR2) 102457599
CMY: 102947040(TGFBR2)
CPIC: 101930851 101936050(TGFBR2)
ACS: 100552899(tgfbr2) 100556560
PVT: 110086832(TGFBR2) 110090113
PBI: 103057562(TGFBR2) 103063579
XLA: 108702885 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2.2.L)
XTR: 100487430(tgfbr2.2) 100488582(tgfbr2)
DRE: 30739(tgfbr2b) 560446(si:dkey-101k6.5)
LCO: 104922506 104923102(tgfbr2)
OLA: 101170689(tgfbr2) 101174785
PRET: 103465886(tgfbr2) 103472661
HCQ: 109516370(tgfbr2) 109530278
SFM: 108918826 108935840(tgfbr2)
LCM: 102346621(TGFBR2) 102356233
CMK: 103176334(tgfbr2) 103188937
CIN: 778778(tgfbr-iib)
SPU: 580712
APLC: 110984215
SKO: 100329004(TGFbRII)
EPA: 110254510
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]

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