KEGG ORTHOLOGY: K04697

ORTHOLOGY: K04697

Entry

K04697                      KO

Symbol

SOCS4

Name

suppressor of cytokine signaling 4

Pathway

map04630

JAK-STAT signaling pathway

map04910

Insulin signaling pathway

map04917

Prolactin signaling pathway

map04930

Type II diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
   04917 Prolactin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04697  SOCS4; suppressor of cytokine signaling 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04697  SOCS4; suppressor of cytokine signaling 4
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul5 complex
    Target recognizing subunit
     K04697  SOCS4; suppressor of cytokine signaling 4

Genes

HSA:	122809(SOCS4)

PTR:	452919(SOCS4)

PPS:	100989690(SOCS4)

GGO:	101131192(SOCS4)

PON:	100171842(SOCS4)

NLE:	100590972(SOCS4)

HMH:	116456249(SOCS4)

MCC:	696146(SOCS4)

MCF:	102141350(SOCS4)

MTHB:

126959337

MNI:	105481786(SOCS4)

CSAB:

103229025(SOCS4)

CATY:

105586646(SOCS4)

PANU:

100997112(SOCS4)

TGE:	112628778(SOCS4)

MLEU:

105553584(SOCS4)

RRO:	104669147(SOCS4)

RBB:	108530661(SOCS4)

TFN:	117069613(SOCS4)

CANG:

105525994(SOCS4)

CJC:	100386210(SOCS4)

SBQ:	101034850(SOCS4)

CIMI:

108294062(SOCS4)

CSYR:

103250822(SOCS4)

MMUR:

105867701(SOCS4)

LCAT:

123648892(SOCS4)

PCOQ:

105825865(SOCS4)

OGA:	100957947(SOCS4)

MMU:	67296(Socs4)

MCAL:

110309072(Socs4)

MPAH:

110325522(Socs4)

RNO:	305828(Socs4)

MCOC:

116085200(Socs4)

ANU:	117705978(Socs4)

MUN:	110550951(Socs4)

CGE:	100750379(Socs4)

MAUA:

101830742(Socs4)

PROB:

127216418(Socs4)

PLEU:

114696036(Socs4)

MORG:

121435011(Socs4)

MFOT:

126513827

AAMP:

119800354(Socs4)

NGI:	103739222(Socs4)

HGL:	101704725(Socs4)

CPOC:

100735753(Socs4)

CCAN:

109693954(Socs4)

DORD:

105982639(Socs4)

DSP:	122110084(Socs4)

PLOP:

125363645(Socs4)

NCAR:

124976869 124980800

MMMA:

107138292(Socs4)

OCU:

100357417

OPI:	101534372(SOCS4)

TUP:	102468675(SOCS4)

CFA:	100687271(SOCS4)

CLUD:

112656872(SOCS4)

VVP:	112921409(SOCS4)

VLG:	121493618(SOCS4)

NPO:	129495910(SOCS4)

AML:	100464791(SOCS4)

UMR:	103673077(SOCS4)

UAH:	113242350(SOCS4)

UAR:	123800746(SOCS4)

ELK:

111140665

LLV:

125103821

MPUF:

101673021(SOCS4)

MNP:	131999965(SOCS4)

MLK:	131836594(SOCS4)

NVS:	122893081(SOCS4)

ORO:	101383881(SOCS4)

EJU:	114207489(SOCS4)

ZCA:	113909623(SOCS4)

MLX:	118002023(SOCS4)

NSU:	110590590(SOCS4)

LWW:	102737585(SOCS4)

FCA:	101080974(SOCS4)

PYU:	121031795(SOCS4)

PCOO:

112856019(SOCS4)

PBG:	122469118(SOCS4)

PVIV:

125167747(SOCS4)

LRUF:

124512171

PTG:	102971697(SOCS4)

PPAD:

109268440(SOCS4)

PUC:

125909485

AJU:

106984332

HHV:	120237265(SOCS4)

BTA:	540412(SOCS4)

BOM:	102270424(SOCS4)

BIU:	109565183(SOCS4)

BBUB:

102391689(SOCS4)

BBIS:

104994214(SOCS4)

CHX:	102185842(SOCS4)

OAS:	101117935(SOCS4)

BTAX:

128053868(SOCS4)

ODA:	120852914(SOCS4)

CCAD:

122443672(SOCS4)

MBEZ:

129562912(SOCS4)

SSC:	100302366(SOCS4)

CFR:	102515584(SOCS4)

CBAI:

105074596(SOCS4)

CDK:	105091440(SOCS4)

VPC:	102532736(SOCS4)

BACU:

103014060(SOCS4)

BMUS:

118890695(SOCS4)

LVE:	103076129(SOCS4)

OOR:	101275711(SOCS4)

DLE:	111173136(SOCS4)

PCAD:

102993244(SOCS4)

PSIU:

116749322(SOCS4)

NASI:

112392871(SOCS4)

ECB:	100050301(SOCS4)

EPZ:	103554102(SOCS4)

EAI:	106846111(SOCS4)

MYB:	102247430(SOCS4)

MYD:	102767035(SOCS4)

MMYO:

118655678(SOCS4)

MLF:	102434218(SOCS4)

PKL:	118717809(SOCS4)

EFUS:

103283718(SOCS4)

MNA:	107525887(SOCS4)

DRO:	112311535(SOCS4)

SHON:

118992421(SOCS4)

AJM:	119057045(SOCS4)

PDIC:

114491820(SOCS4)

PHAS:

123808769(SOCS4)

MMF:	118616174(SOCS4)

PPAM:

129066016(SOCS4)

HAI:	109384171(SOCS4)

RFQ:	117023555(SOCS4)

PALE:

102879275(SOCS4)

PGIG:

120605611(SOCS4)

PVP:	105309162(SOCS4)

RAY:	107503961(SOCS4)

MJV:	108396005(SOCS4)

TOD:	119239113(SOCS4)

SARA:

101542642(SOCS4)

SETR:

125999239(SOCS4)

LAV:	100662743(SOCS4)

TMU:

101358025

ETF:	101656743(SOCS4)

DNM:	101435282(SOCS4)

MDO:	100024207(SOCS4)

GAS:	123235771(SOCS4)

SHR:	100921040(SOCS4)

AFZ:

127549779

PCW:	110211768(SOCS4)

OAA:	100086717(SOCS4)

GGA:	423557(SOCS4)

PCOC:

116236655(SOCS4)

MGP:	100549827(SOCS4)

CJO:	107315453(SOCS4)

TPAI:

128087214(SOCS4)

LMUT:

125695087(SOCS4)

NMEL:

110401367(SOCS4)

APLA:

101804231(SOCS4)

ACYG:

106044059(SOCS4)

CATA:

118250253(SOCS4)

AFUL:

116490340(SOCS4)

TGU:	100230629(SOCS4)

LSR:	110472710(SOCS4)

SCAN:

103826330(SOCS4)

PMOA:

120503863(SOCS4)

OTC:	121340694(SOCS4)

PRUF:

121358540(SOCS4)

GFR:	102043937(SOCS4)

FAB:	101815072(SOCS4) 101816294

OMA:	130253427(SOCS4)

PHI:	102109006(SOCS4)

PMAJ:

107206463(SOCS4)

CCAE:

111929669(SOCS4)

CCW:	104687619(SOCS4)

CBRC:

103618842(SOCS4)

ETL:	114069886(SOCS4)

ZAB:	102065785(SOCS4)

ACHL:

103805619(SOCS4)

SVG:	106850254(SOCS4)

MMEA:

130584961(SOCS4)

HRT:	120754154(SOCS4)

FPG:	101924304(SOCS4)

FCH:	102048310(SOCS4)

CLV:	102086690(SOCS4)

EGZ:	104122986(SOCS4)

NNI:	104019434(SOCS4)

PCRI:

104039047(SOCS4)

PLET:

104621798(SOCS4)

EHS:	104505354(SOCS4)

PCAO:

104043718(SOCS4)

ACUN:

113480674(SOCS4)

TALA:

104361742(SOCS4)

PADL:

103915976(SOCS4)

AFOR:

103907623(SOCS4)

ACHC:

115353378(SOCS4)

HALD:

104312682(SOCS4)

HLE:	104839489(SOCS4)

AGEN:

126050565

GCL:

127016739

CCRI:

104167126(SOCS4)

CSTI:

104555949(SOCS4)

CMAC:

104477539(SOCS4)

MUI:	104536452(SOCS4)

BREG:

104633176(SOCS4)

FGA:	104081754(SOCS4)

GSTE:

104255375(SOCS4)

LDI:	104349955(SOCS4)

MNB:	103768848(SOCS4)

OHA:	104333953(SOCS4)

NNT:	104401344(SOCS4)

SHAB:

115607443(SOCS4)

DPUB:

104307240(SOCS4)

PGUU:

104460665(SOCS4)

ACAR:

104529520(SOCS4)

CPEA:

104387672(SOCS4)

AVIT:

104269693(SOCS4)

CVF:	104294316(SOCS4)

RTD:	128908915(SOCS4)

CUCA:

104057434(SOCS4)

TEO:	104371467(SOCS4)

BRHI:

104500036(SOCS4)

AAM:	106493674(SOCS4)

AROW:

112961262(SOCS4)

NPD:	112957813(SOCS4)

TGT:	104578206(SOCS4)

DNE:	112983142(SOCS4)

SCAM:

104141372(SOCS4)

ASN:	102384587(SOCS4)

AMJ:	102572731(SOCS4)

CPOO:

109320721(SOCS4)

GGN:	109298315(SOCS4)

PSS:	102453072(SOCS4)

CMY:	102931468(SOCS4)

CCAY:

125638339(SOCS4)

DCC:	119857675(SOCS4)

CPIC:

101953043(SOCS4)

TST:	117876943(SOCS4)

CABI:

116819030(SOCS4)

MRV:	120403702(SOCS4)

ACS:	100561266(socs4)

ASAO:

132760993(SOCS4)

PVT:	110070093(SOCS4)

SUND:

121922070(SOCS4)

PBI:	103053679(SOCS4)

PMUR:

107293655(SOCS4)

CTIG:

120297959(SOCS4)

TSR:	106539854(SOCS4)

PGUT:

117675093(SOCS4)

APRI:

131188064(SOCS4)

PTEX:

113435115(SOCS4)

NSS:	113413735(SOCS4)

VKO:	123026799(SOCS4)

PMUA:

114595944(SOCS4)

PRAF:

128414803(SOCS4)

ZVI:	118078072(SOCS4)

HCG:	128334756(SOCS4)

GJA:	107113082(SOCS4)

STOW:

125427025(SOCS4)

EMC:	129323632(SOCS4)

XLA:	108698764(socs4.L) 108699788(socs4.S)

XTR:	549828(socs4)

NPR:	108789412(SOCS4)

RTEM:

120920275(SOCS4)

BGAR:

122922230 122924947(SOCS4)

MUO:	115477844(SOCS4)

DRE:	797891(socs4)

SRX:	107723705 107751808

SANH:

107680769 107693087

SGH:	107564995 107583461

CCAR:

109106892 109106893

CAUA:

113060347 113069470

CGIB:

127933545 127976658

PTET:

122362354(socs4)

LROH:

127179264(socs4)

OMC:	131523508(socs4)

PPRM:

120490736(socs4)

RKG:	130101469(socs4)

MAMB:

125268470(socs4)

CIDE:

127498652

MASI:

127455442

TROS:

130560666(socs4)

TDW:	130437250(socs4)

MANU:

129417311(socs4)

IPU:	108270091(socs4)

IFU:	128613215(socs4)

PHYP:

113534177

SMEO:

124390435(socs4)

TFD:	113651284(socs4)

TVC:	132852304(socs4)

AMEX:

103045167

CMAO:

118823970(socs4)

EEE:

113571142

CHAR:

105896403(socs4)

TRU:	100144313(socs4)

TFS:	130521710(socs4)

TNG:	GSTEN00003045G001

LCO:

104929608

NCC:

104964293

TBEN:

117471818(socs4)

CGOB:

115006088(socs4)

PGEO:

117441303(socs4)

GACU:

117533674(socs4)

EMAC:

134863738(socs4)

ELY:	117259021(socs4)

EFO:	125903782(socs4)

PLEP:

121946374(socs4)

SLUC:

116067324(socs4)

ECRA:

117939807(socs4)

ESP:

116693718

PFLV:

114561322

GAT:	100190867(socs4)

PPUG:

119194767(socs4)

AFB:	129108235(socs4)

CLUM:

117728837(socs4)

PSWI:

130193026(socs4)

MSAM:

119889719(socs4)

SCHU:

122886467(socs4)

CUD:	121513955(socs4)

ALAT:

119018475(socs4)

MZE:

101469365

ONL:	100699329(socs4)

OAU:	116317537(socs4)

OLA:	100144385(socs4)

OML:	112138625(socs4)

CSAI:

133458339(socs4)

XMA:

XCO:

XHE:

PRET:

PFOR:

103142650(socs4)

PLAI:

106935381

PMEI:

106911193

GAF:	122845218(socs4)

CVG:	107083884(socs4)

CTUL:

119772742(socs4)

GMU:	124867350(socs4)

NFU:

107381831

KMR:	108242119(socs4)

ALIM:

106524719(socs4)

NWH:	119430261(socs4)

AOCE:

111575116(socs4)

MCEP:

125005588(socs4)

CSEM:

103398397

POV:

109637204

SSEN:

122772123(socs4)

HHIP:

117752018(socs4)

HSP:	118110616(socs4)

SMAU:

118302850(socs4)

LCF:

108888048

SDU:

111224920

SLAL:

111654712(socs4)

XGL:	120794450(socs4)

HCQ:

109514287

SSCV:

125967251

MALB:

109974789

BSPL:

114851973(socs4)

SJO:	128354946(socs4)

SASA:

106602930(socs4)

STRU:

115162742 115172108

OTW:	112246774 112257113

OMY:	110498687 110504313

OGO:	124001194(socs4) 124045198

ONE:	115138920 115146579

OKI:

109903142

OKE:	118362067 118369284

SALP:

112068333 112068776 112080246

SNH:	120023069 120059963(socs4)

CCLU:

121539653(socs4)

ELS:

105023278

SFM:

108919519

AANG:

118232019(socs4)

LOC:	102683522(socs4)

PSPA:

121324308 121330241

ARUT:

117422193 117963891

PSEX:

120518961(socs4)

LCM:	102362805(SOCS4)

CMK:

RTP:

CPLA:

HOC:

LERI:

EAF:

PPOI:

BGT:

HRF:

HRJ:

OED:

RPHI:

EPA:

ATEN:

DGT:

XEN:

Reference

PMID:12076535

Authors

Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.

Title

The SOCS box: a tale of destruction and degradation.

Journal

Trends Biochem Sci 27:235-41 (2002)
DOI:10.1016/S0968-0004(02)02085-6

Sequence

[hsa:122809]

Reference

PMID:15590694

Authors

Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, Yarden Y

Title

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

Journal

J Biol Chem 280:7038-48 (2005)
DOI:10.1074/jbc.M408575200

Sequence

[hsa:122809]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Gene (658)   
   KEGG GENES (410)   
   KEGG MGENES (84)   
   RefGene (163)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (670)   

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