KEGG   ORTHOLOGY: K04734Help
Entry
K04734                      KO                                     

Name
NFKBIA
Definition
NF-kappa-B inhibitor alpha
Pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04926  Relaxin signaling pathway
ko04931  Insulin resistance
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05134  Legionellosis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00007  Hodgkin lymphoma
H00095  Ectodermal dysplasia associated immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04668 TNF signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04024 cAMP signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04624 Toll and Imd signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04621 NOD-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04622 RIG-I-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04623 Cytosolic DNA-sensing pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04625 C-type lectin receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04660 T cell receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04658 Th1 and Th2 cell differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04659 Th17 cell differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04657 IL-17 signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04662 B cell receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04062 Chemokine signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04926 Relaxin signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05203 Viral carcinogenesis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05215 Prostate cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05222 Small cell lung cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05130 Pathogenic Escherichia coli infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05131 Shigellosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05135 Yersinia infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05134 Legionellosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05170 Human immunodeficiency virus 1 infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05162 Measles
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05164 Influenza A
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05161 Hepatitis B
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05160 Hepatitis C
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05168 Herpes simplex virus 1 infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05163 Human cytomegalovirus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05169 Epstein-Barr virus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05140 Leishmaniasis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05142 Chagas disease (American trypanosomiasis)
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04131 Membrane trafficking
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Ankyrin only
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
Membrane trafficking [BR:ko04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
BRITE hierarchy
Other DBs
GO: 0051059
Genes
HSA: 4792(NFKBIA)
PTR: 467426(NFKBIA)
PPS: 100972867(NFKBIA)
GGO: 101128204(NFKBIA)
PON: 100459445
NLE: 100599351(NFKBIA)
MCC: 695335(NFKBIA)
MCF: 101867458(NFKBIA)
CSAB: 103228823(NFKBIA)
RRO: 104679802(NFKBIA)
RBB: 108519636(NFKBIA)
CJC: 100402266(NFKBIA)
SBQ: 101048714(NFKBIA)
MMU: 18035(Nfkbia)
MCAL: 110306864(Nfkbia)
MPAH: 110324484(Nfkbia)
RNO: 25493(Nfkbia)
MUN: 110562401(Nfkbia)
CGE: 100754153(Nfkbia)
NGI: 103734016(Nfkbia)
HGL: 101709256(Nfkbia)
CCAN: 109697260(Nfkbia)
OCU: 100357341(NFKBIA)
TUP: 102494635(NFKBIA)
CFA: 480291(NFKBIA)
VVP: 112935347(NFKBIA)
AML: 100466997(NFKBIA)
UMR: 103666055(NFKBIA)
UAH: 113266131(NFKBIA)
ORO: 101384149(NFKBIA)
ELK: 111140276
FCA: 101090622(NFKBIA)
PTG: 102956127(NFKBIA)
PPAD: 109253320(NFKBIA)
AJU: 106965509(NFKBIA)
BTA: 282291(NFKBIA)
BOM: 102275402(NFKBIA)
BIU: 109575581(NFKBIA)
BBUB: 102412626(NFKBIA)
CHX: 102169137(NFKBIA)
OAS: 780520(NFKBIA)
SSC: 406188(NFKBIA)
CFR: 102519409(NFKBIA)
CDK: 105092140(NFKBIA)
BACU: 103002206(NFKBIA)
LVE: 103069029(NFKBIA)
OOR: 101289477(NFKBIA)
DLE: 111173225(NFKBIA)
PCAD: 102973672(NFKBIA)
ECB: 100058000(NFKBIA)
EPZ: 103546400(NFKBIA)
EAI: 106838803(NFKBIA)
MYB: 102256580(NFKBIA)
MYD: 102763089(NFKBIA)
MNA: 107526117(NFKBIA)
HAI: 109383860(NFKBIA)
DRO: 112296519(NFKBIA)
PALE: 102891056(NFKBIA)
RAY: 107514416(NFKBIA)
MJV: 108402523(NFKBIA)
LAV: 100675651(NFKBIA)
TMU: 101355353
MDO: 100011769(NFKBIA)
SHR: 100919027(NFKBIA)
PCW: 110211795(NFKBIA)
OAA: 100090081(NFKBIA)
GGA: 396093(NFKBIA)
MGP: 100549878(NFKBIA)
CJO: 107315054(NFKBIA)
NMEL: 110401359(NFKBIA)
APLA: 101791396(NFKBIA)
ACYG: 106038777(NFKBIA)
TGU: 100220015(NFKBIA)
LSR: 110477285(NFKBIA)
SCAN: 103826549(NFKBIA)
GFR: 102042109(NFKBIA)
FAB: 101816754(NFKBIA)
PHI: 102109715(NFKBIA)
PMAJ: 107205249(NFKBIA)
CCAE: 111930016(NFKBIA)
CCW: 104688451(NFKBIA)
ETL: 114065291(NFKBIA)
FPG: 101923842(NFKBIA)
FCH: 102051665(NFKBIA)
CLV: 102094222(NFKBIA)
EGZ: 104133251(NFKBIA)
NNI: 104011799(NFKBIA)
ACUN: 113480478(NFKBIA)
PADL: 103912947(NFKBIA)
AAM: 106483033(NFKBIA)
ASN: 102381268(NFKBIA)
AMJ: 102559903(NFKBIA)
PSS: 102460666(NFKBIA)
CMY: 102937973(NFKBIA)
CPIC: 101937790(NFKBIA)
ACS: 100554664(nfkbia)
PVT: 110083506(NFKBIA)
PBI: 103057929(NFKBIA)
PMUR: 107290218(NFKBIA)
TSR: 106551236(NFKBIA)
PMUA: 114592509(NFKBIA)
GJA: 107119990(NFKBIA)
XLA: 446833(nfkbia.L) 734297(nfkbia.S)
XTR: 448138(nfkbia)
NPR: 108795750(NFKBIA)
DRE: 323099(nfkbiab) 406463(nfkbiaa)
IPU: 108258222(Nfkbia) 108269796(nfkbia)
PHYP: 113524771 113534059(nfkbia)
AMEX: 103038271 103043190(nfkbia)
EEE: 113571141(nfkbia) 113571703
LCO: 104928653(nfkbia) 104931204
MZE: 101464752 101484153(nfkbia)
ONL: 100691089(nfkbia) 100691708
OLA: 101162015 101168165(nfkbia)
XMA: 102217801 102228531(nfkbia)
XCO: 114134154(nfkbia) 114158792
PRET: 103457805 103458779(nfkbia)
CVG: 107094345(nfkbia) 107095483
NFU: 107396025 107396129(nfkbia)
KMR: 108231757 108241774(nfkbia)
AOCE: 111577551 111581711(nfkbia)
CSEM: 103377625(nfkbia) 103380734
LCF: 108895835 108896130(nfkbia)
SDU: 111225264(nfkbia) 111238330
BPEC: 110155259(nfkbia) 110162763
MALB: 109969835 109972831(nfkbia)
SASA: 106571222(IKBA) 106601178(IKBA) 106607598(IKBA) 106611175(IKBA)
ELS: 105015312 105015478(nfkbia)
SFM: 108919418(nfkbia) 108923979
PKI: 111841750 111852632(nfkbia)
LCM: 102347685(NFKBIA)
DME: Dmel_CG5848(cact)
DER: 6541508
DSI: Dsimw501_GD21920(Dsim_cact)
DYA: Dyak_GE19366(Dyak_cact)
DSR: 110181207
DPE: 6595565
DMN: 108161888
DWI: 6641720
DAZ: 108610290
DNV: 115563171
DHE: 111602535
MDE: 101889324
LCQ: 111690732
AGA: AgaP_AGAP007938(CACT)
AAG: 5565922
AME: 411012 725124(cact1)
BIM: 100743215
BTER: 100631059
CCAL: 108623776
OBB: 114877652
SOC: 105201775
HST: 105190318
DQU: 106741205
CFO: 105252756
PCF: 106787186
NVI: 100119352(Cact3)
TCA: 657221(Cact)
DPA: 109538735
ATD: 109594517
NVL: 108561090
BMOR: 100379185(cact)
BMAN: 114247299
PMAC: 106712709
PRAP: 111003662
HAW: 110376896
TNL: 113497565
PXY: 105384975
API: 100165906(Cact)
RMD: 113553728
BTAB: 109032736
CLEC: 106667081
ZNE: 110829682
FCD: 110843006
PVM: 113823636
TUT: 107365267
DPTE: 113791661
CSCU: 111620617
PTEP: 107445253
PCAN: 112570145
CRG: 105319824
OBI: 106873926
ADF: 107347858
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9990853
  Authors
Spencer E, Jiang J, Chen ZJ
  Title
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.
  Journal
Genes Dev 13:284-94 (1999)
DOI:10.1101/gad.13.3.284
Reference
  Authors
Hatakeyama S, Kitagawa M, Nakayama K, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoe K, Good RA, Nakayama K
  Title
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
  Journal
Proc Natl Acad Sci U S A 96:3859-63 (1999)
DOI:10.1073/pnas.96.7.3859
Reference
PMID:1829648
  Authors
Haskill S, Beg AA, Tompkins SM, Morris JS, Yurochko AD, Sampson-Johannes A, Mondal K, Ralph P, Baldwin AS Jr
  Title
Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
  Journal
Cell 65:1281-9 (1991)
DOI:10.1016/0092-8674(91)90022-Q
  Sequence
[hsa:4792]

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