KEGG ORTHOLOGY: K04913

ORTHOLOGY: K04913

Entry

K04913                      KO

Symbol

KCNK2, K2P2.1

Name

potassium channel subfamily K member 2

Pathway

map04024

cAMP signaling pathway

map04261

Adrenergic signaling in cardiomyocytes

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

map04971

Gastric acid secretion

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2
09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2
  09154 Digestive system
   04971 Gastric acid secretion
    K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Potassium channel, two-pore domain (K2P)
   K04913  KCNK2, K2P2.1; potassium channel subfamily K member 2

Other DBs

GO:

0022841

TC:

1.A.1.9.1

Genes

HSA:	3776(KCNK2)

PTR:	457734(KCNK2)

PPS:	100991720(KCNK2)

GGO:	101149331(KCNK2)

PON:	100435329(KCNK2)

NLE:	100601855(KCNK2)

HMH:	116457712(KCNK2)

MCC:	708705(KCNK2)

MCF:	102146456(KCNK2)

MTHB:

126948583

MNI:	105493522(KCNK2)

CSAB:

103230096(KCNK2)

CATY:

105577016(KCNK2)

PANU:

103877952(KCNK2)

TGE:	112612170(KCNK2)

MLEU:

105551031(KCNK2)

RRO:	104657055(KCNK2)

RBB:	108528238(KCNK2)

TFN:	117075253(KCNK2)

PTEH:

111537013(KCNK2)

CANG:

105502778(KCNK2)

CJC:	100400002(KCNK2)

SBQ:	101048117(KCNK2)

CIMI:

108289699(KCNK2)

CSYR:

103267737(KCNK2)

MMUR:

105880580(KCNK2)

LCAT:

123627049(KCNK2)

PCOQ:

105805421(KCNK2)

OGA:

100962107

MMU:	16526(Kcnk2)

MCAL:

110292906(Kcnk2)

MPAH:

110321229(Kcnk2)

RNO:	170899(Kcnk2)

MCOC:

116068612(Kcnk2)

ANU:	117716342(Kcnk2)

MUN:	110553409(Kcnk2)

CGE:	100751502(Kcnk2)

MAUA:

101834841(Kcnk2)

PROB:

127223918(Kcnk2)

PLEU:

114698218(Kcnk2)

MORG:

121435889(Kcnk2)

MFOT:

126505414

AAMP:

119827769(Kcnk2)

NGI:	103727069(Kcnk2)

HGL:	101722094(Kcnk2)

CPOC:

100729832(Kcnk2)

CCAN:

109700240(Kcnk2)

DORD:

105984818(Kcnk2)

DSP:	122109571(Kcnk2)

PLOP:

125359809(Kcnk2)

NCAR:

124961818

MMMA:

107140301(Kcnk2)

OCU:

100356478

OPI:	101518516(KCNK2)

TUP:	102488856(KCNK2)

GVR:	103601215(KCNK2)

CFA:	490295(KCNK2)

CLUD:

112648426(KCNK2)

VVP:	112921786(KCNK2)

VLG:	121501358(KCNK2)

NPO:	129506035(KCNK2)

AML:	100481291(KCNK2)

UMR:	103672450(KCNK2)

UAH:	113262981(KCNK2)

UAR:	123776187(KCNK2)

ELK:

111150823

LLV:

125086380

MPUF:

101679277(KCNK2)

MNP:	132026077(KCNK2)

MLK:	131814901(KCNK2)

NVS:	122918574(KCNK2)

ORO:	101374381(KCNK2)

EJU:	114222904(KCNK2)

ZCA:	113933656(KCNK2)

MLX:	118014336(KCNK2)

NSU:	110573939(KCNK2)

LWW:	102729138(KCNK2)

FCA:	101096695(KCNK2)

PYU:	121011790(KCNK2)

PCOO:

112857752(KCNK2)

PBG:	122476621(KCNK2)

PVIV:

125155364(KCNK2)

LRUF:

124510125

PTG:	102968820(KCNK2)

PPAD:

109254391(KCNK2)

PUC:

125925790

AJU:

106966794

HHV:	120243361(KCNK2)

BTA:	282590(KCNK2)

BOM:	102271922(KCNK2)

BIU:	109570750(KCNK2)

BBUB:

102413225(KCNK2)

BBIS:

104998053(KCNK2)

CHX:	102179222(KCNK2)

OAS:	101111729(KCNK2)

BTAX:

128061611(KCNK2)

ODA:	120880066(KCNK2)

CCAD:

122452379(KCNK2)

MBEZ:

129551275(KCNK2)

SSC:	100627197(KCNK2)

CFR:	102509102(KCNK2)

CBAI:

105064553(KCNK2)

CDK:	105099341(KCNK2)

VPC:	102535203(KCNK2)

BACU:

103013336(KCNK2)

BMUS:

118888608(KCNK2)

LVE:	103089238(KCNK2)

OOR:	101270799(KCNK2)

DLE:	111184609(KCNK2)

PCAD:

102981407(KCNK2)

PSIU:

116760007(KCNK2)

NASI:

112403536(KCNK2)

ECB:	100050114(KCNK2)

EPZ:	103559377(KCNK2)

EAI:	106846819(KCNK2)

MYB:

102263619

MYD:	102773670(KCNK2)

MMYO:

118673572(KCNK2)

MLF:	102424608(KCNK2)

PKL:	118721327(KCNK2)

EFUS:

103290038(KCNK2)

MNA:	107546296(KCNK2)

DRO:	112296671(KCNK2)

SHON:

118979161(KCNK2)

AJM:	119059730(KCNK2)

PDIC:

114512145(KCNK2)

PHAS:

123818398(KCNK2)

MMF:	118637323(KCNK2)

PPAM:

129081869(KCNK2)

HAI:	109379086(KCNK2)

RFQ:	117015436(KCNK2)

PALE:

102885724(KCNK2)

PGIG:

120617544(KCNK2)

PVP:	105295028(KCNK2)

RAY:	107521645(KCNK2)

MJV:	108391322(KCNK2)

TOD:	119234850(KCNK2)

SARA:

101548330(KCNK2)

SETR:

126003349(KCNK2)

LAV:	100654542(KCNK2)

TMU:

101349413

ETF:	101664200(KCNK2)

DNM:	101418402(KCNK2)

MDO:	100023531(KCNK2)

GAS:	123244892(KCNK2)

SHR:	100935232(KCNK2)

AFZ:

127562548

PCW:	110222680(KCNK2)

OAA:	100079421(KCNK2)

GGA:	770954(KCNK2)

PCOC:

116230547(KCNK2)

MGP:	100538823(KCNK2)

CJO:	107311088(KCNK2)

TPAI:

128079696(KCNK2)

LMUT:

125689551(KCNK2)

NMEL:

110395509(KCNK2)

APLA:

101802542(KCNK2)

ACYG:

106031574(KCNK2)

CATA:

118255107(KCNK2)

AFUL:

116488203(KCNK2)

TGU:	100220097(KCNK2)

LSR:	110479967(KCNK2)

SCAN:

103821508(KCNK2)

PMOA:

120497011(KCNK2)

OTC:	121347796(KCNK2)

PRUF:

121358670(KCNK2)

GFR:	102039165(KCNK2)

FAB:	101815844(KCNK2)

OMA:	130251712(KCNK2)

PHI:	102101096(KCNK2)

PMAJ:

107202578(KCNK2)

CCAE:

111926195(KCNK2)

CCW:	104685631(KCNK2)

CBRC:

103612638(KCNK2)

ETL:	114060903(KCNK2)

ZAB:	102068379(KCNK2)

ACHL:

103798264(KCNK2)

SVG:	106853554(KCNK2)

MMEA:

130573028(KCNK2)

HRT:	120750793(KCNK2)

FPG:	101923937(KCNK2)

FCH:	102055556(KCNK2)

CLV:	102086497(KCNK2)

EGZ:	104132858(KCNK2)

NNI:	104019660(KCNK2)

PCRI:

104027046

PLET:

104620605(KCNK2)

PCAO:

104052543

ACUN:

113478704(KCNK2)

TALA:

104358584(KCNK2)

PADL:

103922112(KCNK2)

AFOR:

103899195(KCNK2)

ACHC:

115350332(KCNK2)

HALD:

104319602(KCNK2)

HLE:	104837343(KCNK2)

AGEN:

126052646

GCL:

127014066

CCRI:

104162863(KCNK2)

CSTI:

104557762(KCNK2)

CMAC:

104485255

MUI:

104547162

BREG:

104637310(KCNK2)

FGA:	104070549(KCNK2)

GSTE:

104262457(KCNK2)

LDI:	104348802(KCNK2)

OHA:	104327866(KCNK2)

NNT:	104405155(KCNK2)

SHAB:

115613864(KCNK2)

DPUB:

104299889(KCNK2)

PGUU:

104469087(KCNK2)

CPEA:

104386181(KCNK2)

AVIT:

104274724(KCNK2)

CVF:	104294680(KCNK2)

RTD:	128907051(KCNK2)

CUCA:

104058037(KCNK2)

TEO:	104376330(KCNK2)

BRHI:

104490453

AAM:	106490378(KCNK2)

AROW:

112977015(KCNK2)

NPD:	112955151(KCNK2)

TGT:	104580353(KCNK2)

DNE:	112984463(KCNK2)

SCAM:

104140302(KCNK2)

ASN:	102385689(KCNK2)

AMJ:	102576820(KCNK2)

CPOO:

109319726(KCNK2)

GGN:	109296849(KCNK2)

PSS:	102452042(KCNK2)

CMY:	102947248(KCNK2)

CCAY:

125633628(KCNK2)

DCC:	119853186(KCNK2)

CPIC:

101947567(KCNK2)

TST:	117874415(KCNK2)

CABI:

116823626(KCNK2)

MRV:	120401979(KCNK2)

ACS:	100558061(kcnk2)

ASAO:

132761421(KCNK2)

PVT:	110087179(KCNK2)

SUND:

121919489(KCNK2)

PBI:	103067710(KCNK2)

PMUR:

107289293(KCNK2)

CTIG:

120304963(KCNK2)

TSR:	106555457(KCNK2)

PGUT:

117671707(KCNK2)

APRI:

131189300(KCNK2)

PTEX:

113433039(KCNK2)

NSS:	113420436(KCNK2)

VKO:	123032327(KCNK2)

PMUA:

114594671(KCNK2)

PRAF:

128411136(KCNK2)

ZVI:	118083173(KCNK2)

HCG:	128350695(KCNK2)

GJA:	107125653(KCNK2)

STOW:

125431149(KCNK2)

EMC:	129331071(KCNK2)

XLA:	108716457(kcnk2.L) 108717710(kcnk2.S)

XTR:	100495685(kcnk2)

NPR:	108784775(KCNK2)

RTEM:

120937902(KCNK2)

BBUF:

120997518(KCNK2)

BGAR:

122935517(KCNK2)

MUO:	115465511(KCNK2)

GSH:	117356428(KCNK2)

DRE:	559728(kcnk2a) 568565(kcnk2b)

SRX:	107707328 107731508 107733102 107752820

SANH:

107660545 107674044 107680301 107697693

SGH:	107554930 107592796 107592955 107594834

CCAR:

109064694 109073384

CAUA:

113060629 113117248 113117363 113121292

CGIB:

127933482 127975909 127984077

PTET:

122325244(kcnk2b) 122361776(kcnk2a)

LROH:

127161763(kcnk2b) 127179929(kcnk2a)

OMC:	131522947(kcnk2a) 131527241(kcnk2b)

PPRM:

120479269 120483040(kcnk2a)

RKG:	130083987(kcnk2b) 130100789(kcnk2a)

MAMB:

125269078(kcnk2a) 125277723(kcnk2b)

CIDE:

127498587 127502578

MASI:

127410899 127415845 127455611

TROS:

130559845(kcnk2a) 130566445(kcnk2b)

TDW:	130434729(kcnk2b) 130437060(kcnk2a)

MANU:

129417484(kcnk2a)

IPU:	108261241(kcnk2b)

IFU:	128619494(kcnk2b)

PHYP:

113528844(kcnk2)

SMEO:

124401420(kcnk2b)

TFD:	113654816(kcnk2b)

TVC:	132855371(kcnk2b)

AMEX:

103023432

CMAO:

118800225

EEE:

113591913

CHAR:

105892158 105908158(kcnk2a)

TRU:	101071825(kcnk2) 101075749

TFS:	130516241 130518040

TNG:	GSTEN00006858G001 GSTEN00030357G001 GSTEN00032815G001

LCO:	104920151 104922010

NCC:	104947338(kcnk2) 104966753

TBEN:

117471383(kcnk2a) 117493075

CGOB:

115003845 115004009

PGEO:

117439446(kcnk2a) 117439492

GACU:

117533826 117551441(kcnk2a)

EMAC:

134863374(kcnk2a) 134876967

ELY:	117260159 117271223

EFO:	125881588 125897442

PLEP:

121944085 121955690

SLUC:

116060599(kcnk2a) 116066397

ECRA:

117945419 117961680

ESP:	116692007 116705913(kcnk2)

PFLV:

114553080 114573501(kcnk2)

GAT:	120807879 120811888(kcnk2a)

PPUG:

119195223 119195814

AFB:	129105815(kcnk2a) 129107437(kcnk2b)

CLUM:

117727486 117751689(kcnk2a)

PSWI:

130192603(kcnk2a) 130202861(kcnk2b)

MSAM:

119889689(kcnk2a) 119909339

SCHU:

122862809 122868474(kcnk2a)

CUD:	121521722 121529628

ALAT:

119013145 119018244

MZE:	101474522 101479664(kcnk2)

ONL:	100699231 100708445(kcnk2)

OAU:	116310656(kcnk2b) 116313289

OLA:	101165275(kcnk2) 101168108

OML:	112157616 112160892(kcnk2a)

CSAI:

133421413(kcnk2a) 133464614(kcnk2b)

XMA:	102232358 102238204(kcnk2)

XCO:	114142707 114158719(kcnk2)

XHE:	116718682 116734284(kcnk2)

PRET:

103457649(kcnk2) 103462837

PFOR:

103136484 103138602(kcnk2)

PLAI:

106957408(kcnk2) 106958996

PMEI:

106906464 106928319(kcnk2)

GAF:	122825494 122844753

PPRL:

129351228 129364276

CVG:	107083347(kcnk2) 107092146

CTUL:

119785122 119789648

GMU:	124867359 124881486

NFU:	107377589(kcnk2) 107381183

KMR:	108237338(kcnk2a) 108240075

ALIM:

106513130 106516937(kcnk2)

NWH:	119418196 119426018(kcnk2a)

AOCE:

111568229(kcnk2) 111570296

MCEP:

124999568 125005520

CSEM:

103380829(kcnk2)

POV:	109636214(kcnk2) 109636747

SSEN:

122764932 122772029

HHIP:

117757314 117758432

HSP:	118099908 118109788

SMAU:

118290104(kcnk2b) 118302909(kcnk2a)

LCF:	108877004 108895647

SDU:	111221101 111239238(kcnk2)

SLAL:

111650560 111668854

XGL:	120789080 120789838(kcnk2a)

HCQ:	109516756(kcnk2) 109528781

SSCV:

125967657 125989853

SBIA:

133496588 133497758

PEE:	133415402 133416900

PTAO:

133468040(kcnk2b) 133474318(kcnk2a)

BPEC:

110154405(kcnk2) 110172983

MALB:

109954288(kcnk2) 109954548

BSPL:

114849735 114852788(kcnk2a)

SJO:	128356840(kcnk2a) 128376831(kcnk2b)

SASA:

106603213(kcnk10) 106607929(kcnk2) 106611358

STRU:

115161769 115172218(kcnk10) 115188991(kcnk2)

OTW:	112217700 112255805 112261491

OMY:	110497563 110504244 110522346(kcnk2b)

OGO:	123995682 124001164 124046723

ONE:	115123034 115139318 115145895(kcnk10)

OKI:	109866708 109894237 109904327

OKE:	118362822 118369113 118387012

SALP:

111968425 111972626

SNH:	120019561 120023004 120060079

CCLU:

121538890 121544244 121548816(kcnk2b)

ELS:	105015423(kcnk2)

SFM:	108924047(kcnk2)

PKI:	111841264 111858271

AANG:

118229346

LOC:	102695702(kcnk2)

PSPA:

121316412 121316540(kcnk2a)

ARUT:

117403294 117410373

PSEX:

120516558(kcnk2a)

LCM:	102353730(KCNK2)

CMK:

103186169

RTP:

109919499

CPLA:

122552824

HOC:	132819407(kcnk2a)

LERI:

129699721(kcnk2a)

PMRN:

116943315

LRJ:

133342298

BFO:	118406159 118423789 118425651 118425653 118425655 118428589

BBEL:

109482500 109485852 109487107 109487186 109487188

CIN:

SCLV:

SPU:

LPIC:

APLC:

DSV:

RSAN:

VDE:

VJA:

DFR:

HRF:

HRJ:	124261557 124261558

CRG:

CVN:

CANU:

OED:

MYI:	110449176 110467248

PMAX:

117324529

MMER:

123534026 123544601 123556313 123558754

RPHI:

132752547

DPOL:

127875239

» show all

Reference

PMID:11319556

Authors

Bockenhauer D, Zilberberg N, Goldstein SA

Title

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.

Journal

Nat Neurosci 4:486-91 (2001)
DOI:10.1038/87434

Sequence

[hsa:3776]

Reference

PMID:10784345

Authors

Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG

Title

Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel.

Journal

Pflugers Arch 439:714-22 (2000)
DOI:10.1007/s004249900235

Sequence

[hsa:3776]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   TC (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Gene (938)   
   KEGG GENES (546)   
   KEGG MGENES (91)   
   RefGene (297)   
   OC (4)   
Literature (2)   
   PubMed (2)   
All databases (954)   

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