KEGG   ORTHOLOGY: K04960
Entry
K04960                      KO                                     
Symbol
ITPR3
Name
inositol 1,4,5-triphosphate receptor type 3
Pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04070  Phosphatidylinositol signaling system
map04114  Oocyte meiosis
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04380  Osteoclast differentiation
map04540  Gap junction
map04611  Platelet activation
map04621  NOD-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04713  Circadian entrainment
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04742  Taste transduction
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04922  Glucagon signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map05010  Alzheimer disease
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05017  Spinocerebellar ataxia
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05131  Shigellosis
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05205  Proteoglycans in cancer
Disease
H00264  Charcot-Marie-Tooth disease
H00408  Type 1 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04020 Calcium signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04070 Phosphatidylinositol signaling system
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04022 cGMP-PKG signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04210 Apoptosis
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04218 Cellular senescence
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04621 NOD-like receptor signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04625 C-type lectin receptor signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09152 Endocrine system
   04911 Insulin secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04922 Glucagon signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04929 GnRH secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04912 GnRH signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04915 Estrogen signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04921 Oxytocin signaling pathway
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04935 Growth hormone synthesis, secretion and action
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04918 Thyroid hormone synthesis
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04928 Parathyroid hormone synthesis, secretion and action
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04924 Renin secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04925 Aldosterone synthesis and secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04927 Cortisol synthesis and secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09154 Digestive system
   04970 Salivary secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04971 Gastric acid secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04972 Pancreatic secretion
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09156 Nervous system
   04724 Glutamatergic synapse
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04725 Cholinergic synapse
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04728 Dopaminergic synapse
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04726 Serotonergic synapse
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04720 Long-term potentiation
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04730 Long-term depression
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04723 Retrograde endocannabinoid signaling
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09157 Sensory system
   04742 Taste transduction
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   04750 Inflammatory mediator regulation of TRP channels
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05163 Human cytomegalovirus infection
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05012 Parkinson disease
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05014 Amyotrophic lateral sclerosis
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05017 Spinocerebellar ataxia
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05020 Prion disease
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
   05022 Pathways of neurodegeneration - multiple diseases
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
Ion channels [BR:ko04040]
 Ligand-gated channels
  IP3 receptor
   K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
Other DBs
GO: 0005220
TC: 1.A.3.2
Genes
HSA: 3710(ITPR3)
PTR: 462618(ITPR3)
PPS: 100982024(ITPR3)
GGO: 101124725(ITPR3)
PON: 100434127(ITPR3)
NLE: 100585914(ITPR3)
HMH: 116459671(ITPR3)
MCC: 718040(ITPR3)
MCF: 102116003(ITPR3)
MTHB: 126952707
MNI: 105474470(ITPR3)
CSAB: 103221654(ITPR3)
CATY: 105593244(ITPR3)
PANU: 101001272(ITPR3)
TGE: 112622816(ITPR3)
MLEU: 105544182(ITPR3)
RRO: 104658948(ITPR3)
RBB: 108516255(ITPR3)
TFN: 117087057(ITPR3)
PTEH: 111543148(ITPR3)
CANG: 105514217(ITPR3)
CJC: 100390843
SBQ: 101048916(ITPR3)
CIMI: 108300031(ITPR3)
CSYR: 103269243(ITPR3)
MMUR: 105861402(ITPR3)
LCAT: 123632820(ITPR3)
PCOQ: 105821681(ITPR3)
OGA: 100942290(ITPR3)
MMU: 16440(Itpr3)
MCAL: 110312193(Itpr3)
MPAH: 110338229(Itpr3)
RNO: 25679(Itpr3)
MCOC: 116075536(Itpr3)
ANU: 117724336(Itpr3)
MUN: 110543748(Itpr3)
CGE: 100751775
MAUA: 101838704(Itpr3)
PROB: 127224232(Itpr3)
PLEU: 114706123(Itpr3)
MORG: 121435401(Itpr3)
MFOT: 126499493
AAMP: 119823109(Itpr3)
NGI: 103739696(Itpr3)
HGL: 101706978(Itpr3)
CPOC: 100729184(Itpr3)
CCAN: 109686691(Itpr3)
DORD: 105999871(Itpr3)
DSP: 122111510(Itpr3)
PLOP: 125352691(Itpr3)
NCAR: 124988553
MMMA: 107143606(Itpr3)
OCU: 100008939
OPI: 101516441(ITPR3)
TUP: 102475587(ITPR3)
GVR: 103597698
CFA: 481746(ITPR3)
CLUD: 112641421(ITPR3)
VVP: 112913900(ITPR3)
VLG: 121479576(ITPR3)
NPO: 129512495(ITPR3)
AML: 100471747(ITPR3)
UMR: 103665553(ITPR3)
UAH: 113243814(ITPR3)
UAR: 123790908(ITPR3)
ELK: 111152507
LLV: 125103123
MPUF: 101688102(ITPR3)
MNP: 132017890(ITPR3)
MLK: 131834230(ITPR3)
NVS: 122910530(ITPR3)
ORO: 101380808(ITPR3)
EJU: 114222155(ITPR3)
ZCA: 113927035(ITPR3)
MLX: 118001326(ITPR3)
NSU: 110575641(ITPR3)
LWW: 102745629
FCA: 101087993(ITPR3)
PYU: 121029298(ITPR3)
PCOO: 112862849(ITPR3)
PBG: 122489417(ITPR3)
LRUF: 124528059
PTG: 102967639(ITPR3)
PPAD: 109271454(ITPR3)
PUC: 125938355
AJU: 106976077
HHV: 120238181(ITPR3)
BTA: 281879(ITPR3)
BOM: 102271039(ITPR3)
BIU: 109576552(ITPR3)
BBUB: 102409793(ITPR3)
BBIS: 104995001(ITPR3)
CHX: 102184768(ITPR3)
OAS: 114109674(ITPR3)
BTAX: 128056281(ITPR3)
ODA: 120869823(ITPR3)
CCAD: 122430147(ITPR3)
MBEZ: 129543844(ITPR3)
SSC: 100155015(ITPR3)
CFR: 102524078(ITPR3)
CBAI: 105064212(ITPR3)
CDK: 105101373(ITPR3)
VPC: 102527986(ITPR3)
BACU: 102999302(ITPR3)
LVE: 103070387(ITPR3)
OOR: 101280894(ITPR3)
DLE: 111178692(ITPR3)
PCAD: 102992034(ITPR3)
PSIU: 116761675(ITPR3)
NASI: 112414026(ITPR3)
ECB: 100053019(ITPR3)
EPZ: 103564724(ITPR3)
EAI: 106834634(ITPR3)
MYB: 102241889(ITPR3)
MYD: 102764661(ITPR3)
MMYO: 118679657(ITPR3)
MLF: 102442861(ITPR3)
MNA: 107541588(ITPR3)
PKL: 118705642(ITPR3)
EFUS: 103303043(ITPR3)
HAI: 109392407(ITPR3)
DRO: 112302101(ITPR3)
SHON: 118991502(ITPR3)
AJM: 119041225(ITPR3)
PDIC: 114493819(ITPR3)
PHAS: 123815944(ITPR3)
MMF: 118621173(ITPR3)
RFQ: 117020871(ITPR3)
PPAM: 129067386(ITPR3)
PALE: 102881783(ITPR3)
PGIG: 120597599(ITPR3)
PVP: 105301042(ITPR3)
RAY: 107511965(ITPR3)
MJV: 108402938(ITPR3)
TOD: 119252349(ITPR3)
SARA: 101555935(ITPR3)
LAV: 100659666(ITPR3)
TMU: 101354392
ETF: 101657031(ITPR3)
DNM: 101425999(ITPR3)
MDO: 100025596(ITPR3)
GAS: 123246373(ITPR3)
SHR: 100916996(ITPR3)
AFZ: 127561144
PCW: 110217180(ITPR3)
OAA: 100088770(ITPR3)
GGA: 419910(ITPR3)
PCOC: 116236926(ITPR3)
MGP: 104914537(ITPR3)
CJO: 107324903(ITPR3)
TPAI: 128088141(ITPR3)
LMUT: 125684288(ITPR3)
NMEL: 110388144(ITPR3)
APLA: 101792202(ITPR3)
ACYG: 106046157(ITPR3)
CATA: 118259507(ITPR3)
AFUL: 116498720(ITPR3)
TGU: 100227554(ITPR3)
LSR: 110477170(ITPR3)
SCAN: 103823305(ITPR3)
PMOA: 120495874(ITPR3)
OTC: 121347941(ITPR3)
PRUF: 121353993(ITPR3)
GFR: 102036728(ITPR3)
FAB: 101809694(ITPR3)
OMA: 130263660(ITPR3)
PHI: 102109497(ITPR3)
PMAJ: 107214964(ITPR3)
CCAE: 111939798(ITPR3)
CCW: 104692535(ITPR3)
CBRC: 103625304(ITPR3)
ETL: 114064083(ITPR3)
ZAB: 102072204(ITPR3)
ACHL: 103804766
SVG: 106851022(ITPR3)
MMEA: 130585047(ITPR3)
HRT: 120762731(ITPR3)
FPG: 101911646(ITPR3)
FCH: 102057380(ITPR3)
CLV: 102098742(ITPR3)
EGZ: 104125774(ITPR3)
NNI: 104013165(ITPR3)
PCRI: 104027348(ITPR3)
PLET: 104628694
EHS: 104505934(ITPR3)
PCAO: 104053101
ACUN: 113488982(ITPR3)
TALA: 104366224(ITPR3)
PADL: 103919873(ITPR3)
AFOR: 103893713(ITPR3)
ACHC: 115334771(ITPR3)
HALD: 104313840(ITPR3)
HLE: 104842381(ITPR3)
AGEN: 126052517
GCL: 127026155
CCRI: 104167680(ITPR3)
CMAC: 104481510
MUI: 104537163(ITPR3)
BREG: 104634835(ITPR3)
FGA: 104076543(ITPR3)
GSTE: 104263844(ITPR3)
LDI: 104349817(ITPR3)
MNB: 103772908(ITPR3)
OHA: 104335704(ITPR3)
NNT: 104412975(ITPR3)
SHAB: 115602289(ITPR3)
DPUB: 104305385(ITPR3)
PGUU: 104467564(ITPR3)
ACAR: 104532633(ITPR3)
CPEA: 104397170(ITPR3)
AVIT: 104276386(ITPR3)
CVF: 104289376(ITPR3)
RTD: 128900196(ITPR3)
CUCA: 104067088(ITPR3)
TEO: 104378141(ITPR3)
BRHI: 104493057(ITPR3)
AAM: 106496749(ITPR3)
AROW: 112961456(ITPR3)
NPD: 112959174(ITPR3)
TGT: 104566631(ITPR3)
DNE: 112990188(ITPR3)
SCAM: 104142092(ITPR3)
ASN: 102381395(ITPR3)
AMJ: 102567087(ITPR3)
CPOO: 109317804(ITPR3)
GGN: 109295368(ITPR3)
PSS: 102449833(ITPR3)
CMY: 102939145(ITPR3)
CCAY: 125625000(ITPR3)
DCC: 119846303(ITPR3)
CPIC: 101935702(ITPR3)
TST: 117875864(ITPR3)
CABI: 116818020(ITPR3)
MRV: 120403535(ITPR3)
ACS: 100564450(itpr3)
ASAO: 132773708(ITPR3)
PVT: 110080162(ITPR3)
SUND: 121928090(ITPR3)
PBI: 103048008(ITPR3)
PMUR: 107287061(ITPR3)
CTIG: 120299035(ITPR3)
TSR: 106541215(ITPR3)
PGUT: 117663981(ITPR3)
APRI: 131195056(ITPR3)
VKO: 123030371(ITPR3)
PMUA: 114599227(ITPR3)
PRAF: 128416015(ITPR3)
ZVI: 118089408(ITPR3)
HCG: 128323350(ITPR3)
GJA: 107117556(ITPR3)
STOW: 125433368(ITPR3)
EMC: 129330751(ITPR3)
XLA: 108709441
XTR: 100124749(itpr3)
NPR: 108787281(ITPR3)
RTEM: 120928318(ITPR3)
BBUF: 120995158(ITPR3)
BGAR: 122933262(ITPR3)
MUO: 115481356(ITPR3)
GSH: 117347078(ITPR3)
DRE: 794666(itpr3)
SANH: 107668074(itpr3) 107695219
SGH: 107549213(itpr3) 107555587
CCAR: 109061957
PTET: 122349960
LROH: 127169168(itpr3)
OMC: 131546325(itpr3)
PPRM: 120485173
RKG: 130086199(itpr3)
MAMB: 125279368(itpr3)
CIDE: 127517038
TROS: 130567607(itpr3)
TDW: 130439989(itpr3)
MANU: 129414027(itpr3)
IPU: 108265736
IFU: 128607949(itpr3)
PHYP: 113526579(itpr3)
SMEO: 124399884(itpr3)
TFD: 113655915(itpr3)
TVC: 132854183(itpr3)
CMAO: 118813746(itpr3)
EEE: 113581076(itpr3)
CHAR: 105894296(itpr3)
TRU: 101074918
TFS: 130530401(itpr3)
LCO: 104933529(itpr3)
TBEN: 117478580(itpr3)
CGOB: 115010526(itpr3)
PGEO: 117449155(itpr3)
ELY: 117257969(itpr3)
EFO: 125892424(itpr3)
SLUC: 116063113(itpr3)
PFLV: 114558603
GAT: 120829151(itpr3)
PPUG: 119222835(itpr3)
AFB: 129100010
CLUM: 117733021(itpr3)
MSAM: 119905085(itpr3)
CUD: 121517298(itpr3)
ALAT: 119022453(itpr3)
MZE: 101481255(itpr3)
ONL: 100707448(itpr3)
OAU: 116310193(itpr3)
OLA: 101170574(itpr3)
OML: 112158759(itpr3)
XMA: 102237995(itpr3)
XCO: 114141097(itpr3)
PRET: 103468120(itpr3)
PFOR: 103156233(itpr3)
PLAI: 106955508(itpr3)
PMEI: 106933653(itpr3)
GAF: 122838832(itpr3)
CVG: 107097408(itpr3)
CTUL: 119777951(itpr3)
GMU: 124872108(itpr3)
NFU: 107391515(itpr3)
KMR: 108251566(itpr3)
ALIM: 106527884
NWH: 119417370(itpr3)
MCEP: 125008315(itpr3)
CSEM: 103384462(itpr3)
POV: 109642872
SSEN: 122777265(itpr3)
HHIP: 117764635(itpr3)
HSP: 118111281(itpr3)
LCF: 108879748(itpr3)
SDU: 111235419(itpr3)
SLAL: 111673377(itpr3)
XGL: 120803636(itpr3)
HCQ: 109526465(itpr3)
SSCV: 125988671
SBIA: 133493246(itpr3)
PEE: 133411488(itpr3)
PTAO: 133465533(itpr3)
BPEC: 110158040(itpr3)
MALB: 109970976(itpr3)
BSPL: 114858253(itpr3)
SJO: 128357748(itpr3)
ONE: 115117655 115132159(itpr3)
SALP: 111966445(itpr3) 111976834
ELS: 105027760(itpr3)
SFM: 108931222(itpr3)
PKI: 111844730(itpr3)
AANG: 118208164(itpr3)
LOC: 102696500(itpr3)
PSEX: 120526198(itpr3)
LCM: 102349825(ITPR3)
CMK: 103179112(itpr3)
CPLA: 122563221(itpr3)
HOC: 132828404(itpr3)
LERI: 129708665(itpr3)
LPOL: 106460236
SMIN: v1.2.035044.t1(symbB.v1.2.035044.t1)
EHX: EMIHUDRAFT_209909(IPR1)
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Reference
  Authors
Iwai M, Tateishi Y, Hattori M, Mizutani A, Nakamura T, Futatsugi A, Inoue T, Furuichi T, Michikawa T, Mikoshiba K
  Title
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.
  Journal
J Biol Chem 280:10305-17 (2005)
DOI:10.1074/jbc.M413824200
  Sequence
[mmu:16440]

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