KEGG ORTHOLOGY: K05068

ORTHOLOGY: K05068

Entry

K05068                      KO

Symbol

IL2RA, CD25

Name

interleukin 2 receptor alpha

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

Disease

H00408

Type 1 diabetes mellitus

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04151 PI3K-Akt signaling pathway
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04658 Th1 and Th2 cell differentiation
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04659 Th17 cell differentiation
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   05162 Measles
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04090 CD molecules
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05068  IL2RA, CD25; interleukin 2 receptor alpha
CD molecules [BR:ko04090]
Proteins
  K05068  CD25, IL2RA; interleukin 2 receptor, alpha

Other DBs

GO:

0004911

Genes

HSA:	3559(IL2RA)

PTR:	450884(IL2RA)

PPS:	100974407(IL2RA)

GGO:	101126210(IL2RA)

PON:	100440118(IL2RA)

NLE:	100582107(IL2RA)

HMH:	116467163(IL2RA)

MCC:	574300(IL2RA)

MCF:	102123605(IL2RA)

MTHB:

126962923

MNI:	105494366(IL2RA)

CSAB:

103237839(IL2RA)

CATY:

105597428(IL2RA)

PANU:

101004576(IL2RA)

TGE:	112631620(IL2RA)

MLEU:

105535718(IL2RA)

RRO:	104664846(IL2RA)

RBB:	108529907(IL2RA)

TFN:	117082099(IL2RA)

PTEH:

111554868(IL2RA)

CANG:

105522527(IL2RA)

CJC:	100412016(IL2RA)

SBQ:	101036589(IL2RA)

CIMI:

108292344(IL2RA)

CSYR:

103272187(IL2RA)

MMUR:

105858205(IL2RA)

LCAT:

123623027(IL2RA)

PCOQ:

105826916(IL2RA)

OGA:	100967179(IL2RA)

MMU:	16184(Il2ra)

MCAL:

110289347(Il2ra)

MPAH:

110334116(Il2ra)

RNO:	25704(Il2ra)

MCOC:

116082367(Il2ra)

ANU:	117714153(Il2ra)

MUN:	110556899(Il2ra)

CGE:	100764797(Il2ra)

MAUA:

101838934(Il2ra)

PROB:

127229952(Il2ra)

PLEU:

114708790(Il2ra)

MORG:

121432686(Il2ra)

MFOT:

126506730

AAMP:

119817084(Il2ra)

NGI:	103727306(Il2ra)

HGL:	101696651(Il2ra)

CPOC:

100715332(Il2ra)

CCAN:

109690611(Il2ra)

DORD:

105980358(Il2ra)

DSP:	122113142(Il2ra)

PLOP:

125367340(Il2ra)

NCAR:

124961927

MMMA:

107150214(Il2ra)

OCU:	100338113 100358489

OPI:	101526738(IL2RA)

TUP:	102503225(IL2RA)

GVR:

103607987

CFA:	403870(IL2RA)

CLUD:

112658965(IL2RA)

VVP:	112933655(IL2RA)

VLG:	121496900(IL2RA)

NPO:	129514118(IL2RA)

AML:	100466247(IL2RA)

UMR:	103676245(IL2RA)

UAH:	113241140(IL2RA)

UAR:	123802327(IL2RA)

ELK:

111158621

LLV:

125106633

MPUF:

101683684(IL2RA)

MNP:	132020030(IL2RA)

MLK:	131838068(IL2RA)

NVS:	122891223(IL2RA)

ORO:	101378506(IL2RA)

EJU:	114217727(IL2RA)

ZCA:	113922120(IL2RA)

MLX:	118021614(IL2RA)

NSU:	110586503(IL2RA)

LWW:	102727813(IL2RA)

FCA:	493953(IL2RA)

PYU:	121014860(IL2RA)

PCOO:

112867999(IL2RA)

PBG:	122472215(IL2RA)

PVIV:

125170257(IL2RA)

LRUF:

124501580

PPAD:

109273771(IL2RA)

PUC:

125918586

AJU:

106982335

HHV:	120237209(IL2RA)

BTA:	281861(IL2RA)

BOM:	102274858(IL2RA)

BIU:	109567961(IL2RA)

BBUB:

102405003(IL2RA)

BBIS:

104986784(IL2RA)

CHX:	102170059(IL2RA)

OAS:	443435(IL2RA)

BTAX:

128058762(IL2RA)

ODA:	120869146(IL2RA)

CCAD:

122448159(IL2RA)

MBEZ:

129556783(IL2RA)

SSC:	396814(IL2RA)

CFR:	102520401(IL2RA)

CBAI:

105074697(IL2RA)

CDK:	105091372(IL2RA)

VPC:	102543988(IL2RA)

BACU:

102999308(IL2RA)

BMUS:

118890645(IL2RA)

LVE:	103090256(IL2RA)

OOR:	101275717(IL2RA)

DLE:	111177977(IL2RA)

PCAD:

102974550(IL2RA)

PSIU:

116748786(IL2RA)

NASI:

112391117(IL2RA)

ECB:	100070292(IL2RA)

EPZ:	103548896(IL2RA)

EAI:	106833795(IL2RA)

MYB:	102249529(IL2RA)

MYD:	102769642(IL2RA)

MMYO:

118672311(IL2RA)

MLF:	102427118(IL2RA)

PKL:	118732022(IL2RA)

EFUS:

103304881(IL2RA)

MNA:	107542420(IL2RA)

DRO:	112321040(IL2RA)

SHON:

119000807(IL2RA)

AJM:	119048017(IL2RA)

PDIC:

114491940(IL2RA)

PHAS:

123831329(IL2RA)

MMF:	118632297(IL2RA)

PPAM:

129084544(IL2RA)

HAI:	109383783(IL2RA)

RFQ:	117019205(IL2RA)

PALE:

102891511(IL2RA)

PGIG:

120609005(IL2RA)

PVP:	105307737(IL2RA)

RAY:	107505982(IL2RA)

TOD:	119244171(IL2RA)

SARA:

101546623(IL2RA)

LAV:	100655361(IL2RA)

TMU:

101342095

ETF:	101638943(IL2RA)

DNM:	101410814(IL2RA)

MDO:	103093188(IL2RA)

GAS:	123250369(IL2RA)

SHR:	105750698(IL2RA)

AFZ:

127538217

PCW:	110198993(IL2RA)

OAA:	103165385(IL2RA)

GGA:	395294(IL2RA)

PCOC:

116239606

MGP:

100547769

CJO:

107315066

TPAI:

128079603(IL15RA)

LMUT:

125688167(IL15RA)

NMEL:

110392238(IL15RA)

APLA:

101789606

ACYG:

106038749(IL2RA)

CATA:

118249434(IL15RA)

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:	114067844(IL15RA)

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

113475946(IL15RA)

TALA:

PADL:

AFOR:

ACHC:

HALD:

104315769(IL15RA)

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

104460808(IL2RA)

ACAR:

104532099

CPEA:

104394368

AVIT:

104280119(IL2RA)

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	106737583(IL2RA)

CPOO:

109315828

GGN:

109292241

PSS:

102451419

CMY:	102937403(IL2RA)

CCAY:

125630865(IL2RA)

DCC:	119856193(IL2RA)

CPIC:

101934224(IL2RA)

TST:	117867397(IL2RA)

CABI:

116823520(IL2RA)

ACS:	103278808(il2ra)

ASAO:

132775631(IL2RA)

PVT:

110088980

SUND:

121931967

PMUR:

107294425(IL15RA)

APRI:

131201791

PMUA:

114604914(IL2RA)

PRAF:

128422514(IL2RA)

GJA:

107120141

EMC:	129335925(IL15RA)

GSH:

117367041

LCM:

106704263

» show all

Reference

PMID:6090949

Authors

Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T

Title

Molecular cloning of cDNA encoding human interleukin-2 receptor.

Journal

Nature 311:631-5 (1984)
DOI:10.1038/311631a0

Sequence

[hsa:3559]

Reference

PMID:8476561

Authors

Minami Y, Kono T, Miyazaki T, Taniguchi T

Title

The IL-2 receptor complex: its structure, function, and target genes.

Journal

Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333

Reference

PMID:23529819

Authors

Knevel R, de Rooy DP, Zhernakova A, Grondal G, Krabben A, Steinsson K, Wijmenga C, Cavet G, Toes RE, Huizinga TW, Gregersen PK, van der Helm-van Mil AH

Title

Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis.

Journal

Arthritis Rheum 65:1684-93 (2013)
DOI:10.1002/art.37938

Sequence

[hsa:3559]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (12)   
   KEGG DRUG (12)   
Gene (247)   
   KEGG GENES (246)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (290)   

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