KEGG ORTHOLOGY: K05070

ORTHOLOGY: K05070

Entry

K05070                      KO

Symbol

IL2RG, CD132

Name

interleukin 2 receptor gamma

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05321

Inflammatory bowel disease

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04151 PI3K-Akt signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04659 Th17 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05162 Measles
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05340 Primary immunodeficiency
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04090 CD molecules
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05070  IL2RG, CD132; interleukin 2 receptor gamma
CD molecules [BR:ko04090]
Proteins
  K05070  CD132, IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency)

Other DBs

GO:

0004911

Genes

HSA:	3561(IL2RG)

PTR:	101059843(IL2RG)

PPS:	100986679(IL2RG)

PON:	100454903(IL2RG)

NLE:	100585758(IL2RG)

HMH:	116464897(IL2RG)

MCC:	641338(IL2RG)

MCF:	102144912(IL2RG)

MTHB:

126946182

MNI:	105476651(IL2RG)

CSAB:

103232148(IL2RG)

CATY:

105586122(IL2RG)

PANU:

101008968(IL2RG)

TGE:	112615453(IL2RG)

MLEU:

105548157(IL2RG)

RRO:	104656782(IL2RG)

RBB:	108532108(IL2RG)

TFN:	117077624(IL2RG)

PTEH:

111533635(IL2RG)

CANG:

105512612(IL2RG)

CJC:	100388189(IL2RG)

SBQ:	101047979(IL2RG)

CIMI:

108294787(IL2RG)

CSYR:

103250262(IL2RG)

MMUR:

105855320(IL2RG)

LCAT:

123628744(IL2RG)

PCOQ:

105809985(IL2RG)

OGA:	100961176(IL2RG)

MMU:	16186(Il2rg)

MCAL:

110286942(Il2rg)

MPAH:

110313918(Il2rg)

RNO:	140924(Il2rg)

MCOC:

116087170(Il2rg)

ANU:	117694639(Il2rg)

MUN:	110564656(Il2rg)

CGE:	100756284(Il2rg)

MAUA:

101824015(Il2rg)

PROB:

127218462(Il2rg)

PLEU:

114708654(Il2rg)

MORG:

121443322 121444965

MFOT:

126487061

AAMP:

119804964(Il2rg)

NGI:	103751955(Il2rg)

HGL:	101715243(Il2rg)

CPOC:

100713379(Il2rg)

CCAN:

109673990(Il2rg)

DORD:

105997296(Il2rg)

DSP:	122120620(Il2rg)

PLOP:

125343243(Il2rg)

NCAR:

124972015

MMMA:

107155679(Il2rg)

OCU:

103351862

OPI:	101536616(IL2RG)

TUP:	102476004(IL2RG)

GVR:	103586318(IL2RG)

CFA:	403851(IL2RG)

CLUD:

112671816(IL2RG)

VVP:	112907637(IL2RG)

VLG:	121483086(IL2RG)

NPO:	129518467(IL2RG)

AML:	100468126(IL2RG)

UMR:	103682591(IL2RG)

UAH:	113245610(IL2RG)

ELK:

111161041

LLV:

125092325

MPUF:

101678968(IL2RG)

MNP:	132007353(IL2RG)

MLK:	131821377(IL2RG)

NVS:	122896347(IL2RG)

ORO:	101374379(IL2RG)

EJU:	114203171 114203175

ZCA:	113930805(IL2RG)

MLX:	118025926(IL2RG)

NSU:	110572174(IL2RG)

LWW:	102741990(IL2RG)

FCA:	101090239(IL2RG)

PYU:	121025256(IL2RG)

PCOO:

112871236(IL2RG)

PBG:	122477318(IL2RG)

PVIV:

125157955(IL2RG)

LRUF:

124521570

PTG:	102966580(IL2RG)

PPAD:

109254610(IL2RG)

PUC:

125931753

AJU:

106982399

HHV:	120246070(IL2RG)

BTA:	281862(IL2RG)

BOM:	102266681(IL2RG)

BIU:	109555190(IL2RG)

BBUB:

102402566(IL2RG)

CHX:	102169656(IL2RG)

OAS:	101103538(IL2RG)

BTAX:

128070243(IL2RG)

ODA:	120882006(IL2RG)

CCAD:

122434652(IL2RG)

MBEZ:

129564419(IL2RG)

SSC:	397156(IL2RG)

CBAI:

105083690(IL2RG)

CDK:	105087982(IL2RG)

VPC:	102526609(IL2RG)

BACU:

103016442(IL2RG)

BMUS:

118888758(IL2RG)

LVE:	103087530(IL2RG)

OOR:	101286718(IL2RG)

DLE:	111167807(IL2RG)

PCAD:

102979617(IL2RG)

PSIU:

116747462(IL2RG)

NASI:

112408519(IL2RG)

ECB:	100055911(IL2RG)

EPZ:	103544610(IL2RG)

EAI:	106828880(IL2RG)

MYB:	102241164(IL2RG)

MYD:	102757155(IL2RG)

MMYO:

118654549(IL2RG) 118661694(METTL8)

MLF:	102441989(IL2RG)

PKL:	118704153(IL2RG) 118709172(METTL8)

EFUS:

103283323(METTL8) 103304360(IL2RG)

MNA:	107532895(IL2RG)

DRO:	112300079(IL2RG)

AJM:	119035395(IL2RG)

PDIC:

114504996(IL2RG)

PHAS:

123824325(IL2RG)

MMF:	118635917(IL2RG)

PPAM:

129071133(IL2RG)

HAI:	109385585(IL2RG)

RFQ:	117024055(IL2RG)

PALE:

102888070(IL2RG)

PGIG:

120585387(IL2RG)

PVP:	105299605(IL2RG)

RAY:	107513773(IL2RG)

MJV:	108403309(IL2RG)

TOD:	119246676(IL2RG)

SARA:

101545374(IL2RG)

SETR:

125999240(IL2RG)

LAV:	100664834(IL2RG)

TMU:

101359472

ETF:	101657280(IL2RG)

DNM:	101437298(IL2RG)

MDO:	100619507(IL2RG)

GAS:	123254760(IL2RG)

SHR:	100929781(IL2RG)

AFZ:

127542639

PCW:	110201024(IL2RG)

OAA:	114812802(IL2RG)

GGA:	395199(IL2RG)

PCOC:

116229598(IL2RG)

MGP:	104912104(IL2RG)

CJO:	107312576(IL2RG)

TPAI:

128076089(IL2RG)

LMUT:

125699677(IL2RG)

NMEL:

110403135(IL2RG)

APLA:

101794194(IL2RG)

ACYG:

106037383(IL2RG)

CATA:

118245587(IL2RG)

AFUL:

116494466(IL2RG)

TGU:	100226174(IL2RG)

LSR:	110472683(IL2RG)

SCAN:

103824248(IL2RG)

PMOA:

120506133(IL2RG)

OTC:	121331697(IL2RG)

PRUF:

121363036(IL2RG)

GFR:	102043888(IL2RG)

FAB:	107603321(IL2RG)

OMA:	130253047(IL2RG)

PHI:	102112500(IL2RG)

PMAJ:

107203656(IL2RG)

CCAE:

111929372(IL2RG)

CCW:	104691748(IL2RG)

CBRC:

103617890(IL2RG)

ETL:	114067449(IL2RG)

ZAB:	102065939(IL2RG)

ACHL:

103797625(IL2RG)

SVG:	106853684(IL2RG)

MMEA:

130577338(IL2RG)

HRT:	120762058(IL2RG)

FPG:	101923008(IL2RG)

FCH:	102052025(IL2RG)

CLV:	102094834(IL2RG)

EGZ:	104124289(IL2RG)

NNI:	104012899(IL2RG)

PCRI:

104037364

PLET:

104628689(IL2RG)

PCAO:

104051643

ACUN:

113479902(IL2RG)

TALA:

104369148(IL2RG)

PADL:

103923348(IL2RG)

AFOR:

103905836(IL2RG)

ACHC:

115333600(IL2RG)

HALD:

104315844(IL2RG)

HLE:	104830423(IL2RG)

AGEN:

126050273

GCL:

127019612

CCRI:

104169538

CSTI:

104563317(IL2RG)

CMAC:

104487058

MUI:	104533161(IL2RG)

BREG:

104629114(IL2RG)

FGA:	104081348(IL2RG)

LDI:

104339820

MNB:

103770051

OHA:	104335752(IL2RG)

NNT:

104412205

SHAB:

115603092(IL2RG)

DPUB:

104296345(IL2RG)

PGUU:

104470831

ACAR:

104522005

CPEA:

104388320(IL2RG)

AVIT:

104267159

CVF:	104283545(IL2RG)

RTD:	128915316(IL2RG)

CUCA:

104069038(IL2RG)

TEO:

104373241

BRHI:

104493368

AROW:

112966349(IL2RG)

NPD:	112948661(IL2RG)

DNE:	112989719(IL2RG)

ASN:	102379602(IL2RG)

AMJ:	102575498(IL2RG)

GGN:	109300562(IL2RG)

PSS:	102443813(IL2RG)

CMY:	102933244(IL2RG)

CCAY:

125642589(IL2RG)

DCC:	119861160(IL2RG)

CPIC:

101931356(IL2RG)

TST:	117883178(IL2RG)

CABI:

116833382(IL2RG)

MRV:	120372096(IL2RG)

ACS:	103281066(il2rg)

ASAO:

132762891(IL2RG)

PVT:	110080214(IL2RG)

SUND:

121937400(IL2RG)

PBI:	103061889(IL2RG)

PMUR:

107303211(IL2RG)

PGUT:

117679627(IL2RG)

APRI:

131205123(IL2RG)

PTEX:

113446829(IL2RG)

NSS:	113423068(IL2RG)

VKO:	123034956(IL2RG)

PMUA:

114589433(IL2RG)

PRAF:

128406648(IL2RG)

ZVI:	118078798(IL2RG)

HCG:	128335534(IL2RG)

GJA:	107108490(IL2RG)

STOW:

125442884(IL2RG)

EMC:	129340874(IL2RG)

XLA:	100036958(il2rg.L)

XTR:	100492995(il2rg)

NPR:	108800627(IL2RG)

RTEM:

120921918(IL2RG)

BBUF:

120977619(IL2RG)

BGAR:

122919489(IL2RG)

MUO:	115474690(IL2RG)

GSH:	117361218(IL2RG)

DRE:	100144554(il2rgb) 796604(il2rga)

SRX:	107728855 107734452 107752048

SANH:

107658077 107661390 107686149 107691671

SGH:	107560888 107577653 107589463 107601097

CCAR:

109097914 109102144

CAUA:

113054431 113057950 113078587 113098710 113109907 113109945

CGIB:

127966456 127987755 127987757 128021068 128026960

PTET:

122352820(il2rga) 122357181(il2rgb)

LROH:

127153297 127153303 127172529(il2rga) 127176610(il2rgb)

OMC:	131548538(il2rga) 131553603(il2rgb)

PPRM:

120475010(il2rgb) 120482795(il2rga)

RKG:	130078719(il2rgb) 130105529 130105531

MAMB:

125259092(il2rgb) 125262226 125262227(il2rga)

CIDE:

127494333 127520018

MASI:

127413094 127432535 127433946

TROS:

130545695(il2rga) 130564184(il2rgb)

TDW:	130412252(il2rga) 130437774(il2rgb)

MANU:

129422472(il2rgb) 129446805(il2rga)

IPU:	108269358(il2rgb) 108276805(il2rga)

IFU:	128611749(il2rgb) 128620732(il2rga)

PHYP:

113529255 113538165

SMEO:

124385987(il2rgb) 124393103(il2rga)

TFD:	113636124(il2rgb) 113650230(il2rga)

TVC:	132856064(il2rgb) 132862930(il2rga)

AMEX:

103023433 103037129

CMAO:

118807216(il2rgb) 118824265(il2rga) 118824266

EEE:	113575423 113579244

CHAR:

105890468(il2rga) 116217993(il2rgb)

TRU:	100190946(il2rg)

TFS:

130538136

TNG:	GSTEN00033798G001

LCO:

104938889

NCC:

104967331

TBEN:

117490338 117490339 117493938

CGOB:

115018623

GACU:

117540123

EMAC:

134871732

ELY:	117263382 117266025

EFO:	125893357 125898685

PLEP:

121946054 121953003

SLUC:

116037024

ECRA:

117956151

ESP:	116699939(il2rg)

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101473695 101474000

OAU:	116319686 116319720 120442159

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:	124875956 124876950

NFU:

107386732

KMR:	108238920 108238928

ALIM:

106527375 106527376

NWH:	119420844 119420846

AOCE:

111573091

MCEP:

125021858

CSEM:

103395485(il2rg)

POV:

109635689

SSEN:

122779628

HHIP:

117773898 117773908

HSP:	118121975 118121976

SMAU:

118301277

LCF:	108893180 108893209

SDU:	111217233(il2rg)

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:	128361859 128370872 128371460

SASA:

106563690 106563704

STRU:

115204456 115204470

OTW:	112231157 112231168

OMY:	100136033 101268908(il2rc2)

OGO:	124006721 124006885

ONE:	115101458 115146950

OKI:	109873647 109874333

OKE:	118384975 118385627

SALP:

111964368

SNH:	120021469 120021532 120021552

CCLU:

121541304 121541305

ELS:	105010007 105024667 114828756

SFM:	108923155 108923156 108928942

PKI:	111834615 111836318 111836422

AANG:

118222620 118236490

LOC:	102686346 107077891

PSPA:

121295824 121318888 121318889

ARUT:

117411877 117412087 117430222 117430325

LCM:	102356230(IL2RG)

CMK:	103179046 103179080

RTP:

109930496

CPLA:

122551079 122557372 122557517

HOC:	132820129 132820130

LERI:

129702355

» show all

Reference

PMID:1631559

Authors

Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K

Title

Cloning of the gamma chain of the human IL-2 receptor.

Journal

Science 257:379-82 (1992)
DOI:10.1126/science.1631559

Sequence

[hsa:3561]

Reference

PMID:8476561

Authors

Minami Y, Kono T, Miyazaki T, Taniguchi T

Title

The IL-2 receptor complex: its structure, function, and target genes.

Journal

Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333

Reference

PMID:21715655

Authors

Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M

Title

IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.

Journal

Proc Natl Acad Sci U S A 108:11977-82 (2011)
DOI:10.1073/pnas.1100319108

Sequence

[hsa:3561]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (24)   
   KEGG PATHWAY (24)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (4)   
   KEGG DRUG (4)   
Gene (507)   
   KEGG GENES (472)   
   KEGG MGENES (25)   
   RefGene (7)   
   OC (3)   
Literature (3)   
   PubMed (3)   
All databases (544)   

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