KEGG ORTHOLOGY: K05075

ORTHOLOGY: K05075

Entry

K05075                      KO

Symbol

IL21R, CD360

Name

interleukin 21 receptor

Pathway

map04060

Cytokine-cytokine receptor interaction

map04630

JAK-STAT signaling pathway

map04659

Th17 cell differentiation

map05321

Inflammatory bowel disease

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05075  IL21R, CD360; interleukin 21 receptor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05075  IL21R, CD360; interleukin 21 receptor
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K05075  IL21R, CD360; interleukin 21 receptor
09160 Human Diseases
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05075  IL21R, CD360; interleukin 21 receptor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05075  IL21R, CD360; interleukin 21 receptor
   04090 CD molecules
    K05075  IL21R, CD360; interleukin 21 receptor
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05075  IL21R, CD360; interleukin 21 receptor
CD molecules [BR:ko04090]
Proteins
  K05075  CD360, IL21R; interleukin 21 receptor

Genes

HSA:	50615(IL21R)

PTR:	454006(IL21R)

PPS:	100970355(IL21R)

GGO:	101129403(IL21R)

PON:	100450175(IL21R)

NLE:	100601027(IL21R)

HMH:	116471169(IL21R)

MCC:	705759(IL21R)

MCF:	102135042(IL21R)

MTHB:

126944442

MNI:	105463221(IL21R)

CSAB:

103230109(IL21R)

CATY:

105598474(IL21R)

PANU:

101023386(IL21R)

TGE:	112614329(IL21R)

MLEU:

105541366(IL21R)

RRO:	104670204(IL21R)

RBB:	108518245(IL21R)

TFN:	117068759 117087560(IL21R) 117099254 117099282

PTEH:

111529206(IL21R)

CANG:

105505604(IL21R)

CJC:	100401171(IL21R)

SBQ:	101045058(IL21R)

CIMI:

108308565(IL21R) 108316293

CSYR:

103258572(IL21R)

MMUR:

105879690

LCAT:

123632507(IL21R)

PCOQ:

105810940(IL21R)

OGA:	100956406(IL21R)

MMU:	60504(Il21r)

MCAL:

110298844(Il21r)

MPAH:

110331013(Il21r)

RNO:	308977(Il21r)

MCOC:

116102935(Il21r)

ANU:	117719392(Il21r)

MUN:	110564645(Il21r)

CGE:	100763133(Il21r)

MAUA:

101826670(Il21r)

PROB:

127228312(Il21r)

PLEU:

114692225(Il21r)

MORG:

121457668(Il21r)

MFOT:

126502265

AAMP:

119821328(Il21r)

NGI:	103741072(Il21r)

HGL:	101701307(Il21r)

CPOC:

100721842(Il21r)

CCAN:

109698035(Il21r)

DORD:

106002155(Il21r)

DSP:	122096291(Il21r)

PLOP:

125341059(Il21r)

NCAR:

124970292

MMMA:

107146557(Il21r)

OCU:

103348594

OPI:	101525833(IL21R)

TUP:	102469112(IL21R)

GVR:	103585611(IL21R)

CFA:	608011(IL21R)

CLUD:

112640012(IL21R)

VVP:	112929180(IL21R)

VLG:	121487720(IL21R)

NPO:	129519122(IL21R)

AML:	100467688(IL21R)

UMR:	103657903(IL21R)

UAH:	113267611(IL21R)

UAR:	123778070(IL21R)

ELK:

111162173

LLV:

125090951

MPUF:

101681500(IL21R)

MNP:	132026794(IL21R)

MLK:	131819636(IL21R)

NVS:	122895818(IL21R)

ORO:	101382783(IL21R)

EJU:	114214376(IL21R)

ZCA:	113931780(IL21R)

MLX:	117999672(IL21R)

NSU:	110589781(IL21R)

LWW:	102733616(IL21R)

FCA:	101096026(IL21R)

PYU:	121022464(IL21R)

PCOO:

112856544(IL21R)

PBG:	122471526(IL21R)

PVIV:

125154484(IL21R)

LRUF:

124517803

PTG:	102949594(IL21R)

PPAD:

109256534(IL21R)

PUC:

125927993

AJU:

106966181

HHV:	120249043(IL21R)

BTA:	617967(IL21R)

BOM:	102274052(IL21R)

BIU:	109578841(IL21R)

BBUB:

102393447(IL21R)

BBIS:

104986600(IL21R)

CHX:	102176844(IL21R)

OAS:	100820753(IL21R)

BTAX:

128043756(IL21R)

ODA:	120876446(IL21R)

CCAD:

122433433(IL21R)

MBEZ:

129545475(IL21R)

SSC:	100518723(IL21R)

CFR:	102505205(IL21R)

CBAI:

105073656(IL21R)

CDK:	105098255(IL21R)

VPC:	102530167(IL21R)

BACU:

103018703(IL21R)

BMUS:

118880784(IL21R)

LVE:	103085231(IL21R)

OOR:	101281486(IL21R)

DLE:	111182214(IL21R)

PCAD:

102985030(IL21R)

PSIU:

116739986(IL21R)

NASI:

112399193(IL21R)

ECB:	100066814(IL21R)

EPZ:	103556346(IL21R)

EAI:	106829084(IL21R)

MYB:	102263626(IL21R)

MYD:	102762032(IL21R)

MMYO:

118652925(IL21R)

MLF:	102431862(IL21R)

PKL:	118704928(IL21R)

EFUS:

103300789(IL21R)

MNA:	107539652(IL21R)

DRO:	112304897(IL21R)

AJM:	119045347(IL21R)

PDIC:

114506477(IL21R)

PHAS:

123825697(IL21R)

MMF:	118641932(IL21R)

PPAM:

129078144(IL21R)

HAI:	109385808(IL21R)

RFQ:	117019357(IL21R)

PALE:

102883062(IL21R)

PGIG:

120620493(IL21R)

PVP:	105303236(IL21R)

RAY:	107506152(IL21R)

MJV:	108405151(IL21R)

TOD:	119242350(IL21R)

SARA:

101557905(IL21R)

SETR:

126029899(IL21R)

LAV:	100655109(IL21R)

TMU:

101355640

ETF:	101647537(IL21R)

DNM:	101427503(IL21R)

MDO:	100016040(IL21R)

GAS:	123248519(IL21R)

SHR:	100920794(IL21R)

AFZ:

127555743

PCW:	110221598(IL21R)

OAA:	100079376(IL21R)

GGA:	416586(IL21R)

PCOC:

116237420(IL21R)

MGP:	100547386(IL21R)

CJO:	107320804(IL21R)

TPAI:

128079217(IL21R)

LMUT:

125700870(IL21R)

NMEL:

110405597(IL21R)

APLA:

101796991(IL21R)

ACYG:

106046044(IL21R)

CATA:

118256439(IL21R)

AFUL:

116495153(IL21R)

TGU:	100230851(IL21R)

LSR:	110477759(IL21R)

SCAN:

103817551(IL21R)

PMOA:

120513204(IL21R)

OTC:	121334669(IL21R)

PRUF:

121365863(IL21R)

GFR:	102032622(IL21R)

FAB:	101812777(IL21R)

OMA:	130259443(IL21R)

PHI:	102107481(IL21R)

PMAJ:

107211180(IL21R)

CCAE:

111936217(IL21R)

CCW:	104684905(IL21R)

CBRC:

103615480(IL21R)

ETL:	114061436(IL21R)

ZAB:	102060585(IL21R)

ACHL:

103810296(IL21R)

SVG:	106859295(IL21R)

MMEA:

130576469(IL21R)

HRT:	120759828(IL21R)

FPG:	101913915(IL21R)

FCH:	102059759(IL21R)

CLV:	102087878(IL21R)

EGZ:	104131302(IL21R)

NNI:	104015159(IL21R)

PCRI:

104025470

PLET:

104625417(IL21R)

EHS:	104513838(IL21R)

PCAO:

104044546(IL21R)

ACUN:

113485936(IL21R)

TALA:

104357581(IL21R)

PADL:

103913921(IL21R)

AFOR:

103904949(IL21R)

ACHC:

115335707(IL21R)

HALD:

104310468(IL21R)

HLE:	104833674(IL21R)

AGEN:

126034214

GCL:

127022207

CCRI:

104167272(IL21R)

CSTI:

104555248(IL21R)

CMAC:

104484094(IL21R)

MUI:	104533195(IL21R)

BREG:

104634545(IL21R)

FGA:	104073756(IL21R)

GSTE:

104250492(IL21R)

LDI:	104345861(IL21R)

MNB:	103772824(IL21R)

OHA:	104336153(IL21R)

NNT:	104407407(IL21R)

SHAB:

115607270(IL21R)

DPUB:

104299374(IL21R)

PGUU:

104467461(IL21R)

ACAR:

104525008(IL21R)

CPEA:

104393100(IL21R)

AVIT:

104268483(IL21R)

CVF:	104295091(IL21R)

RTD:	128914373(IL21R)

CUCA:

104065041(IL21R)

TEO:	104382799(IL21R)

BRHI:

104501125(IL21R)

AAM:	106486130(IL21R)

AROW:

112975697(IL21R)

NPD:	112959772(IL21R)

TGT:	104574761(IL21R)

DNE:	112991431(IL21R)

SCAM:

104139047(IL21R)

ASN:	102385153(IL21R)

AMJ:	102563981(IL21R)

CPOO:

109314586(IL21R)

GGN:	109294443(IL21R)

PSS:	102460432(IL21R)

CMY:	102946561(IL21R)

CCAY:

125643572(IL21R)

DCC:	119862998(IL21R)

CPIC:

101943915(IL21R)

TST:	117883821(IL21R)

CABI:

116830028(IL21R)

MRV:	120373986(IL21R)

ACS:	103281084(il21r)

ASAO:

132781894(IL21R)

SUND:

121918026 121937532(IL21R)

PBI:	103064799(IL21R)

PMUR:

107302632(IL21R)

CTIG:

120310820(IL21R)

TSR:	106545984(IL21R)

PGUT:

117667341(IL21R)

APRI:

131185420(IL21R)

PTEX:

113438610(IL21R)

NSS:	113422561(IL21R)

VKO:	123034827(IL21R)

PMUA:

114584164(IL21R)

PRAF:

128401356(IL21R)

ZVI:	118093300(IL21R)

HCG:	128336690(IL21R)

GJA:	107106230(IL21R)

STOW:

125430894(IL21R)

EMC:	129338644(IL21R)

XLA:	108701892(il21r.L) 108702308(il21r.S)

XTR:	100492452(il21r)

NPR:	108794714(IL21R)

RTEM:

120943425(IL21R)

BBUF:

121008239(IL21R)

BGAR:

122945141(IL21R)

MUO:	115475962(IL21R)

GSH:	117345828(IL21R)

DRE:	100134976(il21r.1)

SRX:	107719177 107741796

SANH:

107674618 107703374

SGH:	107550314 107565769

CCAR:

109045629

CAUA:

113049711 113071513

CGIB:

127952390 127953251

PTET:

122341541(il21r.1)

LROH:

127162812(il21r.1)

OMC:	131536816(il21r.1)

PPRM:

120489878(il21r.1)

RKG:	130076609(il21r.1)

MAMB:

125270205(il21r.1)

MASI:

127449958 127451536

TROS:

130561354(il21r.1)

TDW:	130425524(il21r.1)

MANU:

129431789(il21r.1)

IPU:	108257366(il21r.1)

IFU:	128600605(il21r.1)

PHYP:

113535970(il21r)

SMEO:

124375691(il21r.1)

TFD:	113661750(il21r.1)

TVC:	132863818(il21r.1)

AMEX:

103026064(il21r)

CMAO:

118805763(il21r.1)

EEE:	113567475(il21r)

CHAR:

105899284

TRU:	101072306 101078915

TFS:	130526436 130532246(il21r.1)

LCO:	104934035 109143089

NCC:	104944104 104946328

TBEN:

117468582(il21r.1) 117473377

CGOB:

115021365 115024331

PGEO:

117461167(il21r.1) 117464819

GACU:

117543286(il21r.1) 117545084

EMAC:

134861801(il21r.1) 134870814

ELY:	117247447 117266455(il21r.1)

EFO:	125880738 125892735(il21r.1)

PLEP:

121946330(il21r.1) 121958801

SLUC:

116036123(il21r.1) 116044283

ECRA:

117937189 117946767(il21r.1)

ESP:	116671371 116691643

PFLV:

114547911 114557184

GAT:	120810701 120819043

PPUG:

119198167(il21r.1) 119213400

AFB:	129091779 129109651(il21r.1)

CLUM:

117728062(il21r.1)

PSWI:

130203909

MSAM:

119897116(il21r.1) 119915539

SCHU:

122868057 122881876(il21r.1)

CUD:	121513906(il21r.1) 121527840 121528588

ALAT:

119006451(il21r.1) 119009775

MZE:	101470479 101470778 101478529 112430268

ONL:	100693311 100698472 102081866

OAU:	116315408(il21r.1) 116319862

OLA:	101165176 101166750

OML:	112136694 112154319

CSAI:

133419205 133441147(il21r.1)

XMA:	102216922 102218702

XCO:	114138309 114157781

XHE:	116714095 116727742

PRET:

103477569 103477570 103481062

PFOR:

103150799 103155083

PLAI:

106942492 106951768

PMEI:

106907648 106929073

GAF:	122823503 122823504 122831101(il21r.1)

PPRL:

129370953 129377785

CVG:	107089554 107101599

CTUL:

119780945(il21r.1) 119793811

GMU:	124865966(il21r.1) 124875166

NFU:	107379138 107388033

KMR:	108237210 108248883(il21r.1)

ALIM:

106532258

NWH:

119409820

AOCE:

111579090 111584916

MCEP:

125015773(il21r.1) 125022434

CSEM:

103381729 103388857

POV:	109627108 109642155

SSEN:

122759338 122774276(il21r.1)

HHIP:

117752936 117776264(il21r.1)

HSP:	118100819 118113121(il21r.1)

SMAU:

118285214(il21r.1) 118287024

LCF:	108886751 108899446 108899592(il21r.1)

SDU:	111220169 111222613

SLAL:

111655683 111658710

XGL:

120783737

HCQ:	109512103 109530188

SBIA:

133500898

PEE:	133395238 133401842(il21r.1)

PTAO:

133469482 133479171(il21r.1)

BPEC:

110168972

MALB:

109963557 109965565

BSPL:

114843630(il21r.1) 114845718

SJO:	128367080(il21r.1) 128381695

SASA:

106579378 106601102 106607352

STRU:

115159551 115171188 115198724

OTW:	112223298 112226053(il21r.2) 112226054(il21r.1) 112246022

OMY:	110486324 110492884 110538267

OGO:	123999735 124016017(il21r.1) 124030133 124047601

ONE:	115104193 115106185 115110336 115118398 115118429

OKI:	109865471 109893385 109898468

OKE:	118365313(il21r.1) 118371064

SALP:

111978536 111980332 111980357 111981492

SNH:	120033918 120044547

CCLU:

121550907 121569120

ELS:	105013397(il21r) 105021300

SFM:	108923866 108932978(il21r) 114909069

PKI:	111833430 111833431 111846396 111846435

AANG:

118216115 118216888 118217244 118219922

LOC:	102691298(il21r) 107078987

PSPA:

121300646 121330614 121330669

ARUT:

117418059 117431367 117431421

LCM:

CMK:

CPLA:

HOC:

LERI:

Reference

PMID:11081504

Authors

Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D

Title

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.

Journal

Nature 408:57-63 (2000)
DOI:10.1038/35040504

Sequence

[hsa:50615]

Reference

PMID:18467657

Authors

Leonard WJ, Zeng R, Spolski R

Title

Interleukin 21: a cytokine/cytokine receptor system that has come of age.

Journal

J Leukoc Biol 84:348-56 (2008)
DOI:10.1189/jlb.0308149

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Gene (525)   
   KEGG GENES (497)   
   KEGG MGENES (23)   
   OC (5)   
Literature (2)   
   PubMed (2)   
All databases (540)   

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