KEGG   ORTHOLOGY: K05459Help
Entry
K05459                      KO                                     

Name
IGF1
Definition
insulin-like growth factor 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04115  p53 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04960  Aldosterone-regulated sodium reabsorption
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05414  Dilated cardiomyopathy (DCM)
Disease
H00015  Malignant pleural mesothelioma
H02040  Insulin-like growth factor I deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04015 Rap1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04010 MAPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04066 HIF-1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04068 FoxO signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04151 PI3K-Akt signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04152 AMPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04150 mTOR signaling pathway
    K05459  IGF1; insulin-like growth factor 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05459  IGF1; insulin-like growth factor 1
   04115 p53 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05459  IGF1; insulin-like growth factor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K05459  IGF1; insulin-like growth factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian Steroidogenesis
    K05459  IGF1; insulin-like growth factor 1
   04914 Progesterone-mediated oocyte maturation
    K05459  IGF1; insulin-like growth factor 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K05459  IGF1; insulin-like growth factor 1
  09156 Nervous system
   04730 Long-term depression
    K05459  IGF1; insulin-like growth factor 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05459  IGF1; insulin-like growth factor 1
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K05459  IGF1; insulin-like growth factor 1
   04213 Longevity regulating pathway - multiple species
    K05459  IGF1; insulin-like growth factor 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K05459  IGF1; insulin-like growth factor 1
   05202 Transcriptional misregulation in cancers
    K05459  IGF1; insulin-like growth factor 1
   05205 Proteoglycans in cancer
    K05459  IGF1; insulin-like growth factor 1
   05214 Glioma
    K05459  IGF1; insulin-like growth factor 1
   05218 Melanoma
    K05459  IGF1; insulin-like growth factor 1
   05215 Prostate cancer
    K05459  IGF1; insulin-like growth factor 1
   05224 Breast cancer
    K05459  IGF1; insulin-like growth factor 1
  09165 Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K05459  IGF1; insulin-like growth factor 1
   05414 Dilated cardiomyopathy (DCM)
    K05459  IGF1; insulin-like growth factor 1
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05459  IGF1; insulin-like growth factor 1
   01522 Endocrine resistance
    K05459  IGF1; insulin-like growth factor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05459  IGF1; insulin-like growth factor 1
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05459  IGF1; insulin-like growth factor 1
BRITE hierarchy
Other DBs
GO: 0005159
Genes
HSA: 3479(IGF1)
PTR: 741055(IGF1)
PPS: 100982978(IGF1)
GGO: 101154397(IGF1)
PON: 100444645(IGF1)
NLE: 100595306(IGF1)
MCC: 698444(IGF1)
MCF: 102128018(IGF1)
CSAB: 103238957(IGF1)
RRO: 104657459(IGF1)
RBB: 108543134(IGF1)
CJC: 100394985(IGF1)
SBQ: 101036963(IGF1)
MMU: 16000(Igf1)
RNO: 24482(Igf1)
CGE: 100751642(Igf1)
NGI: 103733723(Igf1)
HGL: 101707684(Igf1)
CCAN: 109677734 109697466(Igf1)
OCU: 100008668(IGF1)
TUP: 102490248(IGF1)
CFA: 610255(IGF1)
AML: 100473254(IGF1)
UMR: 103676495(IGF1)
ORO: 101386334(IGF1)
FCA: 101101237(IGF1)
PTG: 102962543(IGF1)
AJU: 106971906(IGF1)
BTA: 281239(IGF1)
BOM: 102272009(IGF1)
BIU: 109559448(IGF1)
PHD: 102318534(IGF1)
CHX: 100860838(IGF1)
OAS: 443318(IGF1)
SSC: 397491(IGF1)
CFR: 102506236(IGF1)
CDK: 105097468(IGF1)
BACU: 103014780(IGF1)
LVE: 103078928(IGF1)
OOR: 101269950(IGF1)
ECB: 100034198(IGF1)
EPZ: 103549360(IGF1)
EAI: 106827264(IGF1)
MYB: 102252071(IGF1)
MYD: 102752580(IGF1)
HAI: 109387785(IGF1)
RSS: 109447628(IGF1)
PALE: 102890331(IGF1)
LAV: 100664710(IGF1)
TMU: 101361934
MDO: 100021295(IGF1)
SHR: 100918816(IGF1)
OAA: 100075905(IGF1)
GGA: 418090(IGF1)
MGP: 678666(IGF1)
CJO: 107316281(IGF1)
APLA: 101793597(IGF1)
ACYG: 106035916(IGF1)
TGU: 100226283(IGF1)
GFR: 102032215(IGF1)
FAB: 101808710(IGF1)
PHI: 102112946(IGF1)
PMAJ: 107204610(IGF1)
CCW: 104696228(IGF1)
FPG: 101922655(IGF1)
FCH: 102060062(IGF1)
CLV: 102092089(IGF1)
EGZ: 104135582(IGF1)
AAM: 106488383(IGF1)
ASN: 102372626(IGF1)
AMJ: 102559209(IGF1)
PSS: 102454948(IGF1)
CMY: 102932263(IGF1)
CPIC: 101939474(IGF1)
ACS: 100566682(igf1)
PVT: 110084792(IGF1)
PBI: 103062109(IGF1)
GJA: 107119991(IGF1)
XLA: 108711020(igf1.L) 108712492 378699(igf1.S)
XTR: 100486334(igf1)
NPR: 108789614(IGF1)
DRE: 114433(igf1)
IPU: 100305062(igf1)
AMEX: 103036238(igf1)
TRU: 100462939(igf1)
NCC: 104956990
MZE: 101464291 101476517(igf1)
OLA: 101168167(igf1) 105354483
XMA: 102221578 102222602(igf1)
PRET: 103459389(igf1) 103466958
NFU: 107386743(igf1) 107391385
CSEM: 103382578(igf1) 103384875
LCF: 108897582(igf1) 108900498
HCQ: 109528351 109530129(igf1)
ELS: 105013816 105030158(igf1)
SFM: 108931632(igf1)
LCM: 102361051(IGF1) 102365620
CMK: 103179868(igf1)
CIN: 100170003(ins-l1)
DME: Dmel_CG14049(Ilp6)
DSI: Dsimw501_GD28130(Dsim_GD28130)
MDE: 101896013
AME: 107964907
BIM: 105680848
BTER: 100648980
SOC: 105197201
AEC: 105154102
ACEP: 105617935
HST: 105186969
CFO: 105257619
PGC: 109855579
BMOR: 100147697(Bbx-c2) 100169656(Bbx-b11) 100169718(Bbx-b8) 100169722(Bbx-b3) 100169724(Bbx-b5) 100270769(Igflp)
PRAP: 110996560
API: 107882462
ZNE: 110826827
CRG: 105319754
SHX: MS3_05637
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3002851
  Authors
de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS
  Title
Organization of the human genes for insulin-like growth factors I and II.
  Journal
FEBS Lett 195:179-84 (1986)
DOI:10.1016/0014-5793(86)80156-9
  Sequence
[hsa:3479]
Reference
  Authors
Zoidis E, Ghirlanda-Keller C, Schmid C
  Title
Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.
  Journal
Mol Cell Biochem 348:33-42 (2011)
DOI:10.1007/s11010-010-0634-z
  Sequence
[hsa:3479]

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