| | ORTHOLOGY: K05632 | |
Entry |
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Symbol |
ITCH, AIP4
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Name |
E3 ubiquitin-protein ligase Itchy [EC: 2.3.2.26]
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Pathway |
map04932 | Non-alcoholic fatty liver disease |
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Disease |
H01232 | Syndromic multisystem autoimmune disease |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
04668 TNF signaling pathway
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
04121 Ubiquitin system
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Enzymes [BR:ko01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Membrane trafficking [BR:ko04131]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
HECT type E3
K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
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Genes |
» show all
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Reference |
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Authors |
Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL |
Title |
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. |
Journal |
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Sequence |
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Reference |
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Authors |
Zhang P, Wang C, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L |
Title |
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. |
Journal |
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Sequence |
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