KEGG   ORTHOLOGY: K05849Help
Entry
K05849                      KO                                     

Name
SLC8A, NCX
Definition
solute carrier family 8 (sodium/calcium exchanger)
Pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04371  Apelin signaling pathway
ko04740  Olfactory transduction
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04974  Protein digestion and absorption
ko04978  Mineral absorption
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ko05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   04020 Calcium signaling pathway
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   04022 cGMP-PKG signaling pathway
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   04261 Adrenergic signaling in cardiomyocytes
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
  09154 Digestive system
   04974 Protein digestion and absorption
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   04978 Mineral absorption
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
  09157 Sensory system
   04740 Olfactory transduction
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   05414 Dilated cardiomyopathy (DCM)
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
   00536 Glycosaminoglycan binding proteins
    K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Others
   K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
BRITE hierarchy
Other DBs
GO: 0005432
TC: 2.A.19.3
Genes
HSA: 6543(SLC8A2) 6546(SLC8A1) 6547(SLC8A3)
PTR: 467491(SLC8A3) 468932(SLC8A2) 470358(SLC8A1)
PPS: 100969645(SLC8A1) 100972309(SLC8A1) 100980273(SLC8A2) 100986811(SLC8A3)
GGO: 101133167(SLC8A2) 101140086(SLC8A1) 101148991(SLC8A3)
PON: 100172867(SLC8A1) 100455240(SLC8A2) 100461670(SLC8A3)
NLE: 100593425(SLC8A1) 100603298(SLC8A3) 100607302(SLC8A2)
MCC: 574193(SLC8A1) 713061(SLC8A3) 718243(SLC8A2)
MCF: 102120906(SLC8A1) 102124700(SLC8A2) 102141225(SLC8A3)
CSAB: 103220428(SLC8A1) 103229257(SLC8A3) 103234942(SLC8A2)
RRO: 104659649(SLC8A3) 104663033(SLC8A1) 104673384(SLC8A2)
RBB: 108520278(SLC8A3) 108540286(SLC8A2) 108542784(SLC8A1)
CJC: 100411164(SLC8A2) 100412198(SLC8A1) 100412630(SLC8A3)
SBQ: 101033343 101042047(SLC8A1) 101046902(SLC8A3) 104653280(SLC8A2)
MMU: 110891(Slc8a2) 110893(Slc8a3) 20541(Slc8a1)
MCAL: 110297788(Slc8a2) 110306723(Slc8a3) 110312337(Slc8a1)
MPAH: 110324185(Slc8a3) 110336146(Slc8a1) 110336599(Slc8a2)
RNO: 140447(Slc8a2) 140448(Slc8a3) 29715(Slc8a1)
CGE: 100760799(Slc8a1) 100765404(Slc8a3) 100765653(Slc8a2)
NGI: 103724972(Slc8a2) 103736381(Slc8a1) 103744201(Slc8a3)
HGL: 101700465(Slc8a3) 101708998(Slc8a2) 101711105(Slc8a1)
CCAN: 109684869(Slc8a1) 109684870 109685996(Slc8a3) 109696537(Slc8a2) 109700068
OCU: 100328570(SLC8A1) 100339605(SLC8A3) 100358483 103345732(SLC8A2)
TUP: 102498817(SLC8A1) 102500864(SLC8A3) 102501744(SLC8A2)
CFA: 475738(SLC8A1) 484420(SLC8A2) 490755(SLC8A3)
VVP: 112927220(SLC8A3) 112931343(SLC8A2) 112935294(SLC8A1)
AML: 100469610(SLC8A2) 100471755(SLC8A3) 100474541(SLC8A1)
UMR: 103657216(SLC8A2) 103671551(SLC8A1) 103674250(SLC8A3)
UAH: 113241704(SLC8A1) 113243369(SLC8A2) 113270386(SLC8A3)
ORO: 101364689(SLC8A2) 101367838(SLC8A1) 101373996(SLC8A3)
FCA: 101081054(SLC8A3) 101097856(SLC8A2) 493807(SLC8A1)
PTG: 102951544(SLC8A3) 102956604(SLC8A2) 102967786(SLC8A1)
PPAD: 109253165(SLC8A2) 109265357(SLC8A1) 109268240(SLC8A3)
AJU: 106974467(SLC8A3) 106984816(SLC8A2) 106986299(SLC8A1)
BTA: 337925(SLC8A1) 535881(SLC8A2) 540307(SLC8A3)
BOM: 102264471(SLC8A1) 102268185(SLC8A3) 102283501(SLC8A2)
BIU: 109565298(SLC8A3) 109566012(SLC8A1) 109572570(SLC8A2)
BBUB: 102394134(SLC8A3) 102396230(SLC8A1) 102399169(SLC8A2)
CHX: 102171644(SLC8A2) 102177443(SLC8A3) 102181964(SLC8A1)
OAS: 101102171(SLC8A2) 101116716(SLC8A1) 101120753(SLC8A3)
SSC: 100152101(SLC8A3) 100519030(SLC8A2) 100622020(SLC8A1)
CFR: 102503880(SLC8A1) 102505429(SLC8A2) 102511639(SLC8A3) 102520561
CDK: 105086149(SLC8A3) 105098943(SLC8A2) 105103660(SLC8A1)
BACU: 103003153(SLC8A2) 103017102(SLC8A3) 103019260(SLC8A1)
LVE: 103074445(SLC8A1) 103080144 103084130(SLC8A3) 103085990(SLC8A2)
OOR: 101274346(SLC8A2) 101284293(SLC8A1) 101289104(SLC8A3)
DLE: 111173015(SLC8A3) 111174840(SLC8A1) 111180685(SLC8A2)
PCAD: 102977412(SLC8A2) 102983208(SLC8A1) 102996390 114483958
ECB: 100034157(SLC8A1) 100053312(SLC8A3) 100146819(SLC8A2)
EPZ: 103552905(SLC8A1) 103562245(SLC8A3) 103563835(SLC8A2) 103567452
EAI: 106825878(SLC8A1) 106845134(SLC8A2) 106847743(SLC8A3)
MYB: 102242099(SLC8A3) 102253731(SLC8A2) 102254673(SLC8A1) 106727887
MYD: 102755776(SLC8A2) 102758739(SLC8A3) 102759624(SLC8A1) 102766425
MNA: 107536251(SLC8A3) 107540036(SLC8A2) 107541794(SLC8A1)
HAI: 109372224(SLC8A2) 109382076(SLC8A3) 109385540(SLC8A1)
DRO: 112297967(SLC8A1) 112311468(SLC8A3) 112312910(SLC8A2)
PALE: 102880752(SLC8A1) 102890460(SLC8A2) 102890976(SLC8A3)
RAY: 107503262(SLC8A3) 107509443(SLC8A1) 107516018(SLC8A2)
MJV: 108393750 108393751(SLC8A3) 108393952(SLC8A1) 108398859(SLC8A2)
LAV: 100658790(SLC8A1) 100661888(SLC8A2) 100666349(SLC8A3)
MDO: 100010180(SLC8A1) 100020311(SLC8A3) 100020329(SLC8A2)
SHR: 100914566 100916944(SLC8A3) 100930572(SLC8A1)
PCW: 110202404(SLC8A2) 110208379(SLC8A3) 110218488(SLC8A1)
OAA: 100074200(SLC8A1) 100088707(SLC8A3) 100092005(SLC8A2)
GGA: 107057643(SLC8A2) 395759(SLC8A3) 395760(SLC8A1)
MGP: 100539239 100540412(SLC8A2) 100541915(SLC8A3)
CJO: 107307098(SLC8A2) 107310925(SLC8A1) 107314907(SLC8A3)
NMEL: 110391923 110396043(SLC8A1) 110401740(SLC8A3)
APLA: 101798929(SLC8A3) 101799858(SLC8A1)
ACYG: 106029700 106031644(SLC8A3) 106045592(SLC8A1)
TGU: 100219043(SLC8A3) 100226150(SLC8A1) 115493175
LSR: 110474852(SLC8A1) 110476076(SLC8A3) 110478801(SLC8A2)
SCAN: 103821334(SLC8A1) 103825387 103826617(SLC8A3)
GFR: 102036956(SLC8A1) 102043721(SLC8A3) 102044668
FAB: 101810176(SLC8A3) 101821181(SLC8A1) 101821580(SLC8A2)
PHI: 102104342(SLC8A1) 102113310(SLC8A3) 102114460(SLC8A2)
PMAJ: 107199525 107202123(SLC8A1) 107205619(SLC8A3)
CCAE: 111926558(SLC8A1) 111930894(SLC8A3) 111942247
CCW: 104683528(SLC8A3) 104696630(SLC8A1)
ETL: 114055492(SLC8A3) 114060055(SLC8A1) 114073408
FPG: 101913700(SLC8A3) 101919694(SLC8A2) 101922583(SLC8A1)
FCH: 102049307(SLC8A2) 102050111(SLC8A3) 102051074(SLC8A1)
EGZ: 104122114(SLC8A3) 104122499 104130460(SLC8A1)
NNI: 104020318(SLC8A3) 104022117(SLC8A1) 104022808
ACUN: 113477732(SLC8A1) 113480628(SLC8A3)
PADL: 103918293(SLC8A3) 103925079(SLC8A1)
ASN: 102375215(SLC8A1) 102377891(SLC8A3) 102380840
AMJ: 102573547(SLC8A1) 102574975(SLC8A2) 102575838(SLC8A3) 106737581
PSS: 102449703 102457724(SLC8A3) 102457966 102463939(SLC8A1)
CMY: 102934393(SLC8A1) 102936911(SLC8A2) 102948103(SLC8A3)
CPIC: 101934751(SLC8A2) 101941418 101944111(SLC8A1) 101952799(SLC8A3)
ACS: 100552737(slc8a3) 100558452(slc8a1) 100567949 103280981
PVT: 110075775(SLC8A2) 110076424(SLC8A3) 110079542(SLC8A1) 110083339
TSR: 106546769 106547618 106553427(SLC8A3) 106553945(SLC8A1)
PMUA: 114586754 114594813(SLC8A1) 114594885(SLC8A3) 114603206(SLC8A2)
GJA: 107107692(SLC8A3) 107115194 107119826(SLC8A1) 107124084
XTR: 100487508(slc8a3) 100487899 100492166(slc8a1) 100495074(slc8a2)
NPR: 108786669(SLC8A2) 108788925(SLC8A1) 108794054 108802331
DRE: 553489(slc8a1a) 560561(slc8a3) 567212(slc8a2b) 568512(slc8a4a) 797199(slc8a1b)
LCM: 102347694(SLC8A3) 102353683(SLC8A2) 102358533(SLC8A1) 102367281
CIN: 100185626
SPU: 575892
DME: Dmel_CG5685(Calx)
DER: 6553512
DSI: Dsimw501_GD19389(Dsim_GD19389)
DSR: 110177233
DPE: 6587917
DMN: 108156679
DWI: 6648128
DAZ: 108608586
DNV: 108651511
DHE: 111603514
LCQ: 111678268
AAG: 5576390
AME: 409818
BIM: 100742282
BTER: 100650276
CCAL: 108626694
SOC: 105202216
MPHA: 105837933
AEC: 105153137
ACEP: 105621872
PBAR: 105425411
VEM: 105561438
HST: 105185602
DQU: 106742408
CFO: 105249726
LHU: 105670518
OBO: 105279893
PCF: 106789738
NVI: 100115543
CSOL: 105361079
MDL: 103572412
TCA: 662969
DPA: 109536407
ATD: 109609331
NVL: 108556790
BMOR: 101741376
BMAN: 114251490
PMAC: 106708563
HAW: 110375865
TNL: 113504869
PXY: 105395228
API: 100167616
DNX: 107165430
AGS: 114127346
RMD: 113560911
ZNE: 110826523
CEL: CELE_C10G8.5(ncx-2) CELE_Y113G7A.4(ncx-1)
CBR: CBG06769(Cbr-ncx-2) CBG12917
BMY: Bm1_02560
EGL: EGR_04067
HMG: 100198590
SMIN: v1.2.003862.t1(symbB.v1.2.003862.t1) v1.2.006764.t1(symbB.v1.2.006764.t1) v1.2.009203.t1(symbB.v1.2.009203.t1) v1.2.011658.t1(symbB.v1.2.011658.t1) v1.2.011659.t1(symbB.v1.2.011659.t1) v1.2.023287.t1(symbB.v1.2.023287.t1) v1.2.023775.t1(symbB.v1.2.023775.t1) v1.2.023775.t2(symbB.v1.2.023775.t2) v1.2.029024.t1(symbB.v1.2.029024.t1) v1.2.033171.t1(symbB.v1.2.033171.t1) v1.2.034297.t1(symbB.v1.2.034297.t1) v1.2.037736.t1(symbB.v1.2.037736.t1) v1.2.037736.t2(symbB.v1.2.037736.t2) v1.2.039499.t1(symbB.v1.2.039499.t1)
EHX: EMIHUDRAFT_454623(NCX1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1374913
  Authors
Komuro I, Wenninger KE, Philipson KD, Izumo S
  Title
Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA.
  Journal
Proc Natl Acad Sci U S A 89:4769-73 (1992)
DOI:10.1073/pnas.89.10.4769
  Sequence
[hsa:6546]

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