KEGG   ORTHOLOGY: K06268
Entry
K06268                      KO                                     

Name
PPP3R, CNB
Definition
serine/threonine-protein phosphatase 2B regulatory subunit
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04114  Oocyte meiosis
ko04218  Cellular senescence
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04720  Long-term potentiation
ko04724  Glutamatergic synapse
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04924  Renin secretion
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05031  Amphetamine addiction
ko05152  Tuberculosis
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04310 Wnt signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04370 VEGF signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04020 Calcium signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04022 cGMP-PKG signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04218 Cellular senescence
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04650 Natural killer cell mediated cytotoxicity
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04660 T cell receptor signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04658 Th1 and Th2 cell differentiation
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04659 Th17 cell differentiation
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04662 B cell receptor signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04921 Oxytocin signaling pathway
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04924 Renin secretion
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09156 Nervous system
   04724 Glutamatergic synapse
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04720 Long-term potentiation
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09158 Development and regeneration
   04360 Axon guidance
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   04380 Osteoclast differentiation
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   05014 Amyotrophic lateral sclerosis
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   05020 Prion disease
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   05022 Pathways of neurodegeneration - multiple diseases
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09165 Substance dependence
   05031 Amphetamine addiction
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   05170 Human immunodeficiency virus 1 infection
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   05163 Human cytomegalovirus infection
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Regulatory subunits
     K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
Other DBs
COG: COG5126
GO: 0004723
Genes
HSA: 5534(PPP3R1) 5535(PPP3R2)
PTR: 100613118(PPP3R1) 736325(PPP3R2)
PPS: 100995767(PPP3R2)
GGO: 101144871(PPP3R2) 115933538(PPP3R1)
PON: 100461146(PPP3R2) 103889825(PPP3R1)
NLE: 100593195(PPP3R1) 100600788(PPP3R2)
MCC: 100428682(PPP3R1) 574258(PPP3R2)
MCF: 101866439(PPP3R2) 102137250(PPP3R1)
CSAB: 103219106(PPP3R2) 103220127(PPP3R1)
RRO: 104653917 104670806(PPP3R2) 104675975(PPP3R1)
RBB: 108537161(PPP3R2)
CJC: 100388148(PPP3R1) 100392986(PPP3R2)
SBQ: 101039659(PPP3R2) 104650539(PPP3R1)
MMU: 19058(Ppp3r1) 19059(Ppp3r2)
MCAL: 110293037(Ppp3r2) 110304839(Ppp3r1)
MPAH: 110322987(Ppp3r2) 110330477(Ppp3r1)
RNO: 29748(Ppp3r1) 29749(Ppp3r2)
MUN: 110558957(Ppp3r1) 110561325
CGE: 100754314(Ppp3r2) 100773706(Ppp3r1)
NGI: 103734750(Ppp3r1) 103749104(Ppp3r2)
HGL: 101706255(Ppp3r1) 101710684(Ppp3r2)
CCAN: 109693705(Ppp3r1) 109696247(Ppp3r2)
OCU: 100344533(PPP3R2)
TUP: 102474096(PPP3R1) 102478386(PPP3R2)
CFA: 610453(PPP3R2) 612559(PPP3R1)
VVP: 112930770(PPP3R2) 112934379(PPP3R1)
AML: 100467683(PPP3R1) 100474742(PPP3R2)
UMR: 103671340(PPP3R1) 103678534(PPP3R2)
UAH: 113244743(PPP3R1) 113260378(PPP3R2)
ORO: 101368686(PPP3R2) 101386271(PPP3R1)
FCA: 101090344(PPP3R1) 101097765(PPP3R2)
PTG: 102965200(PPP3R1) 102967427(PPP3R2)
PPAD: 109262013(PPP3R1) 109270050(PPP3R2)
AJU: 106967692(PPP3R1) 106972076(PPP3R2)
BTA: 282321(PPP3R1) 617585(PPP3R2)
BOM: 102272271(PPP3R1) 102277736(PPP3R2)
BIU: 109563306(PPP3R2) 109566227(PPP3R1)
BBUB: 102400804(PPP3R2) 102406798(PPP3R1)
CHX: 102177339(PPP3R2) 102182602(PPP3R1)
OAS: 101120802(PPP3R2) 114108765(PPP3R1)
SSC: 100625117(PPP3R2) 100627903(PPP3R1)
CFR: 106729683(PPP3R2) 116669020(PPP3R1)
CDK: 116152568(PPP3R2) 116157512(PPP3R1)
BACU: 103009602(PPP3R2)
LVE: 103068473(PPP3R1) 103078845(PPP3R2)
OOR: 101272877(PPP3R1) 105748080(PPP3R2)
DLE: 111186607(PPP3R1) 111188120(PPP3R2)
PCAD: 112065477(PPP3R2) 112067521(PPP3R1)
ECB: 100061874(PPP3R1) 102148270(PPP3R2)
EPZ: 103548960(PPP3R1) 103552460(PPP3R2)
EAI: 106828340(PPP3R1) 106831788(PPP3R2)
MYB: 102247129(PPP3R2) 102250711(PPP3R1)
MYD: 102760712(PPP3R2) 102774846(PPP3R1)
MNA: 107545969(PPP3R1)
HAI: 109379237(PPP3R1)
DRO: 112297858(PPP3R1) 112304508(PPP3R2)
PALE: 102894471(PPP3R1) 102895490(PPP3R2)
RAY: 107499586(PPP3R2) 107506933(PPP3R1)
MJV: 108386668 108393727(PPP3R1)
LAV: 100668807(PPP3R2) 111751572(PPP3R1)
MDO: 100033302(PPP3R1)
SHR: 100918689(PPP3R1)
PCW: 110207663(PPP3R1)
OAA: 100083665(PPP3R1)
GGA: 378804(PPP3R1)
MGP: 100549150(PPP3R1)
CJO: 107310666(PPP3R1)
NMEL: 110396552(PPP3R1)
APLA: 101791746(PPP3R1)
ACYG: 106044692(PPP3R1)
TGU: 100229058(PPP3R1)
LSR: 110484892(PPP3R1)
SCAN: 103821361(PPP3R1)
GFR: 102034017(PPP3R1)
FAB: 101820532(PPP3R1)
PHI: 102111343(PPP3R1)
PMAJ: 107201468(PPP3R1)
CCAE: 111926640(PPP3R1)
CCW: 104696602(PPP3R1)
ETL: 114054864(PPP3R1)
FPG: 101923629(PPP3R1)
FCH: 102050745(PPP3R1)
CLV: 102095954(PPP3R1)
EGZ: 104129247(PPP3R1)
NNI: 104018925(PPP3R1)
ACUN: 113478143(PPP3R1)
PADL: 103917815(PPP3R1)
AAM: 106495909(PPP3R1)
ASN: 102377091(PPP3R1)
AMJ: 106737480(PPP3R1)
PSS: 102448775(PPP3R1)
ACS: 100561213(ppp3r1)
PVT: 110091682(PPP3R1)
PBI: 107326860(PPP3R1)
TSR: 106545814(PPP3R1)
PMUA: 114593583(PPP3R1)
GJA: 107114939(PPP3R1)
XLA: 108716580(ppp3r1.L) 399215(ppp3r1.S)
XTR: 395037(ppp3r1)
NPR: 108795656(PPP3R1)
DRE: 447814(ppp3r1b) 564337(ppp3r1a)
IPU: 108258530 108263224(ppp3r1)
PHYP: 113537343 113541892(ppp3r1)
EEE: 113579658 113585612(ppp3r1)
TRU: 101071292 101074110(ppp3r1)
LCO: 104918540 104930901(ppp3r1)
NCC: 104954071(ppp3r1)
MZE: 101465581 101487274(ppp3r1)
ONL: 100692027 100709118(ppp3r1)
OLA: 101161991(ppp3r1) 101168674
XMA: 102218918(ppp3r1)
XCO: 114137969(ppp3r1)
PRET: 103472014 103476469(ppp3r1)
CVG: 107096927 107098988(ppp3r1)
NFU: 107376079(ppp3r1)
KMR: 108247263(ppp3r1)
ALIM: 106529812(ppp3r1)
AOCE: 111570968(ppp3r1)
CSEM: 103386871(ppp3r1)
POV: 109634942(ppp3r1) 109645661
LCF: 108873404(ppp3r1) 108888732
SDU: 111227385(ppp3r1) 111237590
HCQ: 109526689(ppp3r1)
BPEC: 110157106(ppp3r1) 110173890
MALB: 109961064(ppp3r1)
ELS: 105021516 106024317(ppp3r1)
PKI: 111850760(ppp3r1) 111859769
LCM: 102367157(PPP3R1)
CMK: 103177901(ppp3r1)
RTP: 109934526(ppp3r1)
DME: Dmel_CG11217(CanB2) Dmel_CG4209(CanB)
DSI: Dsimw501_GD15356(Dsim_GD15356) Dsimw501_GD29162(Dsim_GD29162)
DAN: 6496043
MDE: 101894267
LCQ: 111676949
AAG: 5573370
AME: 551313
BIM: 100749634
BTER: 100650453
CCAL: 108631222
OBB: 114879229
SOC: 105201645
MPHA: 105835317
AEC: 105144936
ACEP: 105624663
PBAR: 105422521
HST: 105182789
DQU: 106747742
CFO: 105250886
LHU: 105678532
PGC: 109851930
OBO: 105276504
PCF: 106788783
NVI: 100121135
CSOL: 105365179
MDL: 103579881
TCA: 664163
DPA: 109542598
ATD: 109594538
NVL: 108556329
BMOR: 692578(Cnb)
BMAN: 114250126
PMAC: 106708445
PRAP: 110991898
HAW: 110369812
TNL: 113496220
PXY: 105380958
API: 100162564
DNX: 107163945
RMD: 113548709
BTAB: 109033461
CLEC: 106673033
ZNE: 110826606
FCD: 110842725
PVM: 113803687
TUT: 107372011
DPTE: 113793164
CSCU: 111624490
PTEP: 107442800
CEL: CELE_F55C10.1(cnb-1)
CBR: CBG23183(Cbr-cnb-1)
BMY: Bm1_50880
TSP: Tsp_02876
PCAN: 112570556
CRG: 105335836
MYI: 110459429
OBI: 106878873
LAK: 106163012
SHX: MS3_08636
EGL: EGR_02530
DGT: 114532371
HMG: 100213359
AQU: 100640962
ATH: AT1G64480(CBL8) AT3G18430 AT4G01420(CBL5) AT4G16350(CBL6) AT4G17615(CBL1) AT4G26560(CBL7) AT4G26570(CBL3) AT4G33000(CBL10) AT5G24270(SOS3) AT5G47100(CBL9) AT5G55990(CBL2)
LJA: Lj1g3v0984330.1(Lj1g3v0984330.1) Lj1g3v0984330.2(Lj1g3v0984330.2) Lj1g3v0984330.3(Lj1g3v0984330.3) Lj2g3v1988900.1(Lj2g3v1988900.1) Lj2g3v3318760.1(Lj2g3v3318760.1) Lj3g3v0044110.1(Lj3g3v0044110.1) Lj3g3v0044110.2(Lj3g3v0044110.2) Lj3g3v2442020.1(Lj3g3v2442020.1) Lj3g3v2442020.2(Lj3g3v2442020.2) Lj3g3v2693160.2(Lj3g3v2693160.2) Lj4g3v0095240.2(Lj4g3v0095240.2) Lj4g3v1202210.1(Lj4g3v1202210.1) Lj4g3v2002950.1(Lj4g3v2002950.1) Lj4g3v3014180.1(Lj4g3v3014180.1) Lj4g3v3014180.2(Lj4g3v3014180.2) Lj5g3v0391490.1(Lj5g3v0391490.1) Lj6g3v1707200.1(Lj6g3v1707200.1)
VVI: 100243294(CBL01) 100244675 100246874(CBL04) 100249564(CBL05) 100254259(CBL07) 100254683(CBL08) 100259377(CBL06) 100260894(CBL01) 100262221(CBL03) 100263924 100266945(CBL02) 104878144
DOSA: Os01t0579600-01(Os01g0579600) Os01t0598200-01(Os01g0598200) Os01t0711500-00(Os01g0711500) Os02t0291000-00(Os02g0291000) Os02t0291400-00(Os02g0291400) Os02t0480800-00(Os02g0480800) Os02t0802400-01(Os02g0802400) Os03t0626800-01(Os03g0626800) Os05t0534400-01(Os05g0534400) Os08t0442300-01(Os08g0442300) Os08t0442350-01(Os08g0442350) Os10t0564800-01(Os10g0564800) Os12t0162400-01(Os12g0162400) Os12t0597000-01(Os12g0597000)
ATS: 109732811(LOC109732811) 109733825(LOC109733825) 109739617(LOC109739617) 109740273 109742945(LOC109742945) 109744414(LOC109744414) 109748696(LOC109748696) 109756485(LOC109756485) 109761304(LOC109761304) 109761320 109762527(LOC109762527) 109763262(LOC109763262) 109763576(LOC109763576) 109770914(LOC109770914) 109780615(LOC109780615) 109787363(LOC109787363)
SCE: YKL190W(CNB1)
ERC: Ecym_7012
KMX: KLMA_10636(CNB1)
NCS: NCAS_0A02710(NCAS0A02710)
NDI: NDAI_0D04640(NDAI0D04640)
TPF: TPHA_0B01930(TPHA0B01930)
TBL: TBLA_0I03160(TBLA0I03160)
TDL: TDEL_0H01410(TDEL0H01410)
KAF: KAFR_0A05790(KAFR0A05790)
CAL: CAALFM_C505160CA(CNB1)
SLB: AWJ20_4204(CNB1)
NCR: NCU03833(cnb-1)
NTE: NEUTE1DRAFT144368(NEUTE1DRAFT_144368)
MGR: MGG_06933
SSCK: SPSK_05470
TRE: TRIREDRAFT_52130(calb)
MAW: MAC_00460
MAJ: MAA_07344
CMT: CCM_03871
BFU: BCIN_03g05990(Bccnb1)
MBE: MBM_08246
ANI: AN6566.2
ANG: ANI_1_152134(An15g00870)
ABE: ARB_04150
TVE: TRV_03941
PTE: PTT_18349
ZTR: MYCGRDRAFT_68731(CANB)
CNE: CND00260
CNB: CNBD5950
TASA: A1Q1_02198
PPL: POSPLDRAFT_109275(CAR1)
ABP: AGABI1DRAFT116228(AGABI1DRAFT_116228)
ABV: AGABI2DRAFT135141(AGABI2DRAFT_135141)
MGL: MGL_1603
MRT: MRET_0696
DDI: DDB_G0267446(cnbA) DDB_G0285999(cnbB)
DFA: DFA_07623(cnbA)
EHI: EHI_106670(217.t00005)
PCB: PCHAS_131870(PC001255.02.0)
CPV: cgd1_1370
SMIN: v1.2.028178.t1(symbB.v1.2.028178.t1)
LPAN: LPMP_211940(CNB)
 » show all
Reference
PMID:2558868
  Authors
Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB
  Title
Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.
  Journal
DNA 8:675-82 (1989)
DOI:10.1089/dna.1.1989.8.675
  Sequence
[hsa:5534]

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