KEGG   ORTHOLOGY: K06276Help
Entry
K06276                      KO                                     

Name
PDPK1
Definition
3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
Pathway
ko01524  Platinum drug resistance
ko03320  PPAR signaling pathway
ko04011  MAPK signaling pathway - yeast
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04931  Insulin resistance
ko04960  Aldosterone-regulated sodium reabsorption
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05205  Proteoglycans in cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05223  Non-small cell lung cancer
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04011 MAPK signaling pathway - yeast
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04068 FoxO signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04071 Sphingolipid signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04151 PI3K-Akt signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04152 AMPK signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04150 mTOR signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09143 Cell growth and death
   04210 Apoptosis
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04664 Fc epsilon RI signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   03320 PPAR signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04919 Thyroid hormone signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 09160 Human Diseases
  09161 Cancers
   05231 Choline metabolism in cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05205 Proteoglycans in cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05215 Prostate cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05213 Endometrial cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05223 Non-small cell lung cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09166 Endocrine and metabolic diseases
   04931 Insulin resistance
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09167 Infectious diseases
   05160 Hepatitis C
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05145 Toxoplasmosis
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09168 Drug resistance
   01524 Platinum drug resistance
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  PDK1 family
   K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
BRITE hierarchy
Other DBs
COG: COG0515
GO: 0004676
Genes
HSA: 5170(PDPK1)
PTR: 467875(PDPK1)
PPS: 100971139 100981220
GGO: 101147096(PDPK1) 101147811
PON: 100452403
NLE: 100592336(PDPK1) 100593010
MCC: 697523(PDPK1)
MCF: 101866379(PDPK1)
CSAB: 103247598(PDPK1)
RRO: 104661825 104682713(PDPK1)
RBB: 108514085(PDPK1)
CJC: 100389944(PDPK1)
SBQ: 101032521(PDPK1)
MMU: 18607(Pdpk1)
RNO: 81745(Pdpk1)
CGE: 100772477(Pdpk1)
NGI: 103743959(Pdpk1)
HGL: 101709940(Pdpk1)
CCAN: 109689940(Pdpk1) 109689943
OCU: 100347954(PDPK1)
TUP: 102497633(PDPK1)
CFA: 479875(PDPK1)
AML: 100473305(PDPK1)
UMR: 103668498(PDPK1)
ORO: 101378353(PDPK1)
FCA: 101101686(PDPK1)
PTG: 102960424(PDPK1)
AJU: 106978772(PDPK1)
BTA: 100138102(PDPK1)
BOM: 102264327(PDPK1)
BIU: 109578066(PDPK1)
PHD: 102343964(PDPK1)
CHX: 102184966(PDPK1)
OAS: 101117211(PDPK1)
SSC: 100192445(PDPK1)
CFR: 102504617(PDPK1)
CDK: 105099701(PDPK1)
BACU: 103010966(PDPK1)
LVE: 103081765(PDPK1)
OOR: 101270868(PDPK1)
ECB: 100630736(PDPK1)
EPZ: 103551639(PDPK1)
EAI: 106826000(PDPK1)
MYB: 102262391(PDPK1)
MYD: 102756818(PDPK1)
HAI: 109385875(PDPK1)
RSS: 109439417(PDPK1)
PALE: 102896950(PDPK1)
LAV: 100660030(PDPK1)
TMU: 101353040
MDO: 100018830(PDPK1)
SHR: 100917568(PDPK1)
OAA: 100089083(PDPK1)
GGA: 416588(PDPK1)
MGP: 100541724(PDPK1)
CJO: 107320588(PDPK1)
APLA: 101798010(PDPK1)
ACYG: 106046039(PDPK1)
TGU: 100227045(PDPK1)
GFR: 102032960(PDPK1)
FAB: 101813442(PDPK1)
PHI: 102107665(PDPK1)
PMAJ: 107211032(PDPK1)
CCW: 104684909(PDPK1)
FPG: 101919837(PDPK1)
FCH: 102054066(PDPK1)
CLV: 102092469(PDPK1)
EGZ: 104131301(PDPK1)
AAM: 106486128(PDPK1)
ASN: 102383992(PDPK1)
AMJ: 102575851(PDPK1)
PSS: 102460679(PDPK1)
CMY: 102946336(PDPK1)
CPIC: 101943277(PDPK1)
ACS: 100559955(pdpk1)
PVT: 110085010(PDPK1)
PBI: 103067411(PDPK1)
GJA: 107106228(PDPK1)
XLA: 108703133(pdpk1.S) 444529(pdpk1.L)
XTR: 779524(pdpk1)
NPR: 108794718(PDPK1)
DRE: 403000(pdpk1b)
TRU: 101076701(pdpk1)
LCO: 104923215(pdpk1)
NCC: 104946334(pdpk1)
MZE: 101463568(pdpk1)
OLA: 101164682(pdpk1)
XMA: 102230385(pdpk1)
PRET: 103481066(pdpk1)
NFU: 107388035(pdpk1)
CSEM: 103381714(pdpk1)
LCF: 108886759(pdpk1)
HCQ: 109530196(pdpk1)
BPEC: 110159640(pdpk1)
ELS: 105021296(pdpk1)
SFM: 108923949(pdpk1)
LCM: 102346160(PDPK1)
CMK: 103186641(pdpk1)
SPU: 581490
APLC: 110979717
DME: Dmel_CG1210(Pdk1)
DSI: Dsimw501_GD13545(Dsim_GD13545)
MDE: 101900975
AME: 410732
BIM: 100742861
BTER: 100644761
SOC: 105202789
AEC: 105144913
ACEP: 105620300
PBAR: 105426049
HST: 105186906
CFO: 105258854
LHU: 105672857
PGC: 109859788
NVI: 100115534
TCA: 661920
DPA: 109542293
NVL: 108564485
BMOR: 101746352
PMAC: 106708826
PRAP: 111003009
PXY: 105381681
API: 100159966
ZNE: 110834503
FCD: 110848044
CEL: CELE_H42K12.1(pdk-1)
CBR: CBG08059(Cbr-pdk-1)
BMY: Bm1_30965
TSP: Tsp_11250
CRG: 105331792
MYI: 110450565
LAK: 106155605
SHX: MS3_09906
EPA: 110253154
ADF: 107355943
HMG: 100200349
AQU: 100634673
ATH: AT3G10540 AT5G04510(PDK1)
CPAP: 110809121
CIT: 102606895
TCC: 18586587
EGR: 104421748
VRA: 106771878
VAR: 108321979
CCAJ: 109804760
CAM: 101506953
LJA: Lj5g3v1701510.1(Lj5g3v1701510.1) Lj5g3v1701510.2(Lj5g3v1701510.2)
ADU: 107466702
AIP: 107618205
FVE: 101302872
PPER: 18787083
PMUM: 103332290
PAVI: 110765519
MDM: 103439475
ZJU: 107413089
CSV: 101212874
CMO: 103489417
MCHA: 111010127
RCU: 8263596
JCU: 105648420
VVI: 100264394
SLY: 101262698 544184(Pdk1)
LSV: 111911126
BVG: 104884292
SOE: 110803688
OSA: 4324953
DOSA: Os01t0872800-01(Os01g0872800)
OBR: 102704941
BDI: 100835821
ATS: 109758876(LOC109758876)
SBI: 8060994
ZMA: 103650947
SITA: 101769773
PDA: 103702739
EGU: 105036581
ATR: 18424293
PPP: 112277681
MNG: MNEG_8513
APRO: F751_4489
SCE: YDR466W(PKH3) YDR490C(PKH1) YOL100W(PKH2)
KMX: KLMA_20554(PKH3) KLMA_80265(PKH1)
NCS: NCAS_0A07990(NCAS0A07990) NCAS_0C04940(NCAS0C04940)
NDI: NDAI_0G04290(NDAI0G04290) NDAI_0H01020(NDAI0H01020)
TPF: TPHA_0D02740(TPHA0D02740) TPHA_0P01050(TPHA0P01050)
TBL: TBLA_0B02310(TBLA0B02310) TBLA_0B08250(TBLA0B08250) TBLA_0E02790(TBLA0E02790)
TDL: TDEL_0A04580(TDEL0A04580) TDEL_0D05320(TDEL0D05320)
KAF: KAFR_0C01440(KAFR0C01440) KAFR_0K02490(KAFR0K02490)
PIC: PICST_83871(PKH2) PICST_924(PKH1)
SLB: AWJ20_4178(PKH2)
NCR: NCU03571(stk-23)
NTE: NEUTE1DRAFT130853(NEUTE1DRAFT_130853)
MGR: MGG_01795
MAW: MAC_08750
MAJ: MAA_02689
CMT: CCM_07467
MBE: MBM_07372
ANI: AN3110.2
ANG: ANI_1_1236024(An02g08630)
ABE: ARB_00106
TVE: TRV_06647
PNO: SNOG_06367(SNOG_06366)
PTE: PTT_09636
SPO: SPCC576.15c(ksg1)
ABP: AGABI1DRAFT36927(AGABI1DRAFT_36927)
ABV: AGABI2DRAFT68901(AGABI2DRAFT_68901)
MGL: MGL_1245
DDI: DDB_G0281471(pdkA) DDB_G0284489(pdkB)
DFA: DFA_05743(pdkB) DFA_09142(pdkA)
SMIN: v1.2.010039.t1(symbB.v1.2.010039.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9094314
  Authors
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P
  Title
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
  Journal
Curr Biol 7:261-9 (1997)
DOI:10.1016/S0960-9822(06)00122-9
  Sequence
[hsa:5170]
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
  Sequence
[hsa:5170]
Reference
  Authors
Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR
  Title
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
  Journal
Curr Biol 9:186-97 (1999)
DOI:10.1016/S0960-9822(99)80088-8
  Sequence
Reference
  Authors
Inagaki M, Schmelzle T, Yamaguchi K, Irie K, Hall MN, Matsumoto K
  Title
PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.
  Journal
Mol Cell Biol 19:8344-52 (1999)
DOI:10.1128/MCB.19.12.8344
  Sequence

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