KEGG   ORTHOLOGY: K06277Help
Entry
K06277                      KO                                     

Name
RAPGEF1, GRF2
Definition
Rap guanine nucleotide exchange factor 1
Pathway
ko04015  Rap1 signaling pathway
ko04510  Focal adhesion
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 09160 Human Diseases
  09161 Cancers
   05211 Renal cell carcinoma
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
BRITE hierarchy
Genes
HSA: 2889(RAPGEF1)
PTR: 464812(RAPGEF1)
PPS: 100972192(RAPGEF1)
GGO: 101140063(RAPGEF1)
PON: 100444262(RAPGEF1)
NLE: 100603139(RAPGEF1)
MCC: 715272(RAPGEF1)
MCF: 102137533(RAPGEF1)
CSAB: 103239727(RAPGEF1)
RRO: 104669757(RAPGEF1)
RBB: 108513945(RAPGEF1)
CJC: 100402777(RAPGEF1)
SBQ: 101052399(RAPGEF1)
MMU: 107746(Rapgef1)
RNO: 63881(Rapgef1)
CGE: 100764804(Rapgef1) 103158976
NGI: 103742879(Rapgef1)
HGL: 101714387(Rapgef1)
CCAN: 109691895(Rapgef1)
OCU: 100358044(RAPGEF1)
TUP: 102490444(RAPGEF1)
CFA: 491286(RAPGEF1)
AML: 100478465(RAPGEF1)
UMR: 103670406(RAPGEF1)
ORO: 101367883(RAPGEF1)
FCA: 101099507(RAPGEF1)
PTG: 102962616(RAPGEF1)
AJU: 106985330(RAPGEF1)
BTA: 520454(RAPGEF1)
BOM: 102286409(RAPGEF1)
BIU: 109566561(RAPGEF1)
PHD: 102316375(RAPGEF1)
CHX: 102176334(RAPGEF1)
OAS: 101121164(RAPGEF1)
SSC: 100511735(RAPGEF1)
CFR: 102521802(RAPGEF1)
CDK: 105085169(RAPGEF1)
BACU: 103016774(RAPGEF1)
LVE: 103068519(RAPGEF1)
OOR: 101281077(RAPGEF1)
ECB: 100069527(RAPGEF1)
EPZ: 103553650(RAPGEF1)
EAI: 106845379(RAPGEF1)
MYB: 102249993(RAPGEF1)
MYD: 102755223(RAPGEF1)
HAI: 109380820(RAPGEF1)
RSS: 109445954(RAPGEF1)
PALE: 102882490(RAPGEF1)
LAV: 100668712(RAPGEF1)
TMU: 101344782
MDO: 100016537(RAPGEF1)
SHR: 100914252(RAPGEF1)
OAA: 100075047(RAPGEF1)
GGA: 417173(RAPGEF1)
MGP: 100538909(RAPGEF1)
CJO: 107321760(RAPGEF1)
APLA: 101796594(RAPGEF1)
ACYG: 106044103(RAPGEF1)
TGU: 100223502(RAPGEF1)
GFR: 102041561(RAPGEF1)
FAB: 101819251(RAPGEF1)
PHI: 102101609(RAPGEF1)
PMAJ: 107211975(RAPGEF1)
CCW: 104688313(RAPGEF1)
FPG: 101920279(RAPGEF1)
FCH: 102051437(RAPGEF1)
CLV: 102093050(RAPGEF1)
EGZ: 104129824(RAPGEF1)
AAM: 106490324(RAPGEF1)
ASN: 102376116(RAPGEF1)
AMJ: 102567356(RAPGEF1)
PSS: 102462283(RAPGEF1)
CMY: 102941951(RAPGEF1)
CPIC: 101952144(RAPGEF1)
ACS: 100558908
PVT: 110079600(RAPGEF1)
PBI: 103062364(RAPGEF1)
GJA: 107113979(RAPGEF1) 107125869
XLA: 108698866(rapgef1.L) 444199(rapgef1.S)
XTR: 733953(rapgef1)
NPR: 108795307(RAPGEF1)
DRE: 394101(rapgef1b) 558635(rapgef1a)
IPU: 108265900 108279164(rapgef1)
AMEX: 103035014 103043049(rapgef1)
TRU: 101073444(rapgef1)
LCO: 104924499(rapgef1) 104934753
NCC: 104951347 104967939(rapgef1)
OLA: 101157374(rapgef1) 101158464
XMA: 102230952(rapgef1) 102235637
NFU: 107374772 107386212(rapgef1)
CSEM: 103390102 103397946(rapgef1) 103398993
LCF: 108873981(rapgef1) 108894420
HCQ: 109517154(rapgef1)
BPEC: 110157298(rapgef1)
ELS: 105014664(rapgef1) 105028395
SFM: 108920197 108934417(rapgef1)
LCM: 102362033(RAPGEF1)
CMK: 103184630(rapgef1)
CIN: 100177942
SPU: 100892239
APLC: 110976276
SKO: 102804221
DME: Dmel_CG42328(C3G)
DSI: Dsimw501_GD16179(Dsim_GD16179)
DYA: Dyak_GE16444(Dyak_C3G)
AAG: 5578702
AME: 409856
BIM: 100744546
BTER: 100647525
SOC: 105202120
AEC: 105146240
ACEP: 105622998
PBAR: 105422754
HST: 105191043
CFO: 105251814
LHU: 105675839
PGC: 109859258
NVI: 100118982
TCA: 662211
DPA: 109546149
NVL: 108562411
BMOR: 101746299
PMAC: 106720420
PRAP: 110993770
PXY: 105395627
API: 100167955
ZNE: 110838972
FCD: 110853223
TUT: 107371081
CEL: CELE_Y34B4A.4(Y34B4A.4)
CBR: CBG14649
BMY: Bm1_35190
TSP: Tsp_03304
CRG: 105337544
MYI: 110449856
OBI: 106880457
SHX: MS3_02666
EPA: 110243320
ADF: 107340941
HMG: 100200352
DDI: DDB_G0277913(gefJ)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9266971
  Authors
van den Berghe N, Cool RH, Horn G, Wittinghofer A
  Title
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).
  Journal
Oncogene 15:845-50 (1997)
DOI:10.1038/sj.onc.1201407

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