KEGG   ORTHOLOGY: K06463Help
Entry
K06463                      KO                                     

Name
FCGR3, CD16
Definition
low affinity immunoglobulin gamma Fc receptor III
Pathway
ko04145  Phagosome
ko04380  Osteoclast differentiation
ko04650  Natural killer cell mediated cytotoxicity
ko04666  Fc gamma R-mediated phagocytosis
ko05140  Leishmaniasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00090  NK cell defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04666 Fc gamma R-mediated phagocytosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   05152 Tuberculosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
CD molecules [BR:ko04090]
 Proteins
  K06463  CD16a, FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  K06463  CD16b, FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Receptors
  K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
BRITE hierarchy
Other DBs
GO: 0019770
Genes
HSA: 2214(FCGR3A) 2215(FCGR3B)
PTR: 457457 745350
GGO: 101129837 101143892
PON: 100453994
NLE: 101176357
MCC: 720006(FCGR3)
MCF: 102140945(FCGR3)
CSAB: 103223675
RRO: 104671953
RBB: 108542585
CJC: 100387926
SBQ: 101040447
MMU: 246256(Fcgr4)
MCAL: 110299183
MPAH: 110322271
RNO: 116591(Fcgr2a) 304966(Fcgr3a)
MUN: 110554430
CGE: 103161892
NGI: 103746771
HGL: 101701607
CCAN: 109693505
TUP: 102499391(FCGR3B)
CFA: 478984
VVP: 112914295
AML: 100481923
UMR: 103658250
UAH: 113268656
ORO: 101363133
ELK: 111151151
FCA: 493677(FCGR3A)
PTG: 102959153
PPAD: 109276673(FCGR3A)
AJU: 106986773
BTA: 281766(FCGR3A)
BOM: 102273538
BIU: 109578151
BBUB: 102410092
CHX: 102185698
OAS: 100192433(FCGR3A)
SSC: 397684(FCGR3B)
CFR: 102516303
CDK: 105105185
BACU: 103008795
LVE: 103068717
OOR: 101270000
DLE: 111170413
PCAD: 102990877(FCGR3A)
ECB: 100051526
EPZ: 103540860(FCGR3A)
MYB: 102247789(FCGR3B)
MYD: 102754425(FCGR3A)
MNA: 107535119
HAI: 109392302
DRO: 112297203
PALE: 102893884
RAY: 107502476
LAV: 104846346
MDO: 100015157
SHR: 100924138
PCW: 110209910
LCF: 108902356
MALB: 109967604
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2526846
  Authors
Ravetch JV, Perussia B
  Title
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
  Journal
J Exp Med 170:481-97 (1989)
DOI:10.1084/jem.170.2.481
  Sequence
[hsa:2214 2215]
Reference
  Authors
Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B
  Title
Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.
  Journal
PLoS One 10:e0121788 (2015)
DOI:10.1371/journal.pone.0121788

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