KEGG   ORTHOLOGY: K06631Help
Entry
K06631                      KO                                     

Name
PLK1
Definition
polo-like kinase 1 [EC:2.7.11.21]
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04114  Oocyte meiosis
ko04914  Progesterone-mediated oocyte maturation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K06631  PLK1; polo-like kinase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06631  PLK1; polo-like kinase 1
   04114 Oocyte meiosis
    K06631  PLK1; polo-like kinase 1
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K06631  PLK1; polo-like kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06631  PLK1; polo-like kinase 1
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06631  PLK1; polo-like kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.21  polo kinase
     K06631  PLK1; polo-like kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PLK family [OT]
   K06631  PLK1; polo-like kinase 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     K06631  PLK1; polo-like kinase 1
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K06631  PLK1; polo-like kinase 1
  Sister chromatid separation proteins
   Polo kinases
    K06631  PLK1; polo-like kinase 1
BRITE hierarchy
Genes
HSA: 5347(PLK1)
PTR: 453991(PLK1)
PPS: 100992499(PLK1)
GGO: 101142495(PLK1)
PON: 100437332(PLK1)
NLE: 100596287(PLK1)
MCC: 697686(PLK1)
MCF: 101865340(PLK1)
CSAB: 103229799(PLK1)
RRO: 104658253(PLK1)
RBB: 108517680 108538812(PLK1)
CJC: 100409054(PLK1)
SBQ: 101038450(PLK1)
MMU: 18817(Plk1)
RNO: 25515(Plk1)
CGE: 100760676(Plk1)
NGI: 103742731 103746931(Plk1)
HGL: 101721399(Plk1)
CCAN: 109699641(Plk1)
OCU: 100356287(PLK1)
TUP: 102494746(PLK1)
CFA: 489971(PLK1)
AML: 100478763(PLK1)
UMR: 103668898(PLK1)
ORO: 101381651(PLK1)
FCA: 101098508(PLK1)
PTG: 102953697(PLK1)
AJU: 106970495(PLK1)
BTA: 538238(PLK1)
BOM: 102272163(PLK1)
BIU: 109578571(PLK1)
PHD: 102317772(PLK1)
CHX: 102171678(PLK1)
OAS: 101105713(PLK1)
SSC: 396953(PLK1)
CFR: 102512097(PLK1)
CDK: 105094832(PLK1)
BACU: 103012253(PLK1)
LVE: 103090008(PLK1)
OOR: 101276504(PLK1)
ECB: 100068388(PLK1)
EPZ: 103562657(PLK1)
EAI: 106845827(PLK1)
MYB: 102260682(PLK1)
MYD: 102758132(PLK1)
HAI: 109386529(PLK1)
RSS: 109457357(PLK1)
PALE: 102895334(PLK1)
LAV: 100675411(PLK1)
TMU: 101355942
MDO: 100027403(PLK1)
SHR: 100930498(PLK1)
OAA: 100073533(PLK1)
GGA: 416575(PLK1)
MGP: 100539569(PLK1)
CJO: 107320693(PLK1)
APLA: 101800116(PLK1)
ACYG: 106046017(PLK1)
TGU: 100221581(PLK1)
GFR: 102042745(PLK1)
FAB: 101821878(PLK1)
PHI: 102106048(PLK1)
PMAJ: 107210991(PLK1)
CCW: 104684984(PLK1)
FPG: 101921429(PLK1)
FCH: 102046673(PLK1)
CLV: 102089372(PLK1)
EGZ: 104134547(PLK1)
AAM: 106486200(PLK1)
ASN: 102370156(PLK1)
AMJ: 102561861(PLK1)
PSS: 102446825(PLK1)
CMY: 102931153(PLK1)
CPIC: 101943364(PLK1)
ACS: 100558384(plk1)
PVT: 110084996(PLK1)
PBI: 103059922(PLK1)
GJA: 107126199(PLK1)
XLA: 108701628(plk1.L) 380481(plk1.S)
XTR: 407937(plk1)
NPR: 108790758(PLK1)
DRE: 280649(plk1)
SRX: 107722962 107725406(plk1)
SANH: 107692656(plk1) 107702528
SGH: 107564476(plk1) 107590713
IPU: 108258666(plk1)
AMEX: 103034005(plk1)
TRU: 101072492(plk1)
LCO: 104921165(plk1)
NCC: 104943728(plk1)
MZE: 101467664(plk1)
OLA: 101170155(plk1)
XMA: 102218913(plk1)
PRET: 103462043(plk1)
NFU: 107389935(plk1)
CSEM: 103383451(plk1)
LCF: 108894767(plk1)
HCQ: 109511272(plk1)
BPEC: 110153514(plk1)
ELS: 105029645(plk1)
LCM: 102348600(PLK1)
CMK: 103186623(plk1)
CIN: 100177145
SPU: 579629
APLC: 110981126
SKO: 100375057(PLK1)
DME: Dmel_CG12306(polo)
DSI: Dsimw501_GD14871(Dsim_GD14871)
MDE: 101895764
AAG: 5577816
AME: 413261(polo)
BIM: 100745573
BTER: 100645092
AEC: 105153306
PBAR: 105426410
HST: 105182847
CFO: 105249967
LHU: 105676765
PGC: 109855515
NVI: 100120719(NV_30481)
TCA: 660822(polo)
DPA: 109536032
NVL: 108567985
BMOR: 101740671(PLK1)
PMAC: 106712452
PRAP: 110997850
DNX: 107164321
ZNE: 110839445
TUT: 107366765
CEL: CELE_C14B9.4(plk-1) CELE_F55G1.8(plk-3) CELE_Y71F9B.7(plk-2)
CBR: CBG04120(Cbr-plk-2) CBG09233(Cbr-plk-1)
TSP: Tsp_02561
CRG: 105341494
MYI: 110442904
LAK: 106169017
SHX: MS3_06674
AQU: 100641743
CNE: CNK02500
CNB: CNBK1050
MGL: MGL_2936
DDI: DDB_G0274503(plk)
DFA: DFA_03393(plk)
EHI: EHI_008410(114.t00009)
SMIN: v1.2.013953.t1(symbB.v1.2.013953.t1)
SPAR: SPRG_00035
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
McMillin DW, Delmore J, Negri J, Ooi M, Klippel S, Miduturu CV, Gray NS, Richardson PG, Anderson KC, Kung AL, Mitsiades CS
  Title
Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.
  Journal
PLoS One 6:e20226 (2011)
DOI:10.1371/journal.pone.0020226
  Sequence
[hsa:5347]
Reference
  Authors
Lee K, Rhee K
  Title
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
  Journal
J Cell Biol 195:1093-101 (2011)
DOI:10.1083/jcb.201106093
  Sequence
[hsa:5347]
Reference
  Authors
Chase D, Serafinas C, Ashcroft N, Kosinski M, Longo D, Ferris DK, Golden A
  Title
The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.
  Journal
  Sequence

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