KEGG ORTHOLOGY: K06643

ORTHOLOGY: K06643

Entry

K06643                      KO

Symbol

MDM2

Name

E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]

Pathway

map01522

Endocrine resistance

map01524

Platinum drug resistance

map04068

FoxO signaling pathway

map04110

Cell cycle

map04115

p53 signaling pathway

map04120

Ubiquitin mediated proteolysis

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04218

Cellular senescence

map04625

C-type lectin receptor signaling pathway

map04919

Thyroid hormone signaling pathway

map05131

Shigellosis

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05203

Viral carcinogenesis

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05219

Bladder cancer

map05220

Chronic myeloid leukemia

Disease

H00025

Penile cancer

H00028

Choriocarcinoma

H00036

Osteosarcoma

H00037

Rhabdomyosarcoma

H00042

Glioma

H01513

Retinoblastoma

H01667

Medulloblastoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04151 PI3K-Akt signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09143 Cell growth and death
   04110 Cell cycle
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04115 p53 signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04218 Cellular senescence
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05202 Transcriptional misregulation in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05206 MicroRNAs in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05205 Proteoglycans in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05203 Viral carcinogenesis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09162 Cancer: specific types
   05214 Glioma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05220 Chronic myeloid leukemia
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05218 Melanoma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05219 Bladder cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05215 Prostate cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05169 Epstein-Barr virus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05165 Human papillomavirus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   01522 Endocrine resistance
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04121 Ubiquitin system
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   MDM2/MDM4 proteins
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2

Genes

HSA:	4193(MDM2)

PTR:	742141(MDM2)

PPS:	100968756(MDM2)

GGO:	101129964(MDM2)

PON:	100171532(MDM2)

NLE:	100601465(MDM2)

HMH:	116478988(MDM2)

MCC:	718284(MDM2)

MCF:	102136323(MDM2)

MTHB:

126931704

MNI:	105473404(MDM2)

CSAB:

103238687(MDM2)

CATY:

105600499(MDM2)

PANU:

101016712(MDM2)

TGE:	112634274(MDM2)

MLEU:

105537114(MDM2)

RRO:	104658667(MDM2)

RBB:	108532254(MDM2) 108535938

TFN:	117089769(MDM2)

PTEH:

111528609(MDM2)

CANG:

105502659(MDM2)

CJC:	100396301 100415620

SBQ:	101036938(MDM2)

CIMI:

108300229(MDM2)

CSYR:

103250373

MMUR:

105884627

LCAT:

123627975 123639534(MDM2)

PCOQ:

105812777

OGA:	100947328 100953808 100961605 111727809

MMU:	17246(Mdm2)

MCAL:

110303712(Mdm2)

MPAH:

110326473(Mdm2)

RNO:	314856(Mdm2)

MCOC:

116075923(Mdm2)

ANU:	117696339(Mdm2)

MUN:	110562241(Mdm2)

CGE:	100770120(Mdm2)

MAUA:

101833011(Mdm2) 121134106

PROB:

127215724(Mdm2)

PLEU:

114693314(Mdm2)

MORG:

121460179(Mdm2)

MFOT:

126515657

AAMP:

119803501(Mdm2)

NGI:	103745079(Mdm2)

HGL:	101724821(Mdm2)

CPOC:

100724684(Mdm2)

CCAN:

109693333(Mdm2)

DORD:

105990389(Mdm2)

DSP:	122124078(Mdm2)

PLOP:

125361439(Mdm2)

NCAR:

124971738 124983594

MMMA:

107139728(Mdm2) 107153032 107158442

OPI:	101519018(MDM2) 101533416

TUP:	102473924(MDM2)

GVR:	103601365(MDM2)

CFA:	403693(MDM2)

CLUD:

112677878(MDM2)

VVP:	112922285(MDM2)

VLG:	121491185(MDM2)

NPO:	129511628(MDM2)

AML:	100479481(MDM2)

UMR:	103656869(MDM2)

UAH:	113256295(MDM2)

UAR:	123787146(MDM2)

ELK:

111142120

LLV:

125107551

MPUF:

101689782(MDM2)

MNP:	132019435(MDM2)

MLK:	131839136(MDM2)

NVS:	122892405(MDM2)

ORO:	101385402(MDM2)

EJU:	114214910(MDM2)

ZCA:	113921844(MDM2)

MLX:	118008591(MDM2)

NSU:	110570608(MDM2)

LWW:	102730468(MDM2)

FCA:	493939(MDM2)

PYU:	121040772(MDM2)

PCOO:

112863934(MDM2)

PBG:	122474007(MDM2)

PVIV:

125170075(MDM2)

LRUF:

124501378

PTG:	102965880(MDM2)

PPAD:

109270482(MDM2)

PUC:

125919324

AJU:

106966348

HHV:	120234269 120240795(MDM2)

BTA:	540378(MDM2)

BOM:	102287490(MDM2)

BIU:	109558399(MDM2)

BBUB:

102401535(MDM2)

BBIS:

104989769(MDM2)

CHX:	102173163(MDM2)

OAS:	101103187 101104979(MDM2)

BTAX:

128047314(MDM2)

ODA:	120857720(MDM2)

CCAD:

122427080

MBEZ:

129535751(MDM2)

SSC:	100125959(MDM2)

CFR:	102522420(MDM2)

CBAI:

105081337(MDM2)

CDK:	105101086(MDM2)

VPC:	102536736(MDM2)

BACU:

103017808(MDM2)

BMUS:

118901737(MDM2)

LVE:	103081431(MDM2)

OOR:	101286234(MDM2)

DLE:	111173763(MDM2)

PCAD:

102980125(MDM2)

PSIU:

116760130(MDM2)

NASI:

112394100(MDM2)

ECB:	100052084(MDM2)

EPZ:	103558340(MDM2)

EAI:	106843578(MDM2)

MYB:	102256024(MDM2)

MYD:	102771162(MDM2)

MMYO:

118650326(MDM2)

MLF:	102416898(MDM2)

PKL:	118729242(MDM2)

EFUS:

103292522(MDM2)

MNA:	107526860(MDM2)

DRO:	112319061(MDM2)

SHON:

118989366(MDM2)

AJM:	119052717(MDM2)

PDIC:

114513642(MDM2)

PHAS:

123813040(MDM2)

MMF:	118623649(MDM2)

PPAM:

129075868(MDM2)

HAI:	109381699(MDM2)

RFQ:	117029053(MDM2) 117033422

PALE:

102884281(MDM2)

PGIG:

120605043(MDM2)

PVP:	105301329(MDM2)

RAY:	107512674(MDM2)

MJV:	108394490(MDM2)

TOD:	119247528(MDM2)

SARA:

101546351(MDM2)

LAV:	100669448(MDM2)

TMU:

101349408

ETF:	101658440(MDM2)

DNM:	101418463(MDM2)

MDO:	100021398(MDM2) 103092862

GAS:	123248749(MDM2) 123251829

SHR:	100919874(MDM2) 100920321

AFZ:	127538796 127564477

PCW:	110211045(MDM2)

OAA:	100080712(MDM2)

GGA:	395609(MDM2)

PCOC:

116226594(MDM2)

MGP:	100546889(MDM2)

CJO:	107310502(MDM2)

TPAI:

128073880(MDM2)

LMUT:

125688066(MDM2)

NMEL:

110392787(MDM2)

APLA:

101805150(MDM2)

ACYG:

106046963(MDM2)

CATA:

118246834(MDM2)

AFUL:

116486905(MDM2)

TGU:	100228592(MDM2)

LSR:	110477995(MDM2)

SCAN:

103813452(MDM2)

PMOA:

120499767(MDM2)

OTC:	121339429(MDM2)

PRUF:

121352484(MDM2)

GFR:	102041787(MDM2)

FAB:	101813089(MDM2)

OMA:	130248662(MDM2)

PHI:	102099986(MDM2)

PMAJ:

107204718(MDM2)

CCAE:

111932718(MDM2)

CCW:	104698375(MDM2)

CBRC:

103614817

ETL:	114062165(MDM2)

ZAB:	102063986(MDM2)

ACHL:

103799310(MDM2)

SVG:	106855290(MDM2)

MMEA:

130580165(MDM2)

HRT:	120751367(MDM2)

FPG:	101924125(MDM2)

FCH:	102048171(MDM2)

CLV:	102085264(MDM2)

EGZ:	104132910(MDM2)

NNI:	104011004(MDM2)

PCRI:

104032001(MDM2)

PLET:

104625310(MDM2)

EHS:	104515219(MDM2)

PCAO:

104047943(MDM2)

ACUN:

113490049(MDM2)

TALA:

104361188(MDM2)

PADL:

103919957(MDM2)

AFOR:

103893925(MDM2)

ACHC:

115336119(MDM2)

HALD:

104318061(MDM2)

HLE:	104828224(MDM2)

AGEN:

126034595

GCL:

127023957

CCRI:

104168815(MDM2)

CSTI:

104558169(MDM2)

CMAC:

104483894(MDM2)

MUI:	104538985(MDM2)

BREG:

104632748(MDM2)

FGA:	104074510(MDM2)

GSTE:

104264416(MDM2)

LDI:	104344817(MDM2)

MNB:	103769978(MDM2)

OHA:	104326766(MDM2)

NNT:	104410537(MDM2)

SHAB:

115605367(MDM2)

DPUB:

104305541(MDM2)

PGUU:

104471927(MDM2)

ACAR:

104531859(MDM2)

CPEA:

104388814(MDM2)

AVIT:

104274690(MDM2)

CVF:	104288920(MDM2)

RTD:	128907953(MDM2)

CUCA:

104061323(MDM2)

TEO:	104380288(MDM2)

BRHI:

104493672(MDM2)

AAM:	106488755(MDM2)

AROW:

112970418(MDM2)

NPD:	112958826(MDM2)

TGT:	104574440(MDM2)

DNE:	112983298(MDM2)

SCAM:

104142045(MDM2)

ASN:	102385768(MDM2)

AMJ:	102561091(MDM2)

CPOO:

109315513(MDM2)

GGN:	109295715(MDM2)

PSS:	102447336(MDM2)

CMY:	102948375(MDM2)

CCAY:

125630218(MDM2)

DCC:	119845581(MDM2)

CPIC:

101936483(MDM2)

TST:	117877699(MDM2)

CABI:

116834452(MDM2)

MRV:	120383248(MDM2)

ACS:	100556723(mdm2)

ASAO:

132776175(MDM2)

PVT:	110075109(MDM2)

SUND:

121930774(MDM2)

PBI:	103063483(MDM2)

PMUR:

107284408(MDM2)

CTIG:

120308446(MDM2)

TSR:	106538064(MDM2)

PGUT:

117655615(MDM2)

APRI:

131201822(MDM2)

PTEX:

113435777(MDM2)

NSS:	113412263(MDM2)

VKO:	123033307(MDM2)

PMUA:

114605045(MDM2)

PRAF:

128422095(MDM2)

ZVI:	118090967(MDM2)

HCG:	128327319(MDM2)

GJA:	107105724(MDM2)

STOW:

125434825(MDM2)

EMC:	129335652(MDM2)

XLA:	108711092(mdm2.L) 108713153

XTR:	394853(mdm2)

NPR:	108804551(MDM2)

RTEM:

120931987(MDM2)

BBUF:

120980585(MDM2) 120982885

BGAR:

122922542 122923180 122923379 122924048 122928010(MDM2)

MUO:	115478174(MDM2)

GSH:	117363603(MDM2)

DRE:	30637(mdm2)

SRX:	107710681 107737846

SANH:

107692244 107694202

SGH:	107556775 107590969

CCAR:

109050259 109110269

CAUA:

113048224 113061966

CGIB:

127956464 127972941

PTET:

122342773(mdm2)

LROH:

127164122(mdm2)

OMC:	131539470(mdm2)

PPRM:

120476934(mdm2)

RKG:	130082677(mdm2)

MAMB:

125244871(mdm2)

CIDE:

127510532

MASI:

127435413 127436816

TROS:

130548220(mdm2)

TDW:	130421094(mdm2)

MANU:

129431747(mdm2)

IPU:

108279728

PHYP:

113523888(mdm2) 113525266

SMEO:

124401540(mdm2)

TFD:	113655477(mdm2)

TVC:	132859406(mdm2)

AMEX:

103039064(mdm2)

CMAO:

118812327(mdm2)

EEE:	113569662(mdm2)

CHAR:

105892474(mdm2)

TRU:	101068181(mdm2)

TFS:	130518976(mdm2)

TNG:	GSTEN00035854G001

LCO:

104927096

NCC:

104955413

TBEN:

117469438(mdm2) 117471004 117472282

PGEO:

117439283(mdm2)

GACU:

117557577(mdm2)

EMAC:

134879171(mdm2)

ELY:	117249355(mdm2)

EFO:	125882633(mdm2)

PLEP:

121961511(mdm2)

SLUC:

116047922(mdm2)

ECRA:

117938488(mdm2)

ESP:

116673210

PFLV:

114550246(mdm2)

GAT:	120816876(mdm2)

PPUG:

119211374(mdm2)

AFB:	129112433(mdm2)

CLUM:

117726546(mdm2)

PSWI:

130200788(mdm2)

MSAM:

119894985(mdm2)

SCHU:

122871542(mdm2)

CUD:	121505336(mdm2)

ALAT:

119032385(mdm2)

MZE:	101466094(mdm2)

ONL:	100697160(mdm2)

OAU:	116336464(mdm2)

OLA:	101174634(mdm2)

OML:	112154812(mdm2)

CSAI:

133424218(mdm2)

XMA:	102234130(mdm2)

XCO:	114160947(mdm2)

XHE:	116736905(mdm2)

PRET:

103459095(mdm2)

PFOR:

103154036(mdm2)

PLAI:

106953103(mdm2)

PMEI:

106922714(mdm2)

GAF:	122826435(mdm2)

PPRL:

129351899(mdm2)

CVG:	107090500(mdm2)

CTUL:

119771299(mdm2)

GMU:	124883299(mdm2)

NFU:	107387038(mdm2)

KMR:	108249644(mdm2)

ALIM:

106535795(mdm2)

NWH:	119428312(mdm2)

AOCE:

111586407

MCEP:

124999996(mdm2)

CSEM:

103382446(mdm2)

POV:	109643735(mdm2)

SSEN:

122766520(mdm2)

HHIP:

117757032(mdm2)

HSP:	118101287(mdm2)

SMAU:

118289952(mdm2)

LCF:

108895890

SDU:	111224985(mdm2)

SLAL:

111657669(mdm2)

XGL:	120801175(mdm2)

HCQ:	109532684(mdm2)

SSCV:

125991961

SBIA:

133493987(mdm2)

PEE:	133397344(mdm2)

PTAO:

133471632(mdm2)

BPEC:

110161709(mdm2)

MALB:

109967598(mdm2)

BSPL:

114861484(mdm2)

SJO:	128385133(mdm2)

SASA:

106593772 106594600(mdm2) 106597239 106597260 106597420 106597562 106597585 106597621 106597741 106597762 106609861

STRU:

115182075 115182930

OTW:	112262208(mdm2)

OMY:	110514334 110516940

OGO:	124018750 124018751

OKI:	109885926 109885927

OKE:	118381249(mdm2) 118381606

SALP:

112078930(mdm2)

SNH:	120050142(mdm2)

CCLU:

121553870 121555414 121559174 121559813 121561241

ELS:	105017801(mdm2)

SFM:	108936337(mdm2)

PKI:	111851197(mdm2)

AANG:

118219035(mdm2)

LOC:	102692011(mdm2)

PSPA:

121317976 121320080

ARUT:

117415877 117416320 117419350

PSEX:

120539581(mdm2)

LCM:	102353921(MDM2)

CMK:	103185308(mdm2)

CPLA:

122559328(mdm2)

HOC:	132824843(mdm2)

LERI:

129706415(mdm2)

BFO:

CIN:

SCLV:

SPU:

AAG:

AALB:

CNS:

BCOO:

TCA:

CSET:

NVL:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209973

BANY:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

HAW:	110372415 135117160

HZE:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

DCI:

NLU:

PHU:	Phum_PHUM209440

FOC:

TPAL:

ZNE:

CSEC:

IEL:

DPX:	DAPPUDRAFT_252193

DMK:

PVM:

PJA:

PCHN:

HAME:

PCLA:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

UDV:

SDM:

LGI:	LOTGIDRAFT_232765

PCAN:

112565919

BGT:

106077134

CVN:	111104196 111105462

DPOL:

OSN:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_54791

» show all

Reference

PMID:11351297

Authors

Tamborini E, Della Torre G, Lavarino C, Azzarelli A, Carpinelli P, Pierotti MA, Pilotti S

Title

Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas.

Journal

Int J Cancer 92:790-6 (2001)
DOI:10.1002/ijc.1271

Sequence

[hsa:4193]

Reference

PMID:19965871

Authors

Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K

Title

ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.

Journal

J Biol Chem 285:4909-19 (2010)
DOI:10.1074/jbc.M109.042341

Reference

PMID:1614537

Authors

Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B

Title

Amplification of a gene encoding a p53-associated protein in human sarcomas.

Journal

Nature 358:80-3 (1992)
DOI:10.1038/358080a0

Sequence

[hsa:4193]

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