KEGG   ORTHOLOGY: K07187Help
Entry
K07187                      KO                                     

Name
IRS2
Definition
insulin receptor substrate 2
Pathway
ko04022  cGMP-PKG signaling pathway
ko04068  FoxO signaling pathway
ko04140  Autophagy - animal
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04022 cGMP - PKG signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04152 AMPK signaling pathway
    K07187  IRS2; insulin receptor substrate 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07187  IRS2; insulin receptor substrate 2
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04923 Regulation of lipolysis in adipocyte
    K07187  IRS2; insulin receptor substrate 2
   04920 Adipocytokine signaling pathway
    K07187  IRS2; insulin receptor substrate 2
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K07187  IRS2; insulin receptor substrate 2
   04213 Longevity regulating pathway - multiple species
    K07187  IRS2; insulin receptor substrate 2
 09160 Human Diseases
  09161 Cancers
   05206 MicroRNAs in cancer
    K07187  IRS2; insulin receptor substrate 2
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07187  IRS2; insulin receptor substrate 2
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07187  IRS2; insulin receptor substrate 2
   04931 Insulin resistance
    K07187  IRS2; insulin receptor substrate 2
BRITE hierarchy
Genes
HSA: 8660(IRS2)
PTR: 452657(IRS2)
PPS: 100982406(IRS2)
GGO: 101127585(IRS2)
PON: 100452233(IRS2)
NLE: 100583956(IRS2)
MCC: 698536(IRS2)
MCF: 102122241(IRS2)
CSAB: 103214788(IRS2)
RRO: 104679253(IRS2)
RBB: 108526085 108527055(IRS2)
CJC: 100404822(IRS2)
SBQ: 101038649(IRS2)
MMU: 384783(Irs2)
RNO: 29376(Irs2)
CGE: 100771848(Irs2)
NGI: 103751690(Irs2)
HGL: 101719081(Irs2)
CCAN: 109700963(Irs2)
OCU: 103349114(IRS2)
TUP: 102497747(IRS2) 106733861
CFA: 485548(IRS2)
AML: 100477685(IRS2)
UMR: 103657626(IRS2)
ORO: 101381397(IRS2)
FCA: 101095791(IRS2)
BTA: 100300012(IRS2)
BIU: 109567100(IRS2)
CHX: 108637286(IRS2)
OAS: 106991367(IRS2)
SSC: 110255858(IRS2)
CFR: 106731127(IRS2)
CDK: 105094106(IRS2)
BACU: 103005810(IRS2)
LVE: 103088704(IRS2)
OOR: 101276950(IRS2)
ECB: 100146249(IRS2)
EPZ: 103540833
EAI: 106838201(IRS2)
MYB: 102249810(IRS2)
MYD: 102753060(IRS2)
HAI: 109383948(IRS2)
RSS: 109447072(IRS2)
PALE: 102898575(IRS2)
LAV: 100676904(IRS2)
TMU: 101345051
MDO: 100023831(IRS2) 100025395(IRS4)
SHR: 100924829(IRS2) 100931354(IRS4)
GGA: 101749060(IRS2) 422347(IRS4)
MGP: 100540702(IRS4) 100548754(IRS2)
CJO: 107307936(IRS2) 107312783(IRS4)
APLA: 101801905(IRS4) 101804723(IRS2)
ACYG: 106038523(IRS4) 106044455(IRS2)
TGU: 100220894(IRS2) 100223674(IRS4)
GFR: 102041556(IRS4) 102044059(IRS2)
FAB: 101807499(IRS4) 101814066(IRS2)
PHI: 102103569(IRS4) 102111858(IRS2)
PMAJ: 107203717(IRS4) 107208306(IRS2)
CCW: 104686328(IRS2) 104694453(IRS4)
FPG: 101918515(IRS4) 101924402(IRS2)
FCH: 102046894(IRS2) 102052095(IRS4)
CLV: 102089452(IRS2) 102090441
EGZ: 104133285(IRS4)
ASN: 102374791(IRS2) 102382907(IRS4)
AMJ: 102558545(IRS4) 102565350(IRS2)
PSS: 102457842(IRS4) 106731934
CMY: 102934421(IRS2)
CPIC: 101945214(IRS2) 101951320(IRS4)
ACS: 100555020(irs4) 103279765(irs2)
PVT: 110074287(IRS4) 110090941(IRS2)
PBI: 103051591(IRS2) 103052062
GJA: 107114014(IRS4) 107120743
XLA: 108708462 108709741 399388(irs4.S) 495836(irs4.L)
XTR: 100196925(irs4) 100498409(irs2)
NPR: 108787450(IRS2) 108788816
DRE: 100329897(irs4a) 393285(irs2a) 572001(irs2b) 794462
LCM: 102364884(IRS2) 102366705(IRS4)
CMK: 103178654(irs2) 103179604
LAK: 106181472
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G
  Title
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
  Journal
Diabetes Metab Res Rev 16:434-41 (2000)
DOI:10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8
Reference
  Authors
Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, Nakaya K, Noda M, Ueki K, Kadowaki T
  Title
Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.
  Journal
Diabetes 64:876-86 (2015)
DOI:10.2337/db14-0432
  Sequence
[mmu:384783]

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