KEGG   ORTHOLOGY: K07207Help
Entry
K07207                      KO                                     

Name
TSC2
Definition
tuberous sclerosis 2
Pathway
ko04072  Phospholipase D signaling pathway
ko04115  p53 signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05231  Choline metabolism in cancer
Disease
H00896  Lymphangioleiomyomatosis
H00915  Tuberous sclerosis complex
H01691  Renal angiomyolipoma
H01692  Subependymal giant cell astrocytoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04151 PI3K-Akt signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04152 AMPK signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04150 mTOR signaling pathway
    K07207  TSC2; tuberous sclerosis 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07207  TSC2; tuberous sclerosis 2
  09143 Cell growth and death
   04115 p53 signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04218 Cellular senescence
    K07207  TSC2; tuberous sclerosis 2
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04919 Thyroid hormone signaling pathway
    K07207  TSC2; tuberous sclerosis 2
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K07207  TSC2; tuberous sclerosis 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K07207  TSC2; tuberous sclerosis 2
 09160 Human Diseases
  09161 Cancers
   05231 Choline metabolism in cancer
    K07207  TSC2; tuberous sclerosis 2
  09167 Infectious diseases
   05163 Human cytomegalovirus infection
    K07207  TSC2; tuberous sclerosis 2
   05165 Human papillomavirus infection
    K07207  TSC2; tuberous sclerosis 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins
    K07207  TSC2; tuberous sclerosis 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K07207  TSC2; tuberous sclerosis 2
BRITE hierarchy
Genes
HSA: 7249(TSC2)
PTR: 468086(TSC2)
PPS: 100971050(TSC2)
GGO: 101137934(TSC2)
PON: 100441126(TSC2)
NLE: 100604902(TSC2)
MCC: 694965(TSC2)
MCF: 102140628(TSC2)
CSAB: 103226584(TSC2)
RRO: 104681538(TSC2)
RBB: 108519399(TSC2)
CJC: 100390664(TSC2)
SBQ: 101031475(TSC2)
MMU: 22084(Tsc2)
RNO: 24855(Tsc2)
CGE: 100755849(Tsc2)
NGI: 103752451(Tsc2)
HGL: 101713968(Tsc2)
CCAN: 109690162(Tsc2)
OCU: 100351640(TSC2)
TUP: 102484276(TSC2)
CFA: 479883(TSC2)
AML: 100465690(TSC2)
UMR: 103668779(TSC2)
ORO: 101371494(TSC2)
FCA: 101082969(TSC2)
PTG: 102956176(TSC2)
AJU: 106982748(TSC2)
BTA: 504985(TSC2)
BOM: 102267343(TSC2)
BIU: 109578279(TSC2)
PHD: 102335737(TSC2)
CHX: 100860943(TSC2)
OAS: 101115088(TSC2)
SSC: 100505408(TSC2)
CFR: 102523349(TSC2)
CDK: 105099714(TSC2)
BACU: 103008177(TSC2)
LVE: 103075350(TSC2)
OOR: 101276336(TSC2)
ECB: 100065679(TSC2)
EPZ: 103566788(TSC2)
EAI: 106836234(TSC2)
MYB: 102253389(TSC2)
MYD: 102770093(TSC2)
HAI: 109385868(TSC2)
RSS: 109435319(TSC2)
PALE: 102898762(TSC2)
LAV: 100670924(TSC2)
TMU: 101358131
MDO: 100011431(TSC2)
SHR: 100918445(TSC2)
OAA: 100086661(TSC2)
GGA: 416552(TSC2)
MGP: 100542960(TSC2)
CJO: 107320601(TSC2)
APLA: 101804966(TSC2)
ACYG: 106032149(TSC2)
TGU: 100222231(TSC2)
GFR: 102039715(TSC2)
FAB: 101818727(TSC2)
PHI: 102110699(TSC2)
PMAJ: 107211281(TSC2)
CCW: 104684745(TSC2)
FPG: 101919684(TSC2)
FCH: 102055452(TSC2)
CLV: 102098310(TSC2)
EGZ: 104127720(TSC2)
AAM: 106492227(TSC2)
ASN: 102387523(TSC2)
AMJ: 102558178(TSC2)
PSS: 102448020(TSC2)
CMY: 102946461(TSC2)
CPIC: 101934665(TSC2)
ACS: 100552562(tsc2)
PVT: 110085051(TSC2)
PBI: 103048571(TSC2)
GJA: 107114161(TSC2)
XTR: 100170546(tsc2)
NPR: 108791228(TSC2)
DRE: 567524(tsc2)
IPU: 108258582(tsc2)
AMEX: 103033522(tsc2)
TRU: 101078033(tsc2)
LCO: 104927875(tsc2)
MZE: 101468908(tsc2)
OLA: 101168435(tsc2)
XMA: 102219500(tsc2)
PRET: 103465672(tsc2)
NFU: 107390291(tsc2)
CSEM: 103383928(tsc2)
LCF: 108875623(tsc2)
HCQ: 109527351(tsc2)
ELS: 105031540(tsc2)
SFM: 108939799(tsc2)
LCM: 102365821(TSC2)
CMK: 103189890(tsc2)
CIN: 100181176
SPU: 581860
APLC: 110986148
SKO: 100375549
DME: Dmel_CG6975(gig)
DSI: Dsimw501_GD14854(Dsim_GD14854)
MDE: 101900032
AAG: 5569538
AME: 412278(gig)
BIM: 100750180
SOC: 105202531
AEC: 105148228
ACEP: 105624503
PBAR: 105431653
HST: 105188190
CFO: 105251025
LHU: 105674388
PGC: 109853700
NVI: 100124180
TCA: 660002(TSC2)
DPA: 109536724
NVL: 108558123
BMOR: 101745506
PMAC: 106721369
PRAP: 111002360
PXY: 105387727
API: 100163135
DNX: 107162272
ZNE: 110832471
FCD: 110848171
DPX: DAPPUDRAFT_228923(TSC2)
TUT: 107368740
CRG: 105344173
OBI: 106867843
LAK: 106155018
EPA: 110239965
ADF: 107346885
HMG: 100197539
AQU: 100640651
DFA: DFA_11640
SPAR: SPRG_10646
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8269512
  Title
Identification and characterization of the tuberous sclerosis gene on chromosome 16.
  Journal
Cell 75:1305-15 (1993)
DOI:10.1016/0092-8674(93)90618-Z
  Sequence
[hsa:7249]
Reference
  Authors
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J
  Title
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
  Journal
Proc Natl Acad Sci U S A 99:13571-6 (2002)
DOI:10.1073/pnas.202476899
  Sequence
[hsa:7249]

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