KEGG   ORTHOLOGY: K07415
Entry
K07415                      KO                                     
Symbol
CYP2E1
Name
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03408  
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07046  
R07055  
R07056  
R07066  bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07068  bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07075  4-bromophenol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07088  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07089  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07090  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07107  trichloroethanol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07112  1,2-dibromoethane,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08303  
R08304  
R09421  
R11904  acetylhydrazine,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   04932 Non-alcoholic fatty liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Genes
HSA: 1571(CYP2E1)
PTR: 450857(CYP2E1)
PPS: 100981327(CYP2E1)
GGO: 101151246
PON: 100173813(CYP2E1)
NLE: 100594173
HMH: 116481584
MCC: 114669719 114669866 678688(CYP2E1)
MCF: 102136686
MTHB: 126963293 126963295
MNI: 105471354
CSAB: 103245979(CYP2E1)
MLEU: 105538035
RRO: 104680852
RBB: 108543398
TFN: 117082874
PTEH: 111522057
CANG: 105511789
CJC: 100397922(CYP2E1)
SBQ: 101046377
CIMI: 108297222(CYP2E1)
CSYR: 103265545
MMUR: 105861495
LCAT: 123649856
PCOQ: 105823486
OGA: 100958050
MMU: 13106(Cyp2e1)
MCAL: 110297258
MPAH: 110329381
RNO: 25086(Cyp2e1)
MCOC: 116103187
ANU: 117715822
MUN: 110540184
CGE: 100765891
MAUA: 101843716
PROB: 127228509
PLEU: 114693387
MORG: 121457665
MFOT: 126498260
AAMP: 119809971
NGI: 103725848
HGL: 101722366
CPOC: 100727914
CCAN: 109701182
NCAR: 124974930
MMMA: 107152888
OPI: 101532509
TUP: 102496668
GVR: 103609289
CFA: 415128(CYP2E1)
CLUD: 112672552
VVP: 112928781
VLG: 121485389
NPO: 129523248
AML: 100472056
UMR: 103658635
UAH: 113252104
UAR: 123800068
ELK: 111145414
LLV: 125085126
MPUF: 101673971
MNP: 132016915
MLK: 131830489
NVS: 122899062
ORO: 101365364
EJU: 114221828
ZCA: 113923429
MLX: 117998120
LWW: 102726765
FCA: 554227(CYP2E1)
PYU: 121037436
PCOO: 112854449
PBG: 122493427
PTG: 102969051
PPAD: 109256725
PUC: 125933090
AJU: 106987509
HHV: 120245389
BTA: 282213(CYP2E1)
BOM: 102281471
BIU: 109553162
BBUB: 102416619
BBIS: 104984098
CHX: 102182294
OAS: 100568285(CYP2E1)
BTAX: 128067945
ODA: 120873945
CCAD: 122446540
MBEZ: 129555934
SSC: 403216(CYP2E1)
CFR: 102510124
CBAI: 105067428
CDK: 105096474
VPC: 102526191
BACU: 102997947
LVE: 103086718
OOR: 101275906
DLE: 111172152
PCAD: 102993260
PSIU: 116741596
NASI: 112411197
ECB: 100066422(CYP2E1)
EPZ: 103556383
EAI: 106841091
MYB: 102260262
MYD: 102760593
MMYO: 118669676
MLF: 102427162
PKL: 118719546
EFUS: 103288678
HAI: 109383522
DRO: 112300228
AJM: 119059516
PDIC: 114497239
PHAS: 123828775
MMF: 118632687
RFQ: 117036334
PPAM: 129079804
TOD: 119234161
ETF: 101646741
DNM: 101420221
MDO: 100015828
GAS: 123236454
PCW: 110214053
OAA: 100092254
MMER: 123542169
 » show all
Reference
PMID:3782137
  Authors
Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ
  Title
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
  Journal
J Biol Chem 261:16689-97 (1986)
  Sequence
[hsa:1571]

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