KEGG ORTHOLOGY: K07439

ORTHOLOGY: K07439

Entry

K07439                      KO

Symbol

CYP39A1

Name

24-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.26]

Pathway

map00120

Primary bile acid biosynthesis

Reaction

R07208

(24S)-cholest-5-ene-3beta,24-diol,NADPH-hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K07439  CYP39A1; 24-hydroxycholesterol 7alpha-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07439  CYP39A1; 24-hydroxycholesterol 7alpha-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.26  24-hydroxycholesterol 7alpha-hydroxylase
     K07439  CYP39A1; 24-hydroxycholesterol 7alpha-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP39 family
   K07439  CYP39A1; 24-hydroxycholesterol 7alpha-hydroxylase

Other DBs

GO:

0033782

Genes

HSA:	51302(CYP39A1)

PTR:	462743(CYP39A1)

PPS:	100994949(CYP39A1)

GGO:

PON:

NLE:

HMH:

MCC:	704242(CYP39A1)

MCF:	102145162(CYP39A1)

MTHB:

126952680

MNI:

105490924

CSAB:

103221412(CYP39A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100414008(CYP39A1)

SBQ:

101047750

CIMI:

108286980(CYP39A1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	56050(Cyp39a1)

MCAL:

110283986

MPAH:

110336040

RNO:	301264(Cyp39a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	481825(CYP39A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101100564(CYP39A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	511195(CYP39A1)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	100113410(CYP39A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

TOD:

SARA:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	422058(CYP39A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102560263(CYP39A1)

CPOO:

109311477

GGN:

109300287

PSS:	102457950 102458362

CMY:	102943639 102943860

CCAY:

125634650 125634653

DCC:	119852483 122459199

CPIC:

101934897 101942552

TST:	117875371 117875539

CABI:

116823201 116823202

MRV:	120400208 120401078

ACS:

ASAO:

PVT:

SUND:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

EMC:

XLA:	733346(cyp39a1.L)

XTR:	100486848(cyp39a1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

DRE:	564475(cyp39a1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

AMEX:

EEE:

CHAR:

SASA:

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:

OKE:

SALP:

SNH:

CCLU:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

CPLA:

HOC:

LERI:

BFO:

BBEL:

AJC:

PVUL:

BGT:

GAE:

HRF:

HRJ:	124276705 124282671

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

Reference

PMID:10748047

Authors

Li-Hawkins J, Lund EG, Bronson AD, Russell DW

Title

Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.

Journal

J Biol Chem 275:16543-9 (2000)
DOI:10.1074/jbc.M001810200

Sequence

[mmu:56050] [hsa:51302]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (529)   
   KEGG GENES (331)   
   KEGG MGENES (113)   
   RefGene (82)   
   OC (3)   
Literature (1)   
   PubMed (1)   
All databases (539)   

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