KEGG   ORTHOLOGY: K07827Help
Entry
K07827                      KO                                     

Name
KRAS, KRAS2
Definition
GTPase KRas
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04137  Mitophagy - animal
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04214  Apoptosis - fly
ko04218  Cellular senescence
ko04320  Dorso-ventral axis formation
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04960  Aldosterone-regulated sodium reabsorption
ko05034  Alcoholism
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00003  Acute myeloid leukemia (AML)
H00010  Multiple myeloma
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00030  Cervical cancer
H00032  Thyroid cancer
H00040  Squamous cell carcinoma
H00041  Kaposi sarcoma
H00046  Cholangiocarcinoma
H00047  Gallbladder cancer
H00458  Syndromic craniosynostoses
H00523  Noonan syndrome and related disorders
H01557  Hepatic angiosarcoma
H01592  Medullary thyroid cancer
H01666  Angiosarcoma
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04015 Rap1 signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04010 MAPK signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04013 MAPK signaling pathway - fly
    K07827  KRAS, KRAS2; GTPase KRas
   04012 ErbB signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04370 VEGF signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04371 Apelin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04068 FoxO signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04072 Phospholipase D signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04071 Sphingolipid signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04151 PI3K-Akt signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04150 mTOR signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07827  KRAS, KRAS2; GTPase KRas
   04138 Autophagy - yeast
    K07827  KRAS, KRAS2; GTPase KRas
   04137 Mitophagy - animal
    K07827  KRAS, KRAS2; GTPase KRas
  09143 Cell growth and death
   04210 Apoptosis
    K07827  KRAS, KRAS2; GTPase KRas
   04214 Apoptosis - fly
    K07827  KRAS, KRAS2; GTPase KRas
   04218 Cellular senescence
    K07827  KRAS, KRAS2; GTPase KRas
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K07827  KRAS, KRAS2; GTPase KRas
   04550 Signaling pathways regulating pluripotency of stem cells
    K07827  KRAS, KRAS2; GTPase KRas
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K07827  KRAS, KRAS2; GTPase KRas
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04650 Natural killer cell mediated cytotoxicity
    K07827  KRAS, KRAS2; GTPase KRas
   04660 T cell receptor signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04662 B cell receptor signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04664 Fc epsilon RI signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04062 Chemokine signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04912 GnRH signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04915 Estrogen signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04914 Progesterone-mediated oocyte maturation
    K07827  KRAS, KRAS2; GTPase KRas
   04917 Prolactin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04921 Oxytocin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04926 Relaxin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04919 Thyroid hormone signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
   04916 Melanogenesis
    K07827  KRAS, KRAS2; GTPase KRas
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K07827  KRAS, KRAS2; GTPase KRas
  09156 Nervous system
   04725 Cholinergic synapse
    K07827  KRAS, KRAS2; GTPase KRas
   04726 Serotonergic synapse
    K07827  KRAS, KRAS2; GTPase KRas
   04720 Long-term potentiation
    K07827  KRAS, KRAS2; GTPase KRas
   04730 Long-term depression
    K07827  KRAS, KRAS2; GTPase KRas
   04722 Neurotrophin signaling pathway
    K07827  KRAS, KRAS2; GTPase KRas
  09158 Development
   04320 Dorso-ventral axis formation
    K07827  KRAS, KRAS2; GTPase KRas
   04360 Axon guidance
    K07827  KRAS, KRAS2; GTPase KRas
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K07827  KRAS, KRAS2; GTPase KRas
   04213 Longevity regulating pathway - multiple species
    K07827  KRAS, KRAS2; GTPase KRas
  09159 Environmental adaptation
   04714 Thermogenesis
    K07827  KRAS, KRAS2; GTPase KRas
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05230 Central carbon metabolism in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05231 Choline metabolism in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05206 MicroRNAs in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05205 Proteoglycans in cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05203 Viral carcinogenesis
    K07827  KRAS, KRAS2; GTPase KRas
   05210 Colorectal cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05212 Pancreatic cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05225 Hepatocellular carcinoma
    K07827  KRAS, KRAS2; GTPase KRas
   05226 Gastric cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05214 Glioma
    K07827  KRAS, KRAS2; GTPase KRas
   05216 Thyroid cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05221 Acute myeloid leukemia
    K07827  KRAS, KRAS2; GTPase KRas
   05220 Chronic myeloid leukemia
    K07827  KRAS, KRAS2; GTPase KRas
   05218 Melanoma
    K07827  KRAS, KRAS2; GTPase KRas
   05211 Renal cell carcinoma
    K07827  KRAS, KRAS2; GTPase KRas
   05219 Bladder cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05215 Prostate cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05213 Endometrial cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05224 Breast cancer
    K07827  KRAS, KRAS2; GTPase KRas
   05223 Non-small cell lung cancer
    K07827  KRAS, KRAS2; GTPase KRas
  09164 Substance dependence
   05034 Alcoholism
    K07827  KRAS, KRAS2; GTPase KRas
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K07827  KRAS, KRAS2; GTPase KRas
  09167 Infectious diseases
   05166 HTLV-I infection
    K07827  KRAS, KRAS2; GTPase KRas
   05161 Hepatitis B
    K07827  KRAS, KRAS2; GTPase KRas
   05160 Hepatitis C
    K07827  KRAS, KRAS2; GTPase KRas
   05163 Human cytomegalovirus infection
    K07827  KRAS, KRAS2; GTPase KRas
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07827  KRAS, KRAS2; GTPase KRas
   05165 Human papillomavirus infection
    K07827  KRAS, KRAS2; GTPase KRas
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K07827  KRAS, KRAS2; GTPase KRas
   01522 Endocrine resistance
    K07827  KRAS, KRAS2; GTPase KRas
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07827  KRAS, KRAS2; GTPase KRas
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07827  KRAS, KRAS2; GTPase KRas
Membrane trafficking [BR:ko04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    K07827  KRAS, KRAS2; GTPase KRas
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    K07827  KRAS, KRAS2; GTPase KRas
BRITE hierarchy
Other DBs
COG: COG1100
Genes
HSA: 3845(KRAS)
PTR: 473387(KRAS)
PPS: 100990801(KRAS)
GGO: 101144039(KRAS)
PON: 100462513(KRAS)
NLE: 100593773(KRAS)
MCC: 707977(KRAS)
MCF: 102131483(KRAS)
CSAB: 103218763(KRAS)
RRO: 104670041(KRAS)
RBB: 108523748(KRAS)
SBQ: 101047035(KRAS)
MMU: 16653(Kras)
RNO: 24525(Kras)
NGI: 103736717(Kras)
HGL: 101718997(Kras)
CCAN: 109687060(Kras)
OCU: 100347487(KRAS)
TUP: 102500069(KRAS)
CFA: 403871(KRAS)
AML: 100483919(KRAS)
UMR: 103665244(KRAS)
ORO: 101370458(KRAS)
FCA: 751104(KRAS)
PTG: 102957350(KRAS)
AJU: 106968778(KRAS) 106987957(HRAS)
BTA: 541140(KRAS)
BOM: 102286500(KRAS)
BIU: 109559581(KRAS)
PHD: 102323857(KRAS)
CHX: 102172519(KRAS)
OAS: 101114005(KRAS)
SSC: 100518251(KRAS)
CFR: 102516372(KRAS)
CDK: 105100066(KRAS)
BACU: 103015457(KRAS)
LVE: 103077579(KRAS)
OOR: 101281897(KRAS)
ECB: 100051785 100064473(KRAS)
EPZ: 103546629(KRAS)
EAI: 106825548(KRAS)
MYB: 102244940(KRAS)
MYD: 102762284(KRAS)
HAI: 109389264(KRAS)
RSS: 109450433(KRAS)
PALE: 102895590(KRAS)
LAV: 100661512(KRAS)
TMU: 101347525
MDO: 554186(KRAS)
OAA: 100085430(KRAS)
GGA: 418207(KRAS)
MGP: 100151750(KRAS)
CJO: 107317023(KRAS)
APLA: 101793538(KRAS)
ACYG: 106038277(KRAS)
TGU: 100227892(KRAS)
GFR: 102035876(KRAS)
FAB: 101809651(KRAS)
PHI: 102112893(KRAS)
PMAJ: 107204562(KRAS)
CCW: 104696163(KRAS)
FPG: 101917762(KRAS)
FCH: 102052019(KRAS)
CLV: 102096076(KRAS)
EGZ: 104135137(KRAS)
AAM: 106488640(KRAS)
ASN: 102373235(KRAS) 102381265(RRAS)
AMJ: 102574430(KRAS) 102575936
PSS: 102447251 102450646(KRAS)
CMY: 102941364(KRAS) 102943017
CPIC: 101940651(KRAS) 101951310
ACS: 100559807 100563575(kras)
PVT: 110078528 110082993(KRAS)
PBI: 103056809 103057417(KRAS)
GJA: 107106941(KRAS) 107116614
XLA: 100505423 108697792 108712520 373672(kras.L) 397771(kras.S) 398036(ras) 399470(ralb)
XTR: 100485959 493396(kras)
NPR: 108797553(KRAS) 108803002
DRE: 393228(zgc:55558) 445289(kras)
IPU: 108258948(H-RAS) 108274959
TRU: 101069736 101077708(kras)
NCC: 104950842 104968078(kras)
MZE: 101465888(kras) 101485266
OLA: 100049322(kras) 101154954
XMA: 102232995 102233657(kras)
PRET: 103466102(kras) 103469088
NFU: 107376655 107388963(kras)
CSEM: 103380146(kras) 103392975
LCF: 108875379(kras) 108881007
HCQ: 109527013 109530437(kras)
BPEC: 110158202 110170289(kras)
ELS: 105022136(kras) 105029053
LCM: 102352473(KRAS) 102357700
CMK: 103188873(kras) 103190146
SPU: 578859
APLC: 110987479
SKO: 100376021
DME: Dmel_CG9375(Ras85D)
DSI: Dsimw501_GD20791(Dsim_Ras85D)
DVI: Dvir_GJ23844(Dvir_Ras1)
MDE: 101895899
AAG: 5575808
AME: 410812
BIM: 100748827
BTER: 100644593
SOC: 105204609
AEC: 105154073
ACEP: 105617956
PBAR: 105428488
CFO: 105259246
LHU: 105672246
PGC: 109860608
NVI: 100114262
TCA: 663464
DPA: 109539276
NVL: 108558053
BMOR: 692520(Ras1)
PMAC: 106714669
PRAP: 111003241
PXY: 105381032
API: 100159403
DNX: 107173957
FCD: 110852840
TUT: 107360380
CEL: CELE_ZK792.6(let-60)
CBR: CBG06092(Cbr-let-60)
BMY: Bm1_37960
TSP: Tsp_07908
CRG: 105342014
MYI: 110445501
OBI: 106872004
LAK: 106171253
SHX: MS3_04832
EPA: 110237381
HMG: 100209445(G-protein)
AQU: 100637745
SCE: YNL098C(RAS2) YOR101W(RAS1)
ERC: Ecym_5349
KMX: KLMA_80228(RAS2)
NCS: NCAS_0B06850(NCAS0B06850)
NDI: NDAI_0B04180(NDAI0B04180)
TPF: TPHA_0B03000(TPHA0B03000)
TBL: TBLA_0B01750(TBLA0B01750)
TDL: TDEL_0F01360(TDEL0F01360)
KAF: KAFR_0D02040(KAFR0D02040) KAFR_0J01970(KAFR0J01970)
SLB: AWJ20_3798(RAS2) AWJ20_4884(RAS1)
NCR: NCU03616(smco-7) NCU08823(bd)
NTE: NEUTE1DRAFT61565(NEUTE1DRAFT_61565)
SMP: SMAC_03107(putative ras2) SMAC_09275(putative ras1)
BFU: BCIN_04g03140(Bcras2) BCIN_12g05760(Bcras1)
ANG: ANI_1_306014(An01g02320) ANI_1_48044(An05g00370)
ZTR: MYCGRDRAFT_59862(MgRas1) MYCGRDRAFT_75299(MgRas2)
SPO: SPAC17H9.09c(ras1)
ABP: AGABI1DRAFT121109(AGABI1DRAFT_121109) AGABI1DRAFT81209(AGABI1DRAFT_81209)
ABV: AGABI2DRAFT133440(AGABI2DRAFT_133440) AGABI2DRAFT149467(AGABI2DRAFT_149467)
MGL: MGL_2669
DDI: DDB_G0293434(rasG)
DPP: DICPUDRAFT_92731(rasG)
EHI: EHI_124520 EHI_124610(42.t00004) EHI_137700(64.t00006)
EHX: EMIHUDRAFT_114652(Ras1-1) EMIHUDRAFT_419127(Ras1-2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H
  Title
Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling.
  Journal
Nature 497:638-42 (2013)
DOI:10.1038/nature12205
Reference
PMID:6474169
  Authors
Guerrero I, Villasante A, Corces V, Pellicer A
  Title
Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation.
  Journal
Science 225:1159-62 (1984)
DOI:10.1126/science.6474169
  Sequence
[mmu:16653]

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