KEGG   ORTHOLOGY: K08041Help
Entry
K08041                      KO                                     

Name
ADCY1
Definition
adenylate cyclase 1 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05142  Chagas disease (American trypanosomiasis)
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08041  ADCY1; adenylate cyclase 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04371 Apelin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04020 Calcium signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04072 Phospholipase D signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04024 cAMP signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04022 cGMP - PKG signaling pathway
    K08041  ADCY1; adenylate cyclase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08041  ADCY1; adenylate cyclase 1
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08041  ADCY1; adenylate cyclase 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08041  ADCY1; adenylate cyclase 1
   04062 Chemokine signaling pathway
    K08041  ADCY1; adenylate cyclase 1
  09152 Endocrine system
   04911 Insulin secretion
    K08041  ADCY1; adenylate cyclase 1
   04923 Regulation of lipolysis in adipocyte
    K08041  ADCY1; adenylate cyclase 1
   04912 GnRH signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04913 Ovarian Steroidogenesis
    K08041  ADCY1; adenylate cyclase 1
   04915 Estrogen signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04914 Progesterone-mediated oocyte maturation
    K08041  ADCY1; adenylate cyclase 1
   04921 Oxytocin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04926 Relaxin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04918 Thyroid hormone synthesis
    K08041  ADCY1; adenylate cyclase 1
   04928 Parathyroid hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04916 Melanogenesis
    K08041  ADCY1; adenylate cyclase 1
   04925 Aldosterone synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
   04927 Cortisol synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08041  ADCY1; adenylate cyclase 1
   04270 Vascular smooth muscle contraction
    K08041  ADCY1; adenylate cyclase 1
  09154 Digestive system
   04970 Salivary secretion
    K08041  ADCY1; adenylate cyclase 1
   04971 Gastric acid secretion
    K08041  ADCY1; adenylate cyclase 1
   04972 Pancreatic secretion
    K08041  ADCY1; adenylate cyclase 1
   04976 Bile secretion
    K08041  ADCY1; adenylate cyclase 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04727 GABAergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04725 Cholinergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04720 Long-term potentiation
    K08041  ADCY1; adenylate cyclase 1
   04723 Retrograde endocannabinoid signaling
    K08041  ADCY1; adenylate cyclase 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08041  ADCY1; adenylate cyclase 1
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08041  ADCY1; adenylate cyclase 1
   04213 Longevity regulating pathway - multiple species
    K08041  ADCY1; adenylate cyclase 1
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08041  ADCY1; adenylate cyclase 1
   04714 Thermogenesis
    K08041  ADCY1; adenylate cyclase 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08041  ADCY1; adenylate cyclase 1
  09164 Substance dependence
   05032 Morphine addiction
    K08041  ADCY1; adenylate cyclase 1
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08041  ADCY1; adenylate cyclase 1
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08041  ADCY1; adenylate cyclase 1
  09167 Infectious diseases
   05166 HTLV-I infection
    K08041  ADCY1; adenylate cyclase 1
   05163 Human cytomegalovirus infection
    K08041  ADCY1; adenylate cyclase 1
   05146 Amoebiasis
    K08041  ADCY1; adenylate cyclase 1
   05142 Chagas disease (American trypanosomiasis)
    K08041  ADCY1; adenylate cyclase 1
  09168 Drug resistance
   01522 Endocrine resistance
    K08041  ADCY1; adenylate cyclase 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08041  ADCY1; adenylate cyclase 1
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08041  ADCY1; adenylate cyclase 1
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0008294
Genes
HSA: 107(ADCY1)
PTR: 463392(ADCY1)
PPS: 100984585(ADCY1)
GGO: 101125943(ADCY1)
PON: 100449504(ADCY1)
NLE: 100595636(ADCY1)
MCC: 697230(ADCY1)
MCF: 102147015(ADCY1)
CSAB: 103226115(ADCY1)
RRO: 104671165(ADCY1)
RBB: 108534793(ADCY1)
CJC: 100394265(ADCY1)
SBQ: 101027981(ADCY1)
MMU: 432530(Adcy1)
RNO: 305509(Adcy1)
CGE: 100764561(Adcy1)
NGI: 103741433(Adcy1)
HGL: 101711366(Adcy1)
CCAN: 109694874(Adcy1)
OCU: 103347035 103349521(ADCY1)
TUP: 102468873(ADCY1)
CFA: 607357(ADCY1)
AML: 100472777(ADCY1)
ORO: 101379158(ADCY1)
FCA: 101101375(ADCY1)
PTG: 102961712(ADCY1)
AJU: 106968223(ADCY1)
BTA: 281601(ADCY1)
BOM: 102267116(ADCY1)
BIU: 109557525(ADCY1)
PHD: 102335300(ADCY1)
CHX: 102180724(ADCY1)
OAS: 101117327(ADCY1)
SSC: 100624934(ADCY1)
CFR: 102517882(ADCY1)
CDK: 105095715(ADCY1)
BACU: 102998650(ADCY1)
LVE: 103081539(ADCY1)
OOR: 101278368(ADCY1)
ECB: 100065563(ADCY1)
EPZ: 103550430(ADCY1)
EAI: 106822932(ADCY1)
MYB: 102257679(ADCY1)
MYD: 102759978(ADCY1)
HAI: 109373011(ADCY1)
RSS: 109447331(ADCY1)
PALE: 102887497(ADCY1)
LAV: 100671072(ADCY1)
TMU: 101354868
MDO: 100030463(ADCY1)
SHR: 100922193(ADCY1)
OAA: 103168601
GGA: 420788(ADCY1)
CJO: 107309766(ADCY1)
APLA: 101804073(ADCY1)
ACYG: 106046455(ADCY1)
TGU: 100226080(ADCY1)
GFR: 102040399(ADCY1)
FAB: 101807752(ADCY1)
PHI: 102110269(ADCY1)
PMAJ: 107201036(ADCY1)
CCW: 104689252(ADCY1)
FPG: 101914769(ADCY1)
FCH: 102056699(ADCY1)
CLV: 102094612(ADCY1)
EGZ: 104125965(ADCY1)
AAM: 106492856(ADCY1)
ASN: 102372645(ADCY1)
AMJ: 102573818(ADCY1)
PSS: 102445759(ADCY1)
CMY: 102939135(ADCY1)
CPIC: 101935286(ADCY1)
ACS: 100564004(adcy1)
PVT: 110091617(ADCY1)
GJA: 107119176(ADCY1)
XLA: 108695214 108705348(adcy1.S) 108718988(adcy1.L)
XTR: 100492373(adcy1)
NPR: 108796974(ADCY1)
DRE: 557026(adcy1a) 569499(adcy1b)
IPU: 108257925 108267157(adcy1)
TRU: 101074661(adcy1) 101078286
BPEC: 110159474(adcy1) 110172262
LCM: 102351204(ADCY1)
CMK: 103187011(adcy1)
DME: Dmel_CG9533(rut)
DSI: Dsimw501_GD15838(Dsim_rut)
AAG: 5571379
TCA: 661438(rut)
DPA: 109546607
NVL: 108566779
BMOR: 101741402
PMAC: 106720337
PRAP: 110991594
PXY: 105380532
API: 100164676
DNX: 107168960
ZNE: 110826860
FCD: 110861546
DPX: DAPPUDRAFT_48469(Adcy2)
TUT: 107360550
MYI: 110465124
OBI: 106868905
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9662407
  Authors
Abdel-Majid RM, Leong WL, Schalkwyk LC, Smallman DS, Wong ST, Storm DR, Fine A, Dobson MJ, Guernsey DL, Neumann PE
  Title
Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex.
  Journal
Nat Genet 19:289-91 (1998)
DOI:10.1038/980
  Sequence
[mmu:432530]
Reference
PMID:8314585
  Authors
Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR
  Title
Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase.
  Journal
Genomics 16:473-8 (1993)
DOI:10.1006/geno.1993.1213
  Sequence
[hsa:107]

KEGG   ORTHOLOGY: K08042Help
Entry
K08042                      KO                                     

Name
ADCY2
Definition
adenylate cyclase 2 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08042  ADCY2; adenylate cyclase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04371 Apelin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04020 Calcium signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04072 Phospholipase D signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04024 cAMP signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04022 cGMP - PKG signaling pathway
    K08042  ADCY2; adenylate cyclase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08042  ADCY2; adenylate cyclase 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08042  ADCY2; adenylate cyclase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08042  ADCY2; adenylate cyclase 2
   04062 Chemokine signaling pathway
    K08042  ADCY2; adenylate cyclase 2
  09152 Endocrine system
   04911 Insulin secretion
    K08042  ADCY2; adenylate cyclase 2
   04922 Glucagon signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04923 Regulation of lipolysis in adipocyte
    K08042  ADCY2; adenylate cyclase 2
   04912 GnRH signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04913 Ovarian Steroidogenesis
    K08042  ADCY2; adenylate cyclase 2
   04915 Estrogen signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04914 Progesterone-mediated oocyte maturation
    K08042  ADCY2; adenylate cyclase 2
   04921 Oxytocin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04926 Relaxin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04918 Thyroid hormone synthesis
    K08042  ADCY2; adenylate cyclase 2
   04928 Parathyroid hormone synthesis, secretion and action
    K08042  ADCY2; adenylate cyclase 2
   04916 Melanogenesis
    K08042  ADCY2; adenylate cyclase 2
   04925 Aldosterone synthesis and secretion
    K08042  ADCY2; adenylate cyclase 2
   04927 Cortisol synthesis and secretion
    K08042  ADCY2; adenylate cyclase 2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08042  ADCY2; adenylate cyclase 2
   04270 Vascular smooth muscle contraction
    K08042  ADCY2; adenylate cyclase 2
  09154 Digestive system
   04970 Salivary secretion
    K08042  ADCY2; adenylate cyclase 2
   04971 Gastric acid secretion
    K08042  ADCY2; adenylate cyclase 2
   04972 Pancreatic secretion
    K08042  ADCY2; adenylate cyclase 2
   04976 Bile secretion
    K08042  ADCY2; adenylate cyclase 2
  09156 Nervous system
   04724 Glutamatergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04727 GABAergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04725 Cholinergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04723 Retrograde endocannabinoid signaling
    K08042  ADCY2; adenylate cyclase 2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08042  ADCY2; adenylate cyclase 2
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08042  ADCY2; adenylate cyclase 2
   04213 Longevity regulating pathway - multiple species
    K08042  ADCY2; adenylate cyclase 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08042  ADCY2; adenylate cyclase 2
   04714 Thermogenesis
    K08042  ADCY2; adenylate cyclase 2
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08042  ADCY2; adenylate cyclase 2
  09164 Substance dependence
   05032 Morphine addiction
    K08042  ADCY2; adenylate cyclase 2
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08042  ADCY2; adenylate cyclase 2
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08042  ADCY2; adenylate cyclase 2
  09167 Infectious diseases
   05166 HTLV-I infection
    K08042  ADCY2; adenylate cyclase 2
   05163 Human cytomegalovirus infection
    K08042  ADCY2; adenylate cyclase 2
  09168 Drug resistance
   01522 Endocrine resistance
    K08042  ADCY2; adenylate cyclase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08042  ADCY2; adenylate cyclase 2
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08042  ADCY2; adenylate cyclase 2
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 108(ADCY2)
PTR: 100608010(ADCY2)
PPS: 100992014(ADCY2)
GGO: 101141389(ADCY2)
PON: 100445431(ADCY2)
NLE: 100600367(ADCY2)
MCC: 695328(ADCY2)
MCF: 102130114(ADCY2)
CSAB: 103214981(ADCY2)
RRO: 104674083(ADCY2)
RBB: 108536960(ADCY2)
CJC: 100385658(ADCY2)
SBQ: 101043334(ADCY2)
MMU: 210044(Adcy2)
RNO: 81636(Adcy2)
CGE: 100773811(Adcy2)
NGI: 103735350(Adcy2)
HGL: 101718304(Adcy2)
OCU: 100009201(ADCY2)
TUP: 102492353(ADCY2)
CFA: 478624(ADCY2)
AML: 100473195(ADCY2)
UMR: 103679250(ADCY2)
ORO: 101365382(ADCY2)
FCA: 101094327(ADCY2)
PTG: 102949732(ADCY2)
AJU: 106971248(ADCY2)
BTA: 510708(ADCY2)
BOM: 102274117(ADCY2)
BIU: 109574822(ADCY2)
PHD: 102326467(ADCY2)
CHX: 102171922(ADCY2)
OAS: 101102089(ADCY2)
SSC: 100517503(ADCY2)
CFR: 102510993(ADCY2)
CDK: 105094039(ADCY2)
BACU: 103020085(ADCY2)
LVE: 103084817(ADCY2)
OOR: 101286207(ADCY2)
ECB: 100071337(ADCY2)
EPZ: 103562505
EAI: 106823001(ADCY2)
MYB: 102260356(ADCY2)
MYD: 102774384(ADCY2)
HAI: 109375976(ADCY2)
RSS: 109453572(ADCY2)
PALE: 102893265(ADCY2)
LAV: 100673570(ADCY2)
TMU: 101360334
MDO: 100013164(ADCY2)
SHR: 100922434(ADCY2)
OAA: 100089708(ADCY2)
GGA: 420935(ADCY2)
MGP: 100540738(ADCY2)
CJO: 107309543(ADCY2)
APLA: 101803512(ADCY2)
ACYG: 106036531(ADCY2)
TGU: 100223820(ADCY2)
GFR: 102038853(ADCY2)
FAB: 101808400(ADCY2)
PHI: 102113898(ADCY2)
PMAJ: 107199935(ADCY2)
CCW: 104685925(ADCY2)
FPG: 101911647(ADCY2)
FCH: 102049688(ADCY2)
CLV: 102097532(ADCY2)
EGZ: 104126191(ADCY2)
AAM: 106492356(ADCY2)
ASN: 102383838(ADCY2)
AMJ: 102562034(ADCY2)
PSS: 102444057(ADCY2)
CMY: 102930552(ADCY2)
CPIC: 101952054(ADCY2)
ACS: 100555265(adcy2) 103279577
PVT: 110089596
PBI: 103050340(ADCY2)
GJA: 107108835(ADCY2)
DRE: 557902(adcy2b) 563724(adcy2a)
IPU: 108272199(Adcy2) 108272792(ADCY2)
ELS: 105012408(adcy2)
CMK: 103183192(adcy2)
SPU: 575180
APLC: 110980095
SKO: 102803250
DME: Dmel_CG7978(Ac76E)
DSI: Dsimw501_GD14841(Dsim_GD14841)
MDE: 101893904
AAG: 5571159
AME: 552216
BIM: 100745521
BTER: 100647623
SOC: 105197184
AEC: 105143483
ACEP: 105617405
PBAR: 105425936
HST: 105184375
CFO: 105250746
LHU: 105670932
PGC: 109855918
NVI: 100118148
TCA: 660403
NVL: 108567526
BMOR: 101737606
PMAC: 106718962
PRAP: 110995397
API: 100164066
DNX: 107167195
ZNE: 110829129
FCD: 110849688
CRG: 105336030
MYI: 110458458
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1427768
  Authors
Stengel D, Parma J, Gannage MH, Roeckel N, Mattei MG, Barouki R, Hanoune J
  Title
Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.
  Journal
Hum Genet 90:126-30 (1992)
DOI:10.1007/BF00210755
  Sequence
[hsa:108]
Reference
  Authors
Hardin M, Zielinski J, Wan ES, Hersh CP, Castaldi PJ, Schwinder E, Hawrylkiewicz I, Sliwinski P, Cho MH, Silverman EK
  Title
CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.
  Journal
Am J Respir Cell Mol Biol 47:203-8 (2012)
DOI:10.1165/rcmb.2012-0011OC

KEGG   ORTHOLOGY: K08043Help
Entry
K08043                      KO                                     

Name
ADCY3
Definition
adenylate cyclase 3 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04740  Olfactory transduction
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04962  Vasopressin-regulated water reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05110  Vibrio cholerae infection
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Disease
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08043  ADCY3; adenylate cyclase 3
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04371 Apelin signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04020 Calcium signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04072 Phospholipase D signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04024 cAMP signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04022 cGMP - PKG signaling pathway
    K08043  ADCY3; adenylate cyclase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08043  ADCY3; adenylate cyclase 3
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08043  ADCY3; adenylate cyclase 3
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08043  ADCY3; adenylate cyclase 3
   04062 Chemokine signaling pathway
    K08043  ADCY3; adenylate cyclase 3
  09152 Endocrine system
   04911 Insulin secretion
    K08043  ADCY3; adenylate cyclase 3
   04923 Regulation of lipolysis in adipocyte
    K08043  ADCY3; adenylate cyclase 3
   04912 GnRH signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04913 Ovarian Steroidogenesis
    K08043  ADCY3; adenylate cyclase 3
   04915 Estrogen signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04914 Progesterone-mediated oocyte maturation
    K08043  ADCY3; adenylate cyclase 3
   04921 Oxytocin signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04926 Relaxin signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04918 Thyroid hormone synthesis
    K08043  ADCY3; adenylate cyclase 3
   04928 Parathyroid hormone synthesis, secretion and action
    K08043  ADCY3; adenylate cyclase 3
   04916 Melanogenesis
    K08043  ADCY3; adenylate cyclase 3
   04925 Aldosterone synthesis and secretion
    K08043  ADCY3; adenylate cyclase 3
   04927 Cortisol synthesis and secretion
    K08043  ADCY3; adenylate cyclase 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08043  ADCY3; adenylate cyclase 3
   04270 Vascular smooth muscle contraction
    K08043  ADCY3; adenylate cyclase 3
  09154 Digestive system
   04970 Salivary secretion
    K08043  ADCY3; adenylate cyclase 3
   04971 Gastric acid secretion
    K08043  ADCY3; adenylate cyclase 3
   04972 Pancreatic secretion
    K08043  ADCY3; adenylate cyclase 3
   04976 Bile secretion
    K08043  ADCY3; adenylate cyclase 3
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K08043  ADCY3; adenylate cyclase 3
  09156 Nervous system
   04724 Glutamatergic synapse
    K08043  ADCY3; adenylate cyclase 3
   04727 GABAergic synapse
    K08043  ADCY3; adenylate cyclase 3
   04725 Cholinergic synapse
    K08043  ADCY3; adenylate cyclase 3
   04723 Retrograde endocannabinoid signaling
    K08043  ADCY3; adenylate cyclase 3
  09157 Sensory system
   04740 Olfactory transduction
    K08043  ADCY3; adenylate cyclase 3
   04750 Inflammatory mediator regulation of TRP channels
    K08043  ADCY3; adenylate cyclase 3
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08043  ADCY3; adenylate cyclase 3
   04213 Longevity regulating pathway - multiple species
    K08043  ADCY3; adenylate cyclase 3
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08043  ADCY3; adenylate cyclase 3
   04714 Thermogenesis
    K08043  ADCY3; adenylate cyclase 3
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08043  ADCY3; adenylate cyclase 3
  09164 Substance dependence
   05032 Morphine addiction
    K08043  ADCY3; adenylate cyclase 3
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08043  ADCY3; adenylate cyclase 3
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08043  ADCY3; adenylate cyclase 3
  09167 Infectious diseases
   05110 Vibrio cholerae infection
    K08043  ADCY3; adenylate cyclase 3
   05166 HTLV-I infection
    K08043  ADCY3; adenylate cyclase 3
   05163 Human cytomegalovirus infection
    K08043  ADCY3; adenylate cyclase 3
  09168 Drug resistance
   01522 Endocrine resistance
    K08043  ADCY3; adenylate cyclase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08043  ADCY3; adenylate cyclase 3
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08043  ADCY3; adenylate cyclase 3
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0008294
Genes
HSA: 109(ADCY3)
PTR: 459070(ADCY3)
PPS: 100995134(ADCY3)
GGO: 101144031(ADCY3)
PON: 100431221(ADCY3)
NLE: 100586735(ADCY3)
MCC: 693523(ADCY3)
MCF: 101925741(ADCY3)
CSAB: 103220665(ADCY3)
RRO: 104658457(ADCY3)
RBB: 108543021(ADCY3)
CJC: 100415165(ADCY3)
SBQ: 101040601(ADCY3)
MMU: 104111(Adcy3)
RNO: 64508(Adcy3)
CGE: 100770498(Adcy3)
NGI: 103746460(Adcy3)
HGL: 101713887(Adcy3)
CCAN: 109685686(Adcy3)
OCU: 100343958(ADCY3)
TUP: 102477532(ADCY3)
CFA: 482994(ADCY3)
AML: 100471164(ADCY3)
UMR: 103671685(ADCY3)
ORO: 101368682(ADCY3)
FCA: 101088157(ADCY3)
PTG: 102952000(ADCY3)
BTA: 535603(ADCY3)
BOM: 102282732(ADCY3)
BIU: 109566330(ADCY3)
PHD: 102326984(ADCY3)
CHX: 102169019(ADCY3)
OAS: 101108203(ADCY3)
SSC: 100514402(ADCY3)
CFR: 102512950(ADCY3)
CDK: 105100030(ADCY3)
BACU: 103020845(ADCY3)
LVE: 103076182(ADCY3)
OOR: 101283651(ADCY3)
ECB: 100055961(ADCY3)
EPZ: 103547823(ADCY3)
EAI: 106841140(ADCY3)
MYB: 102261014(ADCY3)
MYD: 102757252(ADCY3)
HAI: 109385186(ADCY3)
RSS: 109435127(ADCY3)
PALE: 102886232(ADCY3)
LAV: 100674724(ADCY3)
TMU: 101349290
MDO: 100025332(ADCY3)
SHR: 100925657(ADCY3) 111718832
OAA: 100085901(ADCY3)
GGA: 422013(ADCY3)
MGP: 100538467(ADCY3)
CJO: 107312346(ADCY3)
APLA: 101791112(ADCY3)
ACYG: 106038094(ADCY3)
PHI: 102112216(ADCY3)
FPG: 101921567(ADCY3)
FCH: 102047195(ADCY3)
CLV: 102092425(ADCY3)
EGZ: 104132021(ADCY3)
AAM: 106488018(ADCY3)
ASN: 102374249(ADCY3)
AMJ: 102566746(ADCY3)
PSS: 102463305(ADCY3)
CMY: 102941584(ADCY3)
CPIC: 101948171(ADCY3)
ACS: 100558229(adcy3)
PVT: 110089954(ADCY3)
PBI: 103053859(ADCY3) 103066699
GJA: 107124706(ADCY3)
XLA: 108717252(adcy3.L) 108718304
XTR: 100038110(dnajc27)
NPR: 108795542(ADCY3)
DRE: 571825(adcy3a)
SGH: 107593287 107598935(adcy3)
IPU: 108271861(adcy3) 108275460
AMEX: 103027936(adcy3) 103034748
TRU: 101066423(adcy3) 101071684
LCO: 104925646(adcy3) 104938398
OLA: 101167167 105355856(adcy3)
XMA: 102219355(adcy3) 102223893
PRET: 103457694 103478767(adcy3)
CSEM: 103380791 103388741(adcy3)
HCQ: 109516699 109521893(adcy3)
BPEC: 110155386 110159121(adcy3)
ELS: 105005964(adcy3) 105017622
SFM: 108929094(adcy3)
LCM: 102352777(ADCY3) 106704621
SPU: 582454
APLC: 110978247
SKO: 100372163(ADCY3)
DSI: Dsimw501_GD24328(Dsim_GD24328) Dsimw501_GD29214(Dsim_GD29214)
MDE: 101889515
AAG: 5571858
AME: 408363(Ac3)
BIM: 100743487
BTER: 100651573
SOC: 105201589
AEC: 105143828
ACEP: 105620050
PBAR: 105427823
HST: 105189653
CFO: 105258159
LHU: 105678451
PGC: 109856042
NVI: 100122644
TCA: 657568
PMAC: 106710670
PRAP: 110998659
PXY: 105387232
API: 100163190
DNX: 107161386
ZNE: 110830923
TUT: 107366670
CRG: 105328828
EPA: 110237571
ADF: 107336781
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2255909
  Authors
Bakalyar HA, Reed RR
  Title
Identification of a specialized adenylyl cyclase that may mediate odorant detection.
  Journal
Science 250:1403-6 (1990)
DOI:10.1126/science.2255909
  Sequence
[rno:64508]

KEGG   ORTHOLOGY: K08044Help
Entry
K08044                      KO                                     

Name
ADCY4
Definition
adenylate cyclase 4 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04742  Taste transduction
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08044  ADCY4; adenylate cyclase 4
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04371 Apelin signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04020 Calcium signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04072 Phospholipase D signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04024 cAMP signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04022 cGMP - PKG signaling pathway
    K08044  ADCY4; adenylate cyclase 4
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08044  ADCY4; adenylate cyclase 4
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08044  ADCY4; adenylate cyclase 4
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08044  ADCY4; adenylate cyclase 4
   04062 Chemokine signaling pathway
    K08044  ADCY4; adenylate cyclase 4
  09152 Endocrine system
   04911 Insulin secretion
    K08044  ADCY4; adenylate cyclase 4
   04923 Regulation of lipolysis in adipocyte
    K08044  ADCY4; adenylate cyclase 4
   04912 GnRH signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04913 Ovarian Steroidogenesis
    K08044  ADCY4; adenylate cyclase 4
   04915 Estrogen signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04914 Progesterone-mediated oocyte maturation
    K08044  ADCY4; adenylate cyclase 4
   04921 Oxytocin signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04926 Relaxin signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04918 Thyroid hormone synthesis
    K08044  ADCY4; adenylate cyclase 4
   04928 Parathyroid hormone synthesis, secretion and action
    K08044  ADCY4; adenylate cyclase 4
   04916 Melanogenesis
    K08044  ADCY4; adenylate cyclase 4
   04925 Aldosterone synthesis and secretion
    K08044  ADCY4; adenylate cyclase 4
   04927 Cortisol synthesis and secretion
    K08044  ADCY4; adenylate cyclase 4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08044  ADCY4; adenylate cyclase 4
   04270 Vascular smooth muscle contraction
    K08044  ADCY4; adenylate cyclase 4
  09154 Digestive system
   04970 Salivary secretion
    K08044  ADCY4; adenylate cyclase 4
   04971 Gastric acid secretion
    K08044  ADCY4; adenylate cyclase 4
   04972 Pancreatic secretion
    K08044  ADCY4; adenylate cyclase 4
   04976 Bile secretion
    K08044  ADCY4; adenylate cyclase 4
  09156 Nervous system
   04724 Glutamatergic synapse
    K08044  ADCY4; adenylate cyclase 4
   04727 GABAergic synapse
    K08044  ADCY4; adenylate cyclase 4
   04725 Cholinergic synapse
    K08044  ADCY4; adenylate cyclase 4
   04723 Retrograde endocannabinoid signaling
    K08044  ADCY4; adenylate cyclase 4
  09157 Sensory system
   04742 Taste transduction
    K08044  ADCY4; adenylate cyclase 4
   04750 Inflammatory mediator regulation of TRP channels
    K08044  ADCY4; adenylate cyclase 4
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08044  ADCY4; adenylate cyclase 4
   04213 Longevity regulating pathway - multiple species
    K08044  ADCY4; adenylate cyclase 4
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08044  ADCY4; adenylate cyclase 4
   04714 Thermogenesis
    K08044  ADCY4; adenylate cyclase 4
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08044  ADCY4; adenylate cyclase 4
  09164 Substance dependence
   05032 Morphine addiction
    K08044  ADCY4; adenylate cyclase 4
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08044  ADCY4; adenylate cyclase 4
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08044  ADCY4; adenylate cyclase 4
  09167 Infectious diseases
   05166 HTLV-I infection
    K08044  ADCY4; adenylate cyclase 4
   05163 Human cytomegalovirus infection
    K08044  ADCY4; adenylate cyclase 4
  09168 Drug resistance
   01522 Endocrine resistance
    K08044  ADCY4; adenylate cyclase 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08044  ADCY4; adenylate cyclase 4
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08044  ADCY4; adenylate cyclase 4
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 196883(ADCY4)
PTR: 452819(ADCY4)
PPS: 100978200(ADCY4)
GGO: 101125890(ADCY4)
PON: 100460806(ADCY4)
NLE: 100603282(ADCY4)
MCC: 714684(ADCY4)
MCF: 102123837(ADCY4)
CSAB: 103228726(ADCY4)
RRO: 104662674(ADCY4)
RBB: 108540946(ADCY4)
CJC: 100415141(ADCY4)
SBQ: 101044688(ADCY4)
MMU: 104110(Adcy4)
RNO: 54223(Adcy4)
CGE: 100768998(Adcy4)
NGI: 103739411(Adcy4)
HGL: 101719464(Adcy4)
CCAN: 109685852(Adcy4)
OCU: 100346742(ADCY4)
TUP: 102490273(ADCY4)
CFA: 480271(ADCY4)
AML: 100471940(ADCY4)
UMR: 103679331(ADCY4)
ORO: 101374313(ADCY4)
FCA: 101097735(ADCY4)
PTG: 102965866(ADCY4)
AJU: 106987869(ADCY4)
BTA: 788151(ADCY4)
BOM: 102286168(ADCY4)
BIU: 109564199(ADCY4)
PHD: 102337499(ADCY4)
CHX: 102185469(ADCY4)
OAS: 101119139(ADCY4)
SSC: 100152067(ADCY4)
CFR: 102524031(ADCY4)
CDK: 105102432(ADCY4)
BACU: 103005549(ADCY4)
LVE: 103075499(ADCY4)
OOR: 101289858(ADCY4)
ECB: 100054305(ADCY4)
EPZ: 103561050(ADCY4)
EAI: 106848607(ADCY4)
MYB: 102247996(ADCY4)
MYD: 102762536(ADCY4)
HAI: 109393593(ADCY4)
RSS: 109436107(ADCY4)
PALE: 102890575(ADCY4)
LAV: 100675525(ADCY4)
TMU: 101350438
MDO: 100030872(ADCY4)
SHR: 100920243(ADCY4)
ASN: 102385636(ADCY4)
AMJ: 102558956(ADCY4)
PSS: 102451515(ADCY4)
CMY: 102946725(ADCY4)
CPIC: 101936524(ADCY4)
ACS: 100562762(adcy4)
PVT: 110091692(ADCY4)
PBI: 103055695(ADCY4)
GJA: 107111738(ADCY4)
XTR: 100497212(adcy4)
NPR: 108788450(ADCY4)
SANH: 107693500
SGH: 107572836
CCAR: 109102764
IPU: 108260803
AMEX: 103031621
CSEM: 103384541
LCF: 108890756
HCQ: 109516520
BPEC: 110158296
SASA: 106608969
ELS: 105030097
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ludwig MG, Seuwen K
  Title
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
  Journal
J Recept Signal Transduct Res 22:79-110 (2002)
DOI:10.1081/RRS-120014589
  Sequence
[hsa:196883]

KEGG   ORTHOLOGY: K08047Help
Entry
K08047                      KO                                     

Name
ADCY7
Definition
adenylate cyclase 7 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08047  ADCY7; adenylate cyclase 7
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04371 Apelin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04020 Calcium signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04072 Phospholipase D signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04024 cAMP signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04022 cGMP - PKG signaling pathway
    K08047  ADCY7; adenylate cyclase 7
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08047  ADCY7; adenylate cyclase 7
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08047  ADCY7; adenylate cyclase 7
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08047  ADCY7; adenylate cyclase 7
   04062 Chemokine signaling pathway
    K08047  ADCY7; adenylate cyclase 7
  09152 Endocrine system
   04911 Insulin secretion
    K08047  ADCY7; adenylate cyclase 7
   04923 Regulation of lipolysis in adipocyte
    K08047  ADCY7; adenylate cyclase 7
   04912 GnRH signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04913 Ovarian Steroidogenesis
    K08047  ADCY7; adenylate cyclase 7
   04915 Estrogen signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04914 Progesterone-mediated oocyte maturation
    K08047  ADCY7; adenylate cyclase 7
   04921 Oxytocin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04926 Relaxin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04918 Thyroid hormone synthesis
    K08047  ADCY7; adenylate cyclase 7
   04928 Parathyroid hormone synthesis, secretion and action
    K08047  ADCY7; adenylate cyclase 7
   04916 Melanogenesis
    K08047  ADCY7; adenylate cyclase 7
   04925 Aldosterone synthesis and secretion
    K08047  ADCY7; adenylate cyclase 7
   04927 Cortisol synthesis and secretion
    K08047  ADCY7; adenylate cyclase 7
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08047  ADCY7; adenylate cyclase 7
   04270 Vascular smooth muscle contraction
    K08047  ADCY7; adenylate cyclase 7
  09154 Digestive system
   04970 Salivary secretion
    K08047  ADCY7; adenylate cyclase 7
   04971 Gastric acid secretion
    K08047  ADCY7; adenylate cyclase 7
   04972 Pancreatic secretion
    K08047  ADCY7; adenylate cyclase 7
   04976 Bile secretion
    K08047  ADCY7; adenylate cyclase 7
  09156 Nervous system
   04724 Glutamatergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04727 GABAergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04725 Cholinergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04723 Retrograde endocannabinoid signaling
    K08047  ADCY7; adenylate cyclase 7
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08047  ADCY7; adenylate cyclase 7
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08047  ADCY7; adenylate cyclase 7
   04213 Longevity regulating pathway - multiple species
    K08047  ADCY7; adenylate cyclase 7
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08047  ADCY7; adenylate cyclase 7
   04714 Thermogenesis
    K08047  ADCY7; adenylate cyclase 7
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08047  ADCY7; adenylate cyclase 7
  09164 Substance dependence
   05032 Morphine addiction
    K08047  ADCY7; adenylate cyclase 7
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08047  ADCY7; adenylate cyclase 7
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08047  ADCY7; adenylate cyclase 7
  09167 Infectious diseases
   05166 HTLV-I infection
    K08047  ADCY7; adenylate cyclase 7
   05163 Human cytomegalovirus infection
    K08047  ADCY7; adenylate cyclase 7
  09168 Drug resistance
   01522 Endocrine resistance
    K08047  ADCY7; adenylate cyclase 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08047  ADCY7; adenylate cyclase 7
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08047  ADCY7; adenylate cyclase 7
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 113(ADCY7)
PTR: 473278(ADCY7)
PPS: 100984225(ADCY7)
GGO: 101126268(ADCY7)
PON: 100436577(ADCY7)
NLE: 100587036(ADCY7)
MCC: 694730(ADCY7)
MCF: 102125718(ADCY7)
CSAB: 103232667(ADCY7)
RRO: 104672569(ADCY7)
RBB: 108522948(ADCY7)
CJC: 100404620(ADCY7)
SBQ: 101032672(ADCY7)
MMU: 11513(Adcy7)
RNO: 84420(Adcy7)
CGE: 100756132(Adcy7)
NGI: 103730120(Adcy7)
HGL: 101712483(Adcy7)
CCAN: 109698373(Adcy7)
OCU: 100357357(ADCY7)
TUP: 102496578(ADCY7)
CFA: 487289(ADCY7)
AML: 100466965(ADCY7)
UMR: 103673916(ADCY7)
ORO: 101377421(ADCY7)
FCA: 101094148(ADCY7)
PTG: 102972917(ADCY7)
AJU: 106985835(ADCY7)
BTA: 281603(ADCY7)
BOM: 102266966(ADCY7)
BIU: 109572478(ADCY7)
PHD: 102326057(ADCY7)
CHX: 102185858(ADCY7)
OAS: 101112667(ADCY7)
SSC: 100620994(ADCY7)
CFR: 102524614(ADCY7)
CDK: 105097528(ADCY7)
BACU: 102997912(ADCY7)
LVE: 103078677(ADCY7)
OOR: 101273592(ADCY7)
ECB: 100058891(ADCY7)
EPZ: 103556685(ADCY7)
EAI: 106824126(ADCY7)
MYB: 102253549(ADCY7)
MYD: 102764043(ADCY7)
HAI: 109383261(ADCY7)
RSS: 109447700(ADCY7)
PALE: 102881535(ADCY7)
LAV: 100653771(ADCY7)
TMU: 101341715
MDO: 100013823(ADCY7)
SHR: 100929278(ADCY7)
OAA: 100076221(ADCY7)
GGA: 415732(ADCY7)
MGP: 100548914(ADCY7)
CJO: 107319017(ADCY7)
APLA: 101794076(ADCY7)
ACYG: 106039584(ADCY7)
TGU: 100225700(ADCY7)
GFR: 102043194(ADCY7)
FAB: 101816007(ADCY7)
PHI: 102106688(ADCY7)
PMAJ: 107209841(ADCY7)
CCW: 104687454(ADCY7)
FPG: 101914615(ADCY7)
FCH: 102052224(ADCY7)
CLV: 102090470(ADCY7)
EGZ: 104125176(ADCY7)
AAM: 106483289(ADCY7)
ASN: 102368976(ADCY7)
AMJ: 102566330(ADCY7)
PSS: 102449192(ADCY7)
CMY: 102946407(ADCY7)
CPIC: 101938536(ADCY7)
ACS: 100558751(adcy7)
PVT: 110086573(ADCY7)
PBI: 103060035(ADCY7) 103063463
GJA: 107117185(ADCY7)
XLA: 399055(adcy7.L)
XTR: 100127741(adcy7)
NPR: 108794932(ADCY7)
DRE: 568726(adcy7)
CCAR: 109080760
IPU: 108259218(adcy7)
TRU: 101066272(adcy7)
LCO: 104940647(adcy7)
MZE: 101480238(adcy7)
OLA: 101164967(adcy7)
PRET: 103462645(adcy7)
NFU: 107381237(adcy7)
CSEM: 103398552
LCF: 108876970(adcy7)
HCQ: 109513976(adcy7)
BPEC: 110175272(adcy7)
ELS: 105025700(adcy7)
SFM: 108932972
LCM: 102351065(ADCY7)
CMK: 103176081(adcy7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7961850
  Authors
Watson PA, Krupinski J, Kempinski AM, Frankenfield CD
  Title
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
  Journal
J Biol Chem 269:28893-8 (1994)
  Sequence
[hsa:113]
Reference
  Authors
Joeyen-Waldorf J, Nikolova YS, Edgar N, Walsh C, Kota R, Lewis DA, Ferrell R, Manuck SB, Hariri AR, Sibille E
  Title
Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.
  Journal
Biol Psychiatry 71:627-32 (2012)
DOI:10.1016/j.biopsych.2011.11.029

KEGG   ORTHOLOGY: K08048Help
Entry
K08048                      KO                                     

Name
ADCY8
Definition
adenylate cyclase 8 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04742  Taste transduction
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08048  ADCY8; adenylate cyclase 8
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04371 Apelin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04020 Calcium signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04072 Phospholipase D signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04024 cAMP signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04022 cGMP - PKG signaling pathway
    K08048  ADCY8; adenylate cyclase 8
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08048  ADCY8; adenylate cyclase 8
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08048  ADCY8; adenylate cyclase 8
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08048  ADCY8; adenylate cyclase 8
   04062 Chemokine signaling pathway
    K08048  ADCY8; adenylate cyclase 8
  09152 Endocrine system
   04911 Insulin secretion
    K08048  ADCY8; adenylate cyclase 8
   04923 Regulation of lipolysis in adipocyte
    K08048  ADCY8; adenylate cyclase 8
   04912 GnRH signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04913 Ovarian Steroidogenesis
    K08048  ADCY8; adenylate cyclase 8
   04915 Estrogen signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04914 Progesterone-mediated oocyte maturation
    K08048  ADCY8; adenylate cyclase 8
   04921 Oxytocin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04926 Relaxin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04918 Thyroid hormone synthesis
    K08048  ADCY8; adenylate cyclase 8
   04928 Parathyroid hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04916 Melanogenesis
    K08048  ADCY8; adenylate cyclase 8
   04925 Aldosterone synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
   04927 Cortisol synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08048  ADCY8; adenylate cyclase 8
   04270 Vascular smooth muscle contraction
    K08048  ADCY8; adenylate cyclase 8
  09154 Digestive system
   04970 Salivary secretion
    K08048  ADCY8; adenylate cyclase 8
   04971 Gastric acid secretion
    K08048  ADCY8; adenylate cyclase 8
   04972 Pancreatic secretion
    K08048  ADCY8; adenylate cyclase 8
   04976 Bile secretion
    K08048  ADCY8; adenylate cyclase 8
  09156 Nervous system
   04724 Glutamatergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04727 GABAergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04725 Cholinergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04720 Long-term potentiation
    K08048  ADCY8; adenylate cyclase 8
   04723 Retrograde endocannabinoid signaling
    K08048  ADCY8; adenylate cyclase 8
  09157 Sensory system
   04742 Taste transduction
    K08048  ADCY8; adenylate cyclase 8
   04750 Inflammatory mediator regulation of TRP channels
    K08048  ADCY8; adenylate cyclase 8
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08048  ADCY8; adenylate cyclase 8
   04213 Longevity regulating pathway - multiple species
    K08048  ADCY8; adenylate cyclase 8
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08048  ADCY8; adenylate cyclase 8
   04714 Thermogenesis
    K08048  ADCY8; adenylate cyclase 8
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08048  ADCY8; adenylate cyclase 8
  09164 Substance dependence
   05032 Morphine addiction
    K08048  ADCY8; adenylate cyclase 8
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08048  ADCY8; adenylate cyclase 8
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08048  ADCY8; adenylate cyclase 8
  09167 Infectious diseases
   05166 HTLV-I infection
    K08048  ADCY8; adenylate cyclase 8
   05163 Human cytomegalovirus infection
    K08048  ADCY8; adenylate cyclase 8
  09168 Drug resistance
   01522 Endocrine resistance
    K08048  ADCY8; adenylate cyclase 8
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08048  ADCY8; adenylate cyclase 8
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08048  ADCY8; adenylate cyclase 8
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0008294
Genes
HSA: 114(ADCY8)
PTR: 464400(ADCY8)
PPS: 100994715(ADCY8)
GGO: 101142672(ADCY8)
PON: 100461383(ADCY8)
NLE: 100592592(ADCY8)
MCC: 695792(ADCY8)
MCF: 102144854(ADCY8)
CSAB: 103237447(ADCY8)
RRO: 104663670 104675683(ADCY8)
RBB: 108514094(ADCY8)
CJC: 100404484(ADCY8)
SBQ: 101034552(ADCY8)
MMU: 11514(Adcy8)
RNO: 29241(Adcy8)
CGE: 103162985
NGI: 103743923(Adcy8)
HGL: 101698293(Adcy8)
CCAN: 109678665(Adcy8)
OCU: 100337882(ADCY8)
TUP: 102472317(ADCY8)
CFA: 482045(ADCY8)
AML: 100474121(ADCY8)
UMR: 103661704(ADCY8)
ORO: 101370350(ADCY8)
FCA: 101087555(ADCY8)
PTG: 102948581(ADCY8)
AJU: 106976879(ADCY8)
BTA: 535017(ADCY8)
BOM: 102272964(ADCY8)
BIU: 109568647(ADCY8)
PHD: 102315306(ADCY8)
CHX: 102184919(ADCY8)
OAS: 101121944(ADCY8)
SSC: 100622999(ADCY8)
CFR: 102521259(ADCY8)
CDK: 105096450(ADCY8)
BACU: 103019172(ADCY8)
LVE: 103085845(ADCY8)
OOR: 101273171(ADCY8)
ECB: 100057796(ADCY8)
EPZ: 103565019 103567623(ADCY8)
EAI: 106824833(ADCY8)
MYB: 102249345(ADCY8)
MYD: 102765722(ADCY8)
HAI: 109372359(ADCY8)
RSS: 109443475(ADCY8)
PALE: 102896789(ADCY8)
LAV: 100661616(ADCY8)
TMU: 101350704
MDO: 100026554(ADCY8)
SHR: 100923926(ADCY8)
OAA: 100077908(ADCY8)
GGA: 420328(ADCY8)
MGP: 100548951(ADCY8)
CJO: 107310566(ADCY8)
APLA: 101794043(ADCY8)
ACYG: 106046364(ADCY8)
TGU: 100230277(ADCY8)
GFR: 102037430(ADCY8)
FAB: 101809046(ADCY8)
PHI: 102108193(ADCY8)
PMAJ: 107200813(ADCY8)
CCW: 104692638(ADCY8)
FPG: 101921528(ADCY8)
FCH: 102056487(ADCY8)
CLV: 102086133(ADCY8)
EGZ: 104134444(ADCY8)
AAM: 106496221(ADCY8)
ASN: 102369910(ADCY8)
AMJ: 102562540(ADCY8)
PSS: 102448969(ADCY8) 106732050
CMY: 102930804(ADCY8)
CPIC: 101947738(ADCY8)
ACS: 100556578(adcy8)
PVT: 110090751(ADCY8)
PBI: 103049018(ADCY8) 103055489
GJA: 107119214(ADCY8)
XLA: 108719413 414729(adcy8.S)
XTR: 100124758(adcy8) 549366
NPR: 108788952(ADCY8)
DRE: 100148976(adcy8) 560410(si:ch211-132f19.7) 560719(si:dkey-206f10.1)
IPU: 108257757 108280230(adcy8)
NCC: 104949485 104955036(adcy8)
CSEM: 103380838 103396830(adcy8)
HCQ: 109518125 109518881(adcy8)
BPEC: 110155800 110165875(adcy8)
SASA: 106568630(adcy8) 106611404
ELS: 105023619(adcy8) 105031560
SFM: 108918520 108937764(adcy8)
LCM: 102346737(ADCY8)
CMK: 103183440(adcy8)
CIN: 100181005
SKO: 100370378
DME: Dmel_CG10564(Ac78C)
DSI: Dsimw501_GD12142(Dsim_GD12142)
MDE: 101893364
AAG: 5563558
AME: 726262(GB19497)
BIM: 100741339
BTER: 100650732
SOC: 105208160
AEC: 105145442
ACEP: 105621896
PBAR: 105425253
HST: 105185447
CFO: 105247922
LHU: 105672367
PGC: 109856473
NVI: 100679362
DPA: 109539855
NVL: 108558843
BMOR: 101744252
PMAC: 106707822
PRAP: 110992313
PXY: 105382561
API: 100161699
DNX: 107163062
ZNE: 110834851
TUT: 107365159
LAK: 106153878
AQU: 100637659
DFA: DFA_04345(acaA)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8076676
  Authors
Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J
  Title
Molecular cloning of the human type VIII adenylyl cyclase.
  Journal
FEBS Lett 351:109-13 (1994)
DOI:10.1016/0014-5793(94)00836-1
  Sequence
[hsa:114]
Reference
  Authors
Roger B, Papin J, Vacher P, Raoux M, Mulot A, Dubois M, Kerr-Conte J, Voy BH, Pattou F, Charpentier G, Jonas JC, Moustaid-Moussa N, Lang J
  Title
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
  Journal
Diabetologia 54:390-402 (2011)
DOI:10.1007/s00125-010-1955-x

KEGG   ORTHOLOGY: K08049Help
Entry
K08049                      KO                                     

Name
ADCY9
Definition
adenylate cyclase 9 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04962  Vasopressin-regulated water reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05110  Vibrio cholerae infection
ko05163  Human cytomegalovirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08049  ADCY9; adenylate cyclase 9
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04371 Apelin signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04020 Calcium signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04072 Phospholipase D signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04024 cAMP signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04022 cGMP - PKG signaling pathway
    K08049  ADCY9; adenylate cyclase 9
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08049  ADCY9; adenylate cyclase 9
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08049  ADCY9; adenylate cyclase 9
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08049  ADCY9; adenylate cyclase 9
   04062 Chemokine signaling pathway
    K08049  ADCY9; adenylate cyclase 9
  09152 Endocrine system
   04911 Insulin secretion
    K08049  ADCY9; adenylate cyclase 9
   04923 Regulation of lipolysis in adipocyte
    K08049  ADCY9; adenylate cyclase 9
   04912 GnRH signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04913 Ovarian Steroidogenesis
    K08049  ADCY9; adenylate cyclase 9
   04915 Estrogen signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04914 Progesterone-mediated oocyte maturation
    K08049  ADCY9; adenylate cyclase 9
   04921 Oxytocin signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04926 Relaxin signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04918 Thyroid hormone synthesis
    K08049  ADCY9; adenylate cyclase 9
   04928 Parathyroid hormone synthesis, secretion and action
    K08049  ADCY9; adenylate cyclase 9
   04916 Melanogenesis
    K08049  ADCY9; adenylate cyclase 9
   04925 Aldosterone synthesis and secretion
    K08049  ADCY9; adenylate cyclase 9
   04927 Cortisol synthesis and secretion
    K08049  ADCY9; adenylate cyclase 9
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08049  ADCY9; adenylate cyclase 9
   04270 Vascular smooth muscle contraction
    K08049  ADCY9; adenylate cyclase 9
  09154 Digestive system
   04970 Salivary secretion
    K08049  ADCY9; adenylate cyclase 9
   04971 Gastric acid secretion
    K08049  ADCY9; adenylate cyclase 9
   04972 Pancreatic secretion
    K08049  ADCY9; adenylate cyclase 9
   04976 Bile secretion
    K08049  ADCY9; adenylate cyclase 9
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K08049  ADCY9; adenylate cyclase 9
   04961 Endocrine and other factor-regulated calcium reabsorption
    K08049  ADCY9; adenylate cyclase 9
  09156 Nervous system
   04724 Glutamatergic synapse
    K08049  ADCY9; adenylate cyclase 9
   04727 GABAergic synapse
    K08049  ADCY9; adenylate cyclase 9
   04725 Cholinergic synapse
    K08049  ADCY9; adenylate cyclase 9
   04723 Retrograde endocannabinoid signaling
    K08049  ADCY9; adenylate cyclase 9
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08049  ADCY9; adenylate cyclase 9
  09149 Aging
   04211 Longevity regulating pathway - mammal
    K08049  ADCY9; adenylate cyclase 9
   04213 Longevity regulating pathway - multiple species
    K08049  ADCY9; adenylate cyclase 9
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08049  ADCY9; adenylate cyclase 9
   04714 Thermogenesis
    K08049  ADCY9; adenylate cyclase 9
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K08049  ADCY9; adenylate cyclase 9
  09164 Substance dependence
   05032 Morphine addiction
    K08049  ADCY9; adenylate cyclase 9
  09165 Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08049  ADCY9; adenylate cyclase 9
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K08049  ADCY9; adenylate cyclase 9
  09167 Infectious diseases
   05110 Vibrio cholerae infection
    K08049  ADCY9; adenylate cyclase 9
   05166 HTLV-I infection
    K08049  ADCY9; adenylate cyclase 9
   05163 Human cytomegalovirus infection
    K08049  ADCY9; adenylate cyclase 9
  09168 Drug resistance
   01522 Endocrine resistance
    K08049  ADCY9; adenylate cyclase 9
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08049  ADCY9; adenylate cyclase 9
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08049  ADCY9; adenylate cyclase 9
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 115(ADCY9)
PTR: 453869(ADCY9)
PPS: 100972356(ADCY9)
GGO: 101145410(ADCY9)
PON: 103889530(ADCY9)
NLE: 100599484(ADCY9)
MCC: 706789(ADCY9)
MCF: 102135189 102135923(ADCY9)
CSAB: 103227576(ADCY9)
RRO: 104672288(ADCY9)
RBB: 108538326(ADCY9)
CJC: 100405403(ADCY9)
SBQ: 101052034(ADCY9)
MMU: 11515(Adcy9)
RNO: 302950(Adcy9)
CGE: 100751372(Adcy9)
NGI: 103744458(Adcy9)
HGL: 101714605(Adcy9)
OCU: 100340877(ADCY9)
TUP: 102477344(ADCY9)
CFA: 490031(ADCY9)
AML: 100476495(ADCY9)
UMR: 103668547(ADCY9)
ORO: 101364108(ADCY9)
FCA: 101095942(ADCY9)
PTG: 102969003(ADCY9)
AJU: 106978803(ADCY9)
BTA: 525482(ADCY9)
BOM: 102285642(ADCY9)
BIU: 109578364(ADCY9)
PHD: 102327009 102334344(ADCY9)
CHX: 102188104(ADCY9)
OAS: 101122401(ADCY9)
SSC: 100625423(ADCY9)
CFR: 102505261(ADCY9)
CDK: 105099828(ADCY9)
BACU: 103016058(ADCY9)
LVE: 103070451(ADCY9)
OOR: 101281654(ADCY9)
ECB: 100066046(ADCY9)
EPZ: 103553014(ADCY9)
EAI: 106826021(ADCY9)
MYB: 102248953(ADCY9)
MYD: 102760324(ADCY9)
HAI: 109392133(ADCY9)
RSS: 109436708(ADCY9)
PALE: 102885676(ADCY9)
LAV: 100663448(ADCY9)
TMU: 101344705
MDO: 100013831(ADCY9)
SHR: 100926025(ADCY9)
OAA: 100080569(ADCY9) 100087431
GGA: 395339(ADCY9)
CJO: 107320968(ADCY9)
APLA: 101800617(ADCY9)
ACYG: 106033354(ADCY9)
TGU: 100231171(ADCY9)
GFR: 102043312(ADCY9)
FAB: 101818533(ADCY9)
PHI: 102103610(ADCY9)
PMAJ: 107211136(ADCY9)
CCW: 104684954(ADCY9)
FPG: 101921768(ADCY9)
FCH: 102047847(ADCY9)
CLV: 102095574(ADCY9)
EGZ: 104121973(ADCY9)
AAM: 106482327(ADCY9)
ASN: 102370673 102373860(ADCY9)
AMJ: 102574362(ADCY9)
PSS: 102448197(ADCY9)
CMY: 102930475(ADCY9) 102945804
CPIC: 101940138(ADCY9)
ACS: 100556223(adcy9)
PVT: 110089110(ADCY9)
PBI: 103051661(ADCY9)
GJA: 107109291(ADCY9)
XLA: 108703189 378610(adcy9.L)
XTR: 100126441(adcy9)
NPR: 108790811(ADCY9)
DRE: 100333702(adcy9) 101884360
IPU: 108259388(adcy9)
AMEX: 103022434(adcy9)
TRU: 101074204 101078598(adcy9)
LCO: 104925375 104925703(adcy9)
MZE: 101466373 101477119(adcy9)
OLA: 101155516(adcy9) 101163149
XMA: 102230840(adcy9) 102231255
PRET: 103464021 103469190(adcy9)
NFU: 107376487(adcy9) 107390534
CSEM: 103384091 103393051(adcy9)
LCF: 108885408 108886159(adcy9)
HCQ: 109527326 109532550(adcy9)
BPEC: 110166178 110168281(adcy9)
SFM: 108928849(adcy9) 108930202
LCM: 102363182(ADCY9)
CMK: 103178726(adcy9)
CIN: 100176999
SPU: 593842
APLC: 110976938
SKO: 100372577
DME: Dmel_CG9210(Ac13E)
DSI: Dsimw501_GD27717(Dsim_GD27717)
MDE: 101898652
AAG: 23687681
AME: 552535
BIM: 100746561
BTER: 100651494
SOC: 105198643
AEC: 105150701
ACEP: 105627205
PBAR: 105427028
HST: 105181099
CFO: 105256088
LHU: 105677518
PGC: 109854881
NVI: 100119583
TCA: 663450
NVL: 108565010
BMOR: 101739269
PMAC: 106721760
PRAP: 110992828
PXY: 105390863
ZNE: 110827835
CEL: CELE_F17C8.1(acy-1)
CBR: CBG18000(Cbr-acy-1)
BMY: Bm1_00615
CRG: 105335675
MYI: 110461839
SHX: MS3_09847
EPA: 110248954
ADF: 107348722
HMG: 100204733
AQU: 100641421
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9628827
  Authors
Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR
  Title
Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9).
  Journal
Genomics 50:97-104 (1998)
DOI:10.1006/geno.1998.5293
  Sequence
[hsa:115]

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