KEGG ORTHOLOGY: K08530

ORTHOLOGY: K08530

Entry

K08530                      KO

Symbol

NR1C3, PPARG

Name

peroxisome proliferator-activated receptor gamma

Pathway

map03320

PPAR signaling pathway

map04148

Efferocytosis

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04380

Osteoclast differentiation

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05016

Huntington disease

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05216

Thyroid cancer

map05417

Lipid and atherosclerosis

Disease

H00032

Thyroid cancer

H00409

Type 2 diabetes mellitus

H00420

Familial partial lipodystrophy

H02106

Genetic obesity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09149 Aging
   04211 Longevity regulating pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09159 Environmental adaptation
   04714 Thermogenesis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
   05202 Transcriptional misregulation in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09162 Cancer: specific types
   05216 Thyroid cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09164 Neurodegenerative disease
   05016 Huntington disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Nuclear receptors [BR:ko03310]
1. Thyroid hormone like
  1C. Peroxisome proliferator-activated receptor (PPAR)
   K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma

Genes

HSA:	5468(PPARG)

PTR:	460178(PPARG)

PPS:	100974825(PPARG)

GGO:	101134077(PPARG)

PON:	100171496(PPARG)

NLE:	100581046(PPARG)

HMH:	116466751(PPARG)

MCC:	574190(PPARG)

MCF:	102120453(PPARG)

MTHB:

126949058

MNI:	105477726(PPARG)

CSAB:

103228027(PPARG)

CATY:

105585799(PPARG)

PANU:

101012073(PPARG)

TGE:	112619480(PPARG)

MLEU:

105542171(PPARG)

RRO:	104673295(PPARG)

RBB:	108517991(PPARG)

TFN:	117083265(PPARG)

PTEH:

111546909(PPARG)

CANG:

105519098(PPARG)

CJC:	100414099(PPARG)

SBQ:	101028278(PPARG)

CIMI:

108284639(PPARG)

CSYR:

103263751(PPARG)

MMUR:

105882670(PPARG)

LCAT:

123638104(PPARG)

PCOQ:

105819019(PPARG)

OGA:	100943160(PPARG)

MMU:	19016(Pparg)

MCAL:

110295901(Pparg)

MPAH:

110317409(Pparg)

RNO:	25664(Pparg)

MCOC:

116099428(Pparg)

ANU:	117715534(Pparg)

MUN:	110550822(Pparg)

CGE:	100689245(Pparg)

MAUA:

101829400(Pparg)

PROB:

127236259(Pparg)

PLEU:

114689632(Pparg)

MORG:

121437699(Pparg)

MFOT:

126505512

AAMP:

119807937(Pparg)

NGI:	103751484(Pparg)

HGL:	101711078(Pparg)

CPOC:

100729138(Pparg)

CCAN:

109694945(Pparg)

DORD:

105981285(Pparg)

DSP:	122107985(Pparg)

PLOP:

125358817(Pparg)

NCAR:

124971234

MMMA:

107150087(Pparg)

OCU:	100008892(PPARG)

OPI:	101533802(PPARG)

TUP:	102495121(PPARG)

GVR:	103590613(PPARG)

CFA:	403606(PPARG)

CLUD:

112661459(PPARG)

VVP:	112933683(PPARG)

VLG:	121494412(PPARG)

NPO:	129521806(PPARG)

AML:	100482938(PPARG)

UMR:	103669544(PPARG)

UAH:	113257185(PPARG)

UAR:	123801980(PPARG)

ELK:

111144031

LLV:

125108518

MPUF:

101688974(PPARG)

MNP:	132011568(PPARG)

MLK:	131824235(PPARG)

NVS:	122909195(PPARG)

ORO:	101370284(PPARG)

EJU:	114207745(PPARG)

ZCA:	113918247(PPARG)

MLX:	118005676(PPARG)

NSU:	110585024(PPARG)

LWW:

102742585

FCA:	101095161(PPARG)

PYU:	121041247(PPARG)

PCOO:

112859366(PPARG)

PBG:	122487517(PPARG)

PVIV:

125154732(PPARG)

LRUF:

124524538

PTG:	102957164(PPARG)

PPAD:

109254341(PPARG)

PUC:

125930730

AJU:

106977134

HHV:	120231290(PPARG)

BTA:	281993(PPARG)

BOM:	102265537(PPARG)

BIU:	109576385(PPARG)

BBIS:

105004745(PPARG)

CHX:	100861309(PPARG)

OAS:	443513(PPARG)

BTAX:

128048702(PPARG)

ODA:	120868104(PPARG)

CCAD:

122424564(PPARG)

MBEZ:

129547724(PPARG)

SSC:	397671(PPARG)

CFR:	102516350(PPARG)

CBAI:

105067470(PPARG)

CDK:	105093103(PPARG)

VPC:	102544597(PPARG)

BACU:

103013413(PPARG)

BMUS:

118903688(PPARG)

LVE:	103085722(PPARG)

OOR:

101272154

DLE:

111168952

PCAD:

102986529(PPARG)

PSIU:

116762744(PPARG)

NASI:

112396459(PPARG)

ECB:	100051258(PPARG)

EPZ:	103554547(PPARG)

EAI:	106829341(PPARG)

MYB:	102254594(PPARG)

MYD:	102771129(PPARG)

MMYO:

118668073(PPARG)

MLF:	102435787(PPARG)

PKL:	118715228(PPARG)

EFUS:

103295703(PPARG)

MNA:	107534765(PPARG)

DRO:	112301119(PPARG)

SHON:

118990275(PPARG)

AJM:	119044811(PPARG)

PDIC:

114501975(PPARG)

PHAS:

123814448(PPARG)

MMF:	118633087(PPARG)

PPAM:

129088213(PPARG)

HAI:	109384577(PPARG)

RFQ:	117037017(PPARG)

PALE:

102892450(PPARG)

PGIG:

120621474(PPARG)

PVP:	105299024(PPARG)

RAY:	107519731(PPARG)

MJV:	108394347(PPARG)

TOD:	119255673(PPARG)

SARA:

101544894(PPARG)

SETR:

125998082(PPARG)

LAV:	100654408(PPARG)

TMU:

101356506

ETF:	101656886(PPARG)

DNM:	101418117(PPARG)

MDO:	100025091(PPARG)

GAS:	123239366(PPARG)

SHR:	100934154(PPARG)

AFZ:

127552073

PCW:	110204887(PPARG)

OAA:	100080852(PPARG)

GGA:	373928(PPARG)

PCOC:

116239018(PPARG)

MGP:	100540960(PPARG)

CJO:	107319697(PPARG)

TPAI:

128078653(PPARG)

LMUT:

125698859(PPARG)

NMEL:

110404711(PPARG)

APLA:

101792429(PPARG)

ACYG:

106040065(PPARG)

CATA:

118253741(PPARG)

AFUL:

116493021(PPARG)

TGU:	100231741(PPARG)

LSR:	110470665(PPARG)

SCAN:

103816936(PPARG)

PMOA:

120501784(PPARG)

OTC:	121348250(PPARG)

PRUF:

121349064(PPARG)

GFR:	102035311(PPARG)

FAB:	101815733(PPARG)

OMA:	130258140(PPARG)

PHI:	102104364(PPARG)

PMAJ:

107210458(PPARG)

CCAE:

111935235(PPARG)

CCW:	104695746(PPARG)

CBRC:

103617698(PPARG)

ETL:	114059219(PPARG)

ZAB:	102062499(PPARG)

ACHL:

103800408(PPARG)

SVG:	106849277(PPARG)

MMEA:

130582954(PPARG)

HRT:	120758135(PPARG)

FPG:	101911405(PPARG)

FCH:	102051838(PPARG)

CLV:	102097513(PPARG)

EGZ:	104124309(PPARG)

NNI:	104022931(PPARG)

PCRI:

104030690(PPARG)

PLET:

104619602(PPARG)

EHS:	104510785(PPARG)

PCAO:

104052479(PPARG)

ACUN:

113484975(PPARG)

TALA:

104358503(PPARG)

PADL:

103915212(PPARG)

AFOR:

103905410(PPARG)

ACHC:

115333378(PPARG)

HALD:

104316809(PPARG)

HLE:	104842229(PPARG)

AGEN:

126049793

GCL:

127021597

CCRI:

104163001(PPARG)

CSTI:

104560598(PPARG)

CMAC:

104483818(PPARG)

MUI:	104547270(PPARG)

BREG:

104631025(PPARG)

FGA:	104083834(PPARG)

GSTE:

104259627(PPARG)

LDI:	104345998(PPARG)

MNB:	103772206(PPARG)

OHA:	104335219(PPARG)

NNT:	104405273(PPARG)

SHAB:

115614322(PPARG)

DPUB:

104301898(PPARG)

PGUU:

104458906(PPARG)

ACAR:

104527114(PPARG)

CPEA:

104398704(PPARG)

AVIT:

104268687(PPARG)

CVF:	104290774(PPARG)

RTD:	128915559(PPARG)

CUCA:

104064614(PPARG)

TEO:	104375714(PPARG)

BRHI:

104489483(PPARG)

AAM:	106488868(PPARG)

AROW:

112966385(PPARG)

NPD:	112953033(PPARG)

TGT:	104570320(PPARG)

DNE:	112982856(PPARG)

SCAM:

104152697(PPARG)

ASN:	102375364(PPARG)

AMJ:	102575176(PPARG)

CPOO:

109311369(PPARG)

GGN:	109289149(PPARG)

PSS:	102460093(PPARG)

CMY:	102947653(PPARG)

CCAY:

125640259(PPARG)

DCC:	119858679(PPARG)

CPIC:

101930880(PPARG)

TST:	117880722(PPARG)

CABI:

116820240(PPARG)

MRV:	120369318(PPARG)

ACS:	100557020(pparg)

ASAO:

132769226(PPARG)

PVT:	110083807(PPARG)

SUND:

121923490(PPARG)

PBI:	103056230(PPARG)

CTIG:

120307441(PPARG)

TSR:

106542303

PGUT:

117677749(PPARG)

APRI:

131190252(PPARG)

PTEX:

113452816(PPARG)

NSS:	113418162(PPARG)

VKO:	123034221(PPARG)

PMUA:

114591638(PPARG)

PRAF:

128408257(PPARG)

ZVI:	118080667(PPARG)

HCG:	128341701(PPARG)

GJA:	107118018(PPARG)

STOW:

125430296(PPARG)

EMC:	129328994(PPARG)

XLA:	108704417(pparg.S) 397769(pparg.L)

XTR:	100144687(pparg)

NPR:	108785475(PPARG)

RTEM:

120945275(PPARG)

BBUF:

120979231(PPARG)

BGAR:

122943713(PPARG) 122944170

MUO:	115472661(PPARG)

GSH:	117351257(PPARG)

DRE:	557037(pparg)

SRX:	107742034 107758005(pparg)

SANH:

107667870 107687310(pparg)

SGH:	107564291(pparg) 107571218

CCAR:

109081042(pparg) 109103539

CAUA:

113054937 113068124

CGIB:

127968264 128022687

PTET:

122353721(pparg)

LROH:

127172994(pparg)

OMC:	131549247(pparg)

PPRM:

120460662(pparg)

RKG:	130100903(pparg)

MAMB:

125256953(pparg)

CIDE:

127522955

MASI:

127425947 127427834

TROS:

130571051(pparg)

TDW:	130409996(pparg)

MANU:

129427338(pparg)

IPU:	108254912 108276331

IFU:	128619537 128625377(pparg)

PHYP:

113537934(pparg) 113545604

SMEO:

124398892 124402213(pparg)

TFD:	113639085(pparg) 113650910

TVC:	132837723(pparg) 132862287

AMEX:

103026166 103030663(pparg)

CMAO:

118799664(pparg) 118822119

EEE:	113589601(pparg)

CHAR:

105900157 105905121(pparg)

TRU:	100049069(pparg)

TFS:	130523681(pparg)

TNG:	GSTEN00027585G001

LCO:	104919339(pparg)

NCC:	104947475(pparg)

TBEN:

117489566(pparg)

CGOB:

115008299(pparg)

PGEO:

117446794(pparg)

GACU:

117548138(pparg)

EMAC:

134882560(pparg)

ELY:	117257221(pparg)

EFO:	125892831(pparg)

PLEP:

121957686(pparg)

SLUC:

116051327(pparg)

ECRA:

117943530(pparg)

ESP:	116687875(pparg)

PFLV:

114554582(pparg)

GAT:	120835430(pparg)

PPUG:

119229736(pparg)

AFB:	129106394(pparg)

CLUM:

117730250(pparg)

PSWI:

130209002(pparg)

MSAM:

119885690(pparg)

SCHU:

122887596(pparg)

CUD:	121506534(pparg)

ALAT:

119021008(pparg)

MZE:	101485991(pparg)

ONL:	100711231(pparg)

OAU:	116313637(pparg)

OLA:	100304459(pparg)

OML:	112144662(pparg)

CSAI:

133448664(pparg)

XMA:	102229218(pparg)

XCO:	114136130(pparg)

XHE:	116711123(pparg)

PRET:

103464445(pparg)

PFOR:

103136305(pparg)

PLAI:

106954729(pparg)

PMEI:

106923766(pparg)

GAF:	122834758(pparg)

PPRL:

129358130(pparg)

CVG:	107087543(pparg)

CTUL:

119798399(pparg)

GMU:	124856811(pparg)

NFU:	107385283(pparg)

KMR:	108231651(pparg)

ALIM:

106513826(pparg)

NWH:	119411830(pparg)

AOCE:

111564578(pparg)

MCEP:

125006753(pparg)

CSEM:

103385631(pparg)

POV:	109635570(pparg)

SSEN:

122768506(pparg)

HHIP:

117760900(pparg)

HSP:	118105123(pparg)

SMAU:

118309229(pparg)

LCF:

108890100

SDU:	111224020(pparg)

SLAL:

111658805 111667647 111670200(pparg)

XGL:	120807084(pparg)

HCQ:	109529222(pparg)

SSCV:

125977474

SBIA:

133507121(pparg)

PEE:	133408284(pparg)

PTAO:

133483353(pparg)

BPEC:

110168463(pparg)

MALB:

109965555(pparg)

BSPL:

114856013(pparg)

SJO:	128354950(pparg)

SASA:

100136393(pparg) 106566754 106583865 106583866

STRU:

115149901 115166142 115168395

OTW:	112215766 112221460 112255114(pparg)

OMY:	100505416 110492412 110528708(pparg)

OGO:	124023950(pparg) 124031699 124045680

ONE:	115102096 115120699 115131884

OKI:	109869769 109891477(pparg) 109907766

OKE:	118359629 118361398 118372504(pparg)

SALP:

111966207 112069430(pparg)

SNH:	120037108(pparg) 120059497 120061319

CCLU:

121538561 121545409 121560752

ELS:	105013043 105029138

SFM:	108929802(pparg)

PKI:	111837542(pparg)

AANG:

118210670(pparg)

LOC:	102692076(pparg)

PSPA:

121297981 121328698

ARUT:

117412001 117413933

PSEX:

120540275(pparg)

LCM:	102360245(PPARG)

CMK:	103185017(pparg)

RTP:	109911575(pparg)

CPLA:

122558958(pparg)

HOC:	132822309(pparg)

LERI:

129704847(pparg)

PMRN:

103091849 116947501 116949271 116951213

LRJ:	133342505 133342738 133350674 133351590(PPARD) 133356535 133356713

BFO:

BBEL:

SPU:

LPIC:

APLC:

SKO:

AGRG:

CCRN:

HVI:

MQU:

DFR:

LGI:	LOTGIDRAFT_238472

PVUL:

126831470 126831746

PCAN:

112568378 112574057

BGT:

106057265

HRF:	124138185 124140499

HRJ:	124264112 124268679

CRG:	105317849 105322741

CVN:	111123084 111126890

CANU:

128164853 128193245

OED:

125645785

MYI:

110455413

PMAX:

117317926 117318076 117339313

MMER:

RPHI:

DPOL:

Reference

PMID:9065481

Authors

Mukherjee R, Jow L, Croston GE, Paterniti JR Jr

Title

Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.

Journal

J Biol Chem 272:8071-6 (1997)
DOI:10.1074/jbc.272.12.8071

Sequence

[hsa:5468]

Reference

PMID:19883731

Authors

Eberhardt NL, Grebe SK, McIver B, Reddi HV

Title

The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.

Journal

Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013

Reference

PMID:20829347

Authors

Park SH, Choi HJ, Yang H, Do KH, Kim J, Lee DW, Moon Y

Title

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.

Journal

J Biol Chem 285:35330-9 (2010)
DOI:10.1074/jbc.M110.136259

Sequence

[hsa:5468]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (24)   
   KEGG PATHWAY (24)   
Disease (4)   
   KEGG DISEASE (4)   
Drug (33)   
   KEGG DRUG (33)   
Gene (807)   
   KEGG GENES (477)   
   KEGG MGENES (176)   
   RefGene (150)   
   OC (4)   
Literature (3)   
   PubMed (3)   
All databases (874)   

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