KEGG   ORTHOLOGY: K08735Help
Entry
K08735                      KO                                     

Name
MSH2
Definition
DNA mismatch repair protein MSH2
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Module
M00295  BRCA1-associated genome surveillance complex (BASC)
Disease
H00020  Colorectal cancer
H00027  Ovarian cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03430 Mismatch repair
    K08735  MSH2; DNA mismatch repair protein MSH2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
   05210 Colorectal cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  Drug resistance
   01524 Platinum drug resistance
    K08735  MSH2; DNA mismatch repair protein MSH2
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Repair system
    M00295  BRCA1-associated genome surveillance complex (BASC)
     K08735  MSH2; DNA mismatch repair protein MSH2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   MMR (mismatch exicision repair)
    Mismatch and loop recognition factors
     K08735  MSH2; DNA mismatch repair protein MSH2
BRITE hierarchy
Genes
HSA: 4436(MSH2)
PTR: 107973458(MSH2)
PPS: 100984592(MSH2)
GGO: 101145372(MSH2)
PON: 100431828(MSH2)
NLE: 100580147(MSH2)
MCC: 718017(MSH2)
MCF: 101867487(MSH2)
CSAB: 103220322(MSH2)
RRO: 104663167(MSH2)
RBB: 108512671(MSH2)
CJC: 100394665(MSH2)
SBQ: 101044013(MSH2)
MMU: 17685(Msh2)
RNO: 81709(Msh2)
CGE: 100768127(Msh2)
NGI: 103725741(Msh2)
HGL: 101706924(Msh2)
CCAN: 109675535 109691600(Msh2)
OCU: 103347805(MSH2)
TUP: 102471638(MSH2)
CFA: 494002(MSH2)
AML: 100471735(MSH2)
UMR: 103671767(MSH2)
ORO: 101367758(MSH2)
FCA: 101082051(MSH2)
PTG: 102954275(MSH2)
AJU: 106977220(MSH2)
BTA: 533115(MSH2)
BOM: 102268614(MSH2)
BIU: 109566059(MSH2)
PHD: 102320356(MSH2)
CHX: 102172730(MSH2)
OAS: 101107944(MSH2)
SSC: 100337661(MSH2)
CFR: 102512861(MSH2)
CDK: 105092361(MSH2)
BACU: 102999324(MSH2)
LVE: 103088025(MSH2)
OOR: 101272233(MSH2)
ECB: 100068146(MSH2)
EPZ: 103558101(MSH2)
EAI: 106826002(MSH2)
MYB: 102244813(MSH2)
MYD: 102756016(MSH2)
HAI: 109389912(MSH2)
RSS: 109456386(MSH2)
PALE: 102893728(MSH2)
LAV: 100653677(MSH2)
TMU: 101346702
MDO: 100033358(MSH2)
OAA: 100083981(MSH2) 100086125
GGA: 378799(MSH2)
MGP: 100542264(MSH2)
CJO: 107310883(MSH2)
APLA: 101802532(MSH2)
ACYG: 106043144(MSH2)
TGU: 100226839(MSH2)
GFR: 102033642(MSH2)
FAB: 101818579(MSH2)
PHI: 102104578(MSH2)
PMAJ: 107202300(MSH2)
CCW: 104685720(MSH2)
FPG: 101910374(MSH2)
FCH: 102053065(MSH2)
CLV: 102091445(MSH2)
EGZ: 104134601(MSH2)
AAM: 106490370(MSH2)
ASN: 102372507(MSH2)
AMJ: 102562032(MSH2)
PSS: 102457455(MSH2)
CMY: 102929651(MSH2)
CPIC: 101937123(MSH2)
ACS: 100562005(msh2)
PVT: 110079560(MSH2)
PBI: 103057506(MSH2)
GJA: 107124258(MSH2)
XLA: 595045(msh2.L)
XTR: 100380043(msh2)
NPR: 108804519(MSH2)
DRE: 406845(msh2)
IPU: 108274345(msh2)
AMEX: 103047089(msh2)
TRU: 101075196(msh2)
LCO: 104923481(msh2)
NCC: 104951045(msh2)
MZE: 101484075(msh2)
OLA: 101167993(msh2)
XMA: 102234491(msh2) 106700380
PRET: 103481547(msh2)
NFU: 107387525(msh2)
CSEM: 103381539(msh2)
LCF: 108882675(msh2)
HCQ: 109530180(msh2)
BPEC: 110174586(msh2)
SASA: 106589405(msh2)
ELS: 105006146(msh2)
SFM: 108931448(msh2)
CMK: 103180793(msh2)
CIN: 100183267
SPU: 589363(msh2)
APLC: 110984624
SKO: 100370530(MSH2)
DME: Dmel_CG4215(spel1)
DSI: Dsimw501_GD23963(Dsim_GD23963)
MDE: 101891948
AAG: 5565480
AME: 725348(spel1)
BIM: 100745953
BTER: 100644548
SOC: 105202417
AEC: 105151743
ACEP: 105618910
HST: 105191066
CFO: 105249227
LHU: 105673743
PGC: 109856928
NVI: 100118035(Msh2)
TCA: 655722
DPA: 109532708
NVL: 108564757
BMOR: 101743378
PMAC: 106713550
PRAP: 110993151
API: 100160952(MSH2)
DNX: 107161324
ZNE: 110838930
FCD: 110845892
TUT: 107369494
CEL: CELE_H26D21.2(msh-2)
CBR: CBG12022(Cbr-msh-2)
BMY: Bm1_40840
TSP: Tsp_09659
CRG: 105335553
MYI: 110460651
OBI: 106868054
LAK: 106156484
SHX: MS3_10731
EPA: 110249970
HMG: 100200908
AQU: 100641505
ATH: AT3G18524(MSH2)
CRB: 17891110
BRP: 103859754
THJ: 104820406
CIT: 102614656
TCC: 18604054
GRA: 105798704
DZI: 111291050
EGR: 104421462
GMX: 100792272
VRA: 106769444
VAR: 108323623
CCAJ: 109809762
CAM: 101505823
ADU: 107469314
AIP: 107630408
LJA: Lj4g3v1787050.1(Lj4g3v1787050.1) Lj4g3v1787050.2(Lj4g3v1787050.2)
FVE: 101293489
PPER: 18777066
PMUM: 103342205
PAVI: 110754162
PXB: 103938503
ZJU: 107418858
CSV: 101215589
CMO: 103494106
MCHA: 111007070
CMAX: 111484889
CMOS: 111430121
CPEP: 111780449
RCU: 8286743
JCU: 105650645
HBR: 110651472
POP: 7484706
VVI: 100268052(MSH2)
SLY: 100462655(MSH2)
SPEN: 107021249
SOT: 102598532
CANN: 107855430
NSY: 104244948
NTO: 104117972
INI: 109184200
OEU: 111406449
HAN: 110941615
LSV: 111915654
DCR: 108192774
SOE: 110789489
NNU: 104603050
OSA: 4338271
DOSA: Os05t0274200-01(Os05g0274200)
OBR: 102704890
BDI: 100842311
ATS: 109751240(LOC109751240)
SBI: 8060623
ZMA: 100279876(mus1)
SITA: 101753902
PDA: 103704345
EGU: 105041044
MUS: 103987730
DCT: 110093633
AOF: 109822519
ATR: 18433612
PPP: 112275272
APRO: F751_2623
SCE: YOL090W(MSH2)
ERC: Ecym_2796
KMX: KLMA_30578(MSH2)
NCS: NCAS_0A08670(NCAS0A08670)
NDI: NDAI_0G05110(NDAI0G05110)
TPF: TPHA_0A00740(TPHA0A00740)
TBL: TBLA_0B02380(TBLA0B02380)
TDL: TDEL_0D05170(TDEL0D05170)
KAF: KAFR_0C01330(KAFR0C01330)
CAL: CAALFM_C407120CA(MSH2)
CAUR: QG37_03635
SLB: AWJ20_1043(MSH2)
NCR: NCU02230(msh2)
NTE: NEUTE1DRAFT124099(NEUTE1DRAFT_124099)
SMP: SMAC_03669(putative msh2)
MGR: MGG_00879
MAW: MAC_04666
MAJ: MAA_04555
CMT: CCM_01340
MBE: MBM_06832
ANI: AN5006.2
ANG: ANI_1_490144(An16g03520)
ABE: ARB_01205
TVE: TRV_05311
PTE: PTT_15308
SPO: SPBC19G7.01c(msh2)
CNE: CNA07480
CNB: CNBA7300
ABP: AGABI1DRAFT131867(AGABI1DRAFT_131867)
ABV: AGABI2DRAFT187339(AGABI2DRAFT_187339)
MGL: MGL_3578
DDI: DDB_G0275809(msh2)
DFA: DFA_02479(msh2)
EHI: EHI_172750(113.t00021)
PYO: PY17X_0807000(PY01096) PY17X_1018600(PY07191)
PCB: PCHAS_080460(PC000592.00.0) PCHAS_101790(PC301346.00.0)
TAN: TA20735
TPV: TP01_0456
BBO: BBOV_I003810(19.m02277)
CPV: cgd8_3950
SMIN: v1.2.002929.t1(symbB.v1.2.002929.t1) v1.2.002929.t2(symbB.v1.2.002929.t2)
FCY: FRACYDRAFT_157228(MSH2_a)
SPAR: SPRG_01049
GTT: GUITHDRAFT_116240(Msh2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8252616
  Authors
Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R
  Title
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
  Journal
Cell 75:1027-38 (1993)
DOI:10.1016/0092-8674(93)90546-3
  Sequence
[hsa:4436]
Reference
  Authors
Seifert M, Scherer SJ, Edelmann W, Bohm M, Meineke V, Lobrich M, Tilgen W, Reichrath J
  Title
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
  Journal
J Invest Dermatol 128:203-13 (2008)
DOI:10.1038/sj.jid.5700941
  Sequence
[hsa:4436]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YOL090W]

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