KEGG   ORTHOLOGY: K08737Help
Entry
K08737                      KO                                     

Name
MSH6
Definition
DNA mismatch repair protein MSH6
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Module
M00295  BRCA1-associated genome surveillance complex (BASC)
Disease
H00020  Colorectal cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03430 Mismatch repair
    K08737  MSH6; DNA mismatch repair protein MSH6
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
   05210 Colorectal cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  Drug resistance
   01524 Platinum drug resistance
    K08737  MSH6; DNA mismatch repair protein MSH6
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Repair system
    M00295  BRCA1-associated genome surveillance complex (BASC)
     K08737  MSH6; DNA mismatch repair protein MSH6
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   MMR (mismatch exicision repair)
    Mismatch and loop recognition factors
     K08737  MSH6; DNA mismatch repair protein MSH6
BRITE hierarchy
Genes
HSA: 2956(MSH6)
PTR: 459218(MSH6)
PPS: 100986695(MSH6)
GGO: 101148740(MSH6)
PON: 100458732(MSH6)
NLE: 100593553(MSH6)
MCC: 715701(MSH6)
MCF: 102143419(MSH6)
CSAB: 103220318(MSH6)
RRO: 104663162(MSH6)
RBB: 108527513(MSH6)
CJC: 100386465(MSH6)
SBQ: 101039649(MSH6)
MMU: 17688(Msh6)
RNO: 100360342(Msh6)
CGE: 100771087(Msh6)
NGI: 103725738(Msh6)
HGL: 101708261(Msh6)
CCAN: 109691597(Msh6)
OCU: 100351645(MSH6)
TUP: 102476727(MSH6)
CFA: 474585(MSH6)
AML: 100471984(MSH6)
UMR: 103671242(MSH6)
ORO: 101368929(MSH6)
FCA: 101082303(MSH6)
PTG: 102953993(MSH6)
AJU: 106977218(MSH6)
BTA: 540526(MSH6)
BOM: 102269162(MSH6)
BIU: 109566061(MSH6)
PHD: 102321074(MSH6)
CHX: 102173474(MSH6)
OAS: 101107426(MSH6)
SSC: 100624450(MSH6)
CFR: 102513599(MSH6)
CDK: 105092358(MSH6)
BACU: 102999040(MSH6)
LVE: 103089181(MSH6)
OOR: 101271574(MSH6)
ECB: 100068065(MSH6)
EPZ: 103558461(MSH6)
EAI: 106825979(MSH6)
MYB: 102245110(MSH6)
MYD: 102755448(MSH6)
HAI: 109389905(MSH6)
RSS: 109456360(MSH6)
PALE: 102892999(MSH6)
LAV: 100677382(MSH6)
TMU: 101345932
MDO: 100033356(MSH6)
SHR: 100919645(MSH6)
GGA: 421291(MSH6)
MGP: 100541959(MSH6)
CJO: 107310861(MSH6)
APLA: 101799348(MSH6)
ACYG: 106043138(MSH6)
TGU: 100227810(MSH6)
GFR: 102033560(MSH6)
FAB: 101815194(MSH6)
PHI: 102104034(MSH6)
PMAJ: 107201864(MSH6)
CCW: 104685591(MSH6)
FPG: 101921710(MSH6)
FCH: 102051882(MSH6)
CLV: 102090300(MSH6)
EGZ: 104134625(MSH6)
AAM: 106490408(MSH6)
ASN: 102388051(MSH6)
AMJ: 102573895(MSH6)
PSS: 102456308(MSH6)
CMY: 102943356(MSH6)
CPIC: 101951836(MSH6)
ACS: 100562407(msh6)
PVT: 110079554(MSH6)
PBI: 103056083(MSH6)
GJA: 107124261(MSH6)
XLA: 734294(msh6.L)
XTR: 100145639(msh6)
NPR: 108787598(MSH6)
DRE: 260437(msh6)
SANH: 107679164(msh6) 107688801
SGH: 107588437
IPU: 108263456(msh6)
AMEX: 103027666(msh6)
TRU: 101079280(msh6)
LCO: 104918635(msh6)
NCC: 104951340(msh6)
MZE: 101470032(msh6)
OLA: 101160935(msh6)
XMA: 102229772(msh6)
PRET: 103477050(msh6)
NFU: 107375752(msh6)
CSEM: 103387561(msh6)
LCF: 108894383(msh6)
HCQ: 109516232(msh6)
BPEC: 110157016(msh6)
SASA: 106589736(msh6)
ELS: 105028409(msh6)
SFM: 108918060(msh6)
LCM: 102366015(MSH6)
CMK: 103180839(msh6)
CIN: 100185806
SPU: 593059
APLC: 110987988
SKO: 102805174
DME: Dmel_CG7003(Msh6)
DSI: Dsimw501_GD12570(Dsim_GD12570)
MDE: 101889577
AAG: 5575374
AME: 408815(Msh6)
BIM: 100745752
BTER: 100647842
AEC: 105147089
ACEP: 105623738
PBAR: 105431572
HST: 105183383
CFO: 105255559
LHU: 105677715
PGC: 109859322
NVI: 100115613(Msh6)
TCA: 660174
DPA: 109543134
NVL: 108567736
BMOR: 101744671
PRAP: 110993015
API: 100166946
DNX: 107173209
ZNE: 110831875
FCD: 110851254
TUT: 107364943
CEL: CELE_Y47G6A.11(msh-6)
CBR: CBG14959(Cbr-msh-6)
BMY: Bm1_41770
CRG: 105344641
OBI: 106880162
LAK: 106155648
SHX: MS3_02714
EPA: 110241459
AQU: 100631829
ATH: AT3G24495(MSH7) AT4G02070(MSH6)
LJA: Lj1g3v0246860.1(Lj1g3v0246860.1) Lj1g3v4862830.1(Lj1g3v4862830.1) Lj1g3v4862840.1(Lj1g3v4862840.1) Lj2g3v0777050.1(Lj2g3v0777050.1) Lj2g3v0777050.2(Lj2g3v0777050.2)
VVI: 100255608 100260983(MSH7)
SLY: 100462656(MSH7)
CANN: 107877977
DOSA: Os01t0180600-01(Os01g0180600) Os09t0407600-01(Os09g0407600)
ATS: 109772035(LOC109772035) 109786772(LOC109786772)
APRO: F751_5249
SCE: YDR097C(MSH6)
ERC: Ecym_3519
KMX: KLMA_30293(MSH6)
NCS: NCAS_0B03980(NCAS0B03980)
NDI: NDAI_0J01520(NDAI0J01520)
TPF: TPHA_0B03370(TPHA0B03370)
TBL: TBLA_0F03840(TBLA0F03840)
TDL: TDEL_0A01290(TDEL0A01290)
KAF: KAFR_0A02370(KAFR0A02370)
PIC: PICST_81012(MSH6)
CAL: CAALFM_C113170CA(MSH6)
CAUR: QG37_00252
SLB: AWJ20_1503(MSH6)
NCR: NCU08135(msh6)
NTE: NEUTE1DRAFT124150(NEUTE1DRAFT_124150)
SMP: SMAC_03612(putative msh56)
MGR: MGG_00704
MAW: MAC_02355
MAJ: MAA_06876
CMT: CCM_06095
MBE: MBM_04714
ANI: AN1708.2
ANG: ANI_1_590184(An04g03050)
ABE: ARB_00228
TVE: TRV_05220
PTE: PTT_11611
SPO: SPCC285.16c(msh6)
CNE: CNK02590
CNB: CNBK0960
ABP: AGABI1DRAFT78171(AGABI1DRAFT_78171)
ABV: AGABI2DRAFT207943(AGABI2DRAFT_207943)
MGL: MGL_2919
DDI: DDB_G0268614(msh6)
DFA: DFA_09956(msh6)
EHI: EHI_193340(139.t00016)
PYO: PY17X_1106200(PY02936)
PCB: PCHAS_110480(PC000601.02.0)
TAN: TA19305
TPV: TP01_0185
BBO: BBOV_I004430(19.m02191)
CPV: cgd8_370
SMIN: v1.2.026874.t1(symbB.v1.2.026874.t1) v1.2.039566.t1(symbB.v1.2.039566.t1)
FCY: FRACYDRAFT_212924(MSH6)
TPS: THAPSDRAFT_261781(MutS)
SPAR: SPRG_05442
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC
  Title
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
  Journal
Oncogene 23:3749-56 (2004)
DOI:10.1038/sj.onc.1207462
  Sequence
[hsa:2956]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YDR097C]

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