KEGG ORTHOLOGY: K08844

ORTHOLOGY: K08844

Entry

K08844                      KO

Symbol

LRRK2

Name

leucine-rich repeat kinase 2 [EC:2.7.11.1]

Pathway

map05012

Parkinson disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00057

Parkinson disease

H00066

Lewy body dementia (LBD)

H01600

Parkinsonian syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08844  LRRK2; leucine-rich repeat kinase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K08844  LRRK2; leucine-rich repeat kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08844  LRRK2; leucine-rich repeat kinase 2
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08844  LRRK2; leucine-rich repeat kinase 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K08844  LRRK2; leucine-rich repeat kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08844  LRRK2; leucine-rich repeat kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  LRRK family
   K08844  LRRK2; leucine-rich repeat kinase 2
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08844  LRRK2; leucine-rich repeat kinase 2
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K08844  LRRK2; leucine-rich repeat kinase 2

Genes

HSA:	120892(LRRK2)

PTR:	745893(LRRK2)

PPS:	100991115(LRRK2)

GGO:	101129744(LRRK2)

PON:	100440374(LRRK2)

NLE:	100582066(LRRK2)

HMH:	116480074(LRRK2)

MCC:	697930(LRRK2)

MCF:	102126106(LRRK2)

MTHB:

126931722

MNI:	105470180(LRRK2)

CSAB:

103238159(LRRK2)

CATY:

105571723(LRRK2)

PANU:

100137384(LRRK2)

TGE:	112634489(LRRK2)

MLEU:

105533890

RRO:	104664577(LRRK2)

RBB:	108538682(LRRK2)

TFN:	117090280(LRRK2)

PTEH:

111520206(LRRK2)

CANG:

105507578(LRRK2)

CJC:	100412740(LRRK2)

SBQ:	101046501(LRRK2)

CIMI:

108305669(LRRK2)

CSYR:

103264290(LRRK2)

MMUR:

105884625(LRRK2)

LCAT:

123639854(LRRK2)

PCOQ:

105805497(LRRK2)

OGA:	100952425(LRRK2)

MMU:	66725(Lrrk2)

MCAL:

110310364(Lrrk2)

MPAH:

110334545(Lrrk2)

RNO:	300160(Lrrk2)

MCOC:

116078213(Lrrk2)

ANU:	117719229(Lrrk2)

MUN:	110541861(Lrrk2)

CGE:	100768191(Lrrk2)

MAUA:

101843291(Lrrk2)

PROB:

127225978(Lrrk2)

PLEU:

114693051(Lrrk2)

MORG:

121461505(Lrrk2)

MFOT:

126494147

AAMP:

119823615(Lrrk2)

NGI:	103731296(Lrrk2)

HGL:	101708809(Lrrk2)

CPOC:

100730338(Lrrk2)

CCAN:

109700877(Lrrk2)

DORD:

105987537(Lrrk2)

DSP:	122106250(Lrrk2)

PLOP:

125365985(Lrrk2)

NCAR:

124982607

MMMA:

107148551(Lrrk2)

OCU:

100343394

OPI:	101517270(LRRK2)

TUP:	102479879(LRRK2)

GVR:	103586022(LRRK2)

CFA:	486608(LRRK2)

CLUD:

112665626(LRRK2)

VVP:	112921054(LRRK2)

VLG:	121480288(LRRK2)

NPO:	129505565(LRRK2)

AML:	100466511(LRRK2)

UMR:	103675581(LRRK2)

UAH:	113257729(LRRK2)

UAR:	123778876(LRRK2)

ELK:

111161332

LLV:

125106618

MPUF:

101684592(LRRK2)

MNP:	132019593(LRRK2)

MLK:	131838874(LRRK2)

NVS:	122892606(LRRK2)

ORO:	101382328(LRRK2)

EJU:	114216561(LRRK2)

ZCA:	113921477(LRRK2)

MLX:	118025506(LRRK2)

NSU:	110580724(LRRK2)

LWW:	102739535(LRRK2)

FCA:	101096157(LRRK2)

PYU:	121038720(LRRK2)

PCOO:

112867739(LRRK2)

PBG:	122473146(LRRK2)

PVIV:

125170172(LRRK2)

LRUF:

124501377

PTG:	102957332(LRRK2)

PPAD:

109268830(LRRK2)

PUC:

125918962

AJU:

106986899

HHV:	120225364(LRRK2)

BTA:	535652(LRRK2)

BOM:	102267844(LRRK2)

BIU:	109559216(LRRK2)

BBUB:

102391863(LRRK2)

BBIS:

104989735(LRRK2)

CHX:	102188019(LRRK2)

OAS:	101111447(LRRK2)

BTAX:

128048048(LRRK2)

ODA:	120857761(LRRK2)

CCAD:

122427106(LRRK2)

MBEZ:

129537027(LRRK2)

SSC:	780403(LRRK2)

CFR:	102505769(LRRK2)

CBAI:

105081372(LRRK2)

CDK:	105089274(LRRK2)

VPC:	102541197(LRRK2)

BACU:

103007107(LRRK2)

BMUS:

118901821(LRRK2)

LVE:

103070824

OOR:	101273162(LRRK2)

DLE:	111174109(LRRK2)

PCAD:

102989961(LRRK2)

PSIU:

116760058(LRRK2)

NASI:

112396658(LRRK2)

ECB:	100052935(LRRK2)

EPZ:	103551980(LRRK2)

EAI:	106822491(LRRK2)

MYB:	102257573(LRRK2)

MYD:	102770006(LRRK2)

MMYO:

118649737(LRRK2)

MLF:	102433338(LRRK2)

PKL:	118729050(LRRK2)

EFUS:

103285200(LRRK2)

MNA:	107528359(LRRK2)

DRO:	112318354(LRRK2)

SHON:

118995204(LRRK2)

AJM:	119045116(LRRK2)

PDIC:

114513131(LRRK2)

PHAS:

123812430(LRRK2)

MMF:	118624172(LRRK2)

PPAM:

129084928(LRRK2)

HAI:	109376683(LRRK2)

RFQ:	117029126(LRRK2)

PALE:

102880438(LRRK2)

PGIG:

120618274(LRRK2)

PVP:	105294106(LRRK2)

RAY:	107514208(LRRK2)

MJV:	108393528(LRRK2)

TOD:	119247121(LRRK2)

SARA:

101546557(LRRK2)

SETR:

126022841(LRRK2)

LAV:	100675822(LRRK2)

TMU:

101360352

ETF:	101650204(LRRK2)

DNM:	101427687(LRRK2)

MDO:	100019429(LRRK2)

GAS:	123250068(LRRK2)

SHR:	100914746(LRRK2)

AFZ:

127563983

PCW:	110199010(LRRK2)

OAA:	100080785(LRRK2)

GGA:	427844(LRRK2)

PCOC:

116233503(LRRK2)

MGP:	100548936(LRRK2)

CJO:	107307980(LRRK2)

TPAI:

128079676(LRRK2)

LMUT:

125693621(LRRK2)

NMEL:

110392392(LRRK2)

APLA:

101799033(LRRK2)

ACYG:

106042027(LRRK2)

CATA:

118249386(LRRK2)

AFUL:

116492337(LRRK2)

TGU:	100230190(LRRK2)

LSR:	110475185(LRRK2)

SCAN:

103813716(LRRK2)

PMOA:

120498124(LRRK2)

OTC:	121336321(LRRK2)

PRUF:

121357375(LRRK2)

GFR:	102035180(LRRK2)

FAB:	101807426(LRRK2)

OMA:	130263318(LRRK2)

PHI:	102105175(LRRK2)

PMAJ:

107204228(LRRK2)

CCAE:

111923010(LRRK2)

CCW:	104686859(LRRK2)

CBRC:

103623474(LRRK2)

ETL:	114060564(LRRK2)

ZAB:	102072055(LRRK2)

ACHL:

103800993(LRRK2)

SVG:	106848817(LRRK2)

MMEA:

130575850(LRRK2)

HRT:	120751618(LRRK2)

FPG:	101912937(LRRK2)

FCH:	102053602(LRRK2)

CLV:	102096289(LRRK2)

EGZ:	104123793(LRRK2)

NNI:	104010796(LRRK2)

PCRI:

104036485(LRRK2)

PLET:

104622193(LRRK2)

EHS:	104506082(LRRK2)

PCAO:

104053790(LRRK2)

ACUN:

113487676(LRRK2)

TALA:

104366479(LRRK2)

PADL:

103917271(LRRK2)

AFOR:

103906999(LRRK2)

ACHC:

115341630(LRRK2)

HALD:

104321072(LRRK2)

HLE:	104840262(LRRK2)

AGEN:

126044530

GCL:

127020074

CCRI:

104164633(LRRK2)

CSTI:

104564216(LRRK2)

CMAC:

104476994(LRRK2)

MUI:	104541975(LRRK2)

BREG:

104642391(LRRK2)

FGA:	104074682(LRRK2)

GSTE:

104262699

LDI:	104349006(LRRK2)

MNB:	103775914(LRRK2)

OHA:	104328736(LRRK2)

NNT:	104408868(LRRK2)

SHAB:

115604957(LRRK2)

DPUB:

104308933(LRRK2)

ACAR:

104523176(LRRK2)

CPEA:

104387984(LRRK2)

AVIT:

104271196(LRRK2)

CVF:	104287265(LRRK2)

RTD:	128914362(LRRK2)

CUCA:

104056085(LRRK2)

TEO:	104376276(LRRK2)

BRHI:

104501933(LRRK2)

AAM:	106487733(LRRK2)

AROW:

112971025(LRRK2)

NPD:	112953344(LRRK2)

TGT:	104580749(LRRK2)

DNE:	112980498(LRRK2)

SCAM:

104138409(LRRK2)

ASN:	102372165(LRRK2)

AMJ:	102569017(LRRK2)

CPOO:

109315707(LRRK2)

GGN:	109292120(LRRK2)

PSS:	102462745(LRRK2)

CMY:	102935365(LRRK2)

CCAY:

125630402(LRRK2)

DCC:	119860816(LRRK2)

CPIC:

103307567(LRRK2)

TST:	117875485(LRRK2)

CABI:

116838640(LRRK2)

MRV:	120391943(LRRK2)

ACS:	100555929(lrrk2)

ASAO:

132776584(LRRK2)

PVT:	110080790(LRRK2)

SUND:

121931647(LRRK2)

PBI:	103054138(LRRK2)

PMUR:

107303316(LRRK2)

CTIG:

120313022(LRRK2)

PGUT:

117675191(LRRK2)

APRI:

131201585(LRRK2)

PTEX:

113436695(LRRK2)

NSS:	113418399(LRRK2)

VKO:	123019959(LRRK2)

PMUA:

114605058(LRRK2)

PRAF:

128422286(LRRK2)

ZVI:	118090597(LRRK2)

HCG:	128325858(LRRK2)

GJA:	107119907(LRRK2)

STOW:

125435394(LRRK2)

EMC:	129335472(LRRK2)

XLA:	445832(lrrk2.L)

XTR:	100145062(lrrk2)

NPR:	108783840(LRRK2)

RTEM:

120931791(LRRK2)

BBUF:

120982356(LRRK2)

BGAR:

122927891(LRRK2)

MUO:	115478973(LRRK2)

GSH:	117366747(LRRK2)

DRE:	559366(lrrk2)

SRX:	107723953 107752478

SANH:

107679955 107695916

SGH:	107555679 107571668

CCAR:

109050968

CAUA:

113067204(lrrk2)

CGIB:

127947111

PTET:

122330777(lrrk2)

LROH:

127156545(lrrk2)

OMC:	131534284(lrrk2)

PPRM:

120468045(lrrk2)

RKG:	130080368(lrrk2)

MAMB:

125247096(lrrk2)

CIDE:

127507429

MASI:

127436274 127437221

TROS:

130551750(lrrk2)

TDW:	130414001(lrrk2)

MANU:

129433403(lrrk2)

IPU:

108274736

IFU:	128618200(lrrk2)

PHYP:

113529688(lrrk2)

SMEO:

124392337(lrrk2)

TFD:	113660055(lrrk2)

TVC:	132856567(lrrk2)

AMEX:

103037394(lrrk2)

CMAO:

118811633(lrrk2)

EEE:	113573141(lrrk2)

CHAR:

105913130(lrrk2)

TRU:	101065896(lrrk2)

TFS:	130536529(lrrk2)

TNG:	GSTEN00025665G001

LCO:	104922606(lrrk2)

TBEN:

117497246(lrrk2)

CGOB:

115009474(lrrk2)

PGEO:

117448247(lrrk2)

GACU:

117539395(lrrk2)

EMAC:

134858432(lrrk2)

ELY:	117262367(lrrk2)

EFO:	125888060(lrrk2)

PLEP:

121950130(lrrk2)

SLUC:

116046849(lrrk2)

ECRA:

117949330(lrrk2)

ESP:	116694533(lrrk2)

PFLV:

114559736(lrrk2)

GAT:	120809096(lrrk2)

PPUG:

119195617(lrrk2)

AFB:	129108205(lrrk2)

CLUM:

117731804(lrrk2)

PSWI:

130195974(lrrk2)

MSAM:

119894463(lrrk2)

SCHU:

122874499(lrrk2)

CUD:	121515087(lrrk2)

ALAT:

119024620(lrrk2)

MZE:	101468617(lrrk2)

ONL:	100693798(lrrk2)

OAU:	116313987(lrrk2)

OLA:	101155093(lrrk2)

OML:	112152410(lrrk2)

CSAI:

133443720 133444833

XMA:	102223156(lrrk2)

XCO:	114136420(lrrk2)

XHE:	116708216(lrrk2)

PRET:

103465740(lrrk2)

PFOR:

103147607(lrrk2)

PLAI:

106946930(lrrk2)

PMEI:

106930828(lrrk2)

GAF:	122835417(lrrk2)

PPRL:

129358159(lrrk2)

CVG:	107102890(lrrk2)

CTUL:

119799219(lrrk2)

GMU:	124878490(lrrk2)

NFU:	107388331(lrrk2)

KMR:	108244226(lrrk2)

ALIM:

106526120(lrrk2)

NWH:	119415933(lrrk2)

AOCE:

111582490(lrrk2)

MCEP:

125015488(lrrk2)

CSEM:

103379674(lrrk2)

POV:	109624654(lrrk2)

SSEN:

122775455(lrrk2)

HHIP:

117762670(lrrk2)

HSP:	118109349(lrrk2)

SMAU:

118315486(lrrk2)

LCF:

108880868

SDU:	111222523(lrrk2)

SLAL:

111672161(lrrk2)

XGL:	120793754(lrrk2)

HCQ:	109530852(lrrk2)

SSCV:

125970415

SBIA:

133502711(lrrk2)

PEE:	133403382(lrrk2)

PTAO:

133478198(lrrk2)

BPEC:

110168304(lrrk2)

MALB:

109956385(lrrk2)

BSPL:

114857784(lrrk2)

SJO:	128359061(lrrk2)

SASA:

106561594(lrrk2)

STRU:

115197574(lrrk2)

OTW:	112218871(lrrk2)

OMY:	110499716(lrrk2)

OGO:	124039694(lrrk2)

ONE:	115133948(lrrk2)

OKI:	109867030(lrrk2)

OKE:	118396057(lrrk2)

SALP:

111962739

SNH:	120065892(lrrk2)

CCLU:

121531659(lrrk2)

ELS:	105026420(lrrk2)

SFM:	108927228(lrrk2)

PKI:	111853401(lrrk2)

AANG:

118231407(lrrk2)

LOC:	102692690(lrrk2)

PSPA:

121319766(lrrk2)

ARUT:

117415587(lrrk2)

PSEX:

120533956(lrrk2)

LCM:	102365848(LRRK2)

CMK:	103189557(lrrk2)

RTP:	109938857(lrrk2)

CPLA:

122561660(lrrk2)

HOC:	132826762(lrrk2)

LERI:

129708038(lrrk2)

PMRN:

116942467(LRRK2)

LRJ:	133349367(LRRK2)

BFO:	118416238 118426249

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

LGI:	LOTGIDRAFT_165219

PVUL:

126828485

PCAN:

112554025 112557488 112572054

BGT:	106061426 106067596

GAE:	121367941 121374371 121387519

HRF:	124116403 124123864 124135715

HRJ:	124271531 124273077 124279291

CRG:	105321951 105327744 105342841 105344416

CVN:

111107387

CANU:

128160596

OED:

125654327

MYI:	110440494 110453480 110454969 110458668

PMAX:

117329409 117334139 117334433 117334925 117341478 117344606

MMER:

RPHI:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114516370 114532307

XEN:	124441402 124443570 124444167

HMG:	100203196 100209958

HSY:

130644497

TAD:	TRIADDRAFT_58269

AQU:

109583022

DDI:	DDB_G0269250(pats1)

DPP:	DICPUDRAFT_159478(pats1)

DFA:	DFA_03616 DFA_06290(pats1)

ACAN:

ACA1_022700 ACA1_024410 ACA1_063470 ACA1_068460 ACA1_071050 ACA1_098030 ACA1_214570 ACA1_214880 ACA1_253160 ACA1_288810 ACA1_360610 ACA1_372740 ACA1_400320

» show all

Reference

PMID:15541309

Authors

Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T

Title

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

Journal

Neuron 44:601-7 (2004)
DOI:10.1016/j.neuron.2004.11.005

Sequence

[hsa:120892]

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1751)   
   KEGG GENES (474)   
   KEGG MGENES (751)   
   RefGene (515)   
   OC (11)   
Literature (1)   
   PubMed (1)   
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