KEGG ORTHOLOGY: K09054

ORTHOLOGY: K09054

Entry

K09054                      KO

Symbol

ATF6A

Name

cyclic AMP-dependent transcription factor ATF-6 alpha

Pathway

map04141

Protein processing in endoplasmic reticulum

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05417

Lipid and atherosclerosis

Disease

H00971

Achromatopsia

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
   05012 Parkinson disease
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
   05014 Amyotrophic lateral sclerosis
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
   05022 Pathways of neurodegeneration - multiple diseases
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha

Genes

HSA:	22926(ATF6)

PTR:	457461(ATF6)

PPS:	100981924(ATF6)

GGO:	101144626(ATF6)

PON:	100451142(ATF6)

NLE:	100584219(ATF6)

HMH:	116473320(ATF6)

MCC:	720056(ATF6)

MCF:	102135853(ATF6)

MNI:	105498227(ATF6)

CSAB:

103223664(ATF6)

CATY:

105589230(ATF6)

PANU:

101014227(ATF6)

TGE:	112626309(ATF6)

MLEU:

105551004(ATF6)

RRO:	104670391(ATF6)

RBB:	108542583(ATF6)

TFN:	117076376(ATF6)

PTEH:

111525029(ATF6)

CANG:

105519596(ATF6)

CJC:	100412913(ATF6)

SBQ:	101043094(ATF6)

CIMI:

108293602(ATF6)

CSYR:

103263709(ATF6)

MMUR:

105873568(ATF6)

LCAT:

123634820(ATF6)

PCOQ:

105806404(ATF6)

OGA:	100945547(ATF6)

MMU:	226641(Atf6)

MCAL:

110292204(Atf6)

MPAH:

110321899(Atf6)

RNO:	304962(Atf6)

MCOC:

116103242(Atf6)

ANU:	117712775(Atf6)

MUN:	110554441(Atf6)

CGE:	100772173(Atf6)

MAUA:

101837685(Atf6)

PROB:

127223556(Atf6)

PLEU:

114689894(Atf6)

MORG:

121442018 121455077

MFOT:

126511184

AAMP:

119827727(Atf6)

NGI:	103746777(Atf6)

HGL:	101706597(Atf6)

CPOC:

100730337(Atf6)

CCAN:

109697613(Atf6)

DORD:

105996547(Atf6)

DSP:	122109183(Atf6)

PLOP:

125359970(Atf6)

NCAR:

124986518

MMMA:

107147457(Atf6)

OCU:

100358536

OPI:	101524018(ATF6)

TUP:	102484816(ATF6)

GVR:	103591149(ATF6)

CFA:	488660(ATF6)

CLUD:

112643044(ATF6)

VVP:	112914298(ATF6)

VLG:	121501527(ATF6)

NPO:	129515280(ATF6)

AML:	100481422(ATF6)

UMR:	103658290(ATF6)

UAH:	113268761(ATF6)

UAR:	123783524(ATF6)

ELK:

111151136

LLV:

125085601

MPUF:

101689116(ATF6)

MNP:	132025748(ATF6)

MLK:	131815162(ATF6)

NVS:	122918895(ATF6)

ORO:	101365204(ATF6)

EJU:	114210449(ATF6)

ZCA:	113932654(ATF6)

MLX:	118014029(ATF6)

NSU:	110588174(ATF6)

LWW:	102738896(ATF6)

FCA:	101086780(ATF6)

PYU:	121020843(ATF6)

PCOO:

112864801(ATF6)

PBG:	122475617(ATF6)

PVIV:

125155037(ATF6)

LRUF:

124509907

PTG:	102967171(ATF6)

PPAD:

109276666(ATF6)

PUC:

125925955

AJU:

106986766

HHV:	120241057(ATF6)

BTA:	530610(ATF6)

BOM:	102274690(ATF6)

BIU:	109556667(ATF6)

BBUB:

102394003(ATF6)

BBIS:

104999179(ATF6)

CHX:	102184016(ATF6)

OAS:	541606(ATF6)

BTAX:

128044797(ATF6) 128052047

ODA:	120855530(ATF6) 120860193 120867976

CCAD:

122430102(ATF6)

MBEZ:

129540459(ATF6)

SSC:	100158076(ATF6)

CFR:	102515280(ATF6)

CBAI:

105068089(ATF6)

CDK:	105092786(ATF6)

VPC:	102535079(ATF6)

BACU:

103016852(ATF6)

BMUS:

118890905(ATF6)

OOR:	101284204(ATF6)

DLE:	111170425(ATF6)

PCAD:

102983292(ATF6)

PSIU:

116757685(ATF6)

NASI:

112403903(ATF6)

ECB:	111773414(ATF6)

EPZ:	103562010(ATF6)

EAI:	106831122(ATF6)

MYB:	102239267(ATF6)

MYD:	102755559(ATF6)

MMYO:

118672678(ATF6)

MLF:	102426868(ATF6)

PKL:	118712025(ATF6)

EFUS:

103296554(ATF6)

MNA:	107535122(ATF6)

DRO:	112322369(ATF6)

SHON:

118979197(ATF6)

AJM:	119052816(ATF6)

PDIC:

114489491(ATF6)

PHAS:

123818349(ATF6)

MMF:	118637539(ATF6)

PPAM:

129082078(ATF6)

HAI:	109392318(ATF6)

RFQ:	117015170(ATF6)

PALE:

102878472(ATF6)

PGIG:

120584186(ATF6)

PVP:	105303424(ATF6)

RAY:	107502472(ATF6)

MJV:	108406222(ATF6)

TOD:	119241336(ATF6)

SARA:

101552652(ATF6)

SETR:

126013393(ATF6)

LAV:	100674349(ATF6)

TMU:

101353266

ETF:	101659622(ATF6)

DNM:	101411485(ATF6)

MDO:	100015495(ATF6)

GAS:	123245395(ATF6)

SHR:	100925183(ATF6)

AFZ:

127562993

PCW:	110209901(ATF6)

OAA:	100091907(ATF6)

GGA:	424365(ATF6)

PCOC:

116230534(ATF6)

MGP:	100545177(ATF6)

CJO:	107317148(ATF6)

TPAI:

128072269(ATF6)

LMUT:

125693247(ATF6)

NMEL:

110402649(ATF6)

APLA:

101798949(ATF6)

ACYG:

106041594(ATF6)

CATA:

118243373(ATF6)

AFUL:

116492069(ATF6)

TGU:	100228575(ATF6)

LSR:	110478967(ATF6)

SCAN:

103824317(ATF6)

PMOA:

120497565(ATF6)

OTC:	121344242(ATF6)

PRUF:

121359753(ATF6)

GFR:	102038347(ATF6)

FAB:	101811583(ATF6)

OMA:	130256104(ATF6)

PHI:	102107126(ATF6)

PMAJ:

107198626(ATF6)

CCAE:

111932685(ATF6)

CCW:	104695431(ATF6)

CBRC:

103612535(ATF6)

ETL:	114067479(ATF6)

ZAB:	102070309(ATF6)

ACHL:

103802295(ATF6)

SVG:	106852222(ATF6)

MMEA:

130579969

HRT:	120756664(ATF6)

FPG:	101919069(ATF6)

FCH:	102053563(ATF6)

CLV:	102093780(ATF6)

EGZ:	104132078(ATF6)

NNI:	104010410(ATF6)

PCRI:

104033499(ATF6)

PLET:

104625090(ATF6)

EHS:	104511062(ATF6)

PCAO:

104045870(ATF6)

ACUN:

113483062(ATF6)

TALA:

104358644(ATF6)

PADL:

103913996(ATF6)

AFOR:

103903999(ATF6)

ACHC:

115348684(ATF6)

HALD:

104311438(ATF6)

HLE:	104840198(ATF6)

AGEN:

126041835

GCL:

127019162

CCRI:

104165385(ATF6)

CSTI:

104560236(ATF6)

CMAC:

104484797(ATF6)

BREG:

104638488(ATF6)

FGA:	104080197(ATF6)

LDI:

104352290

MNB:	103773923(ATF6)

OHA:	104333727(ATF6)

NNT:	104407780(ATF6)

SHAB:

115612351(ATF6)

DPUB:

104308001(ATF6)

PGUU:

104463518(ATF6)

ACAR:

104527563(ATF6)

CPEA:

104390696(ATF6)

CVF:	104293311(ATF6)

CUCA:

104054722(ATF6)

TEO:	104383263(ATF6)

BRHI:

104490675(ATF6)

AAM:	106499712(ATF6)

AROW:

112977153(ATF6)

NPD:	112951142(ATF6)

DNE:	112997386(ATF6)

SCAM:

104140776(ATF6)

ASN:	102381020(ATF6)

AMJ:	102562917(ATF6)

CPOO:

109307066(ATF6)

GGN:	109287070(ATF6)

PSS:	102461928(ATF6)

CMY:	102942511(ATF6)

CCAY:

125640775(ATF6)

DCC:	119859924(ATF6)

CPIC:

101939884(ATF6)

TST:	117881468(ATF6)

CABI:

116839187(ATF6)

MRV:	120370579(ATF6)

ACS:	100565571(atf6)

ASAO:

132774344(ATF6)

PVT:	110081632(ATF6)

SUND:

121929039

PBI:	103051994(ATF6)

PMUR:

107302856(ATF6)

CTIG:

120310511(ATF6)

PGUT:

117661204(ATF6)

APRI:

131194016(ATF6)

PTEX:

113438130(ATF6)

NSS:	113424972(ATF6)

VKO:	123027842(ATF6)

PRAF:

128415230(ATF6)

ZVI:	118089168(ATF6)

HCG:	128323103(ATF6)

GJA:	107121031(ATF6)

STOW:

125433744(ATF6)

EMC:	129330746(ATF6)

XLA:	108714495(atf6.L) 496056(atf6.S)

XTR:	100498199(atf6)

NPR:	108801252(ATF6)

RTEM:

120945523(ATF6)

BBUF:

120978747(ATF6)

BGAR:

122943982(ATF6)

MUO:	115471968(ATF6)

GSH:	117367767(ATF6)

DRE:	558071(atf6)

SRX:	107710557 107726471

SANH:

107696152 107698395

SGH:	107555632 107601246

CCAR:

109112752

CAUA:

113062974 113120801

CGIB:

127938488 127984135

PTET:

122324691(atf6)

LROH:

127182952(atf6)

OMC:	131527006(atf6)

PPRM:

120493487(atf6)

RKG:	130103297(atf6)

MAMB:

125278177(atf6)

CIDE:

127502800

MASI:

127410082 127416388

TROS:

130565831(atf6)

TDW:	130434273(atf6)

MANU:

129429554(atf6)

IPU:

108257823

IFU:	128600953(atf6)

PHYP:

113546871(atf6)

SMEO:

124377235(atf6)

TFD:	113647514(atf6)

TVC:	132843532(atf6)

AMEX:

103039489

CMAO:

118815254(atf6)

EEE:	113590476(atf6)

CHAR:

105907109(atf6)

TRU:	101078942(atf6)

TFS:	130528212(atf6)

TNG:	GSTEN00020188G001

LCO:	104918457(atf6)

TBEN:

117495197(atf6)

CGOB:

115006768(atf6)

PGEO:

117445494(atf6)

GACU:

117550964(atf6)

EMAC:

134869911(atf6)

ELY:	117254309(atf6)

EFO:	125895852(atf6)

PLEP:

121938248(atf6)

SLUC:

116063312(atf6)

ECRA:

117950128(atf6)

ESP:

116696248

PFLV:

114561257(atf6)

GAT:	120824285(atf6)

PPUG:

119216735(atf6)

AFB:	129094364(atf6)

CLUM:

117729241(atf6)

PSWI:

130193519

MSAM:

119900801(atf6)

SCHU:

122877367(atf6)

CUD:	121512009(atf6)

ALAT:

119028779(atf6)

MZE:	101470925(atf6)

ONL:	100693055(atf6)

OAU:	116317756(atf6)

OLA:	101156317(atf6)

OML:	112150282(atf6)

CSAI:

133458346(atf6)

XMA:	102237149(atf6)

XCO:	114150294(atf6)

XHE:	116725550(atf6)

PRET:

103463576(atf6)

PFOR:

103142583(atf6)

PLAI:

106963917(atf6)

PMEI:

106916810(atf6)

GAF:	122839087(atf6)

PPRL:

129374230(atf6)

CVG:	107098581(atf6)

CTUL:

119797482(atf6)

GMU:	124873525(atf6)

NFU:	107393224(atf6)

KMR:	108230853(atf6)

ALIM:

106513903(atf6)

NWH:	119430672(atf6)

AOCE:

111573401

MCEP:

125009976(atf6)

CSEM:

103397986(atf6)

POV:	109625604(atf6)

SSEN:

122780647(atf6)

HHIP:

117760000(atf6)

HSP:	124854817(atf6)

SMAU:

118317858(atf6)

LCF:

108877400

SDU:	111232103(atf6)

SLAL:

111656333(atf6)

XGL:	120791083(atf6)

HCQ:	109532062(atf6)

SSCV:

125971282

SBIA:

133503904(atf6)

PEE:	133406104(atf6)

PTAO:

133480723(atf6)

BPEC:

110167827(atf6)

MALB:

109964064(atf6)

BSPL:

114854017(atf6)

SJO:	128361538(atf6)

SASA:

106560503(atf6) 106568908 106599111

STRU:

115156794 115158845(atf6) 115169904

OTW:	112227060 112251659(atf6) 112260353

OMY:	110508857 110524848(atf6) 110530172

OGO:	123996455(atf6) 124009297 124041974

ONE:	115103203 115114283 115121331

OKI:	109871784 109874578 109902900(atf6)

OKE:	118381098(atf6) 118394543 118402241

SALP:

111956517 111979525

SNH:	120020447 120055087(atf6) 120055830

CCLU:

121534139(atf6) 121535094

SFM:	108935180 108935502

PKI:	111840080 111841038(atf6)

AANG:

118225389(atf6) 118230021

LOC:	102690213(atf6)

PSPA:

121327122(atf6) 121330841

ARUT:

117405564 117417024

PSEX:

120514448(atf6)

LCM:	102350356(ATF6)

CMK:	103184781(atf6)

CPLA:

122554643(atf6)

HOC:	132818952(atf6)

LERI:

129701041(atf6)

DME:	Dmel_CG3136(Atf6)

DER:

6541903

DSE:

6620142

DSI:	Dsimw501_GD17476(Dsim_GD17476)

DYA:	Dyak_GE11351

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20675

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

AGA:

ACOZ:

ASTE:

AFUN:

AAG:

AALB:

CQU:	CpipJ_CPIJ015709

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105558810 105566377

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

FAS:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

ATD:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

BTAB:

CLEC:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM488830

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_255380

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

EAF:

TCF:

PPOI:

DSV:

RSAN:

RMP:

DPTE:

CSCU:

PTEP:

ABRU:

CEL:	CELE_F45E6.2(atf-6)

CBR:	CBG_00118(Cbr-atf-6)

CRQ:	GCK72_024980

LOA:	LOAG_18333

PVUL:

CANU:

OED:

OBI:

EPA:

ADF:

PDAM:

SPIS:

DGT:

TAD:	TRIADDRAFT_53424

AQU:

105312032

» show all

Reference

PMID:9271374

Authors

Zhu C, Johansen FE, Prywes R

Title

Interaction of ATF6 and serum response factor.

Journal

Mol Cell Biol 17:4957-66 (1997)
DOI:10.1128/mcb.17.9.4957

Sequence

[hsa:22926]

Reference

PMID:18360008

Authors

Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K

Title

ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum.

Journal

Cell Struct Funct 33:75-89 (2008)
DOI:10.1247/csf.07044

Sequence

[mmu:226641]

Reference

PMID:11158310

Authors

Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K

Title

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.

Journal

Mol Cell Biol 21:1239-48 (2001)
DOI:10.1128/MCB.21.4.1239-1248.2001

Sequence

[hsa:22926]

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (1187)   
   KEGG GENES (575)   
   KEGG MGENES (106)   
   RefGene (503)   
   OC (3)   
Literature (3)   
   PubMed (3)   
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