KEGG ORTHOLOGY: K12329

ORTHOLOGY: K12329

Entry

K12329                      KO

Symbol

PPP1R12B, MYPT2

Name

protein phosphatase 1 regulatory subunit 12B

Pathway

map04270

Vascular smooth muscle contraction

map04510

Focal adhesion

map04810

Regulation of actin cytoskeleton

map04921

Oxytocin signaling pathway

map05205

Proteoglycans in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B

Genes

HSA:	4660(PPP1R12B)

PTR:	457629(PPP1R12B)

PPS:	100970244(PPP1R12B)

PON:	103890237(PPP1R12B)

NLE:	100592313(PPP1R12B)

HMH:	116457631(PPP1R12B)

MCC:	705775(PPP1R12B)

MCF:	102121021(PPP1R12B)

MTHB:

126938525

MNI:	105484741(PPP1R12B)

CSAB:

103230309(PPP1R12B)

CATY:

105575564(PPP1R12B)

PANU:

101008443(PPP1R12B)

TGE:	112624136(PPP1R12B)

MLEU:

105547100(PPP1R12B)

RRO:	104674509(PPP1R12B)

RBB:	108545061(PPP1R12B)

TFN:	117075738(PPP1R12B)

PTEH:

111522682(PPP1R12B)

CANG:

105504342(PPP1R12B)

CJC:	100404247(PPP1R12B)

SBQ:	101053159(PPP1R12B)

CIMI:

108301984

CSYR:

103275384

MMUR:

105860003(PPP1R12B)

LCAT:

123626957(PPP1R12B)

PCOQ:

105819655(PPP1R12B)

MMU:	329251(Ppp1r12b)

MCAL:

110293509(Ppp1r12b)

MPAH:

110322008(Ppp1r12b)

RNO:	304813(Ppp1r12b)

MCOC:

116099596(Ppp1r12b)

ANU:	117716456(Ppp1r12b)

CGE:	100753601(Ppp1r12b)

MAUA:

101827411(Ppp1r12b)

PROB:

127236425(Ppp1r12b)

PLEU:

114698113(Ppp1r12b)

MORG:

121445870(Ppp1r12b)

MFOT:

126504961

AAMP:

119827265(Ppp1r12b)

NGI:	103731836(Ppp1r12b)

HGL:	101711489(Ppp1r12b)

CPOC:

100729743(Ppp1r12b)

CCAN:

109690053(Ppp1r12b)

DORD:

105986532(Ppp1r12b)

DSP:	122109161(Ppp1r12b)

PLOP:

125359475(Ppp1r12b)

NCAR:

124961505

MMMA:

107140677(Ppp1r12b)

OCU:

100356902

OPI:	101523577(PPP1R12B)

TUP:	102500634(PPP1R12B)

GVR:	103597866(PPP1R12B)

CFA:	490230(PPP1R12B)

CLUD:

112667052(PPP1R12B)

VVP:	112934572(PPP1R12B)

VLG:	121493360(PPP1R12B)

NPO:	129505813(PPP1R12B)

AML:	100470069(PPP1R12B)

UMR:	103657720 103657721(PPP1R12B)

UAH:	113242537(PPP1R12B)

UAR:	123785739(PPP1R12B)

ELK:

111151011

LLV:

125086313

MPUF:

101674914(PPP1R12B)

MNP:	132025613(PPP1R12B)

MLK:	131814757(PPP1R12B)

NVS:	122918797(PPP1R12B)

ORO:	101369772(PPP1R12B)

EJU:	114221938(PPP1R12B)

ZCA:	113931863(PPP1R12B)

MLX:	118014193(PPP1R12B)

NSU:	110574078(PPP1R12B)

LWW:

102743929

FCA:	101098766(PPP1R12B)

PYU:	121021683(PPP1R12B)

PCOO:

112857630(PPP1R12B)

PBG:	122475957(PPP1R12B)

PVIV:

125155200(PPP1R12B)

LRUF:

124510019

PTG:	102950482(PPP1R12B)

PPAD:

109256388(PPP1R12B)

PUC:

125925407

AJU:

106973120

HHV:	120228862(PPP1R12B)

BTA:	107131237(PPP1R12B)

BOM:	102286584(PPP1R12B)

BBUB:

102409062(PPP1R12B)

BBIS:

104981869(PPP1R12B)

CHX:	102181773(PPP1R12B)

OAS:	101114596(PPP1R12B)

BTAX:

128061235(PPP1R12B)

ODA:	120880088(PPP1R12B)

CCAD:

122452339(PPP1R12B)

MBEZ:

129551173(PPP1R12B)

SSC:	100525832(PPP1R12B)

CFR:	102506936(PPP1R12B)

CBAI:

105069988(PPP1R12B)

CDK:	105105927(PPP1R12B)

BACU:

103012518(PPP1R12B)

BMUS:

118901165(PPP1R12B)

LVE:	103071840(PPP1R12B)

OOR:	101289221(PPP1R12B)

DLE:	111168304(PPP1R12B)

PCAD:

102980129(PPP1R12B)

PSIU:

116764804(PPP1R12B)

NASI:

112402620(PPP1R12B)

ECB:	100063928(PPP1R12B)

EPZ:	103561986(PPP1R12B)

EAI:	106840263(PPP1R12B)

MYB:	102263913(PPP1R12B)

MYD:	102762227(PPP1R12B)

MMYO:

118678779(PPP1R12B)

MLF:

102419496

PKL:

118710507

EFUS:

103302945(PPP1R12B)

MNA:	107536013(PPP1R12B)

DRO:	112318742(PPP1R12B)

SHON:

119003932(PPP1R12B)

AJM:	119060723 119060830

PDIC:

114512267(PPP1R12B)

PHAS:

123805100(PPP1R12B)

MMF:	118640525(PPP1R12B)

PPAM:

129072927(PPP1R12B)

HAI:	109380462(PPP1R12B)

RFQ:	117018401(PPP1R12B)

PALE:

102879733(PPP1R12B)

PGIG:

120619279(PPP1R12B)

PVP:

105296949

RAY:	107502991(PPP1R12B)

TOD:	119233942(PPP1R12B)

SARA:

101547060

SETR:

126004175(PPP1R12B)

LAV:	100675940(PPP1R12B)

ETF:	101662729(PPP1R12B)

DNM:	101441649(PPP1R12B)

MDO:	100011797(PPP1R12B)

GAS:	123247236(PPP1R12B)

SHR:	100925265(PPP1R12B)

AFZ:

127562713

PCW:	110219617(PPP1R12B)

OAA:	100077407(PPP1R12B)

GGA:	395478(PPP1R12B)

PCOC:

116238747(PPP1R12B)

MGP:	100545452 104914452(PPP1R12B)

CJO:	107324641(PPP1R12B)

TPAI:

128090296(PPP1R12B)

LMUT:

125684278(PPP1R12B)

NMEL:

110388357(PPP1R12B)

APLA:

101797997(PPP1R12B)

ACYG:

106045864(PPP1R12B)

CATA:

118255436(PPP1R12B)

AFUL:

116498840(PPP1R12B)

TGU:	100224964(PPP1R12B)

LSR:	110469162(PPP1R12B) 110469188

SCAN:

103822442(PPP1R12B)

PMOA:

120497304(PPP1R12B)

OTC:	121345537(PPP1R12B)

PRUF:

121365385(PPP1R12B)

GFR:

102044251

FAB:

101818016

OMA:	130263541(PPP1R12B)

PHI:	102113018(PPP1R12B)

PMAJ:

107214882

CCAE:

111939610(PPP1R12B)

CCW:	104692457(PPP1R12B)

ETL:	114064784(PPP1R12B)

ZAB:	102066150(PPP1R12B)

ACHL:

103805312

SVG:	106851111(PPP1R12B)

MMEA:

130578357

HRT:	120762862(PPP1R12B)

FPG:	101915795(PPP1R12B)

FCH:	102059378(PPP1R12B)

CLV:

102090398

EGZ:	104122002 104122018

NNI:

PCRI:

PLET:

PCAO:

ACUN:

113488963(PPP1R12B)

TALA:

104365770(PPP1R12B)

PADL:

103913809(PPP1R12B)

AFOR:

103901063(PPP1R12B)

ACHC:

115334870(PPP1R12B)

HALD:

104315090

HLE:	104842297(PPP1R12B)

AGEN:

126052146

GCL:

127026148

CCRI:

104168769

CSTI:

104551384(PPP1R12B)

CMAC:

MUI:

BREG:

GSTE:

OHA:	104337064(PPP1R12B)

NNT:

104404715

SHAB:

115602426(PPP1R12B)

PGUU:

104457544

ACAR:

104518099

RTD:	128900369(PPP1R12B)

CUCA:

104059021

TEO:

104377928

BRHI:

104488875

AAM:	106500257(PPP1R12B)

AROW:

112965075(PPP1R12B)

NPD:	112959166(PPP1R12B)

TGT:	104566662(PPP1R12B)

DNE:	112983848(PPP1R12B)

SCAM:

104139261(PPP1R12B)

ASN:	102387200(PPP1R12B)

AMJ:	102561475(PPP1R12B)

CPOO:

109317606(PPP1R12B)

GGN:	109295148(PPP1R12B)

PSS:	102450232(PPP1R12B)

CMY:	102943827(PPP1R12B)

CCAY:

125625093(PPP1R12B)

DCC:	119846205(PPP1R12B)

CPIC:

101931457(PPP1R12B)

TST:	117875973(PPP1R12B)

CABI:

116831705(PPP1R12B)

MRV:	120403388(PPP1R12B)

ACS:	100566099(ppp1r12b)

ASAO:

132773319(PPP1R12B)

PVT:	110073397(PPP1R12B)

SUND:

121927708(PPP1R12B)

PBI:	103051701(PPP1R12B)

PMUR:

107284458(PPP1R12B)

CTIG:

120301785(PPP1R12B)

PGUT:

117663765(PPP1R12B)

APRI:

131194424(PPP1R12B)

PTEX:

113444335(PPP1R12B)

NSS:	113420792(PPP1R12B)

VKO:

123032013

PMUA:

114599419(PPP1R12B)

PRAF:

128416233(PPP1R12B)

ZVI:	118088813(PPP1R12B)

HCG:	128323621(PPP1R12B)

STOW:

125432776(PPP1R12B)

EMC:	129331120(PPP1R12B)

XLA:	108708153(ppp1r12b.L)

XTR:	780217(ppp1r12b)

MUO:	115481446(PPP1R12B)

GSH:	117347170(PPP1R12B)

DRE:

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:	131531555 131532068

RKG:

CIDE:

TROS:

TDW:

MANU:

IFU:

TVC:

AMEX:

CMAO:

EEE:	113588809(ppp1r12b)

CHAR:

105894339 105895864

TRU:	101061865 101062607

TFS:

130530477

TNG:	GSTEN00023629G001

LCO:

TBEN:

PGEO:

GACU:

EMAC:

ELY:

PLEP:

SLUC:

GAT:

PPUG:

AFB:

CLUM:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

PPRL:

CVG:

CTUL:

NFU:

KMR:

ALIM:

AOCE:

MCEP:

CSEM:

POV:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

BPEC:

MALB:

SJO:

SASA:

STRU:

OTW:	112216138 112221953

OMY:	110492173 110532437

OGO:	124032044 124045882

ONE:	115102323 115132302

OKI:

109908122

OKE:	118359845 118360884

SALP:

111966596

SNH:	120059197 120061181

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

CMK:

RTP:

CPLA:

HOC:

LERI:

DCI:

DFR:

Reference

PMID:9570949

Authors

Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M

Title

A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.

Journal

Genomics 49:59-68 (1998)
DOI:10.1006/geno.1998.5222

Sequence

[hsa:4660]

Reference

PMID:21291858

Authors

Grassie ME, Moffat LD, Walsh MP, MacDonald JA

Title

The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.

Journal

Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Gene (973)   
   KEGG GENES (363)   
   KEGG MGENES (155)   
   RefGene (452)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (987)   

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