KEGG ORTHOLOGY: K12649

ORTHOLOGY: K12649

Entry

K12649                      KO

Symbol

DHX58, LGP2

Name

ATP-dependent RNA helicase DHX58 [EC:5.6.2.6]

Pathway

map04622

RIG-I-like receptor signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K12649  DHX58, LGP2; ATP-dependent RNA helicase DHX58
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K12649  DHX58, LGP2; ATP-dependent RNA helicase DHX58
Enzymes [BR:ko01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     K12649  DHX58, LGP2; ATP-dependent RNA helicase DHX58
Pattern recognition receptors [BR:ko04054]
Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   K12649  DHX58, LGP2; ATP-dependent RNA helicase DHX58

Other DBs

GO:

0034458

Genes

HSA:	79132(DHX58)

PTR:	742679(DHX58)

PPS:	100985302(DHX58)

GGO:	101125917(DHX58)

PON:	100171435(DHX58)

NLE:	100602155(DHX58)

HMH:	116474853(DHX58)

MCC:	709116(DHX58)

MTHB:

126938439

MNI:	105472131(DHX58)

CSAB:

103243422(DHX58)

CATY:

105579660(DHX58)

PANU:

100997314(DHX58)

TGE:	112610246(DHX58)

MLEU:

105552964(DHX58)

RRO:	104680381(DHX58)

RBB:	108518348(DHX58)

TFN:	117066971(DHX58)

PTEH:

111537380(DHX58)

CANG:

105503019(DHX58)

CJC:	100403680(DHX58)

SBQ:	101045966(DHX58) 101047410

CIMI:

108289836(DHX58)

CSYR:

103275664(DHX58)

MMUR:

105859440(DHX58)

LCAT:

123620949(DHX58)

PCOQ:

105820248(DHX58)

OGA:	100960762(DHX58)

MMU:	80861(Dhx58)

MCAL:

110304912(Dhx58)

MPAH:

110332373(Dhx58)

RNO:	303538(Dhx58)

MCOC:

116077806(Dhx58)

ANU:	117709891(Dhx58)

MUN:	110550870(Dhx58)

CGE:	100754123(Dhx58)

MAUA:

101832339(Dhx58)

PROB:

127216045(Dhx58)

PLEU:

114682806(Dhx58)

MORG:

121442437(Dhx58)

MFOT:

126510306

AAMP:

119812580(Dhx58)

NGI:	103735886(Dhx58)

HGL:	101697926(Dhx58)

CPOC:

100715966(Dhx58)

CCAN:

109695776(Dhx58)

DORD:

105980086(Dhx58)

DSP:	122103481(Dhx58)

PLOP:

125365989(Dhx58)

NCAR:

124980112

MMMA:

107150577(Dhx58)

OCU:

100347525

OPI:	101526374(DHX58)

TUP:	102490366(DHX58)

GVR:	103595343(DHX58)

CFA:	607803(DHX58)

CLUD:

112655678(DHX58)

VVP:	112910744(DHX58)

VLG:	121474225(DHX58)

NPO:	129511432(DHX58)

AML:	100468505(DHX58)

UMR:	103672617(DHX58)

UAH:	113265431(DHX58)

UAR:	123781937(DHX58)

ELK:

111151529

LLV:

125087085

MPUF:

101670803(DHX58)

MNP:	132003497(DHX58)

MLK:	131815826(DHX58)

NVS:	122906203(DHX58)

ORO:	101370154(DHX58)

EJU:	114201384(DHX58)

ZCA:	113938951(DHX58)

MLX:	118024902(DHX58)

NSU:	110573234(DHX58)

LWW:	102742984(DHX58)

FCA:	101094463(DHX58)

PYU:	121045011(DHX58)

PBG:	122485593(DHX58)

PVIV:

125158706(DHX58)

LRUF:

124522225

PTG:	102956389(DHX58)

PPAD:

109258522(DHX58)

PUC:

125926545

AJU:

106972602

HHV:	120248463(DHX58)

BTA:	508378(DHX58)

BOM:	102285077(DHX58)

BBUB:

102390399(DHX58)

BBIS:

104990448(DHX58)

CHX:	102183820(DHX58)

OAS:	101121528(DHX58)

BTAX:

128065155(DHX58)

ODA:	120867081(DHX58)

CCAD:

122441734(DHX58)

MBEZ:

129544417(DHX58)

SSC:	100524520(DHX58)

CFR:	102509830(DHX58)

CBAI:

105080125(DHX58)

CDK:	105090451(DHX58)

VPC:	102543766(DHX58)

BACU:

102999994 103012685(DHX58)

BMUS:

118886099(DHX58)

LVE:	103080251(DHX58)

OOR:	101278766(DHX58)

DLE:	111166374(DHX58)

PCAD:

102985157(DHX58)

PSIU:

116746030(DHX58)

NASI:

112399595(DHX58)

ECB:	100066316(DHX58)

EPZ:	103550393(DHX58)

EAI:	106826477(DHX58)

MYB:	102244062(DHX58)

MYD:	102758623(DHX58)

MMYO:

118672331(DHX58)

MLF:	102428799(DHX58)

PKL:	118726605(DHX58)

EFUS:

103293099(DHX58)

MNA:	107544201(DHX58)

DRO:	112298824(DHX58)

SHON:

118978137(DHX58)

AJM:	119037552(DHX58)

PDIC:

114503142(DHX58)

PHAS:

123817121(DHX58)

MMF:	118635025(DHX58)

PPAM:

129086887(DHX58)

HAI:	109395785(DHX58)

RFQ:	117012664(DHX58)

PALE:

102886289(DHX58)

PGIG:

120611107(DHX58)

PVP:	105306302(DHX58)

RAY:	107513813(DHX58)

MJV:	108388343(DHX58)

TOD:	119232078(DHX58)

SARA:

101550851(DHX58)

SETR:

126017291(DHX58)

LAV:	100668463(DHX58)

TMU:

101344931

ETF:	101654932(DHX58)

DNM:	101439110(DHX58)

MDO:	100012544(DHX58)

GAS:	123248045(DHX58)

SHR:	100920564(DHX58)

AFZ:

127560130

PCW:	110198475(DHX58)

OAA:	100084566(DHX58)

GGA:	100858653(DHX58)

PCOC:

116233612(DHX58)

MGP:	100548830(DHX58)

CJO:	107325122(DHX58)

TPAI:

128089088(DHX58)

LMUT:

125684579(DHX58)

NMEL:

110388613(DHX58)

APLA:

101792382(DHX58)

ACYG:

125180859(DHX58)

CATA:

118259176(DHX58)

AFUL:

116498584(DHX58)

TGU:	100227527(DHX58)

LSR:	110471848(DHX58)

SCAN:

103821730(DHX58)

PMOA:

120496665(DHX58)

OTC:	121347581(DHX58)

PRUF:

121351108(DHX58)

GFR:	102044160(DHX58)

FAB:	101818813(DHX58)

OMA:	130263969(DHX58)

PHI:	102099724(DHX58)

PMAJ:

107215132(DHX58)

CCAE:

111939999(DHX58)

CCW:	104697810(DHX58)

CBRC:

103624332(DHX58)

ETL:	114063661(DHX58)

ZAB:	102063334(DHX58)

ACHL:

103809345(DHX58)

SVG:	106858634(DHX58)

MMEA:

130581460(DHX58)

HRT:	120763761(DHX58)

FPG:	101920810(DHX58)

FCH:	102051590(DHX58)

CLV:	102091104(DHX58)

EGZ:	104124457(DHX58)

NNI:	104009922(DHX58)

PLET:

104618278(DHX58)

TALA:

116962515(DHX58)

PADL:

103919506(DHX58)

AFOR:

103902192(DHX58)

ACHC:

115345144(DHX58)

HLE:	104842936(DHX58)

AGEN:

126038676

GCL:

127026463

CCRI:

104157433(DHX58)

CSTI:

104557145(DHX58)

MUI:	104533578(DHX58)

BREG:

104633292

LDI:	104343500(DHX58)

SHAB:

115617593(DHX58)

DPUB:

104309587(DHX58)

CPEA:

104385705(DHX58)

CVF:	104294783(DHX58)

RTD:	128919111(DHX58)

CUCA:

104054483(DHX58)

BRHI:

104498635(DHX58)

AAM:	106487622(DHX58)

AROW:

112968733(DHX58)

NPD:	112951803(DHX58)

TGT:	104581037(DHX58)

DNE:	112992603(DHX58)

SCAM:

104152415(DHX58)

ASN:	102384462(DHX58)

AMJ:	102574115(DHX58)

CPOO:

109320355(DHX58)

GGN:	109289886(DHX58)

PSS:	102446063(DHX58)

CMY:	102940723(DHX58)

CCAY:

125626685(DHX58)

DCC:	119849073(DHX58)

CPIC:

101938646(DHX58)

TST:	117869311(DHX58)

CABI:

116829919(DHX58)

MRV:	120392297(DHX58)

ACS:	100566102(dhx58)

ASAO:

132775806(DHX58)

PVT:	110078256(DHX58)

SUND:

121930448(DHX58)

PBI:	103061487(DHX58)

PMUR:

107287194(DHX58)

CTIG:

120307493(DHX58)

TSR:	106538582(DHX58)

PGUT:

117655863(DHX58)

APRI:

131202505(DHX58)

PTEX:

113450441(DHX58)

NSS:	113432856(DHX58)

VKO:	123025360(DHX58)

PMUA:

114605221(DHX58)

PRAF:

128422240(DHX58)

ZVI:	118090641(DHX58)

HCG:	128328447(DHX58)

GJA:	107111854(DHX58)

STOW:

125434712(DHX58)

EMC:	129335886(DHX58)

XLA:	108702463(dhx58.S) 444342(dhx58.L)

XTR:	100492559(dhx58)

NPR:	108788930(DHX58)

RTEM:

120918553 120918555

BBUF:

121003133(DHX58)

BGAR:

122940892 122941463

MUO:	115481643(DHX58)

GSH:	117347800(DHX58)

DRE:	100148871(dhx58)

SRX:	107729198 107755569

SANH:

107687009 107690293

SGH:	107560750 107568305 107576950

CCAR:

109067147

CAUA:

113043337 113046933(dhx58) 113097651

CGIB:

127948370 127953195

PTET:

122335884(dhx58)

LROH:

127155601(dhx58)

OMC:	131536851(dhx58)

PPRM:

120489954(dhx58)

RKG:	130071198(dhx58)

MAMB:

125279571(dhx58)

CIDE:

127508528

MASI:

127450495 127451132

TROS:

130561443(dhx58)

TDW:	130426738(dhx58)

MANU:

129436241(dhx58)

IPU:	101154682(dhx58)

IFU:	128601934(dhx58)

PHYP:

113528643(dhx58)

SMEO:

124397251(dhx58)

TFD:	113661139(dhx58)

TVC:	132861442(dhx58)

AMEX:

103032392(dhx58)

CMAO:

118821352(dhx58)

EEE:	113592226(dhx58)

CHAR:

105890727(dhx58)

TRU:	101071798(dhx58)

TFS:	130514623(dhx58)

TNG:	GSTEN00022053G001

LCO:	104926025(dhx58)

NCC:	104958095(dhx58)

TBEN:

117492722(dhx58)

CGOB:

115012771(dhx58)

PGEO:

117451131(dhx58)

GACU:

117548823(dhx58)

EMAC:

134878613(dhx58)

ELY:	117268501(dhx58)

EFO:	125880169(dhx58)

PLEP:

121956490(dhx58)

SLUC:

116059727(dhx58)

ECRA:

117958422(dhx58)

ESP:	116703297(dhx58)

PFLV:

114569245(dhx58)

GAT:	120828363(dhx58)

PPUG:

119220947(dhx58)

AFB:	129098421(dhx58)

CLUM:

117735329(dhx58)

PSWI:

130188364(dhx58)

MSAM:

119892374(dhx58)

SCHU:

122869483(dhx58)

CUD:	121504014(dhx58)

ALAT:

119013392(dhx58)

MZE:	101468974(dhx58)

ONL:	100702615 100702883(dhx58)

OAU:	116312506 120432704

OLA:	101162602(dhx58)

OML:	112146226 112146763(dhx58)

CSAI:

133422701(dhx58)

XMA:	102225516(dhx58)

XCO:	114159735(dhx58)

XHE:	116735233(dhx58)

PRET:

103469409(dhx58)

PFOR:

103142191(dhx58)

PLAI:

106950778(dhx58)

PMEI:

106921570(dhx58)

GAF:	122821819(dhx58)

PPRL:

129373873(dhx58)

CVG:	107099614(dhx58)

CTUL:

119778884(dhx58)

GMU:	124863156 124864656

NFU:	107381934(dhx58)

KMR:	108243781(dhx58)

ALIM:

106528029(dhx58)

NWH:	119421908(dhx58)

AOCE:

111584798(dhx58)

MCEP:

124997762(dhx58)

CSEM:

103392605(dhx58)

POV:	109634039(dhx58)

SSEN:

122785803(dhx58)

HHIP:

117765942 117765943

HSP:	118124096 118124097 118124098

SMAU:

118289509(dhx58)

LCF:

108901265

SDU:	111217601(dhx58)

SLAL:

111652805(dhx58)

XGL:	120788279(dhx58)

HCQ:	109532229(dhx58)

SSCV:

125983314

SBIA:

133514345(dhx58)

PEE:	133415487(dhx58)

PTAO:

133465543(dhx58)

BPEC:

110161483(dhx58)

MALB:

109964256(dhx58)

BSPL:

114860952(dhx58)

SJO:	128379622 128379623 128379624

SASA:

100195148(dhx58) 106607291

STRU:

115171111 115197943

OTW:	112225985 112258655(dhx58)

OMY:	100499613(dhx58) 110485163

OGO:	123999305 124016347

ONE:	115104123 115110278(dhx58)

OKI:	109893318 116375859

OKE:	118365264 118372177

SALP:

111981321 111981328

SNH:	120034113 120035870

CCLU:

121550975 121569585

ELS:	105013344(dhx58)

SFM:	108941544(dhx58)

PKI:	111855900(dhx58)

AANG:

118216109 118221594(dhx58)

LOC:	102685073(dhx58)

PSPA:

121324066(dhx58)

ARUT:

117433262 117434584(dhx58)

PSEX:

120520580(dhx58)

LCM:	102349457(DHX58)

CMK:	103189183(dhx58)

RTP:	109922223(dhx58)

CPLA:

122539846(dhx58)

HOC:	132831014(dhx58)

LERI:

129710197(dhx58)

BBEL:

HRF:

MMER:

DPOL:

Reference

PMID:16116171

Authors

Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M Jr, Akira S, Yonehara S, Kato A, Fujita T

Title

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.

Journal

J Immunol 175:2851-8 (2005)
DOI:10.4049/jimmunol.175.5.2851

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (762)   
   KEGG GENES (409)   
   KEGG MGENES (286)   
   RefGene (65)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (770)   

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