KEGG   ORTHOLOGY: K15791Help
Entry
K15791                      KO                                     

Name
DHKTD1
Definition
probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]
Pathway
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Disease
H00264  Charcot-Marie-Tooth disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
   00380 Tryptophan metabolism
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
BRITE hierarchy
Other DBs
RN: R01933 R01940
GO: 0004591
Genes
HSA: 55526(DHTKD1)
PTR: 736115(DHTKD1)
PPS: 100977202(DHTKD1)
GGO: 101146441(DHTKD1)
PON: 100173320(DHTKD1)
NLE: 100601330(DHTKD1)
MCC: 696445(DHTKD1)
MCF: 102119673(DHTKD1)
CSAB: 103238141(DHTKD1)
RRO: 104664886(DHTKD1)
RBB: 108538522(DHTKD1)
CJC: 100385948(DHTKD1)
SBQ: 101035476(DHTKD1)
MMU: 209692(Dhtkd1)
MCAL: 110283664(Dhtkd1)
MPAH: 110333984(Dhtkd1)
RNO: 361272(Dhtkd1)
MUN: 110560545(Dhtkd1)
CGE: 100753689(Dhtkd1)
NGI: 103738703(Dhtkd1)
HGL: 101721202(Dhtkd1)
CCAN: 109682443(Dhtkd1)
OCU: 100356735(DHTKD1)
TUP: 102477878(DHTKD1)
CFA: 478008(DHTKD1)
VVP: 112933405(DHTKD1)
AML: 100484376(DHTKD1)
UMR: 103676290(DHTKD1)
UAH: 113241065(DHTKD1)
ORO: 101364717(DHTKD1)
ELK: 111155533
FCA: 101086155(DHTKD1)
PTG: 102950462(DHTKD1)
PPAD: 109273731(DHTKD1)
AJU: 106971004(DHTKD1)
BTA: 517113(DHTKD1)
BOM: 102284154(DHTKD1)
BIU: 109567875(DHTKD1)
BBUB: 102411718(DHTKD1)
CHX: 102173669(DHTKD1)
OAS: 101117008(DHTKD1)
SSC: 102166829(DHTKD1)
CFR: 102505405(DHTKD1)
CDK: 105100312(DHTKD1)
BACU: 103016269(DHTKD1)
LVE: 103088004(DHTKD1)
OOR: 101270888(DHTKD1)
DLE: 111178001(DHTKD1)
PCAD: 102985620(DHTKD1)
ECB: 100056844(DHTKD1)
EPZ: 103563359(DHTKD1)
EAI: 106836524(DHTKD1)
MYB: 102255818(DHTKD1)
MYD: 102774163(DHTKD1)
MNA: 107530246(DHTKD1)
HAI: 109390477(DHTKD1)
DRO: 112322617(DHTKD1)
PALE: 102895062(DHTKD1)
RAY: 107504853(DHTKD1)
MJV: 108395805(DHTKD1)
LAV: 100677553(DHTKD1)
TMU: 101351336
MDO: 100013507(DHTKD1)
SHR: 100931159(DHTKD1)
PCW: 110217338(DHTKD1)
OAA: 100085444(DHTKD1)
GGA: 426076(DHTKD1)
MGP: 100540782(DHTKD1)
CJO: 107317305(DHTKD1)
NMEL: 110392260(DHTKD1)
APLA: 101799410(DHTKD1)
ACYG: 106046213(DHTKD1)
TGU: 100227746(DHTKD1)
LSR: 110470969(DHTKD1)
SCAN: 103813742(DHTKD1)
GFR: 102045028(DHTKD1)
FAB: 101819529(DHTKD1)
PHI: 102106815(DHTKD1)
PMAJ: 107204632(DHTKD1)
CCAE: 111923121(DHTKD1)
CCW: 104694504(DHTKD1)
ETL: 114066624(DHTKD1)
FPG: 101914531(DHTKD1)
FCH: 102046202(DHTKD1)
CLV: 102086057(DHTKD1)
EGZ: 104135760(DHTKD1)
NNI: 104014635(DHTKD1)
ACUN: 113491537(DHTKD1)
PADL: 103915024(DHTKD1)
AAM: 106485083(DHTKD1)
ASN: 102376609(DHTKD1)
AMJ: 102561159(DHTKD1)
PSS: 102453971(DHTKD1)
CMY: 102945253(DHTKD1)
CPIC: 101940398(DHTKD1)
ACS: 100551958(dhtkd1)
PVT: 110081244(DHTKD1)
PBI: 103051773
PMUR: 107297191(DHTKD1) 107300248
TSR: 106550932(DHTKD1)
PMUA: 114605061(DHTKD1)
GJA: 107111049(DHTKD1)
XLA: 403360(dhtkd1.L)
XTR: 100493977(dhtkd1)
NPR: 108784821(DHTKD1)
DRE: 494076(dhtkd1)
CCAR: 109053636(dhtkd1)
IPU: 108275231(dhtkd1)
PHYP: 113530129(dhtkd1)
AMEX: 103041509(dhtkd1)
EEE: 113584502(dhtkd1)
TRU: 101070517(dhtkd1)
LCO: 104940683(dhtkd1)
NCC: 104940829
MZE: 101480158(dhtkd1)
ONL: 100705674(dhtkd1)
OLA: 101175318(dhtkd1)
XMA: 102229655(dhtkd1)
XCO: 114155128(dhtkd1)
CVG: 107095058(dhtkd1)
NFU: 107388455(dhtkd1)
KMR: 108230154(dhtkd1)
ALIM: 106523641(dhtkd1)
AOCE: 111566787(dhtkd1)
CSEM: 103380546(dhtkd1)
POV: 109624521(dhtkd1)
LCF: 108888513(dhtkd1)
SDU: 111229832(dhtkd1)
SLAL: 111670862(dhtkd1)
HCQ: 109522972(dhtkd1)
BPEC: 110169356(dhtkd1)
MALB: 109974702(dhtkd1)
ELS: 105021851(dhtkd1)
SFM: 108931528(dhtkd1)
PKI: 111842368(dhtkd1)
LCM: 102356663(DHTKD1)
CMK: 103187915(dhtkd1)
RTP: 109929690(dhtkd1)
CIN: 100179490
SPU: 764393
APLC: 110979468
SKO: 102808810
DME: Dmel_CG1544(CG1544)
DER: 6554810
DSI: Dsimw501_GD21563(Dsim_GD21563)
DSR: 110187006
DPE: 6595098
DMN: 108154619
DWI: 6649550
DAZ: 108621342
DNV: 108660392
DHE: 111597832
MDE: 101890127
LCQ: 111681550
AAG: 5566495
AME: 412569
BIM: 100746454
BTER: 100651648
CCAL: 108632091
OBB: 114880363
MPHA: 105837687
AEC: 105153258
ACEP: 105621467
PBAR: 105426032
VEM: 105564292
HST: 105187265
DQU: 106741705
CFO: 105254757
LHU: 105671323
PGC: 109860826
OBO: 105285114
PCF: 106784155
NVI: 100123741
CSOL: 105362936
MDL: 103574888
TCA: 656360(DHTKD1)
DPA: 109537220
ATD: 109599346
NVL: 108566386
BMOR: 101740126
BMAN: 114252985
PMAC: 106712864
PRAP: 110995686
HAW: 110375316
PXY: 105382046
CLEC: 106667210
ZNE: 110838858
FCD: 110859206
PVM: 113818707
TUT: 107364834
DPTE: 113789891
CSCU: 111634585
PTEP: 107447474
CEL: CELE_ZK836.2(ogdh-2)
CBR: CBG23406
PCAN: 112570201
CRG: 105317940
MYI: 110455544
OBI: 106874001
EPA: 110232683
AMIL: 114966664
PDAM: 113684930
SPIS: 111327291
DGT: 114520034
AQU: 100640196
ABP: AGABI1DRAFT123391(AGABI1DRAFT_123391)
ABV: AGABI2DRAFT179884(AGABI2DRAFT_179884)
DDI: DDB_G0280353(odhA)
DFA: DFA_02482(odhA)
SPAR: SPRG_03427
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z
  Title
DHTKD1 is essential for mitochondrial biogenesis and function maintenance.
  Journal
FEBS Lett 587:3587-92 (2013)
DOI:10.1016/j.febslet.2013.08.047
Reference
  Authors
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O
  Title
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
  Journal
DNA Res 7:273-81 (2000)
DOI:10.1093/dnares/7.4.271
Reference
  Authors
Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F
  Title
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.
  Journal
Free Radic Biol Med 115:136-145 (2018)
DOI:10.1016/j.freeradbiomed.2017.11.018

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