KEGG   ORTHOLOGY: K16195
Entry
K16195                      KO                                     

Name
EIF2AK2
Definition
eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko04217  Necroptosis
ko05010  Alzheimer disease
ko05160  Hepatitis C
ko05162  Measles
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05171  Coronavirus disease - COVID-19
ko05203  Viral carcinogenesis
Disease
H02457  Developmental delay, leukoencephalopathy, and neurologic decompensation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09172 Infectious disease: viral
   05160 Hepatitis C
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05171 Coronavirus disease - COVID-19
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05164 Influenza A
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05162 Measles
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05168 Herpes simplex virus 1 infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05169 Epstein-Barr virus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05165 Human papillomavirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   01009 Protein phosphatases and associated proteins
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Other DBs
GO: 0004694
Genes
HSA: 5610(EIF2AK2)
PTR: 459155(EIF2AK2)
PPS: 100982543(EIF2AK2)
GGO: 101133221(EIF2AK2)
PON: 100173054(EIF2AK2)
NLE: 100579484(EIF2AK2)
MCC: 708912(EIF2AK2)
MCF: 102124745(EIF2AK2)
CSAB: 103220482(EIF2AK2)
RRO: 104669977(EIF2AK2)
RBB: 108520352(EIF2AK2)
CJC: 100399251(EIF2AK2)
SBQ: 101053943(EIF2AK2)
MMU: 19106(Eif2ak2)
MCAL: 110312307(Eif2ak2)
MPAH: 110335815(Eif2ak2)
RNO: 54287(Eif2ak2)
MUN: 110564188
CGE: 100757909(Eif2ak2)
NGI: 103725269(Eif2ak2)
HGL: 101724844(Eif2ak2)
CCAN: 109688641(Eif2ak2)
OCU: 100009013(EIF2AK2)
TUP: 102469861(EIF2AK2)
CFA: 611397(EIF2AK2)
VVP: 112935312(EIF2AK2)
AML: 100469151(EIF2AK2)
UMR: 103671577(EIF2AK2)
UAH: 113241346(EIF2AK2)
ORO: 101373670(EIF2AK2)
ELK: 111158436
FCA: 101082744(EIF2AK2)
PTG: 102951575(EIF2AK2)
PPAD: 109265829(EIF2AK2)
AJU: 106978970(EIF2AK2)
BTA: 347700(EIF2AK2)
BOM: 102281444(EIF2AK2)
BIU: 109565977(EIF2AK2)
BBUB: 102391649(EIF2AK2)
CHX: 102171521(EIF2AK2)
OAS: 101121673(EIF2AK2)
SSC: 397588(EIF2AK2)
CFR: 102517994(EIF2AK2)
CDK: 105105818(EIF2AK2)
BACU: 103006520(EIF2AK2)
LVE: 103075964(EIF2AK2)
OOR: 101270256(EIF2AK2)
DLE: 111174878(EIF2AK2)
PCAD: 102977777(EIF2AK2)
ECB: 100147679(EIF2AK2)
EPZ: 103548399(EIF2AK2)
EAI: 106825858(EIF2AK2)
MYB: 102242739(EIF2AK2)
MNA: 107541819(EIF2AK2)
HAI: 109385455(EIF2AK2)
DRO: 112298045(EIF2AK2)
PALE: 102890643(EIF2AK2)
RAY: 107519635(EIF2AK2)
MJV: 108392233(EIF2AK2)
LAV: 100665908(EIF2AK2)
TMU: 101359071
MDO: 103106286(EIF2AK2)
SHR: 100931721(EIF2AK2)
PCW: 110212711(EIF2AK2)
OAA: 100077821(EIF2AK2)
GGA: 395147(EIF2AK2)
MGP: 100543196 104909671
CJO: 107311230(EIF2AK2)
NMEL: 110397137(EIF2AK2)
APLA: 110353866
ACYG: 106029410(EIF2AK2)
TGU: 100223594(EIF2AK2)
LSR: 110469407(EIF2AK2)
SCAN: 103817583(EIF2AK2)
GFR: 102039637(EIF2AK2)
FAB: 101807308(EIF2AK2)
PHI: 102111278(EIF2AK2)
PMAJ: 107201738(EIF2AK2)
CCAE: 111926977(EIF2AK2)
CCW: 104684377(EIF2AK2)
ETL: 114065176(EIF2AK2)
FPG: 101910588(EIF2AK2)
FCH: 102051537(EIF2AK2)
CLV: 102085389(EIF2AK2)
EGZ: 104124114(EIF2AK2)
NNI: 104018710(EIF2AK2)
ACUN: 113478166(EIF2AK2)
PADL: 103922839(EIF2AK2)
AAM: 106485536(EIF2AK2)
ASN: 102379754(EIF2AK2)
AMJ: 102558195(EIF2AK2)
PSS: 102449543(EIF2AK2)
CMY: 102934103(EIF2AK2)
CPIC: 101940470(EIF2AK2)
ACS: 100561872(eif2ak2)
PVT: 110083920(EIF2AK2)
PBI: 103059200(EIF2AK2)
PMUR: 107287469(EIF2AK2)
PMUA: 114594483(EIF2AK2)
XLA: 100037060(eif2ak2.L) 108716648 108716649 108716650
XTR: 100141483(pkr3) 779992(eif2ak2)
NPR: 108792731
DRE: 100001092(eif2ak2)
SANH: 107689757
SGH: 107562393
CCAR: 109064588
IPU: 108263213(eif2ak2)
PHYP: 113542164(eif2ak2)
AMEX: 107197130
EEE: 113579882(eif2ak2)
TRU: 100144316(eif2ak2)
LCO: 104918202
NCC: 104951309
MZE: 101480023 101480319 101480895
ONL: 100691607 100700343
OLA: 100144382 110016550
XMA: 102232776
XCO: 114138280
PRET: 103477270
CVG: 107096530
NFU: 107375439
KMR: 108248129(eif2ak2)
ALIM: 106515883
AOCE: 111573721
CSEM: 103387634(eif2ak2)
POV: 109636756
LCF: 108885802(eif2ak2) 108885818
SDU: 111220787
SLAL: 111658980
HCQ: 109516199(eif2ak2)
BPEC: 110156836
MALB: 109959079
OTW: 112253229
SALP: 112073823
ELS: 105008364
SFM: 108927142
PKI: 111835715
LCM: 102365233(EIF2AK2)
CMK: 103187174(eif2ak2)
RTP: 109918246
ZTR: MYCGRDRAFT_30507
DPP: DICPUDRAFT_9913
PTI: PHATRDRAFT_bd152 PHATRDRAFT_bd165
TPS: THAPSDRAFT_16613
GTT: GUITHDRAFT_84326
TVA: TVAG_288500
 » show all
Reference
PMID:1695551
  Authors
Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG
  Title
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
  Journal
Cell 62:379-90 (1990)
DOI:10.1016/0092-8674(90)90374-N
  Sequence
[hsa:5610]

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Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (24)   
   KEGG PATHWAY (24)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (442)   
   KEGG GENES (157)   
   KEGG MGENES (39)   
   RefGene (235)   
   OC (11)   
Literature (1)   
   PubMed (1)   
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