KEGG ORTHOLOGY: K16311

ORTHOLOGY: K16311

Entry

K16311                      KO

Symbol

SIK2

Name

serine/threonine-protein kinase SIK2 [EC:2.7.11.1]

Pathway

map04922

Glucagon signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K16311  SIK2; serine/threonine-protein kinase SIK2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16311  SIK2; serine/threonine-protein kinase SIK2
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K16311  SIK2; serine/threonine-protein kinase SIK2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16311  SIK2; serine/threonine-protein kinase SIK2
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  CAMKL family
   K16311  SIK2; serine/threonine-protein kinase SIK2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K16311  SIK2; serine/threonine-protein kinase SIK2

Genes

HSA:	23235(SIK2)

PTR:	451540(SIK2)

PPS:	100995431(SIK2)

GGO:	101133594(SIK2)

PON:	100171614(SIK2)

NLE:	100604913(SIK2)

HMH:	116476924(SIK2)

MCC:	711453(SIK2)

MCF:	102125528(SIK2)

MTHB:

126935782

MNI:	105493623(SIK2)

CSAB:

103248443(SIK2)

CATY:

105588700(SIK2)

PANU:

101003571(SIK2)

TGE:	112605717(SIK2)

MLEU:

105537398(SIK2)

RRO:	104677338(SIK2)

RBB:	108536464(SIK2)

PTEH:

111540118(SIK2)

CANG:

105501009(SIK2)

CJC:	100395360(SIK2)

SBQ:	101032802(SIK2)

CIMI:

108295459(SIK2)

CSYR:

103256339(SIK2)

MMUR:

105862926(SIK2)

LCAT:

123641706(SIK2)

PCOQ:

105822254(SIK2)

OGA:	100959358(SIK2)

MMU:	235344(Sik2)

MCAL:

110302128(Sik2)

MPAH:

110328278(Sik2)

MCOC:

116073309(Sik2)

ANU:	117699504(Sik2)

MUN:	110560603(Sik2)

CGE:	100754772(Sik2)

MAUA:

101837051(Sik2)

PROB:

127231726(Sik2)

PLEU:

114690257(Sik2)

MORG:

121438279(Sik2)

MFOT:

126510087

AAMP:

119810131(Sik2)

NGI:	103733890(Sik2)

HGL:	101724122(Sik2)

CPOC:

100718040(Sik2)

CCAN:

109687775(Sik2)

DORD:

105980606(Sik2)

DSP:	122110278(Sik2)

PLOP:

125349566(Sik2)

NCAR:

124958286

MMMA:

107145868(Sik2)

OCU:

100350619

OPI:	101535765(SIK2)

TUP:	102476473(SIK2)

GVR:	103598632(SIK2)

CFA:	489410(SIK2)

CLUD:

112671355(SIK2)

VVP:	112925971(SIK2)

VLG:	121499586(SIK2)

NPO:	129497381(SIK2)

AML:	100481352(SIK2)

UMR:	103662532(SIK2)

UAH:	113260071(SIK2)

UAR:	123792555(SIK2)

ELK:

111153733

LLV:

125078653

MPUF:

101687778(SIK2)

MNP:	132028465(SIK2)

MLK:	131835743(SIK2)

NVS:	122912264(SIK2)

ORO:	101362583(SIK2)

EJU:	114211330(SIK2)

ZCA:	113913853(SIK2)

MLX:	118013219(SIK2)

NSU:	110586117(SIK2)

LWW:	102746795(SIK2)

FCA:	101091894(SIK2)

PYU:	121035372(SIK2)

PCOO:

112865440(SIK2)

PBG:	122482941(SIK2)

PVIV:

125176420(SIK2)

LRUF:

124504616

PTG:	102961815(SIK2)

PPAD:

109278669(SIK2)

PUC:

125909957

AJU:

106984438

HHV:	120229914(SIK2)

BTA:	539570(SIK2)

BOM:	102264410(SIK2)

BIU:	109569422(SIK2)

BBUB:

102410525(SIK2)

BBIS:

105005028(SIK2)

CHX:	102175697(SIK2)

OAS:	101107630(SIK2)

BTAX:

128060693(SIK2)

ODA:	120876224(SIK2)

CCAD:

122450319(SIK2)

MBEZ:

129554316(SIK2)

SSC:	100624404(SIK2)

CFR:	102507370(SIK2)

CBAI:

105080071(SIK2)

CDK:	105094221(SIK2)

VPC:	102545793(SIK2)

BACU:

103002622(SIK2)

BMUS:

118899951(SIK2)

LVE:	103069585(SIK2)

OOR:	101276597(SIK2)

DLE:	111168061(SIK2)

PCAD:

102991842(SIK2)

PSIU:

116757414(SIK2)

NASI:

112405713(SIK2)

ECB:	100070391(SIK2)

EPZ:	103555596(SIK2)

EAI:	106840204(SIK2)

MYB:	102254216(SIK2)

MYD:	102758915(SIK2)

MMYO:

118664326(SIK2)

MLF:	102441528(SIK2)

PKL:	118713298(SIK2)

EFUS:

103293768(SIK2)

MNA:	107531288(SIK2)

DRO:	112314294(SIK2)

SHON:

119000515(SIK2)

AJM:	119042442(SIK2)

PDIC:

114499531(SIK2)

PHAS:

123818216(SIK2)

MMF:	118627486(SIK2)

PPAM:

129086001(SIK2)

HAI:	109388693(SIK2)

RFQ:	117030067(SIK2)

PALE:

102888580(SIK2)

PGIG:

120621981(SIK2)

PVP:	105295646(SIK2)

RAY:	107521183(SIK2)

MJV:	108409552(SIK2)

TOD:	119240374(SIK2)

SARA:

101558225(SIK2)

SETR:

126016109(SIK2)

LAV:	100663250(SIK2)

TMU:

101343973

ETF:	101642690(SIK2)

DNM:	101415009(SIK2)

MDO:	100026530(SIK2)

GAS:	123241815(SIK2)

SHR:	100918623(SIK2)

AFZ:

127554974

PCW:	110210694(SIK2)

OAA:	100090344(SIK2)

GGA:	768557(SIK2)

PCOC:

116233016(SIK2)

MGP:	100542921(SIK2)

CJO:	107324108(SIK2)

TPAI:

128087632(SIK2)

LMUT:

125703599(SIK2)

NMEL:

110387580(SIK2)

APLA:

101794173(SIK2)

ACYG:

106039719(SIK2)

CATA:

118252446(SIK2)

AFUL:

116497901(SIK2)

TGU:	100229187(SIK2)

LSR:	110475966(SIK2)

SCAN:

103823031(SIK2)

PMOA:

120508375(SIK2)

OTC:	121340829(SIK2)

PRUF:

121355737(SIK2)

GFR:	102045593(SIK2)

FAB:	101812000(SIK2)

OMA:	130262493(SIK2)

PHI:	102114452(SIK2)

PMAJ:

107214348(SIK2)

CCAE:

111939236(SIK2)

CCW:	104692088(SIK2)

CBRC:

103618594(SIK2)

ETL:	114067817(SIK2)

ZAB:	102066878(SIK2)

ACHL:

103807758

SVG:	106858179(SIK2)

MMEA:

130586069(SIK2)

HRT:	120762572(SIK2)

FPG:	101914007(SIK2)

FCH:	102059749(SIK2)

CLV:	102091067(SIK2)

EGZ:	104125941(SIK2)

NNI:	104008770(SIK2)

PCRI:

104032101(SIK2)

PLET:

104613639(SIK2)

EHS:	104511123(SIK2)

PCAO:

104049414(SIK2)

ACUN:

113488540(SIK2)

TALA:

104366071(SIK2)

PADL:

103921575(SIK2)

AFOR:

103906134(SIK2)

ACHC:

115344466(SIK2)

HALD:

104322578(SIK2)

HLE:	104840497(SIK2)

AGEN:

126038271

GCL:

127025730

CCRI:

104162370(SIK2)

CSTI:

104553833(SIK2)

CMAC:

104478583(SIK2)

MUI:	104543982(SIK2)

BREG:

104637611(SIK2)

FGA:	104080940(SIK2)

GSTE:

104257191(SIK2)

LDI:	104350542(SIK2)

MNB:	103769798(SIK2)

OHA:	104336447(SIK2)

NNT:	104406792(SIK2)

SHAB:

115616306(SIK2)

DPUB:

104303152(SIK2)

PGUU:

104465014(SIK2)

ACAR:

104517501(SIK2)

CPEA:

104388552(SIK2)

AVIT:

104277247(SIK2)

CVF:	104284153(SIK2)

RTD:	128918705(SIK2)

CUCA:

104067211(SIK2)

TEO:	104382374(SIK2)

BRHI:

104502026(SIK2)

AAM:	106495795(SIK2)

AROW:

112967477(SIK2)

NPD:	112948712(SIK2)

TGT:	104572273(SIK2)

DNE:	112986523(SIK2)

SCAM:

104141117(SIK2)

ASN:	102374412(SIK2)

AMJ:	102562583(SIK2)

CPOO:

109317946(SIK2)

GGN:	109292835(SIK2)

PSS:	102452516(SIK2)

CMY:	102934919(SIK2)

CCAY:

125625412(SIK2)

DCC:	119846741(SIK2)

CPIC:

101942104(SIK2)

TST:	117868611(SIK2)

CABI:

116829301(SIK2)

MRV:	120375632(SIK2)

ACS:	100553206(sik2)

ASAO:

132782283(SIK2)

PVT:	110078624(SIK2)

SUND:

121934663(SIK2)

PBI:	103052181(SIK2)

PMUR:

107284504(SIK2)

CTIG:

120311271(SIK2)

TSR:	106554247(SIK2)

PGUT:

117670159(SIK2)

APRI:

131203766(SIK2)

PTEX:

113441945(SIK2)

NSS:	113420898(SIK2)

VKO:	123036824(SIK2)

PMUA:

114585767(SIK2)

PRAF:

128402941(SIK2)

ZVI:	118097419(SIK2)

HCG:	128333653(SIK2)

GJA:	107114147(SIK2)

STOW:

125441755(SIK2)

EMC:	129342032(SIK2)

XLA:	100502576(sik2.L) 108697582(sik2.S)

XTR:	100125196(sik2)

NPR:	108793092(SIK2)

RTEM:

120915137(SIK2)

BBUF:

120996516(SIK2)

BGAR:

122926297(SIK2) 122926298

MUO:	115481533(SIK2)

GSH:	117347364(SIK2)

DRE:	567919(sik2b)

SRX:	107709128 107709983 107717286 107745129

SANH:

107657230 107663770 107670961(sik2) 107691747

SGH:	107586235 107600780 107601680 107603193

CCAR:

109090649 109103188

CAUA:

113049791(sik2) 113058423 113081906 113115098

CGIB:

127958612 127972777 127994500 128029236

PTET:

122345310(sik2a) 122358370(sik2b)

LROH:

127165439(sik2a) 127176844(sik2b)

OMC:	131541490(sik2a) 131554287(sik2b)

PPRM:

120472216(sik2a) 120478754(sik2b) 120483554

RKG:	130086754(sik2a) 130096715(sik2b)

MAMB:

125248356(sik2b) 125267947(sik2a)

CIDE:

127495001 127513381

MASI:

127422091 127426823 127429726 127439846

TROS:

130546082(sik2a) 130564672(sik2b)

TDW:	130420166(sik2a) 130428103(sik2b)

MANU:

129437973(sik2b) 129440862(sik2a)

IPU:	108260121(sik2a) 108277697(sik2b)

IFU:	128603503(sik2a) 128621468(sik2b)

PHYP:

113531665(sik2) 113532509

SMEO:

124379025(sik2a) 124394496(sik2b)

TFD:	113660432(sik2b) 113663391(sik2a)

TVC:	132841118(sik2a) 132858052(sik2b)

AMEX:

103031934 103032550(sik2)

CMAO:

118800513(sik2b) 118814290(sik2a)

EEE:	113579600 113591350

CHAR:

105903767(sik2b)

TRU:	101075462(sik2)

TFS:	130535581(sik2b)

TNG:	GSTEN00014865G001

LCO:	104918017(sik2)

NCC:	104965970(sik2)

TBEN:

117470338(sik2b)

CGOB:

115017884(sik2)

PGEO:

117457384(sik2b)

GACU:

117552170(sik2b)

EMAC:

134879859(sik2b)

ELY:	117260142(sik2b)

EFO:	125888414(sik2b)

PLEP:

121943518(sik2b)

SLUC:

116047958(sik2b)

ECRA:

117942410(sik2b)

ESP:	116687131(sik2)

PFLV:

114552291(sik2)

GAT:	120817675(sik2b)

PPUG:

119216676(sik2b)

AFB:	129089804(sik2b)

CLUM:

117741996(sik2b)

PSWI:

130210476(sik2b)

MSAM:

119882310(sik2b)

SCHU:

122879562(sik2b)

CUD:	121521573(sik2b)

ALAT:

119030901(sik2b)

MZE:	101483918(sik2)

ONL:	100695941(sik2)

OAU:	116328171(sik2b)

OLA:	101167310(sik2)

OML:	112149489(sik2b)

CSAI:

133441748(sik2b)

XMA:	102225985(sik2)

XCO:	114161876(sik2)

XHE:	116707846(sik2)

PRET:

103474594(sik2)

PFOR:

103136232(sik2)

PLAI:

106960966(sik2)

PMEI:

106919979(sik2)

GAF:	122833210(sik2b)

PPRL:

129359402(sik2b)

CVG:	107086376(sik2)

CTUL:

119792088(sik2b)

GMU:	124883765(sik2b)

NFU:	107380331(sik2)

KMR:	108243523(sik2b)

ALIM:

106515439(sik2)

NWH:	119410614(sik2b)

AOCE:

111564950(sik2)

MCEP:

125013003(sik2b)

CSEM:

103378419(sik2)

POV:	109630352(sik2)

SSEN:

122773862(sik2b)

HHIP:

117773353(sik2b)

HSP:	118105926(sik2b)

SMAU:

118299654(sik2b)

LCF:	108886412(sik2b)

SDU:	111228028(sik2)

SLAL:

111655983(sik2)

XGL:	120791674(sik2b)

HCQ:	109526400(sik2)

SSCV:

125972772

SBIA:

133505156(sik2b)

PEE:	133404721(sik2b)

PTAO:

133481990(sik2b)

BPEC:

110154145(sik2)

MALB:

109960186(sik2)

BSPL:

114867940(sik2b)

SJO:	128360182(sik2b)

SASA:

106612460(sik2)

STRU:

115162919 115205878

OTW:	112265055(sik2b) 112266710

OMY:	110503529 110507361(sik2b)

OGO:	123993116(sik2b) 124005622

ONE:	115137137 115141478

OKI:	109905371 109908855

OKE:	118386570 118397074(sik2b)

SALP:

111949358 111960565

SNH:	120018433(sik2b) 120028324

CCLU:

121561148(sik2b) 121567337

ELS:	105011491(sik2)

SFM:	108928736 108936192(sik2)

PKI:	111844795(sik2) 111851375

AANG:

118209777(sik2b) 118236418

LOC:	102698176(sik2)

PSPA:

121303967

ARUT:

117397458 117966527

PSEX:

120535840

LCM:	102366218(SIK2)

CMK:	103187705(sik2b)

RTP:	109912894(sik2a)

CPLA:

122540645(sik2a)

HOC:	132829485(sik2a)

LERI:

129712340(sik2a)

PMRN:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG4290(Sik2)

DER:

6555562

DSE:

6616076

DSI:	Dsimw501_GD24618(Dsim_GD24618)

DYA:	Dyak_GE16985

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15425

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206646

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM287820

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

EAF:

LSM:	121128474 121128997

DSV:

RSAN:

RMP:

CSCU:

LPOL:

106464977 106467797 106478581

PMEO:

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

HSY:

Reference

PMID:12624099

Authors

Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M

Title

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

Journal

J Biol Chem 278:18440-7 (2003)
DOI:10.1074/jbc.M211770200

Sequence

[mmu:235344]

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2286)   
   KEGG GENES (646)   
   KEGG MGENES (158)   
   RefGene (1478)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (2294)   

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