KEGG   ORTHOLOGY: K17446Help
Entry
K17446                      KO                                     

Name
IRS4
Definition
insulin receptor substrate 4
Pathway
ko04022  cGMP-PKG signaling pathway
ko04068  FoxO signaling pathway
ko04140  Autophagy - animal
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04935  Growth hormone synthesis, secretion and action
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04022 cGMP-PKG signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04152 AMPK signaling pathway
    K17446  IRS4; insulin receptor substrate 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17446  IRS4; insulin receptor substrate 4
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04923 Regulation of lipolysis in adipocytes
    K17446  IRS4; insulin receptor substrate 4
   04920 Adipocytokine signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04935 Growth hormone synthesis, secretion and action
    K17446  IRS4; insulin receptor substrate 4
  09149 Aging
   04211 Longevity regulating pathway
    K17446  IRS4; insulin receptor substrate 4
   04213 Longevity regulating pathway - multiple species
    K17446  IRS4; insulin receptor substrate 4
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K17446  IRS4; insulin receptor substrate 4
BRITE hierarchy
Genes
HSA: 8471(IRS4)
PTR: 473846(IRS4)
PPS: 100991292(IRS4)
GGO: 109024862(IRS4)
PON: 100458662(IRS4)
NLE: 100588594(IRS4)
MCC: 703846(IRS4)
MCF: 102128819(IRS4)
CSAB: 103232472(IRS4)
RRO: 104676250(IRS4)
RBB: 108541574(IRS4)
CJC: 100410200(IRS4)
SBQ: 101035392(IRS4)
MMU: 16370(Irs4)
MCAL: 110287491(Irs4)
MPAH: 110313986(Irs4)
RNO: 315350(Irs4)
MUN: 110540163(Irs4)
CGE: 100773159
NGI: 103750027(Irs4)
HGL: 101719321(Irs4)
CCAN: 109675517(Irs4)
OCU: 103351932(IRS4)
TUP: 102489416(IRS4)
CFA: 492059(IRS4)
VVP: 112932035(IRS4)
AML: 105240373(IRS4)
UMR: 103679770(IRS4)
UAH: 113241174(IRS4)
ORO: 101371781(IRS4)
ELK: 111161266
FCA: 101093251(IRS4)
PTG: 102952189(IRS4)
PPAD: 109253661(IRS4)
AJU: 106973150(IRS4)
BTA: 514607(IRS4)
BOM: 102273597(IRS4)
BIU: 109555543(IRS4)
BBUB: 102400715(IRS4)
CHX: 102179643(IRS4)
OAS: 101112456(IRS4)
SSC: 100622674(IRS4)
CFR: 102521714(IRS4)
CDK: 105099556(IRS4)
BACU: 102998877(IRS4)
LVE: 103068740(IRS4)
OOR: 101290244(IRS4)
DLE: 111165800(IRS4)
PCAD: 102989579(IRS4)
ECB: 100059954(IRS4)
EPZ: 103545515(IRS4)
EAI: 106839711(IRS4)
MYB: 102242347(IRS4)
MYD: 102753243(IRS4)
MNA: 107526265(IRS4)
HAI: 109393345(IRS4)
DRO: 112296869(IRS4)
PALE: 102895007(IRS4)
RAY: 107506967(IRS4)
MJV: 108406099(IRS4)
LAV: 100667324(IRS4)
TMU: 101350401
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9261155
  Authors
Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE
  Title
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.
  Journal
J Biol Chem 272:21403-7 (1997)
DOI:10.1074/jbc.272.34.21403
  Sequence
[hsa:8471]
Reference
  Authors
Schreyer S, Ledwig D, Rakatzi I, Kloting I, Eckel J
  Title
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
  Journal
Endocrinology 144:1211-8 (2003)
DOI:10.1210/en.2002-220723
  Sequence
[hsa:8471]

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