KEGG ORTHOLOGY: K17951

ORTHOLOGY: K17951

Entry

K17951                      KO

Symbol

CYP27C1

Name

all-trans-retinol 3,4-desaturase [EC:1.14.19.53]

Pathway

map00830

Retinol metabolism

Reaction

R11952

all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17951  CYP27C1; all-trans-retinol 3,4-desaturase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17951  CYP27C1; all-trans-retinol 3,4-desaturase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.53  all-trans-retinol 3,4-desaturase
     K17951  CYP27C1; all-trans-retinol 3,4-desaturase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP27 family
   K17951  CYP27C1; all-trans-retinol 3,4-desaturase

Other DBs

GO:

0061896

Genes

HSA:	339761(CYP27C1)

PTR:

470525

PPS:	100975504(CYP27C1)

GGO:

PON:

NLE:

HMH:

MCC:

MCF:	102138872(CYP27C1)

MTHB:

126933065

MNI:

105492430

CSAB:

103216882(CYP27C1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:

SBQ:

CIMI:

108297966(CYP27C1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	483869(CYP27C1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101096908(CYP27C1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	617338(CYP27C1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100051659(CYP27C1)

EPZ:

EAI:

SARA:

SETR:

TMU:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	424227(CYP27C1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102574953(CYP27C1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108701260 447625(cyp27c1.L) 735141(cyp27c1.S)

XTR:	496805(cyp27c1)

NPR:

RTEM:

BBUF:

BGAR:

DRE:	558396(cyp27c1)

SRX:	107705550 107706664

SANH:

107660023 107677575

SGH:	107581347 107584837

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

LCO:

NCC:	104966145 104966146

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116670746 116671237

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112242330 121838678

OMY:	110510834 110519502

OGO:	124021071 124027374

OKI:

116361459

OKE:

118382529

SNH:	120035602 120040682

CCLU:

121563781

ELS:

105020091

SFM:	108920654 108942618

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

PCHN:

HRF:

HRJ:

CVN:

PMAX:

Reference

PMID:27059013

Authors

Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP

Title

Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.

Journal

FEBS Lett 590:1304-12 (2016)
DOI:10.1002/1873-3468.12167

Sequence

[hsa:339761]

Reference

PMID:26549260

Authors

Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC

Title

Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

Journal

Curr Biol 25:3048-57 (2015)
DOI:10.1016/j.cub.2015.10.018

Sequence

[dre:558396]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (898)   
   KEGG GENES (366)   
   KEGG MGENES (356)   
   RefGene (170)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (909)   

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