KEGG ORTHOLOGY: K18497

ORTHOLOGY: K18497

Entry

K18497                      KO

Symbol

FGF2

Name

fibroblast growth factor 2

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04810

Regulation of actin cytoskeleton

map05167

Kaposi sarcoma-associated herpesvirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05207

Chemical carcinogenesis - receptor activation

map05218

Melanoma

map05224

Breast cancer

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04014 Ras signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04015 Rap1 signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04020 Calcium signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04151 PI3K-Akt signaling pathway
    K18497  FGF2; fibroblast growth factor 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K18497  FGF2; fibroblast growth factor 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K18497  FGF2; fibroblast growth factor 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K18497  FGF2; fibroblast growth factor 2
   05205 Proteoglycans in cancer
    K18497  FGF2; fibroblast growth factor 2
   05207 Chemical carcinogenesis - receptor activation
    K18497  FGF2; fibroblast growth factor 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K18497  FGF2; fibroblast growth factor 2
   05218 Melanoma
    K18497  FGF2; fibroblast growth factor 2
   05224 Breast cancer
    K18497  FGF2; fibroblast growth factor 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K18497  FGF2; fibroblast growth factor 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K18497  FGF2; fibroblast growth factor 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K18497  FGF2; fibroblast growth factor 2
   00536 Glycosaminoglycan binding proteins
    K18497  FGF2; fibroblast growth factor 2
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K18497  FGF2; fibroblast growth factor 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K18497  FGF2; fibroblast growth factor 2

Other DBs

GO:

0005104

Genes

HSA:	2247(FGF2)

PTR:	641462(FGF2)

PPS:	100968351(FGF2)

GGO:	101137337(FGF2)

PON:	100459751(FGF2)

NLE:	100593123(FGF2)

HMH:	116463600(FGF2)

MCC:	574136(FGF2)

MCF:	102133679(FGF2)

MTHB:

126954986

MNI:	105486416(FGF2)

CSAB:

103236710(FGF2)

CATY:

105595795(FGF2)

PANU:

101003965(FGF2)

TGE:	112624619(FGF2)

MLEU:

105538400(FGF2)

RRO:	104661758(FGF2)

RBB:	108515579(FGF2)

TFN:	117085877(FGF2)

PTEH:

111546245(FGF2)

CANG:

105516422(FGF2)

CJC:	118152209(FGF2)

SBQ:	101030554(FGF2)

CIMI:

108304180(FGF2)

MMUR:

105882072(FGF2)

LCAT:

123638827(FGF2)

PCOQ:

105815256(FGF2)

OGA:	100942631(FGF2)

MMU:	14173(Fgf2)

MCAL:

110291557(Fgf2)

MPAH:

110320512(Fgf2)

RNO:	54250(Fgf2)

MCOC:

116095116(Fgf2)

ANU:	117706759(Fgf2)

MUN:	110545886(Fgf2)

CGE:	100757429(Fgf2)

MAUA:

101834448(Fgf2)

PROB:

127223306(Fgf2)

PLEU:

114707170(Fgf2)

MORG:

121452838(Fgf2)

MFOT:

126499184

AAMP:

119826229(Fgf2)

NGI:	103746947(Fgf2)

HGL:	101720583(Fgf2)

CPOC:

100721182(Fgf2)

DORD:

105989908(Fgf2)

DSP:	122119078(Fgf2)

PLOP:

125341650(Fgf2)

OCU:

100009068

OPI:	101520285(FGF2)

TUP:	102498637(FGF2)

CFA:	403857(FGF2)

CLUD:

112642713(FGF2)

VVP:	112933647(FGF2)

VLG:	121493095(FGF2)

NPO:	129504328(FGF2)

AML:	100479986(FGF2)

UMR:	103661850(FGF2)

UAH:	113255677(FGF2)

UAR:	123793143(FGF2)

ELK:

111156005

LLV:

125093355

MPUF:

101671799(FGF2)

MNP:	132028444(FGF2)

MLK:	131828225(FGF2)

NVS:	122890262(FGF2)

ORO:	101369428(FGF2)

EJU:	114208195(FGF2)

ZCA:	113925505(FGF2)

MLX:	118022565(FGF2)

NSU:	110573062(FGF2)

LWW:

102741264

FCA:	100135772(FGF2)

PYU:	121030066(FGF2)

PBG:	122469044(FGF2)

PVIV:

125164816(FGF2)

LRUF:

124521134

PTG:	102969772(FGF2)

PPAD:

109246691(FGF2)

PUC:

125923095

AJU:

106977090

HHV:	120238033(FGF2)

BTA:	281161(FGF2)

BOM:	102284897(FGF2)

BIU:	109570879(FGF2)

BBUB:

102393273(FGF2)

BBIS:

105003247(FGF2)

CHX:	102186892(FGF2)

OAS:	443306(FGF2)

BTAX:

128062082(FGF2)

ODA:	120871375(FGF2)

CCAD:

122453183(FGF2)

MBEZ:

129542296(FGF2)

SSC:	397643(FGF2)

CBAI:

105067112(FGF2)

CDK:	105093669(FGF2)

VPC:	102536146(FGF2)

BACU:

103015722(FGF2)

BMUS:

118895460(FGF2)

LVE:	103090898(FGF2)

OOR:	101280803(FGF2)

DLE:	111186075(FGF2)

PCAD:

102989017(FGF2)

PSIU:

116753904(FGF2) 116758288

NASI:

112399728(FGF2)

ECB:	100033955(FGF2)

MYB:	102246008(FGF2)

MYD:	102762815(FGF2)

MMYO:

118657980(FGF2)

MLF:	111825710(FGF2)

PKL:	118711281(FGF2)

EFUS:

129149245(FGF2)

MNA:	107529795(FGF2)

DRO:	112312217(FGF2)

SHON:

118995576(FGF2)

AJM:	119037695(FGF2)

PDIC:

114502553(FGF2)

PHAS:

123813667(FGF2)

MMF:	118616042(FGF2)

PPAM:

129061435(FGF2)

HAI:	109374154(FGF2)

RFQ:	117037862(FGF2)

PALE:

107196088(FGF2)

PGIG:

120616271(FGF2)

RAY:	107518501(FGF2)

SARA:

101555369(FGF2)

SETR:

126003833(FGF2)

LAV:	100657533(FGF2)

TMU:

101342442

ETF:	101640090(FGF2)

DNM:	101423570(FGF2)

MDO:	619384(FGF2)

GAS:	123251436(FGF2)

SHR:	100934542(FGF2)

AFZ:

127541481

PCW:	110222958(FGF2)

OAA:	114815531(FGF2)

GGA:	396413(FGF2)

PCOC:

116231214(FGF2)

MGP:	100550388(FGF2)

CJO:	107313543(FGF2)

TPAI:

128080445(FGF2)

LMUT:

125692512(FGF2)

NMEL:

110398111(FGF2)

APLA:

101798064(FGF2)

ACYG:

106042430(FGF2)

CATA:

118251228(FGF2)

AFUL:

116488431(FGF2)

TGU:	100227798(FGF2)

LSR:	110484373(FGF2)

SCAN:

103821418(FGF2)

PMOA:

120508667(FGF2)

OTC:	121339852(FGF2)

PRUF:

121361519(FGF2)

GFR:	102035880(FGF2)

FAB:	101807010(FGF2)

OMA:	130252458(FGF2)

PHI:	102104728(FGF2)

PMAJ:

107202986(FGF2)

CCW:	120409622(FGF2)

ETL:	114061094(FGF2)

ZAB:	102068443(FGF2)

SVG:	106859414(FGF2)

MMEA:

130579961(FGF2)

HRT:	120752523(FGF2)

FPG:	101918253(FGF2)

FCH:	102054561(FGF2)

CLV:	110364865(FGF2)

PCAO:

104045159(FGF2)

ACUN:

113479640(FGF2)

TALA:

116962816(FGF2)

PADL:

103926140(FGF2)

AFOR:

103907355(FGF2)

ACHC:

115343528(FGF2)

HALD:

104311887(FGF2)

AGEN:

126044714

GCL:

127015769

CMAC:

104480529(FGF2)

MUI:	104544126(FGF2)

BREG:

104635922(FGF2)

GSTE:

104261300(FGF2)

LDI:	104342836(FGF2)

NNT:

104401254

SHAB:

115604795(FGF2)

DPUB:

104296220(FGF2)

ACAR:

114819061(FGF2)

CPEA:

104398817(FGF2)

CVF:	104289001(FGF2)

RTD:	128910384(FGF2)

AAM:	106491847(FGF2)

AROW:

112973481(FGF2)

NPD:	112950246(FGF2)

DNE:	112996800(FGF2)

SCAM:

104149676(FGF2)

ASN:	102385563(FGF2)

AMJ:	102567370(FGF2)

CPOO:

109309334(FGF2)

GGN:	109301132(FGF2)

PSS:	102444616(FGF2)

CMY:	102931444(FGF2)

CCAY:

125635468(FGF2)

DCC:	119854425(FGF2)

CPIC:

122174672(FGF2)

CABI:

116834788(FGF2)

MRV:	120406846(FGF2)

ACS:	100559071(fgf2)

ASAO:

132776870(FGF2)

PVT:	110072861(FGF2)

SUND:

121931107(FGF2)

PBI:	103053614(FGF2)

PMUR:

107283368(FGF2)

CTIG:

120297492(FGF2)

TSR:	106542651(FGF2)

PGUT:

117654575(FGF2)

APRI:

131203162(FGF2)

PTEX:

113434610(FGF2)

NSS:	113411891(FGF2)

PMUA:

114604525(FGF2)

PRAF:

128421141(FGF2)

ZVI:	118083517(FGF2)

HCG:	128327609(FGF2)

GJA:	107109560(FGF2)

STOW:

125439948(FGF2)

EMC:	129336499(FGF2)

XLA:	100101279(fgf2) 108706695(fgf2.S)

XTR:	550087(fgf2)

NPR:	108790780(FGF2)

RTEM:

120918763(FGF2)

BBUF:

120989950(FGF2)

BGAR:

122944017(FGF2)

GSH:	117357714(FGF2)

DRE:	404231(fgf2)

SRX:	107714902 107717315

SANH:

107694403(fgf2) 107700884

SGH:	107559624(fgf1) 107568661

CCAR:

109065695

CAUA:

113058100 113114424 113114425

CGIB:

127971710 128027403

PTET:

122333592(fgf2)

LROH:

127176164(fgf2)

OMC:	131553310(fgf2)

PPRM:

120465410(fgf2)

RKG:	130075364(fgf2)

MAMB:

125267517(fgf2)

CIDE:

127494051

MASI:

127412776 127418115

TROS:

130545075(fgf2)

TDW:	130437687(fgf2)

MANU:

129421766(fgf2)

IPU:

108258196

IFU:	128623094(fgf2)

PHYP:

113528646

SMEO:

124396724(fgf2)

TFD:	113659263(fgf2)

TVC:	132861733(fgf2)

TRN:	134336086(fgf2)

AMEX:

103037892(fgf2)

CMAO:

118821109(fgf2)

EEE:	113589363(fgf2)

CHAR:

105901770(fgf2)

TRU:	101071373 115252306

TFS:	130530886(fgf2)

TNG:	GSTEN00024480G001

LCO:	104931006(fgf2)

NCC:	104957748(fgf2)

TBEN:

117485247(fgf2)

CGOB:

115014705(fgf2)

PGEO:

117453594(fgf2)

GACU:

117535102(fgf2)

EMAC:

134859725(fgf2)

ELY:	117260751(fgf2)

EFO:	125894199(fgf2)

PLEP:

121947824(fgf2)

SLUC:

116062503(fgf2)

ECRA:

117951309(fgf2)

ESP:	116696412(fgf2)

PFLV:

114563146(fgf2)

GAT:	120817426(fgf2)

PPUG:

119210066(fgf2)

AFB:	129090393(fgf2)

CLUM:

117737301(fgf2)

PSWI:

130209937(fgf2)

MSAM:

119889114(fgf2)

SCHU:

122879892(fgf2)

CUD:	121516087(fgf2)

ALAT:

119007245(fgf2)

MZE:	101483487(fgf2)

ONL:	100696875(fgf2)

OAU:	116322839(fgf2)

OML:	112151220(fgf2)

CSAI:

133447443(fgf2)

XMA:	102225642(fgf2)

XCO:	114139089(fgf2)

XHE:	116714813(fgf2)

PRET:

103471877(fgf2)

PFOR:

103137295(fgf2)

PLAI:

106948218(fgf2)

PMEI:

106924838(fgf2)

GAF:	122836704(fgf2)

PPRL:

129360495 129360508

CVG:	107099215(fgf2)

CTUL:

119798711(fgf2)

GMU:	124859969(fgf2)

NFU:	107380334(fgf2)

KMR:	108236605(fgf2)

NWH:	119408776(fgf2)

AOCE:

111570066(fgf2)

MCEP:

125008184(fgf2)

CSEM:

103390695(fgf2)

POV:	109641290(fgf2)

SSEN:

122778971(fgf2)

HHIP:

117769009(fgf2)

HSP:	118112066(fgf2)

PPLT:

128445840(fgf2)

SMAU:

118319853(fgf2)

LCF:

108901525

SDU:	111232376(fgf2)

SLAL:

111644654(fgf2)

XGL:	120785334(fgf2)

HCQ:	109529054(fgf2)

SSCV:

125986786

SBIA:

133508314(fgf2)

PEE:	133408191(fgf2)

PTAO:

133484625(fgf2)

BPEC:

110153728(fgf2)

MALB:

109956730(fgf2)

BSPL:

114864904(fgf2)

SJO:	128362565(fgf2)

SASA:

106604591 106611625(fgf2)

STRU:

115171295 115205150(fgf2)

OTW:	112244661 112256299(fgf2)

OMY:	100136280 110505088(fgf2)

OGO:	123993474 124010408

ONE:	115129521 115130781

OKI:	109864944 109905247(fgf2)

OKE:	118363560(fgf2) 118378991

SALP:

111965796 111967553(fgf2)

SNH:	120048001 120062265

CCLU:

121534224(fgf2) 121541760

ELS:	105028130(fgf2)

SFM:	108938772(fgf2)

PKI:	111832812 111835519(fgf2)

AANG:

118226718 118231483(fgf2)

LOC:	102692334(fgf2)

PSPA:

121323680(fgf2) 121328899

ARUT:

117409611 117421144

PSEX:

120527622(fgf2)

LCM:	102351407(FGF2)

CMK:	103188323(fgf2)

CPLA:

122539338(fgf2)

HOC:	132833422(fgf2)

LERI:

129704302(fgf2)

APLC:

OTU:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

HMG:

Reference

PMID:3780670

Authors

Abraham JA, Whang JL, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC

Title

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

Journal

EMBO J 5:2523-8 (1986)
DOI:10.1002/j.1460-2075.1986.tb04530.x

Sequence

[hsa:2247]

Reference

PMID:10716624

Authors

Okada-Ban M, Thiery JP, Jouanneau J

Title

Fibroblast growth factor-2.

Journal

Int J Biochem Cell Biol 32:263-7 (2000)
DOI:10.1016/S1357-2725(99)00133-8

Sequence

[hsa:2247]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (30)   
   KEGG PATHWAY (30)   
Gene (522)   
   KEGG GENES (389)   
   KEGG MGENES (97)   
   RefGene (33)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (558)   

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